Requirement of α4β1 and α5β1 integrin expression in bone-marrow-derived progenitor cells in preventing endotoxin-induced lung vascular injury and edema in mice

Stem Cells

Volumn 27, Issue 12, 2009, Pages 3112-3120

  Wary, Kishore K ^a   Vogel, Stephen M ^a   Garrean, Sean ^a   Zhao, Yidan D ^a   Malik, Asrar B ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Acute lung injury; Endothelial barrier; Endothelial progenitor cells; Integrins; Stem Cells

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; FOCAL ADHESION KINASE; RED FLUORESCENT PROTEIN; SHORT HAIRPIN RNA; VASCULOTROPIN RECEPTOR 2; VERY LATE ACTIVATION ANTIGEN 4; VERY LATE ACTIVATION ANTIGEN 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; BLOOD VESSEL PERMEABILITY; CD34 SELECTION; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; GENE SILENCING; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; LUNG EDEMA; LUNG INJURY; LUNG VASCULAR INJURY; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTIGEN PRESENTATION; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL ADHESION; CELL DIFFERENTIATION; CELL MOVEMENT; CELLS, CULTURED; EDEMA; ENDOTOXINS; INTEGRIN ALPHA4BETA1; INTEGRIN ALPHA5BETA1; LIPOPOLYSACCHARIDES; LUNG; LUNG INJURY; MALE; MICE; MICE, INBRED C57BL; RNA INTERFERENCE; STEM CELLS;

BACTERIA (MICROORGANISMS); MUS;

EID: 73349113950     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.241     Document Type: Article

References (50)

1. Fleischman RA, Custer RP, Mintz B. Totipotent hematopoietic stem cells: Normal self-renewal and differentiation after transplantation between mouse fetuses. Cell 1982;30:351-359.
2. Hall PA, Watt FM. Stem cells: The generation and maintenance of cellular diversity. Development 1989;106:619-633.
3. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997;276:71-74.
4. Scadden DT. Circadian rhythms: Stem cells traffic in time. Nature 2008;452:416-417.
5. Krause DS, Theise ND, Collector MI et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001;105:369-377.
6. Grunewald M, Avraham I, Dor Y et al. VEGF-induced adult neovascularization: Recruitment, retention, and role of accessory cells. Cell 2006;124:175-189.
7. Kajstura J, Leri A, Bolli R et al. Endothelial progenitor cells: Neovascularization or more? J Mol Cell Cardiol 2006;40:1-8.
8. Asahara T, Murohara T, Sullivan A et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-967.
9. Shi Q, Rafii S, Wu MH et al. Evidence for circulating bone marrowderived endothelial cells. Blood 1998;92:362-367.
10. Takahashi T, Kalka C, Masuda H et al. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999;5:434-438.
11. Hill JM, Zalos G, Halcox JP et al. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003;348:593-600.
12. Assmus B, Honold J, Schachinger V et al. Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 2006;355:1222-1232.
13. Schachinger V, Erbs S, Elsasser A et al. Intracoronary bone marrowderived progenitor cells in acute myocardial infarction. N Engl J Med 2006;355:1210-1221.
14. Kawamoto A, Iwasaki H, Kusano K et al. CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells. Circulation 2006;114:2163-2169.
15. Urbich C, Dimmeler S. Endothelial progenitor cells: Characterization and role in vascular biology. Circ Res 2004;95:343-353.
16. Yoder MC, Mead LE, Prater D et al. Redefining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood 2007;109:1801-1809.
17. Prater DN, Case J, Ingram DA et al. Working hypothesis to redefine endothelial progenitor cells. Leukemia 2007;21:1141-1149.
18. + cells are not endothelial progenitor cells but distinct, primitive hematopoietic progenitors. Exp Hematol 2007;35:1109-1118.
19. Gao D, Nolan DJ, Mellick AS et al. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis. Science 2008;319:195-198.
20. Lin Y, Weisdorf DJ, Solovey A et al. Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest 2000;105:71-77.
21. Hirschi KK, Ingram DA, Yoder MC. Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2008;28:1584-1595.
22. Weiss DJ, Kolls JK, Ortiz LA et al. Stem cells and cell therapies in lung biology and lung diseases. Proc Am Thorac Soc 2008;5:637-667.
23. Chavakis E, Aicher A, Heeschen C. Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med 2005;201:63-72.
24. Qin G, Ii M, Silver M et al. Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med 2006;203:153-163.
25. Jin H, Aiyer A, Su J et al. A homing mechanism for bone marrowderived progenitor cell recruitment to the neovasculature. J Clin Invest 2006;116:652-662.
26. Humtsoe JO, Feng S, Thakker GD et al. Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP. EMBO J 2003;22:1539-1554.
27. Wary KK, Humtsoe JO. Anti-lipid phosphate phosphohydrolase-3 (LPP3) antibody inhibits bFGF- and VEGF-induced capillary morphogenesis of endothelial cells. Cell Commun Signal 2005;3:9.
28. Humtsoe JO, Kim JK, Xu Y et al. A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling. J Biol Chem 2005;280:13848-13857.
29. Zhao YY, Gao XP, Zhao YD et al. Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury. J Clin Invest 2006;116:2333-2343.
30. Bachmaier K, Toya S, Gao X et al. E3 ubiquitin ligase Cblb regulates the acute inflammatory response underlying lung injury. Nat Med 2007;13:920-926.
31. Garrean S, Gao XP, Brovkovych V et al. Caveolin-1 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide. J Immunol 2006;177:4853-4860.
32. Zhao YD, Courtman DW, Deng Y et al. Rescue of monocrotalineinduced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: Efficacy of combined cell and eNOS gene therapy in established disease. Circ Res 2005;96:442-450.
33. Fan J, Frey RS, Rahman A et al. Role of neutrophil NADPH oxidase in the mechanism of tumor necrosis factor-alpha -induced NF-kappa B activation and intercellular adhesion molecule-1 expression in endothelial cells. J Biol Chem 2002;277:3404-3411.
34. Gao X, Kouklis P, Xu N et al. Reversibility of increased microvessel permeability in response to VE-cadherin disassembly. Am J Physiol Lung Cell Mol Physiol 2000;279:L1218-L1225.
35. Ong ES, Gao XP, Xu N et al. E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeability. Am J Physiol Lung Cell Mol Physiol 2003;285:L879-L888.
36. Brovkovych V, Gao XP, Ong E et al. Augmented iNOS expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice. Am J Physiol Lung Cell Mol Physiol 2008;295:L96-L103.
37. Yang JT, Rayburn H, Hynes RO. Cell adhesion events mediated by alpha 4 integrins are essential in placental and cardiac development. Development 1995;121:549-560.
38. Yang JT, Rayburn H, Hynes RO. Embryonic mesodermal defects in alpha 5 integrin deficient mice. Development 1993;119:1093-1105.
39. Gonzalez AM, Gonzales M, Herron GS et al. Complex interactions between the laminin alpha 4 subunit and integrins regulate endothelial cell behavior in vitro and angiogenesis in vivo. Proc Natl Acad Sci U S A 2002;99:16075-16080.
40. Kim S, Bell K, Mousa SA et al. Regulation of angiogenesis in vivo by ligation of integrin alpha5beta1 with the central cell-binding domain of fibronectin. Am J Pathol 2000;156:1345-1362.
41. Miyamoto S, Katz BZ, Lafrenie RM et al. Fibronectin and integrins in cell adhesion, signaling, and morphogenesis. Ann N Y Acad Sci 1998;857:119-129.
42. Grinnell F, Billingham RE, Burgess L. Distribution of fibronectin during wound healing in vivo. J Invest Dermatol 1981;76:181-189.
43. Ruoslahti E, Engvall E. Integrins and vascular extracellular matrix assembly. J Clin Invest 1997;99:1149-1152.
44. Scatena M, Liaw L, Giachelli CM. Osteopontin: A multifunctional molecule regulating chronic inflammation and vascular disease. Arterioscler Thromb Vasc Biol 2007;27:2302-2309.
45. Leen LL, Filipe C, Billon A et al. Estrogen-stimulated endothelial repair requires osteopontin. Arterioscler Thromb Vasc Biol 2008;28:2131-2136.
46. Wary KK, Mainiero F, Isakoff SJ et al. The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Cell 1996;87:733-743.
47. Johnston CJ, Williams JP, Elder A et al. Inflammatory cell recruitment following thoracic irradiation. Exp Lung Res 2004;30:369-382.
48. Zhang R, Ghosh SN, Zhu D et al. Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: Injury and recovery. Int J Radiat Biol 2008;84:487-497.
49. Goldsmith EC, Carver W, McFadden A et al. Integrin shedding as a mechanism of cellular adaptation during cardiac growth. Am J Physiol Heart Circ Physiol 2003;284:H2227-H2234.
50. Zhao YD, Ohkawara H, Rehman J et al. Bone marrow progenitor cells induce endothelial adherens junction integrity by sphingosine-1-phosphate-mediated Rac1 and Cdc42 signaling. Circ Res 2009;105:696-704