Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation

Drug Metabolism and Disposition

Volumn 41, Issue 6, 2013, Pages 1220-1230

  Higuchi, Ryota ^a   Fukami, Tatsuki ^a   Nakajima, Miki ^a   Yokoi, Tsuyoshi ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLANILINE; 2,6 DIMETHYLANILINE; 4 HYDROXY 2,6 XYLIDINE; 4 HYDROXY O TOLUIDINE; 6 HYDROXY O TOLUIDINE; ARYLACETAMIDE DEACYTELASE; BIS(4 NITROPHENYL) PHOSPHATE; CARBOXYLESTERASE; CHEMICAL COMPOUND; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DYFLOS; HYDROLASE; LIDOCAINE; PRILOCAINE; RECOMBINANT CARBOXYLESTERASE 1A; RECOMBINANT CARBOXYLESTERASE 2; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG HYDROXYLATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; LIVER MICROSOME; MALE; METHEMOGLOBINEMIA; MICHAELIS MENTEN KINETICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SPECIES DIFFERENCE;

ADULT; ANIMALS; CARBOXYLESTERASE; CYTOCHROME P-450 CYP2E1; CYTOCHROME P-450 CYP3A; DOWN-REGULATION; ENZYME ACTIVATION; HUMANS; LIDOCAINE; MALE; METHEMOGLOBINEMIA; MICE; MICE, INBRED C57BL; MICROSOMES, LIVER; PRILOCAINE; UP-REGULATION; YOUNG ADULT;

EID: 84878256661     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.051714     Document Type: Article

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