Examination of blood-brain barrier (BBB) integrity in a mouse brain tumor model

Journal of Neuro-Oncology

Volumn 111, Issue 2, 2013, Pages 133-143

  On, Ngoc H ^a   Mitchell, Ryan ^a   Savant, Sanjot D ^b   Bachmeier, Corbin J ^b   Hatch, Grant M ^a   Miller, Donald W ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Blood Brain Barrier (BBB); Brain Tumor; Lewis Lung Carcinoma (3LL); Magnetic resonance imaging (MRI); P glycoprotein; Permeability

Indexed keywords

GADOLINIUM PENTETATE; MANNITOL; MULTIDRUG RESISTANCE PROTEIN; DIAGNOSTIC AGENT; PENTETIC ACID; TRITIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BLOOD VESSEL PARAMETERS; BLOOD VESSEL PERMEABILITY; BODY POSTURE; BRAIN BLOOD VESSEL; BRAIN TUMOR; CANCER GROWTH; CANCER STAGING; CAPILLARY DEPLETION; CAPILLARY ENDOTHELIAL CELL; CAPILLARY PELLET; CEREBRAL VASCULAR PERMEABILITY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMALE; HEMISPHERE; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PROTEIN TRANSPORT; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SURVIVAL TIME; TUMOR VOLUME; WEIGHT REDUCTION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; BLOOD EYE BARRIER; BRAIN; CANCER TRANSPLANTATION; CAPILLARY PERMEABILITY; DISEASE MODEL; HEMISPHERIC DOMINANCE; LEWIS CARCINOMA; METABOLISM; METASTASIS; MORTALITY; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TIME;

ANIMALS; BLOOD-AQUEOUS BARRIER; BRAIN; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CARCINOMA, LEWIS LUNG; DISEASE MODELS, ANIMAL; FEMALE; FUNCTIONAL LATERALITY; MAGNETIC RESONANCE IMAGING; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; P-GLYCOPROTEIN; PENTETIC ACID; TIME FACTORS; TRITIUM;

MLCS; MLOWN;

EID: 84878280513     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-012-1006-1     Document Type: Article

References (43)

1. Chan AW, Loeffler JS (2001) Controversies in the management of patients with brain metastases. Cancer J 7(2):105-107
2. Wong ET, Berkenblit A (2004) The role of topotecan in the treatment of brain metastases. Oncologist 9(1):68-79
3. Cohen MH, Matthews MJ (1978) Small cell bronchogenic carcinoma: a distinct clinicopathologic entity. Semin Oncol 5(3):234-243
4. Bart J, Groen HJ, Hendrikse NH, van der Graaf WT, Vaalburg W, de Vries EG (2000) The blood-brain barrier and oncology: new insights into function and modulation. Cancer Treat Rev 26(6):449-462
5. Goldstein GW, Betz AL (1986) The blood-brain barrier. Sci Am 255(3):74-83
6. Loscher W, Potschka H (2005) Blood-brain barrier active efflux transporters: ATP-binding cassette gene family. NeuroRx 2(1):86-98
7. Loscher W, Potschka H (2005) Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases. Prog Neurobiol 76(1):22-76
8. Wiranowska M, Gonzalvo AA, Saporta S, Gonzalez OR, Prockop LD (1992) Evaluation of blood-brain barrier permeability and the effect of interferon in mouse glioma model. J Neurooncol 14(3):225-236
9. Fidler IJ, Yano S, Zhang RD, Fujimaki T, Bucana CD (2002) The seed and soil hypothesis: vascularisation and brain metastases. Lancet Oncol 3(1):53-57
10. Benarroch EE (2011) Circumventricular organs: receptive and homeostatic functions and clinical implications. Neurology 77(12):1198-1204
11. Triguero D, Buciak J, Pardridge WM (1990) Capillary depletion method for quantification of blood-brain barrier transport of circulating peptides and plasma proteins. J Neurochem 54(6):1882-1888
12. Nayak L, Lee EQ, Wen PY (2012) Epidemiology of brain metastases. Curr Oncol Rep 14(1):48-54
13. Giglio P, Gilbert MR (2010) Neurologic complications of cancer and its treatment. Curr Oncol Rep 12(1):50-59
14. Kamar FG, Posner JB (2010) Brain metastases. Semin Neurol 30(3):217-235
15. Schuette W (2004) Treatment of brain metastases from lung cancer: chemotherapy. Lung Cancer 45(Suppl 2):S253-S257
16. Taimur S, Edelman MJ (2003) Treatment options for brain metastases in patients with non-small-cell lung cancer. Curr Oncol Rep 5(4):342-346
17. Wowra B, Muacevic A, Tonn JC (2012) CyberKnife radiosurgery for brain metastases. Prog Neurol Surg 25:201-209
18. Kawabe T, Phi JH, Yamamoto M, Kim DG, Barfod BE, Urakawa Y (2012) Treatment of brain metastasis from lung cancer. Prog Neurol Surg 25:148-155
19. Nieder C, Grosu AL, Spanne O, Andratschke NH, Geinitz H (2012) Brain metastases in patients under 50 years of age: retrospective analysis. Clin Exp Metastasis. doi: 10.1007/s10585-012-9484-2
20. Kim KH, Lee J, Lee JI, Nam do H, Kong DS, Ahn YC et al (2010) Can upfront systemic chemotherapy replace stereotactic radiosurgery or whole brain radiotherapy in the treatment of non-small cell lung cancer patients with asymptomatic brain metastases? Lung Cancer 68(2):258-263
21. Vogelbaum MA, Masaryk T, Mazzone P, Mekhail T, Fazio V, McCartney S et al (2005) S100beta as a predictor of brain metastases: brain versus cerebrovascular damage. Cancer 104(4):817-824
22. Stewart PA, Hayakawa K, Farrell CL, Del Maestro RF (1987) Quantitative study of microvessel ultrastructure in human peritumoral brain tissue. Evidence for a blood-brain barrier defect. J Neurosurg 67(5):697-705
23. Regina A, Demeule M, Laplante A, Jodoin J, Dagenais C, Berthelet F et al (2001) Multidrug resistance in brain tumors: roles of the blood-brain barrier. Cancer Metastasis Rev 20(1-2):13-25
24. Weiss L (1980) Metastasis: differences between cancer cells in primary and secondary tumors. Pathobiol Annu 10:51-81
25. Wolff JE, Trilling T, Molenkamp G, Egeler RM, Jurgens H (1999) Chemosensitivity of glioma cells in vitro: a meta analysis. J Cancer Res Clin Oncol 125(8-9):481-486
26. Talmadge JE, Fidler IJ (1982) Enhanced metastatic potential of tumor cells harvested from spontaneous metastases of heterogeneous murine tumors. J Natl Cancer Inst 69(4):975-980
27. Isakov N, Feldman M, Segal S (1982) An immune response against the alloantigens of the 3LL Lewis lung carcinoma prevents the growth of lung metastases, but not of local allografts. Invasion Metastasis 2(1):12-32
28. Conley FK (1979) Development of a metastatic brain tumor model in mice. Cancer Res 39(3):1001-1007
29. Zhang Z, Hatori T, Nonaka H (2008) An experimental model of brain metastasis of lung carcinoma. Neuropathology 28(1):24-28
30. Taskar KS, Rudraraju V, Mittapalli RK, Samala R, Thorsheim HR, Lockman J et al (2012) Lapatinib distribution in HER2 overexpressing experimental brain metastases of breast cancer. Pharm Res 29(3):770-781
31. Fathallah-Shaykh HM, Zhao LJ, Kafrouni AI, Smith GM, Forman J (2000) Gene transfer of IFN-gamma into established brain tumors represses growth by antiangiogenesis. J Immunol 164(1):217-222
32. Zhang RD, Price JE, Fujimaki T, Bucana CD, Fidler IJ (1992) Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice. Am J Pathol 141(5):1115-1124
33. Cranmer LD, Trevor KT, Bandlamuri S, Hersh EM (2005) Rodent models of brain metastasis in melanoma. Melanoma Res 15(5):325-356
34. Essig M, Weber MA, von Tengg-Kobligk H, Knopp MV, Yuh WT, Giesel FL (2006) Contrast-enhanced magnetic resonance imaging of central nervous system tumors: agents, mechanisms, and applications. Top Magn Reson Imaging 17(2):89-106
35. Rice A, Michaelis ML, Georg G, Liu Y, Turunen B, Audus KL (2003) Overcoming the blood-brain barrier to taxane delivery for neurodegenerative diseases and brain tumors. J Mol Neurosci 20(3):339-343
36. Bachmeier CJ, Spitzenberger TJ, Elmquist WF, Miller DW (2005) Quantitative assessment of HIV-1 protease inhibitor interactions with drug efflux transporters in the blood-brain barrier. Pharm Res 22(8):1259-1268
37. Fellner S, Bauer B, Miller DS, Schaffrik M, Fankhanel M, Spruss T et al (2002) Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. J Clin Invest 110(9):1309-1318
38. Henson JW, Cordon-Cardo C, Posner JB (1992) P-glycoprotein expression in brain tumors. J Neurooncol 14(1):37-43
39. Sakata S, Fujiwara M, Ohtsuka K, Kamma H, Nagane M, Sakamoto A et al (2011) ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells. Oncol Rep 25(2):333-339
40. Ginguene C, Champier J, Maallem S, Strazielle N, Jouvet A, Fevre-Montange M et al (2010) P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) localize in the microvessels forming the blood-tumor barrier in ependymomas. Brain Pathol 20(5):926-935
41. Hall WA, Doolittle ND, Daman M, Bruns PK, Muldoon L, Fortin D et al (2006) Osmotic blood-brain barrier disruption chemotherapy for diffuse pontine gliomas. J Neurooncol 77(3):279-284
42. Meairs S, Alonso A (2007) Ultrasound, microbubbles and the blood-brain barrier. Prog Biophys Mol Biol 93(1-3):354-362
43. Sato S, Kawase T, Harada S, Takayama H, Suga S (1998) Effect of hyperosmotic solutions on human brain tumour vasculature. Acta Neurochir (Wien) 140(11):1135-1141; discussion 1141-1142