메뉴 건너뛰기




Volumn 44, Issue 6, 2013, Pages 1529-1536

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3

Author keywords

Insulin like peptide 7; Rat mouse relaxin 3; Relaxin 3; RXFP3; Solid phase peptide synthesis

Indexed keywords

G PROTEIN COUPLED RECEPTOR; RELAXIN 3; RELAXIN FAMILY PEPTIDE 3 RECEPTOR; UNCLASSIFIED DRUG; WATER;

EID: 84878254157     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-013-1478-0     Document Type: Article
Times cited : (14)

References (47)
  • 3
    • 33644589069 scopus 로고    scopus 로고
    • International Union of Pharmacology LVII: Recommendations for the nomenclature of receptors for relaxin family peptides
    • 16507880 10.1124/pr.58.1.9 1:CAS:528:DC%2BD28XjtlCqsL8%3D
    • Bathgate RAD, Ivell R, Sanborn BM, Sherwood OD, Summers RJ (2006a) International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides. Pharmacol Rev 58:7-31
    • (2006) Pharmacol Rev , vol.58 , pp. 7-31
    • Bathgate, R.A.D.1    Ivell, R.2    Sanborn, B.M.3    Sherwood, O.D.4    Summers, R.J.5
  • 6
    • 0036734781 scopus 로고    scopus 로고
    • Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain
    • 12354304 10.1046/j.1471-4159.2002.01114.x 1:CAS:528:DC%2BD38XnsV2hsLo%3D
    • Burazin TCD, Bathgate RAD, Macris M, Layfield S, Gundlach AL, Tregear GW (2002) Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain. J Neurochem 82:1553-1557
    • (2002) J Neurochem , vol.82 , pp. 1553-1557
    • Burazin, T.C.D.1    Bathgate, R.A.D.2    Macris, M.3    Layfield, S.4    Gundlach, A.L.5    Tregear, G.W.6
  • 7
    • 11244333436 scopus 로고    scopus 로고
    • Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species
    • 15367576 10.1124/jpet.104.073486 1:CAS:528:DC%2BD2MXhtVWmt7w%3D
    • Chen J, Kuei C, Sutton SW, Bonaventure P, Nepomuceno D, Eriste E, Sillard R, Lovenberg TW, Liu C (2005) Pharmacological characterization of relaxin-3/INSL7 receptors GPCR135 and GPCR142 from different mammalian species. J Pharmacol Exp Ther 312:83-95
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 83-95
    • Chen, J.1    Kuei, C.2    Sutton, S.W.3    Bonaventure, P.4    Nepomuceno, D.5    Eriste, E.6    Sillard, R.7    Lovenberg, T.W.8    Liu, C.9
  • 8
    • 84880226636 scopus 로고    scopus 로고
    • Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus
    • 10.1038/gt.2012.83 23135160
    • Ganella DE, Callander GE, Ma S, Bye CR, Gundlach AL, Bathgate RA (2012a) Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus. Gene Ther. doi: 10.1038/gt.2012.83
    • (2012) Gene Ther
    • Ganella, D.E.1    Callander, G.E.2    Ma, S.3    Bye, C.R.4    Gundlach, A.L.5    Bathgate, R.A.6
  • 9
    • 84864868683 scopus 로고    scopus 로고
    • Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: Functional and therapeutic implications
    • 22854307 10.1097/FBP.0b013e3283576999 1:CAS:528:DC%2BC38XhtFCmsr7M
    • Ganella DE, Ryan PJ, Bathgate RA, Gundlach AL (2012b) Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: functional and therapeutic implications. Behav Pharmacol 23:516-525
    • (2012) Behav Pharmacol , vol.23 , pp. 516-525
    • Ganella, D.E.1    Ryan, P.J.2    Bathgate, R.A.3    Gundlach, A.L.4
  • 13
    • 0003412980 scopus 로고
    • Experimental relaxation of the pubic ligament of the guinea pig
    • Hisaw F (1926) Experimental relaxation of the pubic ligament of the guinea pig. Proc Soc Exp Biol Med 23:661-663
    • (1926) Proc Soc Exp Biol Med , vol.23 , pp. 661-663
    • Hisaw, F.1
  • 14
    • 0035225475 scopus 로고    scopus 로고
    • Relaxin and drinking in pregnant rats
    • 11589133 10.1016/S0079-6123(01)33017-0 1:CAS:528:DC%2BD3MXns1yqsrY%3D
    • Hornsby DJ, Wilson BC, Summerlee AJ (2001) Relaxin and drinking in pregnant rats. Prog Brain Res 133:229-240
    • (2001) Prog Brain Res , vol.133 , pp. 229-240
    • Hornsby, D.J.1    Wilson, B.C.2    Summerlee, A.J.3
  • 15
    • 47749116027 scopus 로고    scopus 로고
    • The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors
    • 18434306 10.1074/jbc.M801911200 1:CAS:528:DC%2BD1cXntFSntb4%3D
    • Hossain MA, Rosengren KJ, Haugaard-Jonsson LM, Zhang S, Layfield S, Ferraro T, Daly NL, Tregear GW, Wade JD, Bathgate RA (2008) The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors. J Biol Chem 283:17287-17297
    • (2008) J Biol Chem , vol.283 , pp. 17287-17297
    • Hossain, M.A.1    Rosengren, K.J.2    Haugaard-Jonsson, L.M.3    Zhang, S.4    Layfield, S.5    Ferraro, T.6    Daly, N.L.7    Tregear, G.W.8    Wade, J.D.9    Bathgate, R.A.10
  • 16
    • 58149097764 scopus 로고    scopus 로고
    • The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5
    • 19152634 10.1111/j.1747-0285.2008.00756.x 1:CAS:528: DC%2BD1MXptFCnsg%3D%3D
    • Hossain MA, Bathgate RA, Rosengren KJ, Shabanpoor F, Zhang S, Lin F, Tregear GW, Wade JD (2009) The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5. Chem Biol Drug Des 73:46-52
    • (2009) Chem Biol Drug des , vol.73 , pp. 46-52
    • Hossain, M.A.1    Bathgate, R.A.2    Rosengren, K.J.3    Shabanpoor, F.4    Zhang, S.5    Lin, F.6    Tregear, G.W.7    Wade, J.D.8
  • 17
    • 80955127759 scopus 로고    scopus 로고
    • The chemically synthesized human relaxin-2 analog, B-R13/17 K H2, is an RXFP1 antagonist
    • 20043231 10.1007/s00726-009-0454-1 1:CAS:528:DC%2BC3cXotVaisrY%3D
    • Hossain MA, Samuel CS, Binder C, Hewitson TD, Tregear GW, Wade JD, Bathgate RA (2010) The chemically synthesized human relaxin-2 analog, B-R13/17 K H2, is an RXFP1 antagonist. Amino Acids 39:409-416
    • (2010) Amino Acids , vol.39 , pp. 409-416
    • Hossain, M.A.1    Samuel, C.S.2    Binder, C.3    Hewitson, T.D.4    Tregear, G.W.5    Wade, J.D.6    Bathgate, R.A.7
  • 19
    • 84862770544 scopus 로고    scopus 로고
    • Identification of peptide sequences that target to the brain using in vivo phage display
    • 21792566 10.1007/s00726-011-0979-y 1:CAS:528:DC%2BC38XmvFGks7s%3D
    • Li J, Zhang Q, Pang Z, Wang Y, Liu Q, Guo L, Jiang X (2012) Identification of peptide sequences that target to the brain using in vivo phage display. Amino Acids 42:2373-2381
    • (2012) Amino Acids , vol.42 , pp. 2373-2381
    • Li, J.1    Zhang, Q.2    Pang, Z.3    Wang, Y.4    Liu, Q.5    Guo, L.6    Jiang, X.7
  • 20
    • 10744224962 scopus 로고    scopus 로고
    • Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135
    • 14522968 10.1074/jbc.M308995200 1:CAS:528:DC%2BD3sXpslSqu7g%3D
    • Liu C, Eriste E, Sutton S, Chen J, Roland B, Kuei C, Farmer N, Jornvall H, Sillard R, Lovenberg TW (2003) Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. J Biol Chem 278:50754-50764
    • (2003) J Biol Chem , vol.278 , pp. 50754-50764
    • Liu, C.1    Eriste, E.2    Sutton, S.3    Chen, J.4    Roland, B.5    Kuei, C.6    Farmer, N.7    Jornvall, H.8    Sillard, R.9    Lovenberg, T.W.10
  • 21
    • 11244347812 scopus 로고    scopus 로고
    • Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7
    • 15465925 10.1124/mol.104.006700 1:CAS:528:DC%2BD2MXlt12qtw%3D%3D
    • Liu C, Chen J, Kuei C, Sutton S, Nepomuceno D, Bonaventure P, Lovenberg TW (2005) Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. Mol Pharmacol 67:231-240
    • (2005) Mol Pharmacol , vol.67 , pp. 231-240
    • Liu, C.1    Chen, J.2    Kuei, C.3    Sutton, S.4    Nepomuceno, D.5    Bonaventure, P.6    Lovenberg, T.W.7
  • 22
    • 27644578878 scopus 로고    scopus 로고
    • Relaxin receptor activation in the basolateral amygdala impairs memory consolidation
    • 16262650 10.1111/j.1460-9568.2005.04374.x
    • Ma S, Roozendaal B, Burazin TC, Tregear GW, McGaugh JL, Gundlach AL (2005) Relaxin receptor activation in the basolateral amygdala impairs memory consolidation. Eur J Neurosci 22:2117-2122
    • (2005) Eur J Neurosci , vol.22 , pp. 2117-2122
    • Ma, S.1    Roozendaal, B.2    Burazin, T.C.3    Tregear, G.W.4    McGaugh, J.L.5    Gundlach, A.L.6
  • 23
    • 33749059602 scopus 로고    scopus 로고
    • Comparative localization of leucine-rich repeat-containing G-protein-coupled receptor-7 (RXFP1) mRNA and [33P]-relaxin binding sites in rat brain: Restricted somatic co-expression a clue to relaxin action?
    • 16725278 10.1016/j.neuroscience.2006.03.076 1:CAS:528: DC%2BD28Xms1emurw%3D
    • Ma S, Shen PJ, Burazin TC, Tregear GW, Gundlach AL (2006) Comparative localization of leucine-rich repeat-containing G-protein-coupled receptor-7 (RXFP1) mRNA and [33P]-relaxin binding sites in rat brain: restricted somatic co-expression a clue to relaxin action? Neuroscience 141:329-344
    • (2006) Neuroscience , vol.141 , pp. 329-344
    • Ma, S.1    Shen, P.J.2    Burazin, T.C.3    Tregear, G.W.4    Gundlach, A.L.5
  • 24
    • 33751503663 scopus 로고    scopus 로고
    • Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat
    • 17071007 10.1016/j.neuroscience.2006.08.072 1:CAS:528:DC%2BD28Xht12qsL3L
    • Ma S, Bonaventure P, Ferraro T, Shen PJ, Burazin TCD, Bathgate RAD, Liu C, Tregear GW, Sutton SW, Gundlach AL (2007) Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat. Neuroscience 144:165-190
    • (2007) Neuroscience , vol.144 , pp. 165-190
    • Ma, S.1    Bonaventure, P.2    Ferraro, T.3    Shen, P.J.4    Burazin, T.C.D.5    Bathgate, R.A.D.6    Liu, C.7    Tregear, G.W.8    Sutton, S.W.9    Gundlach, A.L.10
  • 31
    • 77952111806 scopus 로고    scopus 로고
    • Centrally administered relaxin-3 induces Fos expression in the osmosensitive areas in rat brain and facilitates water intake
    • 20214940 10.1016/j.peptides.2010.02.020 1:CAS:528:DC%2BC3cXmtFCjur8%3D
    • Otsubo H, Onaka T, Suzuki H, Katoh A, Ohbuchi T, Todoroki M, Kobayashi M, Fujihara H, Yokoyama T, Matsumoto T, Ueta Y (2010) Centrally administered relaxin-3 induces Fos expression in the osmosensitive areas in rat brain and facilitates water intake. Peptides 31:1124-1130
    • (2010) Peptides , vol.31 , pp. 1124-1130
    • Otsubo, H.1    Onaka, T.2    Suzuki, H.3    Katoh, A.4    Ohbuchi, T.5    Todoroki, M.6    Kobayashi, M.7    Fujihara, H.8    Yokoyama, T.9    Matsumoto, T.10    Ueta, Y.11
  • 33
    • 0026254055 scopus 로고
    • Parameters of helix-coil transition theory for alanine-based peptides of varying chain lengths in water
    • 1814498 10.1002/bip.360311304 1:CAS:528:DyaK38Xht12mur0%3D
    • Scholtz JM, Qian H, York EJ, Stewart JM, Baldwin RL (1991) Parameters of helix-coil transition theory for alanine-based peptides of varying chain lengths in water. Biopolymers 31:1463-1470
    • (1991) Biopolymers , vol.31 , pp. 1463-1470
    • Scholtz, J.M.1    Qian, H.2    York, E.J.3    Stewart, J.M.4    Baldwin, R.L.5
  • 34
    • 79751515312 scopus 로고    scopus 로고
    • General method for selective labelling of double-chain cysteine-rich peptides with a lanthanide chelate via solid-phase synthesis
    • 21308873 10.1002/psc.1307 1:CAS:528:DC%2BC3MXhs1ylt7s%3D
    • Shabanpoor F, Separovic F, Wade JD (2011) General method for selective labelling of double-chain cysteine-rich peptides with a lanthanide chelate via solid-phase synthesis. J Pept Sci 17:169-173
    • (2011) J Pept Sci , vol.17 , pp. 169-173
    • Shabanpoor, F.1    Separovic, F.2    Wade, J.D.3
  • 36
    • 3042610399 scopus 로고    scopus 로고
    • Relaxin's physiological roles and other diverse actions
    • 15082520 10.1210/er.2003-0013 1:CAS:528:DC%2BD2cXktFSqtLg%3D
    • Sherwood OD (2004) Relaxin's physiological roles and other diverse actions. Endocr Rev 25:205-234
    • (2004) Endocr Rev , vol.25 , pp. 205-234
    • Sherwood, O.D.1
  • 37
    • 77955707182 scopus 로고    scopus 로고
    • Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain
    • 20737598 10.1002/cne.22442 1:CAS:528:DC%2BC3cXhtFKktbjK
    • Smith CM, Shen PJ, Banerjee A, Bonaventure P, Ma S, Bathgate RA, Sutton SW, Gundlach AL (2010) Distribution of relaxin-3 and RXFP3 within arousal, stress, affective, and cognitive circuits of mouse brain. J Comp Neurol 518:4016-4045
    • (2010) J Comp Neurol , vol.518 , pp. 4016-4045
    • Smith, C.M.1    Shen, P.J.2    Banerjee, A.3    Bonaventure, P.4    Ma, S.5    Bathgate, R.A.6    Sutton, S.W.7    Gundlach, A.L.8
  • 38
    • 80555126793 scopus 로고    scopus 로고
    • Relaxin-3 systems in the brain-The first 10 years
    • 21693186 10.1016/j.jchemneu.2011.05.013 1:CAS:528:DC%2BC3MXhsVahtrrK
    • Smith CM, Ryan PJ, Hosken IT, Ma S, Gundlach AL (2011) Relaxin-3 systems in the brain-The first 10 years. J Chem Neuroanat 42:262-275
    • (2011) J Chem Neuroanat , vol.42 , pp. 262-275
    • Smith, C.M.1    Ryan, P.J.2    Hosken, I.T.3    Ma, S.4    Gundlach, A.L.5
  • 39
    • 84855719720 scopus 로고    scopus 로고
    • Relaxin-3 null mutation mice display a circadian hypoactivity phenotype
    • 21899720 10.1111/j.1601-183X.2011.00730.x 1:CAS:528:DC%2BC38XjsFCjs7o%3D
    • Smith CM, Hosken IT, Sutton SW, Lawrence AJ, Gundlach AL (2012) Relaxin-3 null mutation mice display a circadian hypoactivity phenotype. Genes Brain Behav 11:94-104
    • (2012) Genes Brain Behav , vol.11 , pp. 94-104
    • Smith, C.M.1    Hosken, I.T.2    Sutton, S.W.3    Lawrence, A.J.4    Gundlach, A.L.5
  • 40
    • 0037424265 scopus 로고    scopus 로고
    • H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2
    • 12506116 10.1074/jbc.M212457200 1:CAS:528:DC%2BD3sXhsF2itLw%3D
    • Sudo S, Kumagai J, Nishi S, Layfield S, Ferraro T, Bathgate RA, Hsueh AJ (2003) H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. J Biol Chem 278:7855-7862
    • (2003) J Biol Chem , vol.278 , pp. 7855-7862
    • Sudo, S.1    Kumagai, J.2    Nishi, S.3    Layfield, S.4    Ferraro, T.5    Bathgate, R.A.6    Hsueh, A.J.7
  • 43
    • 18444395865 scopus 로고    scopus 로고
    • Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress
    • 15845093 10.1111/j.1460-9568.2005.03980.x
    • Tanaka M, Iijima N, Miyamoto Y, Fukusumi S, Itoh Y, Ozawa H, Ibata Y (2005) Neurons expressing relaxin 3/INSL 7 in the nucleus incertus respond to stress. Eur J Neurosci 21:1659-1670
    • (2005) Eur J Neurosci , vol.21 , pp. 1659-1670
    • Tanaka, M.1    Iijima, N.2    Miyamoto, Y.3    Fukusumi, S.4    Itoh, Y.5    Ozawa, H.6    Ibata, Y.7
  • 44
    • 84872678746 scopus 로고    scopus 로고
    • Chemical synthesis and biological evaluation of a peptide gonococcal growth inhibitor
    • 22555649 10.1007/s00726-012-1305-z 1:CAS:528:DC%2BC38Xhs1GhtrfM
    • Wade JD, Lin F, Hossain MA, Dawson RM (2012) Chemical synthesis and biological evaluation of a peptide gonococcal growth inhibitor. Amino Acids 43:2279-2283
    • (2012) Amino Acids , vol.43 , pp. 2279-2283
    • Wade, J.D.1    Lin, F.2    Hossain, M.A.3    Dawson, R.M.4
  • 45
    • 79951675001 scopus 로고    scopus 로고
    • Relaxin-3/INSL7 Regulates the Stress-response System in the Rat Hypothalamus
    • 21072619 10.1007/s12031-010-9468-0
    • Watanabe Y, Miyamoto Y, Matsuda T, Tanaka M (2010) Relaxin-3/INSL7 Regulates the Stress-response System in the Rat Hypothalamus. J Mol Neurosci 43:169-174
    • (2010) J Mol Neurosci , vol.43 , pp. 169-174
    • Watanabe, Y.1    Miyamoto, Y.2    Matsuda, T.3    Tanaka, M.4
  • 46
    • 33745107170 scopus 로고    scopus 로고
    • Strategies to improve plasma half life time of peptide and protein drugs
    • 10.1007/s00726-005-0289-3
    • Werle M, Bernkop-Schnurch A (2010) Strategies to improve plasma half life time of peptide and protein drugs. Amino Acids 30:351-367
    • (2010) Amino Acids , vol.30 , pp. 351-367
    • Werle, M.1    Bernkop-Schnurch, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.