Premenopausal women with a distal radial fracture have deteriorated trabecular bone density and morphology compared with controls without a fracture

Journal of Bone and Joint Surgery

Volumn 95, Issue 7, 2013, Pages 633-642

  Rozental, Tamara D ^a   Deschamps, Laura N ^a   Taylor, Alexander ^b   Earp, Brandon ^c   Zurakowski, David ^d   Day, Charles S ^a   Bouxsein, Mary L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BODY MASS; BONE DENSITY; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORTICAL BONE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; FOLLOW UP; FRACTURE TREATMENT; HUMAN; LUMBAR SPINE; MORPHOLOGY; PREMENOPAUSE; PRIORITY JOURNAL; RADIUS; RADIUS FRACTURE; THICKNESS; TRABECULAR BONE; TRAFFIC ACCIDENT; CASE CONTROL STUDY; COMPUTER ASSISTED TOMOGRAPHY; HIP; LUMBAR VERTEBRA; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PHOTON ABSORPTIOMETRY; PROSPECTIVE STUDY; RADIOGRAPHY; RISK FACTOR; STATISTICAL MODEL; WRIST;

ABSORPTIOMETRY, PHOTON; ADULT; BONE DENSITY; CASE-CONTROL STUDIES; FEMALE; HIP JOINT; HUMANS; LOGISTIC MODELS; LUMBAR VERTEBRAE; PREMENOPAUSE; PROSPECTIVE STUDIES; RADIUS FRACTURES; RISK FACTORS; STATISTICS, NONPARAMETRIC; TOMOGRAPHY, X-RAY COMPUTED; WRIST JOINT;

MLCS; MLOWN;

EID: 84878229183     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.L.00588     Document Type: Article

References (64)

1. Looker AC, Orwoll ES, Johnston CC Jr, Lindsay RL, Wahner HW, Dunn WL, Calvo MS, Harris TB, Heyse SP. Prevalence of low femoral bone density in older U.S. adults from NHANES III. J Bone Miner Res. 1997 Nov;12(11): 1761-8
2. Court-Brown CM, Caesar B. Epidemiology of adult fractures: A review. Injury 2006 Aug;37(8):691-7
3. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025. J Bone Miner Res. 2007 Mar;22(3):465-75
4. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures Lancet. 2002 May 18;359(9319):1761-7
5. Kanis JA, Johnell O, Oden A, Dawson A, De Laet C, Jonsson B. Ten year probabilities of osteoporotic fractures according to BMD and diagnostic thresholds Osteoporos Int. 2001 Dec;12(12):989-95
6. Kanis JA, Johnell O, De Laet C, Jonsson B, Oden A, Ogelsby AK. International variations in hip fracture probabilities: implications for risk assessment. J Bone Miner Res. 2002 Jul;17(7):1237-44
7. Stone KL, Seeley DG, Lui LY, Cauley JA, Ensrud K, Browner WS, Nevitt MC, Cummings SR; Osteoporotic Fractures Research Group. BMD at multiple sites and risk of fracture of multiple types: long-term results from the Study of Osteoporotic Fractures. J Bone Miner Res. 2003 Nov;18(11): 1947-54
8. Wainwright SA, Marshall LM, Ensrud KE, Cauley JA, Black DM, Hillier TA, Hochberg MC, Vogt MT, Orwoll ES; Study of Osteoporotic Fractures Research Group Hip fracture in women without osteoporosis. J Clin Endocrinol Metab. 2005 May;90(5):2787-93
9. Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JP, Pols HA. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004 Jan;34(1):195-202
10. Leslie WD, Lix LM, Johansson H, Oden A, McCloskey E, Kanis JA; Manitoba Bone Density Program. Independent clinical validation of a Canadian FRAX tool: fracture prediction and model calibration. J Bone Miner Res. 2010 Nov;25(11):2350-8
11. Trémollieres FA, Pouillès JM, Drewniak N, Laparra J, Ribot CA, Dargent-Molina P Fracture risk prediction using BMD and clinical risk factors in early postmenopausal women: sensitivity of the WHO FRAX tool. J Bone Miner Res. 2010 May;25(5): 1002-9
12. Pressman AR, Lo JC, ChandraM, Ettinger B. Methods for assessing fracture risk prediction models: experience with FRAX in a large integrated health care delivery system. J Clin Densitom. 2011 Oct-Dec;14(4):407-15
13. Boutroy S, Bouxsein ML, Munoz F, Delmas PD. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography J Clin Endocrinol Metab. 2005 Dec;90(12):6508-15
14. Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD. Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res. 2007 Mar;22(3):425-33
15. Vico L, Zouch M, Amirouche A, Frère D, Laroche N, Koller B, Laib A, Thomas T, Alexandre C. High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures. J Bone Miner Res. 2008 Nov;23(11):1741-50
16. Vilayphiou N, Boutroy S, Sornay-Rendu E, Van Rietbergen B, Munoz F, Delmas PD, Chapurlat R. Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in postmenopausal women. Bone. 2010 Apr;46(4):1030-7
17. Szulc P, Boutroy S, Vilayphiou N, Chaitou A, Delmas PD, Chapurlat R. Crosssectional analysis of the association between fragility fractures and bone microarchitecture in older men: the STRAMBO study. J Bone Miner Res. 2011 Jun;26(6):1358-67
18. Vilayphiou N, Boutroy S, Szulc P, van Rietbergen B, Munoz F, Delmas PD, Chapurlat R. Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in men. J Bone Miner Res. 2011 May; 26(5):965-73
19. Liu XS, Stein EM, Zhou B, Zhang CA, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Cosman F, Nieves J, Shane E, Guo XE. Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements. J Bone Miner Res. 2012 Feb;27(2):263-72
20. Melton LJ 3rd. Application of technology to push epidemiology forward. Osteoporos Int. 2009 May;20(Suppl 3):S235-6
21. Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Yin PT, Cosman F, Nieves J, Guo XE, Shane E. Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. J Bone Miner Res. 2010 Dec;25(12):2572-81
22. Liu XS, Cohen A, Shane E, Yin PT, Stein EM, Rogers H, Kokolus SL, McMahon DJ, Lappe JM, Recker RR, Lang T, Guo XE. Bone density, geometry, microstructure, and stiffness: Relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women. J Bone Miner Res. 2010 Oct;25(10):2229-38
23. Khosla S, Riggs BL, Atkinson EJ, Oberg AL, McDaniel LJ, Holets M, Peterson JM, Melton LJ 3rd. Effects of sex and age on bone microstructure at the ultradistal radius: a population-based noninvasive in vivo assessment. J Bone Miner Res. 2006 Jan;21(1):124-31
24. Riggs BL, Melton III LJ 3rd, Robb RA, Camp JJ, Atkinson EJ, Peterson JM, Rouleau PA, McCollough CH, Bouxsein ML, Khosla S. Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites. J Bone Miner Res. 2004 Dec;19(12):1945-54
25. Macdonald HM, Nishiyama KK, Kang J, Hanley DA, Boyd SK. Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: a population-based HR-pQCT study. J Bone Miner Res. 2011 Jan;26(1):50-62
26. Wareham NJ, Jakes RW, Rennie KL, Schuit J, Mitchell J, Hennings S, Day NE Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr. 2003 Jun;6(4):407-13
27. Müller M, Nazarian S, Koch P, Schatzker J. The comprehensive classification of fractures of long bones. 1st ed. Berlin, Heidelberg, New York: Springer-Verlag; 1990
28. Riggs BL, Melton LJ, Robb RA, Camp JJ, Atkinson EJ, McDaniel L, Amin S, Rouleau PA, Khosla S. A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. J Bone Miner Res. 2008 Feb;23(2):205-14
29. Boutroy S, Van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD. Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res. 2008 Mar;23(3):392-9
30. Wehrli FW. Structural and functional assessment of trabecular and cortical bone by micro magnetic resonance imaging. J Magn Reson Imaging. 2007 Feb;25(2): 390-409
31. Goulding A, Cannan R, Williams SM, Gold EJ, Taylor RW, Lewis-Barned NJ. Bone mineral density in girls with forearm fractures. J Bone Miner Res. 1998 Jan;13(1):143-8
32. Goulding A, Grant AM, Williams SM. Bone and body composition of children and adolescents with repeated forearm fractures. J Bone Miner Res. 2005 Dec;20(12):2090-6
33. Pye SR, Tobias J, Silman AJ, Reeve J, O'Neill TW; EPOS Study Group. Childhood fractures do not predict future fractures: results from the European Prospective Osteoporosis Study. J Bone Miner Res. 2009 Jul;24(7):1314-8
34. Matkovic V, Jelic T, Wardlaw GM, Ilich JZ, Goel PK, Wright JK, Andon MB, Smith KT, Heaney RP. Timing of peak bone mass in Caucasian females and its implication for the prevention of osteoporosis. Inference from a cross-sectional model. J Clin Invest. 1994 Feb;93(2):799-808
35. Cohen A, Liu XS, Stein EM, McMahon DJ, Rogers HF, Lemaster J, Recker RR, Lappe JM, Guo XE, Shane E. Bonemicroarchitecture and stiffness in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab. 2009 Nov;94(11):4351-60
36. Mackey DC, Lui LY, Cawthon PM, Bauer DC, Nevitt MC, Cauley JA, Hillier TA, Lewis CE, Barrett-Connor E, Cummings SR; Study of Osteoporotic Fractures (SOF) and Osteoporotic Fractures in Men Study (MrOS) Research Groups. High-trauma fractures and low bone mineral density in older women and men. JAMA. 2007 Nov 28;298(20):2381-8
37. Sigurdsson G, Halldorsson BV, Styrkarsdottir U, Kristjansson K, Stefansson K Impact of genetics on low bone mass in adults. J Bone Miner Res. 2008 Oct;23(10):1584-90
38. Fox KM, Cummings SR, Powell-Threets K, Stone K; Study of Osteoporotic Fractures Research Group. Family history and risk of osteoporotic fracture. Osteoporos Int. 1998;8(6):557-62
39. Chevalley T, Bonjour JP, Ferrari S, Rizzoli R. Deleterious effect of late menarche on distal tibia microstructure in healthy 20-year-old and premenopausal middle-aged women. J Bone Miner Res. 2009 Jan;24(1):144-52
40. Armamento-Villareal R, Villareal DT, Avioli LV, Civitelli R. Estrogen status and heredity are major determinants of premenopausal bone mass. J Clin Invest. 1992 Dec;90(6):2464-71
41. Galuska DA, Sowers MR. Menstrual history and bone density in young women J Womens Health Gend Based Med. 1999 Jun;8(5):647-56
42. Ruffing JA, Nieves JW, Zion M, Tendy S, Garrett P, Lindsay R, Cosman F. The influence of lifestyle, menstrual function and oral contraceptive use on bone mass and size in female military cadets. Nutr Metab (Lond). 2007;4:17
43. Cadogan J, Eastell R, Jones N, Barker ME. Milk intake and bone mineral acquisition in adolescent girls: randomised, controlled intervention trial. BMJ. 1997 Nov 15;315(7118):1255-60
44. Chan GM, Hoffman K, McMurry M. Effects of dairy products on bone and body composition in pubertal girls. J Pediatr. 1995 Apr;126(4):551-6
45. Modlesky CM, Majumdar S, Dudley GA. Trabecular bone microarchitecture in female collegiate gymnasts. Osteoporos Int. 2008 Jul;19(7):1011-8
46. Nickols-Richardson SM, Modlesky CM, O'Connor PJ, Lewis RD. Premenarcheal gymnasts possess higher bone mineral density than controls. Med Sci Sports Exerc 2000 Jan;32(1):63-9
47. Heinonen A, Kannus P, Sievänen H, Oja P, Pasanen M, Rinne M, Uusi-Rasi K, Vuori I. Randomised controlled trial of effect of high-impact exercise on selected risk factors for osteoporotic fractures. Lancet. 1996 Nov 16;348(9038): 1343-7
48. Modlesky CM, Majumdar S, Narasimhan A, Dudley GA. Trabecular bone microarchitecture is deteriorated in men with spinal cord injury. J Bone Miner Res 2004 Jan;19(1):48-55
49. Slade JM, Bickel CS, Modlesky CM, Majumdar S, Dudley GA. Trabecular bone is more deteriorated in spinal cord injured versus estrogen-free postmenopausal women. Osteoporos Int. 2005 Mar;16(3):263-72
50. Ingle BM, Hay SM, Bottjer HM, Eastell R. Changes in bone mass and bone turnover following distal forearm fracture. Osteoporos Int. 1999;10(5):399-407
51. Singer BR, McLauchlan GJ, Robinson CM, Christie J. Epidemiology of fractures in 15,000 adults: the influence of age and gender. J Bone Joint Surg Br. 1998 Mar;80(2):243-8
52. Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev. 1985;7:178-208
53. Cummings SR, Black DM, Rubin SM. Lifetime risks of hip, Colles', or vertebral fracture and coronary heart disease among white postmenopausal women. Arch Intern Med. 1989 Nov;149(11):2445-8
54. Cooper C, Atkinson EJ, Jacobsen SJ, O'Fallon WM, Melton LJ 3rd. Populationbased study of survival after osteoporotic fractures. Am J Epidemiol. 1993 May 1;137(9):1001-5
55. Mallmin H, Ljunghall S, Persson I, Naessén T, Krusemo UB, Bergström R Fracture of the distal forearm as a forecaster of subsequent hip fracture: a population-based cohort study with 24 years of follow-up. Calcif Tissue Int. 1993 Apr;52(4):269-72
56. Lauritzen JB, Schwarz P, McNair P, Lund B, Transbøl I. Radial and humeral fractures as predictors of subsequent hip, radial or humeral fractures in women, and their seasonal variation. Osteoporos Int. 1993 May;3(3):133-7
57. Cuddihy MT, Gabriel SE, Crowson CS, O'Fallon WM, Melton LJ 3rd. Forearm fractures as predictors of subsequent osteoporotic fractures. Osteoporos Int 1999;9(6):469-75
58. Kanis JA, Burlet N, Cooper C, Delmas PD, Reginster JY, Borgstrom F, Rizzoli R; European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008 Apr;19(4):399-428
59. Preventive OUS, Task S; U.S. Preventive Services Task Force. Screening for osteoporosis: U.S. preventive services task force recommendation statement Ann Intern Med. 2011 Mar 1;154(5):356-64
60. U.S. Department of Health and Human Services. Bone health and osteoporosis: a report of the surgeon general. Rockville; U.S. Department of Health and Human Services, Office of the Surgeon General; 2004
61. Weycker D, Macarios D, Edelsberg J, Oster G. Compliance with drug therapy for postmenopausal osteoporosis. Osteoporos Int. 2006;17(11):1645-52
62. Wade SW, Curtis JR, Yu J, White J, Stolshek BS, Merinar C, Balasubramanian A, Kallich JD, Adams JL, Viswanathan HN. Medication adherence and fracture risk among patients on bisphosphonate therapy in a large United States health plan Bone. 2012 Apr;50(4):870-5
63. Siris ES, Selby PL, Saag KG, Borgström F, Herings RM, Silverman SL. Impact of osteoporosis treatment adherence on fracture rates in North America and Europe Am J Med. 2009 Feb;122(2)(Suppl):S3-13
64. Landfeldt E, Ström O, Robbins S, Borgström F. Adherence to treatment of primary osteoporosis and its association to fractures-the Swedish Adherence Register Analysis (SARA). Osteoporos Int. 2012 Feb;23(2):433-43