Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements

Journal of Bone and Mineral Research

Volumn 27, Issue 2, 2012, Pages 263-272

  Liu, X Sherry ^a   Stein, Emily M ^a   Zhou, Bin ^b   Zhang, Chiyuan A ^a   Nickolas, Thomas L ^a   Cohen, Adi ^a   Thomas, Valerie ^a   McMahon, Donald J ^a   Cosman, Felicia ^c   Nieves, Jeri ^c   Shane, Elizabeth ^a   Guo, X Edward ^b  

^a Columbia University ^*  (United States)

^b Clinical Research Center ^*  (United States)

^c HELEN HAYES HOSPITAL   (United States)

Author keywords

BONE MICROARCHITECTURE; FRAGILITY FRACTURES; HIGH RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; INDIVIDUAL TRABECULA SEGMENTATION; TRABECULAR PLATE ROD

Indexed keywords

AGED; ARTICLE; BONE DENSITY; BONE PLATE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FINITE ELEMENT ANALYSIS; FRAGILITY FRACTURE; HIGH RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; HIP FRACTURE; HUMAN; INDIVIDUAL TRABECULA SEGMENTATION; MAJOR CLINICAL STUDY; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; RADIUS; RADIUS FRACTURE; SPINE FRACTURE; TIBIA; TRABECULAR BONE;

EID: 84862948886     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.562     Document Type: Article

References (41)

1. 1991 NIH Consensus Development Panel on Osteoporosis Prevention. Consensus Development Conference Report: prophylaxis and treatment of osteoporosis. Osteoporosis Int. 1991; 1 (2): 114-7.
2. Genant HK, Delmas PD, Chen P, Jiang Y, Eriksen EF, Dalsky GP, Marcus R, San Martin J,. Severity of vertebral fracture reflects deterioration of bone microarchitecture. Osteoporos Int. 2007; 18 (1): 69-76. (Pubitemid 44885497)
3. Qiu S, Rao DS, Palnitkar S, Parfitt AM,. Independent and combined contributions of cancellous and cortical bone deficits to vertebral fracture risk in postmenopausal women. J Bone Miner Res. 2006; 21 (11): 1791-6. (Pubitemid 46141235)
4. Miller PD,. Clinical use of bone mass measurements in adults for the assessment and management of osteoporosis. In:, Favus MJ, editor. Primer on the metabolic bone disease and disorders of mineral metabolism. 6th ed. Washington (DC): American Society for Bone and Mineral Research; 2006. p. 150-61.
5. Hui SL, Slemenda CW, Johnston CC Jr., Age and bone mass as predictors of fracture in a prospective study. J Clin Invest. 1988; 81 (6): 1804-9.
6. Siris ES, Miller PD, Barrett-Connor E, Faulkner KG, Wehren LE, Abbott TA, Berger ML, Santora AC, Sherwood LM,. Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA. 2001; 286 (22): 2815-22. (Pubitemid 33126923)
7. Schuit SC, van der Klift M, Weel AE, de Laet CE, Burger H, Seeman E, Hofman A, Uitterlinden AG, van Leeuwen JP, Pols HA,. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone. 2004; 34 (1): 195-202. (Pubitemid 38142449)
8. Liu XS, Shane E, McMahon DJ, Guo XE,. Individual trabecula segmentation (ITS)-based morphological analysis of micro-scale images of human tibial trabecular bone at limited spatial resolution. J Bone Miner Res. 2011; 26 (9): 2184-93.
9. Liu XS, Zhang XH, Sekhon KK, Adams MF, McMahon DJ, Bilezikian JP, Shane E, Guo XE,. High-resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone. J Bone Miner Res. 2010; 25 (4): 746-56.
10. MacNeil JA, Boyd SK,. Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality. Med Eng Phys. 2007; 29 (10): 1096-105. (Pubitemid 350052626)
11. Macneil JA, Boyd SK,. Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method. Bone. 2008; 42 (6): 1203-13.
12. Cohen A, Liu XS, Stein EM, McMahon DJ, Rogers HF, Lemaster J, Recker RR, Lappe JM, Guo XE, Shane E,. Bone microarchitecture and stiffness in premenopausal women with idiopathic osteoporosis. J Clin Endocrinol Metab. 2009; 94 (11): 4351-60.
13. Liu XS, Bevill G, Keaveny TM, Sajda P, Guo XE,. Micromechanical analyses of vertebral trabecular bone based on individual trabeculae segmentation of plates and rods. J Biomech. 2009; 42 (3): 249-56.
14. Boutroy S, Van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD,. Finite element analysis based on in vivo HR-pQCT images of the distal radius is associated with wrist fracture in postmenopausal women. J Bone Miner Res. 2008; 23 (3): 392-9. (Pubitemid 351304669)
15. Melton LJ 3rd, Riggs BL, Keaveny TM, Achenbach SJ, Hoffmann PF, Camp JJ, Rouleau PA, Bouxsein ML, Amin S, Atkinson EJ, Robb RA, Khosla S,. Structural determinants of vertebral fracture risk. J Bone Miner Res. 2007; 22 (12): 1885-92. (Pubitemid 351229305)
16. Melton LJ 3rd, Riggs BL, van Lenthe GH, Achenbach SJ, Muller R, Bouxsein ML, Amin S, Atkinson EJ, Khosla S,. Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women. J Bone Miner Res. 2007; 22 (9): 1442-8. (Pubitemid 351339689)
17. Melton LJ 3rd, Christen D, Riggs BL, Achenbach SJ, Muller R, van Lenthe GH, Amin S, Atkinson EJ, Khosla S,. Assessing forearm fracture risk in postmenopausal women. Osteoporos Int. 2010; 21: 1161-9.
18. Vilayphiou N, Boutroy S, Sornay-Rendu E, Van Rietbergen B, Munoz F, Delmas PD, Chapurlat R,. Finite element analysis performed on radius and tibia HR-pQCT images and fragility fractures at all sites in postmenopausal women. Bone. 2010; 46: 1030-7.
19. Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Yin PT, Cosman F, Nieves J, Guo XE, Shane E,. Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. J Bone Miner Res. 2010; 25 (12): 2296-305.
20. Liu XS, Sajda P, Saha PK, Wehrli FW, Bevill G, Keaveny TM, Guo XE,. Complete volumetric decomposition of individual trabecular plates and rods and its morphological correlations with anisotropic elastic moduli in human trabecular bone. J Bone Miner Res. 2008; 23 (2): 223-35. (Pubitemid 351160036)
21. Liu XS, Sajda P, Saha PK, Wehrli FW, Guo XE,. Quantification of the roles of trabecular microarchitecture and trabecular type in determining the elastic modulus of human trabecular bone. J Bone Miner Res. 2006; 21 (10): 1608-17. (Pubitemid 44484606)
22. Fields AJ, Lee GL, Liu XS, Jekir MG, Guo XE, Keaveny TM,. Influence of vertical trabeculae on the compressive strength of the human vertebra. J Bone Miner Res. 2011; 26 (2): 263-9.
23. Liu XS, Cohen A, Shane E, Stein E, Rogers HF, Kokolus SL, Yin PT, McMahon DJ, Lappe JM, Recker RR, Guo XE,. Individual trabeculae segmentation (ITS)-based morphological analyses of high resolution peripheral quantitative computed tomography images detect abnormal trabecular plate and rod microarchitecture in premenopausal women with idiopathic osteoporosis. J Bone Miner Res. 2010; 25 (7): 1486-505.
24. Liu XS, Walker MD, McMahon DJ, Udesky J, Liu G, Bilezikian JP, Guo XE,. Better skeletal microstructure confers greater mechanical advantages in Chinese-American women versus Caucasian women. J Bone Miner Res. 2011; 26 (8): 1783-92.
25. Genant HK, Wu CY, van Kuijk C, Nevitt MC,. Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res. 1993; 8 (9): 1137-48. (Pubitemid 23261108)
26. Boutroy S, Bouxsein ML, Munoz F, Delmas PD,. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab. 2005; 90 (12): 6508-15. (Pubitemid 41759306)
27. Boutroy S, van Rietbergen B, Sornay-Rendu E, Munoz F, Bouxsein ML, Delmas PD,. Finite Element Analyses Based on In Vivo HR-pQCT Images of the Distal Radius is Associated with Wrist Fracture in Postmenopausal Women. J Bone Miner Res. 2008; 23 (3): 392-9. (Pubitemid 351304669)
28. Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD,. Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res. 2007; 22 (3): 425-33. (Pubitemid 46797126)
29. Laib A, Hauselmann HJ, Ruegsegger P,. In vivo high resolution 3D-QCT of the human forearm. Technol Health Care. 1998; 6 (5-6): 329-37. (Pubitemid 29090456)
30. Saha PK, Chaudhuri BB, Majumder DD,. A new shape preserving parallel thinning algorithm for 3D digital images. Pattern Recogn. 1997; 30 (12): 1939-55. (Pubitemid 127410229)
31. Saha PK, Chaudhuri BB,. Detection of 3-D simple points for topology preserving. IEEE Trans Pattern Anal Mach Intell. 1994; 16 (10): 1028-32.
32. Saha PK, Chaudhuri BB, Chanda B, Dutta Majumder D,. Topology preservation in 3D digital space. Pattern Recogn. 1994; 27: 295-300. (Pubitemid 124017409)
33. Saha PK, Chaudhuri BB,. 3D digital topology under binary transformation with applications. Comput Vis Image Underst. 1996; 63 (3): 418-29. (Pubitemid 126405178)
34. Guo XE, Goldstein SA,. Is trabecular bone tissue different from cortical bone tissue?. Forma. 1997; 12: 185-96.
35. Melton LJ 3rd, Christen D, Riggs BL, Achenbach SJ, Muller R, van Lenthe GH, Amin S, Atkinson EJ, Khosla S,. Assessing forearm fracture risk in postmenopausal women. Osteoporos Int. 2010; 21 (7): 1161-9.
36. Hollister SJ, Brennan JM, Kikuchi N,. A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stress. J Biomech. 1994; 27 (4): 433-44. (Pubitemid 24102056)
37. Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Cosman F, Nieves J, Greisberg J, Guo XE, Shane E,. Abnormal Microarchitecture and Stiffness in Postmenopausal Women with Ankle Fractures. J Clin Endocrinol Metab. 2011; 96 (7): 2041-8.
38. Liu XS, Cohen A, Shane E, Yin PT, Stein EM, Rogers H, Kokolus SL, McMahon DJ, Lappe JM, Recker RR, Lang T, Guo XE,. Bone density, geometry, microstructure and stiffness: relationships between peripheral and central skeletal sites assessed by DXA, HR-pQCT, and cQCT in premenopausal women. J Bone Miner Res. 2010; 25 (10): 2229-38.
39. Sornay-Rendu E, Cabrera-Bravo JL, Boutroy S, Munoz F, Delmas PD,. Severity of vertebral fractures is associated with alterations of cortical architecture in postmenopausal women. J Bone Miner Res. 2009; 24 (4): 737-43.
40. Vico L, Zouch M, Amirouche A, Frere D, Laroche N, Koller B, Laib A, Thomas T, Alexandre C,. High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures. J Bone Miner Res. 2008; 23 (11): 1741-50.
41. Zhang XH, Liu XS, Vasilic B, Wehrli FW, Benito M, Rajapakse CS, Snyder PJ, Guo XE,. In vivo μMRI based finite element and morphological analyses of tibial trabecular bone in eugonadal and hypogonadal men before and after testosterone treatment. J Bone Miner Res. 2008; 23 (9): 1426-34.