Lack of association between residual insulin production and glucagon response to hypoglycemia in youth with short duration of type 1 diabetes

Diabetes Care

Volumn 36, Issue 6, 2013, Pages 1470-1476

  Sherr, Jennifer ^a   Xing, Dongyuan ^b   Ruedy, Katrina J ^b   Beck, Roy W ^b   Kollman, Craig ^b   Buckingham, Bruce ^c   White, Neil H ^d   Fox, Larry ^e   Tsalikian, E V A ^f   Weinzimer, Stuart ^a   Arbelaez, Ana Maria ^d   Tamborlane, William V ^a  

^a YALE UNIVERSITY   (United States)

^b JAEB CENTER FOR HEALTH RESEARCH   (United States)

^c STANFORD UNIVERSITY   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NEMOURS CHILDREN S CLINIC   (United States)

^f UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCAGON; INSULIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CORRELATION ANALYSIS; DIAGNOSTIC TEST; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HORMONE ACTION; HUMAN; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SYNTHESIS; MALE; MIXED MEAL TOLERANCE TEST; PANCREAS ISLET BETA CELL; SCHOOL CHILD;

ADOLESCENT; CHILD; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCAGON; HUMANS; HYPOGLYCEMIA; INSULIN; MALE; YOUNG ADULT;

EID: 84878264637     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc12-1697     Document Type: Article

References (30)

1. Cryer PE. Minireview: Glucagon in the pathogenesis of hypoglycemia and hyperglycemia in diabetes. Endocrinology 2012;153:1039-1048
2. White NH, Skor DA, Cryer PE, Levandoski LA, Bier DM, Santiago JV. Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 1983;308:485-491 (Pubitemid 13195475)
3. Santiago JV, White NH, Skor DA, Levandoski LA, Bier DM, Cryer PE. Defective glucose counterregulation limits intensive therapy of diabetes mellitus. Am J Physiol 1984;247:E215-E220 (Pubitemid 14064255)
4. Dagogo-Jack SE, Craft S, Cryer PE. Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia. J Clin Invest 1993;91:819-828 (Pubitemid 23095255)
5. Jones TW, Porter P, Sherwin RS, et al. Decreased epinephrine responses to hypoglycemia during sleep. N Engl J Med 1998;338:1657-1662 (Pubitemid 28267910)
6. Banarer S, Cryer PE. Sleep-related hypoglycemia-associated autonomic failure in type 1 diabetes: reduced awakening from sleep during hypoglycemia. Diabetes 2003;52:1195-1203 (Pubitemid 36523356)
7. Gerich JE, Langlois M, Noacco C, Karam JH, Forsham PH. Lack of glucagon response to hypoglycemia in diabetes: evidence for an intrinsic pancreatic alpha cell defect. Science 1973;182:171-173
8. Bolli G, de Feo P, Compagnucci P, et al. Abnormal glucose counterregulation in insulin-dependent diabetes mellitus. Interaction of anti-insulin antibodies and impaired glucagon and epinephrine secretion. Diabetes 1983;32:134-141 (Pubitemid 13180346)
9. Amiel SA, Tamborlane WV, Simonson DC, Sherwin RS. Defective glucose counterregulation after strict glycemic control of insulin-dependent diabetes mellitus. N Engl J Med 1987;316:1376-1383 (Pubitemid 17079681)
10. Amiel SA, Sherwin RS, Simonson DC, Tamborlane WV. Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 1988;37:901-907 (Pubitemid 19043718)
11. Singer-Granick C, Hoffman RP, Kerensky K, Drash AL, Becker DJ. Glucagon responses to hypoglycemia in children and adolescents with IDDM. Diabetes Care 1988;11:643-649
12. Tsalikian E, Tamborlane W, Xing D, et al.; Diabetes Research in Children Network (DirecNet) Study Group. Blunted counterregulatory hormone responses to hypoglycemia in young children and adolescents with well-controlled type 1 diabetes. Diabetes Care 2009;32:1954-1959
13. Hoffman RP, Arslanian S, Drash AL, Becker DJ. Impaired counterregulatory hormone responses to hypoglycemia in children and adolescents with new onset IDDM. J Pediatr Endocrinol Metab 1994;7:235-244 (Pubitemid 24288942)
14. Siafarikas A, Johnston RJ, Bulsara MK, O'Leary P, Jones TW, Davis EA. Early loss of the glucagon response to hypoglycemia in adolescents with type 1 diabetes. Diabetes Care 2012;35:1757-1762
15. Pörksen S, Nielsen LB, Kaas A, et al.; Hvidøre Study Group on Childhood Diabetes. Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes. J Clin Endocrinol Metab 2007;92:2910-2916 (Pubitemid 47236349)
16. Brown RJ, Sinaii N, Rother KI. Too much glucagon, too little insulin: time course of pancreatic islet dysfunction in new-onset type 1 diabetes. Diabetes Care 2008;31:1403-1404
17. Cooperberg BA, Cryer PE. β-Cell-mediated signaling predominates over direct α-cell signaling in the regulation of glucagon secretion in humans. Diabetes Care 2009;32:2275-2280
18. Gromada J, Franklin I, Wollheim CB. α-Cells of the endocrine pancreas: 35 years of research but the enigma remains. Endocr Rev 2007;28:84-116 (Pubitemid 46220851)
19. Peacey SR, Rostami-Hodjegan A, George E, Tucker GT, Heller SR. The use of tolbutamide-induced hypoglycemia to examine the intraislet role of insulin in mediating glucagon release in normal humans. J Clin Endocrinol Metab 1997;82:1458-1461 (Pubitemid 27200418)
20. Banarer S, McGregor VP, Cryer PE. Intraislet hyperinsulinemia prevents the glucagon response to hypoglycemia despite an intact autonomic response. Diabetes 2002;51:958-965 (Pubitemid 34438337)
21. Østergård T, Degn KB, Gall MA, et al. The insulin secretagogues glibenclamide and repaglinide do not influence growth hormone secretion in humans but stimulate glucagon secretion during profound insulin deficiency. J Clin Endocrinol Metab 2004;89:297-302 (Pubitemid 38183896)
22. Gosmanov NR, Szoke E, Israelian Z, et al. Role of the decrement in intraislet insulin for the glucagon response to hypoglycemia in humans. Diabetes Care 2005;28:1124-1131 (Pubitemid 40616623)
23. Israelian Z, Gosmanov NR, Szoke E, et al. Increasing the decrement in insulin secretion improves glucagon responses to hypoglycemia in advanced type 2 diabetes. Diabetes Care 2005;28:2691-2696 (Pubitemid 43951161)
24. Raju B, Cryer PE. Loss of the decrement in intaislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans. Diabetes 2005;54:757-764 (Pubitemid 40322079)
25. Gibb I, Parnham A, Fonfrède M, Lecock F. Multicenter evaluation of Tosoh glycohemoglobin analyzer. Clin Chem 1999;45:1833-1841 (Pubitemid 29477343)
26. The Diabetes Control and Complications Trial Research Group. The effect of intensive diabetes treatment in the DCCT on residual insulin secretion in IDDM. Ann Intern Med 1998;28:517-523
27. Sherr J, Tamborlane WV, Xing D, et al.; Diabetes Research in Children Network (DirecNet) Study Group. Achievement of target A1C levels with negligible hypoglycemia and low glucose variability in youth with short-term type 1 diabetes and residual β-cell function. Diabetes Care 2012;35:817-820
28. Arbelaez AM, Tsalikian E, Mauras N, et al. Counterregulatory hormone responses in youth with short duration of type 1 diabetes (Abstract). Diabetes 2012;61 (Suppl. 1):A320
29. Page KA, Arora J, Qiu M, Relwani R, Constable RT, Sherwin RS. Small decrements in systemic glucose provoke increases in hypothalamic blood flow prior to the release of counterregulatory hormones. Diabetes 2009;58:448-452
30. Palmer J, Fleming G, Greenbaum C, et al. C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 2004;53:250-264 (Pubitemid 38044724)