Median effective dose (ED50) of paracetamol and nefopam for postoperative pain: Isobolographic analysis of their antinociceptive interaction

Minerva Anestesiologica

Volumn 79, Issue 3, 2013, Pages 232-239

  Van Elstraete, A C ^a   Sitbon, P ^b  

^a Department of Anesthesiology   (France)

^b INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Analgesia; Nefopam; Pain, postoperative

Indexed keywords

NEFOPAM; PARACETAMOL;

ADULT; ANTINOCICEPTION; CONTINUOUS INFUSION; CONTROLLED STUDY; DIZZINESS; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; GENERAL ANESTHESIA; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; NAUSEA; POSTOPERATIVE ANALGESIA; POSTOPERATIVE PAIN; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REVIEW; SIDE EFFECT; SURGICAL PATIENT; SWEATING; TACHYCARDIA; TONSILLECTOMY; VOMITING; XEROSTOMIA;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; ANESTHESIA, GENERAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEFOPAM; PAIN, POSTOPERATIVE; TONSILLECTOMY;

EID: 84878183230     PISSN: 03759393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (33)

1. Dahl JB, Rosenberg J, Dirkes WE, Mogensen T, Kehlet H. Prevention of postoperative pain by balanced analgesia. Br J Anaesth 1990;64:518-20. (Pubitemid 20134238)
2. Phillips G, Vickers MD. Nefopam in postoperative pain. Br J Anaesth 1979;51:961-5. (Pubitemid 10250300)
3. Guirimand F, Dupont X, Bouhassira D, Brasseur L, Chauvin M. Nefopam strongly depresses the nociceptive flexion (RIII) reflex in humans Pain 1999;80:399-404. (Pubitemid 29151726)
4. Piercey MF, Schroeder LA. Spinal and supraspinal sites for morphine and nefopam analgesia in the mouse. Eur J Pharmacol 1981;74:135-40. (Pubitemid 11002097)
5. Girard P, Coppe MC, Verniers D, Pansart Y, Gillardin JM. Role of catecholamines and serotonin receptor subtypes in nefopam-induced antinociception. Pharmacol Res 2006;54:195-202. (Pubitemid 44119199)
6. Verleye M, Andre N, Heulard I, Gillardin JM. Nefopam blocks voltage-sensitive sodium channels and modulates glutaminergic transmission in rodents. Brain Res 2004;1013:249-55. (Pubitemid 38757432)
7. Fernandez-Sanchez MT, Diaz-Trelles R, Groppetti A, Manfredi B, Brini AT, Biella G et al. Nefopam, an analogue of orphenadrine, protects against both NMDA receptor-dependent and independent veratridine-induced neurotoxicity. Amino Acids 2002;23:31-6.
8. Fletcher D, Fermanian C, Mardaye A, Aegerter P. A patient-based national survey on postoperative pain management in France reveals significant achievements and persistent challenges. Pain 2008;137:441-51.
9. Pini LA, Sandrini M, Vitale G. The antinociceptive action of paracetamol is associated with changes in the serotonergic system in the rat brain. Eur J Pharmacol 1996;308:31-40. (Pubitemid 26233012)
10. Pickering G, Loriot MA, Libert F, Eschalier A, Beaune P, Dubray C. Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clin Pharmacol Ther. 2006;79:371-8.
11. Raffa RB, Codd EE. Lack of binding of acetaminophen to 5-HT receptor or uptake sites (or eleven other binding/uptake assays). Life Sci. 1996;59:37-40. (Pubitemid 126334935)
12. Muth-Selbach US, Tegeder J, Brune K, Geisslinger G. Acetaminophen inhibits spinal prostaglandin E2 release after peripheral noxious stimulation. Anesthesiology 1999;91:231-9. (Pubitemid 29307357)
13. Schwab JM, Schuesener HJ, Laufer S. Cox-3: just another Cox or the solitary elusive target of paracetamol? Lanct 2003;361:981-2. (Pubitemid 36351364)
14. Lee YS, Kim H, Brahim JS, Rowan J, Lee G, Dionne RA. Acetaminophen selectively suppresses peripheral prostaglandin E2 release and increases COX-2 gene expression in a clinical model of acute inflammation. Pain 2007;129:279-86. (Pubitemid 46754568)
15. Sandrini M, Romualdi P, Capobianco A, Vitale G, Morelli G, Pini LA et al. The effect of paracetamol on nociception and dynorphin A levels in the rat brain. Neuropeptides 2001;35:110-6. (Pubitemid 32575054)
16. Mimoz O, Incagnoli P, Josse C, Gillon MC, Kuhlman I, Mirand A et al. Analgesic efficacy and safety of nefopam vs propacetamol following hepatic resection. Anaesthesia 2001;56:520-5. (Pubitemid 32529613)
17. Du Manoir B, Aubrun F, Langlois M, Le Guern ME, Alquier C, Chauvin M et al. Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery. Br J Anesth 2003;91:836-41. (Pubitemid 37508827)
18. Delbos A, Boccard E. The morphine-sparing effect of propacetamol in orthopaedic postoperative pain. J Pain Symptom Manage 1995;10:279-86.
19. Peduto VA, Ballabio M, Stefarini S. Efficacy of propacetamol in the treatment of postoperative pain. Morphine-sparing effect in orthopaedic surgery. Acta Anesthesiol Scand 1998;42:293-8. (Pubitemid 28131377)
20. Hahn TW, Mogensen T, Lund C, Jacobsen LS, Hjortsoe NC, Rasmussen SN et al. Analgesic effect of IV paracetamol in postoperative pain. Acta Anaesthesiol Scand 2003;47:138-45.
21. Varassi G, Marinangeli F, Agro F, Aloe L, De Cillis P, De Nicola A et al. A double-blinded evaluation of propacetamol versus ketorolac in combination with patient-controlled morphine: analgesic efficacy and tolerability after gynaecologic surgery. Anesth Analg 1999;88:611-6. (Pubitemid 29109031)
22. Dixon WJ, Mood AM. A method for obtaining and analyzing sensitivity data. J Am Stat Assoc 1948;48:109-26.
23. Dixon WJ. Staircase bioassay: the up-and-down method. Neurosci Biobehav Rev 1991;15:47-50.
24. Tallarida RJ, Porreca F, Cowan A. Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sci 1989;45:947-61. (Pubitemid 19251921)
25. Delage N, Maaliki H, Beloeil H, Benhamou D, Mazoit JX. Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients. A study of interaction using sequential analysis and isobolographic analysis. Anesthesiology 2005;102:1211-6. (Pubitemid 40745841)
26. Miranda HF, Puig MM, Prieto JC, Pinardi G. Synergism between paracetamol and nonsteroidal anti-inflammatory drugs in experimental acute pain. Pain 2006;121:22-8. (Pubitemid 43261628)
27. Qiu HX, Liu J, Kong H, Liu Y, Mei XG. Isobolographic analysis of the antinociceptive interactions between ketoprofen and paracetamol. Eur J Pharmacol 2007;557:141-6. (Pubitemid 46186289)
28. Filitz J, Ihmsen H, Günther W, Tröster A, Schwilden H, Schüttler J et al. Supra-additive effects of tramadol and acetaminophen in a human pain model. Pain 2008;136:262-70. (Pubitemid 351680244)
29. Beloeil H, Delage N, Nègre I, Mazoit JX, Benhamou D. The median effective dose of nefopam and morphine administered intravenously for postoperative pain after minor surgery: a prospective randomized double-blinded isobolographic study of their analgesic action. Anesth Analg 2004;98:395-400. (Pubitemid 38129387)
30. Troïtzky A, Tirault M, Lefeuvre S, Lepage B, Debaene B. Physico-chemical stability and sterility of non-opioid analgesics in solution. Ann Fr Anesth Rean 2008;27:813-8.
31. Beloeil H, Eurin M, Thévenin A, Benhamou D, Mazoit JX. Effective dose of nefopam in 80% of patients (ED80): a study using the continual reassessment method. Br J Pharmacol 2007;64:686-93. (Pubitemid 47568823)
32. Aymard G, Warot D, Demolis P, Giudicelli JF, Lechat P, Le Guern ME et al. Comparative pharmacokinetics of intravenous and oral nefopam in healthy volunteers. Pharmacol Toxicol 2003;92:279-86. (Pubitemid 36734986)
33. Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E et al. Plasma and cerebrospinal fluid concentrations of paracetamol after single intravenous dose of propacetamol. Br J Clin Pharmacol 1992;34:79-81.