Nefopam, an analogue of orphenadrine, protects against both NMDA receptor-dependent and independent veratridine-induced neurotoxicity

Amino Acids

Volumn 23, Issue 1-3, 2002, Pages 31-36

  Fernandez Sanchez M T ^a   Diaz Trelles R ^a   Groppetti, A ^b   Manfredi, B ^b   Brini, A T ^b   Biella, G ^b   Sotgiu, M L ^c   Novelli, A ^a  

^a UNIVERSITY OF OVIEDO   (Spain)

^b UNIVERSITY OF MILAN   (Italy)

^c CNR   (Italy)

Author keywords

Cerebellar neurons in culture; Excitotoxicity; NMDA receptor antagonist; Voltage sensitive sodium channels

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; DIZOCILPINE; GLUTAMIC ACID; MUSCIMOL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEFOPAM; ORPHENADRINE; SODIUM CHANNEL; VERATRIDINE;

ANIMAL CELL; ANIMAL EXPERIMENT; BRAIN NERVE CELL; CELL CULTURE; CEREBELLUM; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BINDING; DRUG EFFECT; DRUG EFFICACY; HIPPOCAMPUS; MALE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALGESICS, NON-NARCOTIC; ANIMALS; CELLS, CULTURED; CEREBELLUM; DIZOCILPINE MALEATE; GABA AGONISTS; GLUTAMIC ACID; MALE; MUSCIMOL; NEFOPAM; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; ORPHENADRINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; VERATRIDINE;

ANIMALIA;

EID: 0036391951     PISSN: 09394451     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00726-001-0106-6     Document Type: Conference Paper

References (31)

1. Besson JM (1999) The neurobiology of pain. Lancet 353: 1610-1615
2. Biella GEM, Groppetti A, Novelli A, Fernández-Sánchez MT, Manfredi B, Sotgiu ML (2002) Neuronal sensitization and its behavioral correlates in a rat model of neuropathy are prevented by a cyclic analog of orphenadrine. J Neurotrauma (in press)
3. Deffois A, Fage D, Carter C (1996) Inhibition of synaptosomal veratridine-induced sodium influx by antidepressants and neuroleptics used in chronic pain. Neurosci Lett 220: 117-120
4. Díaz-Trelles R, Novelli A, Puia G, Baraldi M, Fernández-Sánchez MT (2000) NMDA receptor dependent and independent components of veratridine toxicity in cultured cerebellar neurons are prevented by nanomolar concentrations of terfenadine. Amino Acids 19: 263-272
5. Ebert B, Wong EH, Krogsgaard-Larsen P (1991) Identification of a novel NMDA receptor in rat cerebellum. Eur J Pharmacol 208: 49-52
6. Fasmer OB, Berge OG, Jçrgensen HA, Hole K (1987) antinociceptive effects of (±)-, (+)- and (-) nefopam in mice. J Pharm Pharmacol 39: 508-511
7. Fernández MT, Zitko V, Gascón S, Novelli A (1991) The marine toxin okadaic acid is a potent neurotoxin for cultured cerebellar neurons. Life Sci 49: PL157-PL162
8. Fernández-Sánchez MT, Diaz-Trelles R, Groppetti A, Manfredi B, Brini AT, Biella G, Sotgiu ML, Novelli A (2002) Novel effect of nefopam preventing cGMP increase, oxygen radical formation and neuronal death induced by veratridine. Neuropharmacology 41: 935-942
9. Gallo V, Ciotti MT, Aloisi F, Levi, G (1982) Selective release of glutamate from cerebellar granule cells differentiating in culture. Proc Acad Sci USA 79: 7919-7923
10. 35S]-t-butylbicyclophosphonothionate binding to cerebellar granule cells. J Neurosci 5: 2432-2438
11. Gasser JC, Bellville JW (1975) Respiratory effects of nefopam. Clin Pharmacol Ther 18: 175-179
12. Gerbershagen HU, Schaffner E (1979) Respiratory effect of nefopam. Clin Ther 2 [Suppl B]: 39-42
13. Guirimand F, Dupont X, Bouhassira D, Brasseur L, Chauvin M (1999) Nefopam strongly depresses the nociceptive flexion (R(III)) reflex in humans. Pain 80: 399-404
14. Harke H, Gretenkort P, Ladleif HU, Rahman S, Harke O (2001) The response of neuropathic pain and pain in complex regional pain syndrome I to carbamazepine and sustained-release morphine in patients pretreated with spinal cord stimulation: a double-blinded randomized study. Anesth Analg 92: 488-495
15. Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS (1980) Nefopam: a review of its pharmacological properties and therapeutic efficacy. Drugs 19: 249-267
16. Hunskaar S, Fasmer OB, Broch OJ, Hole K (1987) Involvement of central serotonergic pathways in nefopam-induced antinociception. Eur J Pharmacol 138: 77-82
17. Kawamata M, Omote K (1996) Involvement of increased excitatory amino acids and intracellular Ca2+ concentration in the spinal dorsal horn in an animal model of neuropathic pain. Pain 68: 85-96
18. Kim YI, Na HS, Yoo YW, Han HC, Ko KH, Hong SK (1997) NMDA receptors are important for both mechanical and thermal allodynia from peripheral nerve injury in rats. Neuroreport 8: 149-153
19. Klamt JG (1998) Effects of intrathecally administered lamotrigine, a glutamate release inhibitor, on short- and long-term models of hyperalgesia in rats. Anesthesiology 88: 487-494
20. Kornhuber J, Parsons CG, Hartmann S, Retz W, Kamolz S, Thome J, Riederer P (1995) Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: binding and patch clamp studies. J Neural Transm 102: 237-246
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurements with the Folin phenol reagent. J Biol Chem 193: 265-275
22. Nicoletti F, Wroblewski JT, Novelli A, Alho H, Guidotti A, Costa, E (1986) The activation of inositol phospholipid metabolism as a signal-transducing system for excitatory amino acids in primary cultures of cerebellar granule cells. J Neurosci 6: 1905-1911
23. Novelli A, Reilly JA, Lysko PG, Henneberry RC (1988) Glutamate becomes neurotoxic via the NMDA receptor when intracellular energy levels are reduced. Brain Res 451: 205-212
24. Novelli A, Kispert J, Fernández-Sánchez MT, Torreblanca A, Zitko V (1992) Domoic acid-containing toxic mussels produce neurotoxicity in neuronal cultures through a synergism between excitatory amino acids. Brain Res 577: 41-48
25. Piper SN, Suttner SW, Schmidt CC, Maleck WH, Kumle B, Boldt J (1999) Nefopam and clonidine in the prevention of postanaesthetic shivering. Anaesthesia 54: 695-699
26. Quarum ML, Parker JD, Keana JF, Weber E (1990) (+)-[3H]MK801 binding sites in postmortem human brain. J Neurochem 54: 1163-1168
27. Reynolds IJ, Palmer AM (1991) Regional variations in [3H]MK801 binding to rat brain N-methyl-D-aspartate receptors. J Neurochem 56: 1731-1740
28. Rizzo MA (1997) Successful treatment of painful traumatic mononeuropathy with carbamazepine: insights into a possible molecular pain mechanism. J Neurol Sci 152: 103-106
29. Rosa G, Pinto G, Orsi P, de Blasi RA, Conti G, Sanita R, La Rosa I, Gasparetto A (1995) Control of post anaesthetic shivering with nefopam hydrochloride in mildly hypothermic patients after neurosurgery. Acta Anaeshesiol Scand 39: 90-95
30. Terlau H, Heinemann SH, Stümer W, Pusch M, Conti F, Imoto K, Numa S (1991) Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II. FEBS Letters 293: 93-96
31. Wong EHF, Kemp JA, Priestley T, Knight AR, Woodruff GN, Iversen LI (1986) The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci 83: 7104-7108