Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1

Journal of Medicinal Chemistry

Volumn 55, Issue 4, 2012, Pages 1671-1681

  Shabanpoor, Fazel ^a   Akhter Hossain, Mohammad ^a   Ryan, Philip J ^a   Belgi, Alessia ^a   Layfield, Sharon ^a   Kocan, Martina ^b   Zhang, Suode ^a   Samuel, Chrishan S ^a   Gundlach, Andrew L ^a   Bathgate, Ross A D ^a   Separovic, Frances ^a   Wade, John D ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RECEPTOR; RELAXIN 3; RELAXIN FAMILY PEPTIDE 3 RECEPTOR; RELAXIN FAMILY PEPTIDE RECEPTOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DISULFIDE BOND; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; FOOD INTAKE; HUMAN; HUMAN CELL; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; COLLAGEN; CRICETINAE; CRICETULUS; CYCLIC AMP; EATING; FIBROBLASTS; HEK293 CELLS; HUMANS; INJECTIONS, INTRAVENTRICULAR; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN STRUCTURE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PEPTIDE; RELAXIN; SKIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863151357     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201505p     Document Type: Article

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