Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: Updates from the WHO Classification of Tumours of the Breast 2012

Journal of Clinical Pathology

Volumn 66, Issue 6, 2013, Pages 465-470

  Tan, Puay Hoon ^a   Ellis, Ian O ^b  

^a SINGAPORE GENERAL HOSPITAL   (Singapore)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOMYOEPITHELIOMA; BREAST FIBROADENOMA; BREAST LESION; CELL DIFFERENTIATION; CYSTOSARCOMA PHYLLOIDES; FASCIITIS; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; MEDICAL TERMINOLOGY; MYOEPITHELIOMA; MYOEPITHELIUM CELL; PLEOMORPHIC ADENOMA; PRIORITY JOURNAL; REVIEW; TUMOR CLASSIFICATION; TUMOR RECURRENCE; VASCULAR LESION; WORLD HEALTH ORGANIZATION;

BREAST; BREAST CANCER; BREAST PATHOLOGY;

ADENOMYOEPITHELIOMA; BREAST NEOPLASMS; FASCIITIS; FEMALE; FIBROADENOMA; HUMANS; MYOEPITHELIOMA; NEOPLASMS, GLANDULAR AND EPITHELIAL; PHYLLODES TUMOR; WORLD HEALTH ORGANIZATION;

EID: 84878280871     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jclinpath-2012-201078     Document Type: Review

References (74)

1. Tavassoli FA, Devilee P. Pathology & genetics. Tumours of the breast and female genital organs. Lyon, France: IARC, 2003.
2. Lakhani SR, Ellis IO, Schnitt SJ, et al. WHO classification of tumours of the breast. Lyon: IARC, 2012.
3. Tavassoli FA. Myoepithelial lesions of the breast. Myoepitheliosis, adenomyoepithelioma, and myoepithelial carcinoma. Am J Surg Pathol 1991;15:554-68.
4. Hayes MM. Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation. J Clin Pathol 2011;64:477-84.
5. Wells CA, Wells CW, Yeomans P, et al. Spherical connective tissue inclusions in epithelial hyperplasia of the breast ("collagenous spherulosis"). J Clin Pathol 1990;43:905-8. (Pubitemid 20359870)
6. Resetkova E, Albarracin C, Sneige N. Collagenous spherulosis of breast: morphologic study of 59 cases and review of the literature. Am J Surg Pathol 2006;30:20-7. (Pubitemid 43740205)
7. Reis-Filho JS, Fulford LG, Crebassa B, et al . Collagenous spherulosis in an adenomyoepithelioma of the breast. J Clin Pathol 2004;57:83-6. (Pubitemid 38091319)
8. Rabban JT, Swain RS, Zaloudek CJ, et al. Immunophenotypic overlap between adenoid cystic carcinoma and collagenous spherulosis of the breast: potential diagnostic pitfalls using myoepithelial markers. Mod Pathol 2006;19:1351-7. (Pubitemid 44423083)
9. Ogata K, Sakamoto G, Sakurai T. Adenoid cystic carcinoma with collagenous spherulosis-like structures in the breast: report of a case. Pathol Int 2004;54:332-6. (Pubitemid 38716494)
10. Mooney EE, Kayani N, Tavassoli FA. Spherulosis of the breast. A spectrum of municous and collagenous lesions. Arch Pathol Lab Med 1999;123:626-30. (Pubitemid 29307672)
11. Guarino M, Tricomi P, Cristofori E. Collagenous spherulosis of the breast with atypical epithelial hyperplasia. Pathologica 1993;85:123-7.
12. Grignon DJ, Ro JY, Mackay BN, et al. Collagenous spherulosis of the breast. Immunohistochemical and ultrastructural studies. Am J Clin Pathol 1989;91:386-92. (Pubitemid 19097063)
13. Clement PB, Young RH, Azzopardi JG. Collagenous spherulosis of the breast. Am J Surg Pathol 1987;11:411-17. (Pubitemid 17085826)
14. Schurch W, Potvin C, Seemayer TA. Malignant myoepithelioma (myoepithelial carcinoma) of the breast: an ultrastructural and immunocytochemical study. Ultrastruct Pathol 1985;8:1-11. (Pubitemid 16255805)
15. Lakhani SR, O'Hare MJ, Monaghan P, et al. Malignant myoepithelioma (myoepithelial carcinoma) of the breast: a detailed cytokeratin study. J Clin Pathol 1995;48:164-7.
16. Chen PC, Chen CK, Nicastri AD, et al. Myoepithelial carcinoma of the breast with distant metastasis and accompanied by adenomyoepitheliomas. Histopathology 1994;24:543-8. (Pubitemid 24199257)
17. Coyne JD, Dervan PA, Barr L. High-grade carcinomas of the breast showing patterns of mixed ductal and myoepithelial differentiation (including myoepithelial cell-rich carcinoma of the breast). Histopathology 2004;44:580-4. (Pubitemid 38845104)
18. Buza N, Zekry N, Charpin C, et al. Myoepithelial carcinoma of the breast: a clinicopathological and immunohistochemical study of 15 diagnostically challenging cases. Virchows Arch 2010;457:337-45.
19. Jones C, Nonni AV, Fulford L, et al. CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation. Br J Cancer 2001;85:422-7. (Pubitemid 32747712)
20. Behranwala KA, Nasiri N, A'Hern R, et al. Clinical presentation and long-term outcome of pure myoepithelial carcinoma of the breast. Eur J Surg Oncol 2004;30:357-61. (Pubitemid 38528918)
21. Yigit S, Pehlivan FS, Evcim G, et al. Clinicopathologic features of the mixed epithelial and mesenchymal type metaplastic breast carcinoma with myoepithelial differentiation in a subset of six cases. Pathol Res Pract 2012;208:147-50.
22. Han B, Mori I, Nakamura M, et al. Myoepithelial carcinoma arising in an adenomyoepithelioma of the breast: case report with immunohistochemical and mutational analysis. Pathol Int 2006;56:211-16.
23. Diaz NM, McDivitt RW, Wick MR. Pleomorphic adenoma of the breast: a clinicopathologic and immunohistochemical study of 10 cases. Hum Pathol 1991;22:1206-14.
24. Ballance WA, Ro JY, el-Naggar AK, et al. Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature. Am J Clin Pathol 1990;93:795-801. (Pubitemid 20180942)
25. Rosen PP. Adenomyoepithelioma of the breast. Hum Pathol 1987;18:1232-7. (Pubitemid 18018952)
26. Young RH, Clement PB. Adenomyoepithelioma of the breast. A report of three cases and review of the literature. Am J Clin Pathol 1988;89:308-14. (Pubitemid 18081230)
27. Jabi M, Dardick I, Cardigos N. Adenomyoepithelioma of the breast. Arch Pathol Lab Med 1988;112:73-6. (Pubitemid 18025598)
28. McLaren BK, Smith J, Schuyler PA, et al. Adenomyoepithelioma: clinical, histologic, and immunohistologic evaluation of a series of related lesions. Am J Surg Pathol 2005;29:1294-9. (Pubitemid 41368763)
29. Cai RZ, Tan PH. Adenomyoepithelioma of the breast with squamous and sebaceous metaplasia. Pathology 2005;37:557-9. (Pubitemid 43030879)
30. Loh HL, Kumarasinghe P, Tan PH. Test and Teach. Recurrent breast lumps in a Chinese woman. Adenomyoepithelioma of the breast. Pathology 2004;36:269-72. (Pubitemid 38748089)
31. Jones C, Tooze R, Lakhani SR. Malignant adenomyoepithelioma of the breast metastasizing to the liver. Virchows Arch 2003;442:504-6. (Pubitemid 36718320)
32. Ahmed AA, Heller DS. Malignant adenomyoepithelioma of the breast with malignant proliferation of epithelial and myoepithelial elements: a case report and review of the literature. Arch Pathol Lab Med 2000;124:632-6. (Pubitemid 30211002)
33. Simpson RH, Cope N, Skalova A, et al. Malignant adenomyoepithelioma of the breast with mixed osteogenic, spindle cell, and carcinomatous differentiation. Am J Surg Pathol 1998;22:631-6. (Pubitemid 28213751)
34. Rasbridge SA, Millis RR. Adenomyoepithelioma of the breast with malignant features. Virchows Arch 1998;432:123-30. (Pubitemid 28072603)
35. Michal M, Baumruk L, Burger J, et al. Adenomyoepithelioma of the breast with undifferentiated carcinoma component. Histopathology 1994;24:274-6. (Pubitemid 24192304)
36. Trojani M, Guiu M, Trouette H, et al . Malignant adenomyoepithelioma of the breast. An immunohistochemical, cytophotometric, and ultrastructural study of a case with lung metastases. Am J Clin Pathol 1992;98:598-602.
37. Loose JH, Patchefsky AS, Hollander IJ, et al. Adenomyoepithelioma of the breast. A spectrum of biologic behavior. Am J Surg Pathol 1992;16:868-76.
38. Vranic S, Bender R, Palazzo J, et al. A review of adenoid cystic carcinoma of the breast with emphasis on its molecular and genetic characteristics. Hum Pathol 2013;44:301-9.
39. Trendell-Smith NJ, Peston D, Shousha S. Adenoid cystic carcinoma of the breast: a tumour commonly devoid of oestrogen receptors and related proteins. Histopathology 1999;35:241-8. (Pubitemid 29468958)
40. Soon SR, Yong WS, Ho GH, et al. Adenoid cystic breast carcinoma: a salivary gland-type tumour with excellent prognosis and implications for management. Pathology 2008;40:413-15. (Pubitemid 351630892)
41. Rosen PP. Adenoid cystic carcinoma of the breast. A morphologically heterogeneous neoplasm. Pathol Annu 1989;(24 Pt 2):237-54.
42. Page DL. Adenoid cystic carcinoma of breast, a special histopathologic type with excellent prognosis. Breast Cancer Res Treat 2005;93:189-90. (Pubitemid 41441287)
43. Mastropasqua MG, Maiorano E, Pruneri G, et al. Immunoreactivity for c-kit and p63 as an adjunct in the diagnosis of adenoid cystic carcinoma of the breast. Mod Pathol 2005;18:1277-82. (Pubitemid 41348645)
44. Kasami M, Olson SJ, Simpson JF, et al. Maintenance of polarity and a dual cell population in adenoid cystic carcinoma of the breast: an immunohistochemical study. Histopathology 1998;32:232-8. (Pubitemid 28140945)
45. Gillett CE, Bobrow LG, Millis RR. S100 protein in human mammary tissue - immunoreactivity in breast carcinoma, including Paget 's disease of the nipple, and value as a marker of myoepithelial cells. J Pathol 1990;160:19-24. (Pubitemid 20040645)
46. Joshi MG, Lee AK, Pedersen CA, et al. The role of immunocytochemical markers in the differential diagnosis of proliferative and neoplastic lesions of the breast. Mod Pathol 1996;9:57-62. (Pubitemid 26061128)
47. Tramm T, Kim JY, Tavassoli FA. Diminished number or complete loss of myoepithelial cells associated with metaplastic and neoplastic apocrine lesions of the breast. Am J Surg Pathol 2011;35:202-11.
48. Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations in myoepithelial cells associated with benign sclerosing lesions of the breast. Am J Surg Pathol 2010;34:896-900.
49. Hilson JB, Schnitt SJ, Collins LC. Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: biologic and diagnostic implications. Am J Surg Pathol 2009;33:227-32.
50. Dewar R, Fadare O, Gilmore H, et al. Best practices in diagnostic immunohistochemistry: myoepithelial markers in breast pathology. Arch Pathol Lab Med 2011;135:422-9.
51. Moriya T, Kozuka Y, Kanomata N, et al . The role of immunohistochemistry in the differential diagnosis of breast lesions. Pathology 2009;41:68-76.
52. Tan PH, Aw MY, Yip G, et al. Cytokeratins in papillary lesions of the breast: is there a role in distinguishing intraductal papilloma from papillary ductal carcinoma in situ? Am J Surg Pathol 2005;29:625-32. (Pubitemid 40577872)
53. Carter MR, Hornick JL, Lester S, et al. Spindle cell (sarcomatoid) carcinoma of the breast: a clinicopathologic and immunohistochemical analysis of 29 cases. Am J Surg Pathol 2006;30:300-9. (Pubitemid 43740161)
54. Dunne B, Lee AH, Pinder SE, et al. An immunohistochemical study of metaplastic spindle cell carcinoma, phyllodes tumor and fibromatosis of the breast. Hum Pathol 2003;34:1009-15. (Pubitemid 37315252)
55. Dahlstrom J, Buckingham J, Bell S, et al. Nodular fasciitis of the breast simulating breast cancer on imaging. Australas Radiol 2001;45:67-70. (Pubitemid 32239057)
56. Birdsall SH, Shipley JM, Summersgill BM, et al. Cytogenetic findings in a case of nodular fasciitis of the breast. Cancer Genet Cytogenet 1995;81:166-8.
57. Koizumi H, Mikami M, Doi M, et al . Clonality analysis of nodular fasciitis by HUMARA-methylation-specific PCR. Histopathology 2005;47:320-1. (Pubitemid 41243270)
58. Erickson-Johnson MR, Chou MM, Evers BR, et al. Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion. Lab Invest 2011;91:1427-33.
59. Hartel PH, Bratthauer G, Hartel JV, et al. Primary malignant fibrous histiocytoma (myxofibrosarcoma/pleomorphic sarcoma not otherwise specified) of the breast: clinicopathologic study of 19 cases. Ann Diagn Pathol 2011;15:407-13.
60. Mandrell J, Mehta S, McClure S. Atypical vascular lesion of the breast. J Am Acad Dermatol 2010;63:337-40.
61. Lucas DR. Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion. Arch Pathol Lab Med 2009;133:1804-9.
62. Brodie C, Provenzano E. Vascular proliferations of the breast. Histopathology 2008;52:30-44. (Pubitemid 350265182)
63. Patton KT, Deyrup AT, Weiss SW. Atypical vascular lesions after surgery and radiation of the breast: a clinicopathologic study of 32 cases analyzing histologic heterogeneity and association with angiosarcoma. Am J Surg Pathol 2008;32:943-50.
64. Tavassoli FA, Weiss S. Hemangiopericytoma of the breast. Am J Surg Pathol 1981;5:745-52. (Pubitemid 12170329)
65. Magro G, Fraggetta F, Torrisi A, et al. Myofibroblastoma of the breast with hemangiopericytoma-like pattern and pleomorphic lipoma-like areas. Report of a case with diagnostic and histogenetic considerations. Pathol Res Pract 1999;195:257-62. (Pubitemid 29197093)
66. Nascimento AF, Raut CP, Fletcher CD. Primary angiosarcoma of the breast: clinicopathologic analysis of 49 cases, suggesting that grade is not prognostic. Am J Surg Pathol 2008;32:1896-904.
67. Tan PH, Thike AA, Tan WJ, et al. Predicting clinical behaviour of breast phyllodes tumours: a nomogram based on histological criteria and surgical margins. J Clin Pathol 2012;65:69-76.
68. Giri D. Recurrent challenges in the evaluation of fibroepithelial lesions. Arch Pathol Lab Med 2009;133:713-21.
69. Tan PH, Jayabaskar T, Chuah KL, et al . Phyllodes tumors of the breast: the role of pathologic parameters. Am J Clin Pathol 2005;123:529-40. (Pubitemid 40418548)
70. Grady I, Gorsuch H, Wilburn-Bailey S. Long-term outcome of benign fibroadenomas treated by ultrasound-guided percutaneous excision. Breast J 2008;14:275-8. (Pubitemid 351678060)
71. Nigro DM, Organ CH Jr. Fibroadenoma of the female breast. Some epidemiologic surprises. Postgrad Med 1976;59:113-17.
72. Organ CH Jr, Organ BC. Fibroadenoma of the female breast: a critical clinical assessment. J Natl Med Assoc 1983;75:701-4.
73. Barth RJ Jr. Histologic features predict local recurrence after breast conserving therapy of phyllodes tumors. Breast Cancer Res Treat 1999;57:291-5.
74. Jones AM, Mitter R, Springall R, et al. A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence. J Pathol 2008;214:533-44. (Pubitemid 351482269)