Raf kinase inhibitor protein inhibits esophageal cancer cell invasion through downregulation of matrix metalloproteinase expression

Oncology Reports

Volumn 30, Issue 1, 2013, Pages 304-312

  Zhao, Dongqiang ^a   Ma, Junji ^a   Shi, Junli ^a   Cheng, Lijuan ^a   Li, Fangfang ^a   Jiang, Xiaoyu ^b   Jiang, Huiqing ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Esophageal cancer; Invasion; Proliferation; Raf kinase inhibitor protein

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOVIRUS VECTOR; CELL PROTEIN; EOSIN; G PROTEIN COUPLED RECEPTOR KINASE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GREEN FLUORESCENT PROTEIN; HEMATOXYLIN; MATRIX METALLOPROTEINASE 14; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PARAFORMALDEHYDE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PROTEIN LIN28; RAF PROTEIN; UNCLASSIFIED DRUG;

ADULT; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CLASSIFICATION; CANCER INHIBITION; CANCER TISSUE; CELL ASSAY; CELL INVASION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISTANT METASTASIS; DOWN REGULATION; ENZYME ASSAY; ESOPHAGUS CANCER; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TISSUE PREPARATION; TISSUE SECTION; TUMOR LOCALIZATION; WESTERN BLOTTING;

APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; ESOPHAGEAL NEOPLASMS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; G-PROTEIN-COUPLED RECEPTOR KINASE 2; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE (PHOSPHORYLATING); HUMANS; LYMPHATIC METASTASIS; MALE; MATRIX METALLOPROTEINASE 14; MIDDLE AGED; NEOPLASM INVASIVENESS; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; PROTO-ONCOGENE PROTEINS C-RAF; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS;

EID: 84878196322     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2464     Document Type: Article

References (40)

1. Klein CA and Stoecklein NH: Lessons from an aggressive cancer: evolutionary dynamics in esophageal carcinoma. Cancer Res 69: 5285-5288, 2009.
2. Mao WM, Zheng WH and Ling ZQ: Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev 12: 2461-2466, 2011.
3. Lepage C, Rachet B, Jooste V, Faivre J and Coleman MP: Continuing rapid increase in esophageal adenocarcinoma in England and Wales. Am J Gastroenterol 103: 2694-2699, 2008.
4. Tew WP, Kelsen DP and Ilson DH: Targeted therapies for esophageal cancer. Oncologist 10: 590-601, 2005. (Pubitemid 41429122)
5. Yeung K, Seitz T, Li S, Janosch P, McFerran B, Kaiser C, Fee F, Katsanakis KD, Rose DW, Mischak H, Sedivy JM and Kolch W: Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 401: 173-177, 1999. (Pubitemid 29436321)
6. Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W and Sedivy JM: Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol 21: 7207-7217, 2001. (Pubitemid 32953475)
7. Deiss K, Kisker C, Lohse MJ and Lorenz K: Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2. J Biol Chem 287: 23407-23417, 2012.
8. al-Mulla F, Bitar MS, Taqi Z, Rath O and Kolch W: RAF kinase inhibitory protein (RKIP) modulates cell cycle kinetics and motility. Mol Biosyst 7: 928-941, 2011.
9. Ma J, Li F, Liu L, Cui D, Wu X, Jiang X and Jiang H: Raf kinase inhibitor protein inhibits cell proliferation but promotes cell migration in rat hepatic stellate cells. Liver Int 29: 567-574, 2009.
10. Keller ET: Role of Raf kinase inhibitor protein in pathophysiology of prostate cancer. For Immunopathol Dis Therap 2: 89-94, 2011.
11. Khamis ZI, Iczkowski KA and Sang QX: Metastasis suppressors in human benign prostate, intraepithelial neoplasia, and invasive cancer: their prospects as therapeutic agents. Med Res Rev 32: 1026-1077, 2012.
12. Bevilacqua E, Frankenberger CA and Rosner MR: RKIP suppresses breast cancer metastasis to the bone by regulating stroma-associated genes. Int J Breast Cancer 2012: 124704, 2012.
13. Granovsky AE and Rosner MR: Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor. Cell Res 18: 452-457, 2008. (Pubitemid 351498852)
14. Klysik J, Theroux SJ, Sedivy JM, Moffit JS and Boekelheide K: Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction. Cell Signal 20: 1-9, 2008. (Pubitemid 350138364)
15. Zeng L, Imamoto A and Rosner MR: Raf kinase inhibitory protein (RKIP): a physiological regulator and future therapeutic target. Expert Opin Ther Targets 12: 1275-1287, 2008.
16. Wang J, Yang YH, Wang AQ, Yao B, Xie G, Feng G, Zhang Y, Cheng ZS, Hui L, Dai TZ, Du XB and Wang D: Immunohistochemical detection of the Raf kinase inhibitor protein in nonneoplastic gastric tissue and gastric cancer tissue. Med Oncol 27: 219-223, 2010.
17. Chatterjee D, Sabo E, Tavares R and Resnick MB: Inverse association between Raf kinase inhibitory protein and signal transducers and activators of transcription 3 expression in gastric adenocarcinoma patients: implications for clinical outcome. Clin Cancer Res 14: 2994-3001, 2008.
18. Zlobec I, Baker K, Minoo P, Jass JR, Terracciano L and Lugli A: Node-negative colorectal cancer at high risk of distant metastasis identified by combined analysis of lymph node status, vascular invasion, and Raf-1 kinase inhibitor protein expression. Clin Cancer Res 14: 143-148, 2008. (Pubitemid 351377989)
19. Minoo P, Zlobec I, Baker K, Tornillo L, Terracciano L, Jass JR and Lugli A: Loss of raf-1 kinase inhibitor protein expression is associated with tumor progression and metastasis in colorectal cancer. Am J Clin Pathol 127: 820-827, 2007.
20. Al-Mulla F, Hagan S, Behbehani AI, Bitar MS, George SS, Going JJ, García JJ, Scott L, Fyfe N, Murray GI and Kolch W: Raf kinase inhibitor protein expression in a survival analysis of colorectal cancer patients. J Clin Oncol 24: 5672-5679, 2006. (Pubitemid 46631308)
21. Zlobec I, Baker K, Terracciano L, Peter S, Degen L, Beglinger C and Lugli A: Two-marker protein profile predicts poor prognosis in patients with early rectal cancer. Br J Cancer 99: 1712-1717, 2008.
22. Kim HS, Won KY, Kim GY, Kim SC, Park YK and Kim YW: Reduced expression of Raf-1 kinase inhibitory protein predicts regional lymph node metastasis and shorter survival in esophageal squamous cell carcinoma. Pathol Res Pract 208: 292-299, 2012.
23. Birner P, Jesch B, Schultheis A and Schoppmann SF: RAF-kinase inhibitor protein (RKIP) downregulation in esophageal cancer and its metastases. Clin Exp Metastasis 29: 551-559, 2012.
24. Gao C, Pang L, Ren C and Ma T: Prognostic value of raf kinase inhibitor protein in esophageal squamous cell carcinoma. Pathol Oncol Res 18: 471-477, 2012.
25. Bray F, Jemal A, Grey N, Ferlay J and Forman D: Global cancer transitions according to the Human Development Index (2008-2030): a population-based study. Lancet Oncol 13: 790-801, 2012.
26. Lambert R, Saito H, Lucas E and Sankaranarayanan R: Survival from digestive cancer in emerging countries in Asia and Africa. Eur J Gastroenterol Hepatol 24: 605-612, 2012.
27. Bosetti C, Levi F, Ferlay J, Garavello W, Lucchini F, Bertuccio P, Negri E and La Vecchia C: Trends in oesophageal cancer incidence and mortality in Europe. Int J Cancer 122: 1118-1129, 2008. (Pubitemid 351214012)
28. Brown LM, Devesa SS and Chow WH: Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age. J Natl Cancer Inst 100: 1184-1187, 2008.
29. Shibata A, Matsuda T, Ajiki W and Sobue T: Trend in incidence of adenocarcinoma of the esophagus in Japan, 1993-2001. Jpn J Clin Oncol 38: 464-468, 2008.
30. Woods Ignatoski KM, Grewal NK, Markwart SM, Vellaichamy A, Chinnaiyan AM, Yeung K, Ray ME and Keller ET: Loss of Raf kinase inhibitory protein induces radioresistance in prostate cancer. Int J Radiat Oncol Biol Phys 72: 153-160, 2008.
31. Yun J, Frankenberger CA, Kuo WL, Boelens MC, Eves EM, Cheng N, Liang H, Li WH, Ishwaran H, Minn AJ and Rosner MR: Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer. EMBO J 30: 4500-4514, 2011.
32. Zaravinos A, Bizakis J and Spandidos DA: RKIP and BRAF aberrations in human nasal polyps and the adjacent turbinate mucosae. Cancer Lett 264: 288-298, 2008.
33. Li HZ, Gao Y, Zhao XL, Liu YX, Sun BC, Yang J and Yao Z: Effects of raf kinase inhibitor protein expression on metastasis and progression of human breast cancer. Mol Cancer Res 7: 832-840, 2009.
34. Li HZ, Wang Y, Gao Y, Shao J, Zhao XL, Deng WM, Liu YX, Yang J and Yao Z: Effects of raf kinase inhibitor protein expression on metastasis and progression of human epithelial ovarian cancer. Mol Cancer Res 6: 917-928, 2008.
35. Dangi-Garimella S, Yun J, Eves EM, Newman M, Erkeland SJ, Hammond SM, Minn AJ and Rosner MR: Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7. EMBO J 28: 347-358, 2009.
36. Akutsu Y and Matsubara H: The significance of lymph node status as a prognostic factor for esophageal cancer. Surg Today 41: 1190-1195, 2011.
37. Sgourakis G, Gockel I, Lyros O, Lanitis S, Dedemadi G, Polotzek U, Karaliotas C and Lang H: The use of neural networks in identifying risk factors for lymph node metastasis and recommending management of t1b esophageal cancer. Am Surg 78: 195-206, 2012.
38. Ben-Neriah Y and Karin M: Inflammation meets cancer, with NF-κB as the matchmaker. Nat Immunol 12: 715-723, 2011.
39. Bromberg J and Wang TC: Inflammation and cancer: IL-6 and STAT3 complete the link. Cancer Cell 15: 79-80, 2009.
40. Beshir AB, Ren G, Magpusao AN, Barone LM, Yeung KC and Fenteany G: Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. Cancer Lett 299: 137-149, 2010.