RU486, a glucocorticoid receptor antagonist, induces apoptosis in U937 human lymphoma cells through reduction in mitochondrial membrane potential and activation of p38 MAPK

Oncology Reports

Volumn 30, Issue 1, 2013, Pages 506-512

  Jang, Ji Hoon ^a   Woo, Seon Min ^a   Um, Hee Jung ^a   Park, Eun Jung ^a   Min, Kyoung Jin ^a   Lee, Tae Jin ^b   Kim, Sang Hyun ^c   Choi, Yung Hyun ^d   Kwon, Taeg Kyu ^a  

^a Keimyung University   (South Korea)

^b Yeungnam University College of Medicine   (South Korea)

^c Kyungpook National University School of Medicine   (South Korea)

^d Dong Eui University   (South Korea)

Author keywords

Apoptosis; Caspase 3; Mitochondrial membrane potential; p38 MAPK; RU486

Indexed keywords

CYTOCHROME C; MIFEPRISTONE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CELL STRAIN U937; COLORECTAL CARCINOMA; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; LYMPHOMA; LYMPHOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; COLORECTAL NEOPLASMS; CYTOCHROMES C; ENZYME ACTIVATION; FEMALE; HCT116 CELLS; HORMONE ANTAGONISTS; HUMANS; LEUKEMIA; LUNG NEOPLASMS; LYMPHOMA; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MIFEPRISTONE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RECEPTORS, GLUCOCORTICOID; U937 CELLS;

EID: 84878199419     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2432     Document Type: Article

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