Vitamin C and lifespan in model organisms

Food and Chemical Toxicology

Volumn 58, Issue , 2013, Pages 255-263

  Pallauf, K ^a   Bendall, J K ^b   Scheiermann, C ^a   Watschinger, K ^b   Hoffmann, J ^a   Roeder, T ^a   Rimbach, G ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Ageing; Antioxidant; Ascorbic acid; Longevity; Vitamin supplementation

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; APOLIPOPROTEIN E; ASCORBIC ACID; ASCORBYL 2 POLYPHOSPHATE; ASCORBYL PALMITATE; BETA CAROTENE; DEHYDROASCORBIC ACID; DEOXYGLUCOSE; LIPOSOME; MENADIONE SODIUM BISULFITE; PYCNOGENOL; SODIUM SELENITE; UNCLASSIFIED DRUG; ZINC;

CAENORHABDITIS ELEGANS; CHOLESTEROL DIET; DEVELOPMENTAL STAGE; DIET RESTRICTION; DROSOPHILA MELANOGASTER; DRUG EFFECT; GINKGO BILOBA; GLUCOSE INTAKE; GUINEA PIG; HOUSE FLY; HYPERLIPOPROTEINEMIA TYPE 3; LIFE CYCLE STAGE; LIFESPAN; LIPID DIET; LONGEVITY; NONHUMAN; OXIDATION; OXIDATIVE STRESS; REVIEW; RODENT; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION;

2-DEOXY-D-GLUCOSE; AGEING; ANTIOXIDANT; APOE; APOLIPOPROTEIN E; ASCORBIC ACID; DOG; GLO; HFHC; HIGH FAT/HIGH CHOLESTEROL; L-GULONOLACTONE OXIDASE; LONGEVITY; NRF2; NUCLEAR FACTOR LIKE 2; ODS; OSTEOGENIC DISORDER SHIONOGI; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR; PGC; REACTIVE OXYGEN SPECIES; ROS; SAMP8; SAMR1; SENESCENCE-ACCELERATED MOUSE PRONE 8; SENESCENCEACCELERATED MOUSE-RESISTANT 1; SOD; SUPEROXIDE DISMUTASE; VITAMIN SUPPLEMENTATION;

ANIMALS; ASCORBIC ACID; HUMANS; LIFE EXPECTANCY; MODELS, BIOLOGICAL;

EID: 84878250338     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.04.046     Document Type: Review

References (61)

1. Adler L.N., Gomez T.A., Clarke S.G., Linster C.L. A novel GDP-d-glucose phosphorylase involved in quality control of the nucleoside diphosphate sugar pool in Caenorhabditis elegans and mammals. The Journal of Biological Chemistry 2011, 286:21511-21523.
2. Ahmad K.A., Clement M.V., Pervaiz S. Pro-oxidant activity of low doses of resveratrol inhibits hydrogen peroxide-induced apoptosis. Annals of the New York Academy of Sciences 2003, 1010:365-373.
3. Ames B.N. Micronutrients prevent cancer and delay aging. Toxicology Letters 1998, 102-103:5-18.
4. Avery L., Thomas J.H. Feeding and defecation. C. elegans II 1997, Cold Spring Harbor, NY. second ed. D.L. Riddle, T. Blumenthal, B.J. Meyer, J.R. Priess (Eds.).
5. Bahadorani S., Hilliker A.J. Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease. Genome/National Research Council Canada=Genome/Conseil National de Recherches Canada 2008, 51:392-395.
6. Bahadorani S., Bahadorani P., Phillips J.P., Hilliker A.J. The effects of vitamin supplementation on Drosophila life span under normoxia and under oxidative stress. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2008, 63:35-42.
7. Bakaev, V., Bakaeva, M., 2011. Effect of ascorbic acid on longevity in the Nematoda Caenorhabditis elegans. < http://www.quantium.plus.com/lr/lr88.htm.
8. Bayram, B., Nikolai, S., Huebbe, P., Ozcelik, B., Grimm, S., Grune, T., Frank, J., Rimbach, G., 2012. Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8. Age (Dordr). http://dx.doi.org/10.1007/s11357-012-9448-0.
9. Bezlepkin V.G., Sirota N.P., Gaziev A.I. The prolongation of survival in mice by dietary antioxidants depends on their age by the start of feeding this diet. Mechanisms of Ageing and Development 1996, 92:227-234.
10. Birney E.C., Jenness R., Ayaz K.M. Inability of bats to synthesise l-ascorbic acid. Nature 1976, 260:626-628.
11. Bjelakovic G., Gluud L.L., Nikolova D., Bjelakovic M., Nagorni A., Gluud C. Meta-analysis: antioxidant supplements for liver diseases - the Cochrane Hepato-Biliary Group. Alimentary Pharmacology & Therapeutics 2010, 32:356-367.
12. Bornstein S.R., Yoshida-Hiroi M., Sotiriou S., Levine M., Hartwig H.G., Nussbaum R.L., Eisenhofer G. Impaired adrenal catecholamine system function in mice with deficiency of the ascorbic acid transporter (SVCT2). FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 2003, 17:1928-1930.
13. Burns J.J. Missing step in man, monkey and guinea pig required for the biosynthesis of l-ascorbic acid. Nature 1957, 180:553.
14. Carr A.C., Frei B. Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. The American Journal of Clinical Nutrition 1999, 69:1086-1107.
15. Clark J., Reddy S., Zheng K., Betensky R.A., Simon D.K. Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease. BMC Medical Genetics 2011, 12:69.
16. Copeland N.G., Jenkins N.A., O'Brien S.J. Genomics. Mmu 16 - comparative genomic highlights. Science 2002, 296:1617-1618.
17. Davies J.E., Ellery P.M., Hughes R.E. Dietary ascorbic acid and life span of guinea-pigs. Experimental Gerontology 1977, 12:215-216.
18. Deana R., Bharaj B.S., Verjee Z.H., Galzigna L. Changes relevant to catecholamine metabolism in liver and brain of ascorbic acid deficient guinea-pigs. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 1975, 45:175-182.
19. Drouin G., Godin J.R., Page B. The genetics of vitamin C loss in vertebrates. Current Genomics 2011, 12:371-378.
20. Ernst I.M., Pallauf K., Bendall J.K., Paulsen L., Nikolai S., Huebbe P., Roeder T., Rimbach G. Vitamin E supplementation and lifespan in model organisms. Ageing Research Reviews 2013, 12:365-375.
21. Gems D., Riddle D.L. Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans. Genetics 2000, 154:1597-1610.
22. Harman D. Aging: a theory based on free radical and radiation chemistry. Journal of Gerontology 1956, 11:298-300.
23. Helfand S.L., Inouye S.K. Aging, life span, genetics and the fruit fly. Clinical Neuroscience Research 2003, 2:270-278.
24. Holloszy J.O. Longevity of exercising male rats: effect of an antioxidant supplemented diet. Mechanisms of Ageing and Development 1998, 100:211-219.
25. Hulse J.D., Ellis S.R., Henderson L.M. Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenase. The Journal of Biological Chemistry 1978, 253:1654-1659.
26. Kondo Y., Inai Y., Sato Y., Handa S., Kubo S., Shimokado K., Goto S., Nishikimi M., Maruyama N., Ishigami A. Senescence marker protein 30 functions as gluconolactonase in l-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proceedings of the National Academy of Sciences of the United States of America 2006, 103:5723-5728.
27. Levine M., Conry-Cantilena C., Wang Y., Welch R.W., Washko P.W., Dhariwal K.R., Park J.B., Lazarev A., Graumlich J.F., King J., Cantilena L.R. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:3704-3709.
28. Levine M., Padayatty S.J., Espey M.G. Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. Advances in Nutrition: An International Review Journal 2011, 2:78-88.
29. Li Y.M., Chan H.Y.E., Huang Y., Chen Z.Y. Green tea catechins upregulate superoxide dismutase and catalase in fruit flies. Molecular Nutrition and Food Research 2007, 51:546-554.
30. Linster C.L., Van Schaftingen E. Vitamin C biosynthesis, recycling and degradation in mammals. The FEBS Journal 2007, 274:1-22.
31. Maeda N., Hagihara H., Nakata Y., Hiller S., Wilder J., Reddick R. Aortic wall damage in mice unable to synthesize ascorbic acid. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:841-846.
32. Majewicz J., Rimbach G., Proteggente A.R., Lodge J.K., Kraemer K., Minihane A.M. Dietary vitamin C down-regulates inflammatory gene expression in apoE4 smokers. Biochemical and Biophysical Research Communications 2005, 338:951-955.
33. Masoro E.J. Role of hormesis in life extension by caloric restriction. Dose-Response: a Publication of International Hormesis Society 2007, 5:163-173.
34. Massie H.R., Baird M.B., Piekielniak M.J. Ascorbic acid and longevity in Drosophila. Experimental Gerontology 1976, 11:37-41.
35. Massie H.R., Aiello V.R., Doherty T.J. Dietary vitamin C improves the survival of mice. Gerontology 1984, 30:371-375.
36. Massie H.R., Shumway M.E., Whitney S.J., Sternick S.M., Aiello V.R. Ascorbic acid in Drosophila and changes during aging. Experimental Gerontology 1991, 26:487-494.
37. Mizushima Y., Harauchi T., Yoshizaki T., Makino S. A rat mutant unable to synthesize vitamin C. Experientia 1984, 40:359-361.
38. Mockett R.J., Sohal R.S., Orr W.C. Overexpression of glutathione reductase extends survival in transgenic Drosophila melanogaster under hyperoxia but not normoxia. The FASEB Journal 1999, 13:1733-1742.
39. Parkes T.L., Elia A.J., Dickinson D., Hilliker A.J., Phillips J.P., Boulianne G.L. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nature Genetics 1998, 19:171-174.
40. Podmore I.D., Griffiths H.R., Herbert K.E., Mistry N., Mistry P., Lunec J. Vitamin C exhibits pro-oxidant properties. Nature 1998, 392:559.
41. Pun P.B., Gruber J., Tang S.Y., Schaffer S., Ong R.L., Fong S., Ng L.F., Cheah I., Halliwell B. Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?. Biogerontology 2010, 11:17-30.
42. Ristow M., Schmeisser S. Extending life span by increasing oxidative stress. Free Radical Biology & Medicine 2011, 51:327-336.
43. Ristow M., Zarse K., Oberbach A., Kloting N., Birringer M., Kiehntopf M., Stumvoll M., Kahn C.R., Bluher M. Antioxidants prevent health-promoting effects of physical exercise in humans. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:8665-8670.
44. 2 induced oxidative DNA damage in Jurkat cells. Free Radical Biology & Medicine 2006, 40:2071-2079.
45. Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005, 434:113-118.
46. Scherz-Shouval R., Shvets E., Fass E., Shorer H., Gil L., Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. The EMBO Journal 2007, 26:1749-1760.
47. Schulz T.J., Zarse K., Voigt A., Urban N., Birringer M., Ristow M. Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress. Cell Metabolism 2007, 6:280-293.
48. Selman C., Grune T., Stolzing A., Jakstadt M., McLaren J.S., Speakman J.R. The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, Microtus agrestis. Free Radical Biology & Medicine 2002, 33:259-265.
49. Selman C., McLaren J.S., Meyer C., Duncan J.S., Redman P., Collins A.R., Duthie G.G., Speakman J.R. Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes. Mechanisms of Ageing and Development 2006, 127:897-904.
50. Shibamura A., Ikeda T., Nishikawa Y. A method for oral administration of hydrophilic substances to Caenorhabditis elegans: effects of oral supplementation with antioxidants on the nematode lifespan. Mechanisms of Ageing and Development 2009, 130:652-655.
51. Sohal R.S., Allen R.G., Farmer K.J., Newton R.K., Toy P.L. Effects of exogenous antioxidants on the levels of endogenous antioxidants, lipid-soluble fluorescent material and life span in the housefly, Musca domestica. Mechanisms of Ageing and Development 1985, 31:329-336.
52. Sotiriou S., Gispert S., Cheng J., Wang Y., Chen A., Hoogstraten-Miller S., Miller G.F., Kwon O., Levine M., Guttentag S.H., Nussbaum R.L. Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival. Nature Medicine 2002, 8:514-517.
53. Surco-Laos F., Cabello J., Gomez-Orte E., Gonzalez-Manzano S., Gonzalez-Paramas A.M., Santos-Buelga C., Duenas M. Effects of O-methylated metabolites of quercetin on oxidative stress, thermotolerance, lifespan and bioavailability on Caenorhabditis elegans. Food & Function 2011, 2:445-456.
54. Tappel A., Fletcher B., Deamer D. Effect of antioxidants and nutrients on lipid peroxidation fluorescent products and aging parameters in the mouse. Journal of Gerontology 1973, 28:415-424.
55. Traber M.G., Stevens J.F. Vitamins C and E: beneficial effects from a mechanistic perspective. Free Radical Biology & Medicine 2011, 51:1000-1013.
56. Van Robertson W.B., Schwartz B. Ascorbic acid and the formation of collagen. The Journal of Biological Chemistry 1953, 201:689-696.
57. Venditti P., De Rosa R., Portero-Otin M., Pamplona R., Di Meo S. Cold-induced hyperthyroidism produces oxidative damage in rat tissues and increases susceptibility to oxidants. The International Journal of Biochemistry & Cell Biology 2004, 36:1319-1331.
58. Veurink G., Liu D., Taddei K., Perry G., Smith M.A., Robertson T.A., Hone E., Groth D.M., Atwood C.S., Martins R.N. Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants. Free Radical Biology & Medicine 2003, 34:1070-1077.
59. Wagner A.E., Boesch-Saadatmandi C., Breckwoldt D., Schrader C., Schmelzer C., Doring F., Hashida K., Hori O., Matsugo S., Rimbach G. Ascorbic acid partly antagonizes resveratrol mediated heme oxygenase-1 but not paraoxonase-1 induction in cultured hepatocytes - role of the redox-regulated transcription factor Nrf2. BMC Complementary and Alternative Medicine 2011, 11:1.
60. Young I.S., Trouton T.G., Torney J.J., McMaster D., Callender M.E., Trimble E.R. Antioxidant status and lipid peroxidation in hereditary haemochromatosis. Free Radical Biology & Medicine 1994, 16:393-397.
61. Yu R., Schellhorn H.E. Recent applications of engineered animal antioxidant deficiency models in human nutrition and chronic disease. The Journal of Nutrition 2013, 143:1-11.