Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery

British Journal of Anaesthesia

Volumn 91, Issue 6, 2003, Pages 836-841

  Du Manoir, B ^a   Aubrun, F ^b   Langlois, M ^a   Le Guern, M E ^c   Alquier, C ^c   Chauvin, M ^a   Fletcher, Dominique ^a  

^a RAYMOND POINCARÉ HOSPITAL   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c Service de Pharmacologie   (France)

Author keywords

Analgesia, balanced; Analgesia, patient controlled; Analgesics non opioid, nefopam; Complications, hyperalgesia

Indexed keywords

ATRACURIUM; HYDROXYZINE; ISOFLURANE; MORPHINE; NEFOPAM; NITROUS OXIDE PLUS OXYGEN; PLACEBO; PROPACETAMOL; PROPOFOL; SUFENTANIL; SUXAMETHONIUM; THIOPENTAL; VECURONIUM;

ADULT; AGED; ANALGESIC ACTIVITY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG TOLERANCE; FEMALE; HIP ARTHROPLASTY; HUMAN; MALE; MULTICENTER STUDY; NAUSEA; ORTHOPEDIC SURGERY; OUTCOMES RESEARCH; PAIN ASSESSMENT; PATIENT CONTROLLED ANALGESIA; PATIENT SATISFACTION; POSTOPERATIVE CARE; POSTOPERATIVE PAIN; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; SCORING SYSTEM; SIDE EFFECT; STATISTICAL ANALYSIS; SWEATING; URINE RETENTION; VERTIGO; VISUAL ANALOG SCALE; VOMITING;

EID: 0345099553     PISSN: 00070912     EISSN: None     Source Type: Journal    
DOI: 10.1093/bja/aeg264     Document Type: Article

References (27)

1. Kehlet H, Dahl JB. The value of 'multimodal' or 'balanced analgesia' in postoperative pain treatment. Anesth Analg 1993; 77: 1048-56
2. Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Nefopam: a review of its pharmacological properties and therapeutic efficacy. Drugs 1980; 19: 249-67
3. Mather GG, Labroo R, Le Guern ME, Lepage F, Gillardin JM, Levy R.H. Nefopam enantiomers: preclinical pharmacology/toxicology and pharmacokinetic characteristics in healthy subjects after intravenous administration. Chirality 2000; 12: 153-9
4. Rosland JH, Hole K. The effect of nefopam and its enantiomers on the uptake of 5-hydroxytryptamine, noradrenaline and dopamine in crude rat brain synaptosomal preparations. J Pharm Pharmacol 1990; 42: 437-8
5. Buritova J, Besson JM. Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat. Eur J Pharmacol 2002; 441: 67-74
6. Guirimand F, Dupont X, Bouhassira D, Brasseur L, Chauvin M. Nefopam strongly depresses the nociceptive flexion (R(III)) reflex in humans. Pain 1999; 80: 399-404
7. Bhatt AM, Pleuvry BJ, Maddison SE. Respiratory and metabolic effects of oral nefopam in human volunteers. Br J Clin Pharmacol 1981; 11: 209-11
8. Dordoni PL, Della Ventura M, Stefanelli A, et al. Effect of ketorolac, ketoprofen and nefopam on platelet function. Anaesthesia 1994; 49: 1046-9
9. Urwin SC, Smith HS. Fatal nefopam overdose. Br J Anaesth 1999; 83: 501-2
10. Tracqui A, Berthelon L, Ludes B. Fatal overdosage with nefopam (Acupan). J Anal Toxicol 2002; 26: 239-43
11. Hedges A, Wadsworth J, Turner P. A double-blind comparison of nefopam and placebo in post-operative pain. Curr Med Res Opin 1978; 5: 614-7
12. Trop D, Kenny L, Grad BR. Comparison of nefopam hydrochloride and propoxyphene hydrochloride in the treatment of postoperative pain. Can Anaesth Soc J 1979; 26: 296-304
13. Beaver WT, Feise GA. A comparison of the analgesic effect of intramuscular nefopam and morphine in patients with postoperative pain. J Clin Pharmacol 1977; 17: 579-91
14. Sunshine A, Laska E. Nefopam and morphine in man. Clin Pharmacol Ther 1975; 18: 530-4
15. Tigerstedt I, Sipponen J, Tammisto T, Turunen M. Comparison of nefopam and pethidine in postoperative pain. Br J Anaesth 1977; 49: 1133-8
16. McLintock TT, Kenny GN, Howie JC, McArdle CS, Lawrie S, Aitken H. Assessment of the analgesic efficacy of nefopam hydrochloride after upper abdominal surgery: a study using patient controlled analgesia. Br J Surg 1988; 75: 779-81
17. Mimoz O, Incagnoli P, Josse C, et al. Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection. Anaesthesia 2001; 56: 520-5
18. Fletcher D, Zetlaoui P, Monin S, et al. Influence of timing on the analgesic effect of intravenous ketorolac after orthopedic surgery. Pain 1995; 61: 291-7
19. Hyllested M, Jones S, Pedersen JL, Kehlet H. Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth 2002; 88: 199-214
20. Slappendel R, Weber EW, Bugter ML, Dirksen R. The intensity of preoperative pain is directly correlated with the amount of morphine needed for postoperative analgesia. Anesth Analg 1999; 88: 146-8
21. Wilder-Smith OH, Tassonyi E, Arendt-Nielsen L. Preoperative back pain is associated with diverse manifestations of central neuroplasticity. Pain 2002; 97: 189-94
22. Fletcher D, Negre I, Barbin C, et al. Postoperative analgesia with i.v. propacetamol and ketoprofen combination after disc surgery. Can J Anaesth 1997; 44: 479-85
23. Dahl JB, Kehlet H. Non-steroidal anti-inflammatory drugs: rationale for use in severe postoperative pain. Br J Anaesth 1991; 66: 703-12
24. Tang J, Li S, White PF, et al. Effect of parecoxib, a novel intravenous cyclooxygenase type-2 inhibitor, on the postoperative opioid requirement and quality of pain control. Anesthesiology 2002; 96: 1305-9
25. Grass JA, Sakima NT, Valley M, et al. Assessment of ketorolac as an adjuvant to fentanyl patient-controlled epidural analgesia after radical retropubic prostatectomy. Anesthesiology 1993; 78: 642-8
26. Kehlet H, Werner M, Perkins F. Balanced analgesia: what is it and what are its advantages in postoperative pain? Drugs 1999; 58: 793-7
27. Maaliki H, Delage N, Mazoit JX, Benhamou D. Synergie de l'association néfopam-kétoprofène en période postopératoire. Ann Fr Anesth Réanim 2002; 21 (Suppl. 2):