p21-activated kinase-2 is a critical mediator of transforming growth factor-β-induced hepatoma cell migration

Journal of Gastroenterology and Hepatology (Australia)

Volumn 28, Issue 6, 2013, Pages 1047-1055

  Sato, Munehiro ^a   Matsuda, Yasunobu ^b   Wakai, Toshifumi ^a   Kubota, Masayuki ^a   Osawa, Mami ^b   Fujimaki, Shun ^b   Sanpei, Ayumi ^a   Takamura, Masaaki ^a   Yamagiwa, Satoshi ^a   Aoyagi, Yutaka ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Cell migration; Hepatocellular carcinoma (HCC); P21 activated kinase 2 (PAK2); Transforming growth factor (TGF )

Indexed keywords

P21 ACTIVATED KINASE 2; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; P21 ACTIVATED KINASE;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER PROGNOSIS; CANCER RECURRENCE; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; FEMALE; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR INVASION; WESTERN BLOTTING; CELL MOTION; LIVER TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE;

AGED; CARCINOMA, HEPATOCELLULAR; CELL MOVEMENT; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; P21-ACTIVATED KINASES; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR CELLS, CULTURED;

EID: 84878177784     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/jgh.12150     Document Type: Article

References (29)

1. Concepts C, El-serag HB. Hepatocellular carcinoma. N. Engl. J. Med. 2011; 365: 1118-1127.
2. de Lope CR, Tremosini S, Forner A, Reig M, Bruix J. Management of HCC. J. Hepatol. 2012; 56: S75-S87.
3. Matsuda Y, Ichida T, Fukumoto M. Hepatocellular carcinoma and liver transplantation: clinical perspective on molecular targeted strategies. Med. Mol. Morphol. 2011; 44: 117-124.
4. Caldwell S, Park SH. The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology. J. Gastroenterol. 2009; 44 (Suppl. 19): 96-101.
5. Giannelli G, Mazzocca A, Fransvea E, Lahn M, Antonaci S. Inhibiting TGF-β signaling in hepatocellular carcinoma. Biochim. Biophys. Acta 2011; 1815: 214-223.
6. Javelaud D, Mauviel A. Crosstalk mechanisms between the mitogen-activated protein kinase pathways and Smad signaling downstream of TGF-β: implications for carcinogenesis. Oncogene 2005; 24: 5742-5750.
7. Parsons CJ, Takashima M, Rippe RA. Molecular mechanisms of hepatic fibrogenesis. J. Gastroenterol. Hepatol. 2007; 22 (Suppl. 1): S79-84.
8. Ravanti L, Häkkinen L, Larjava H etal. Transforming growth factor-β induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase. J. Biol. Chem. 1999; 274: 37292-37300.
9. Johansson N, Ala-aho R, Uitto V etal. Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinase. J. Cell Sci. 2000; 113 (Pt 2): 227-235.
10. Wilkes MC, Murphy SJ, Garamszegi N, Leof EB. Cell-type-specific activation of PAK2 by transforming growth factor β independent of Smad2 and Smad3. Mol. Cell. Biol. 2003; 23: 8878-8889.
11. Wilkes MC, Mitchell H, Penheiter SG etal. Transforming growth factor-β activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res. 2005; 65: 10431-10440.
12. Wilkes MC, Leof EB. Transforming growth factor β activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-Kinase and PAK2 in mesenchymal cultures. J. Biol. Chem. 2006; 281: 27846-27854.
13. Coniglio SJ, Zavarella S, Marc H, Mechanisms S. Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol. Cell. Biol. 2008; 28: 4162-4172.
14. Fujimaki S, Matsuda Y, Wakai T etal. Blockade of ataxia telangiectasia mutated sensitizes hepatoma cell lines to sorafenib by interfering with Akt signaling. Cancer Lett. 2012; 320: 31-39.
15. Siu MKY, Wong ESY, Chan HY etal. Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion. Int. J. Cancer 2010; 31: 21-31.
16. Siu MKY, Yeung MCW, Zhang H, Kong DSH, Chan DCW, Cheung ANY. p21-activated kinase-1 promotes aggressive phenotype, cell proliferation, and invasion in gestational trophoblastic disease. Am. J. Pathol. 2010; 176: 3015-3022.
17. Damdinsuren B, Nagano H, Kondo M etal. TGF-β1-induced cell growth arrest and partial differentiation is related to the suppression of Id1 in human hepatoma cells. Oncol. Rep. 2006; 15: 401-408.
18. Zhan Q, Ge Q, Ohira T, Dyke TV, Badwey JA. p21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases. J. Immunol. 2003; 171: 3785-3793.
19. Wang S, Wilkes MC, Leof EB, Hirschberg R. Imatinib mesylate blocks a non-Smad TGF-β pathway and reduces renal fibrogenesis in vivo. FASEB J. 2005; 19: 1-11.
20. Yan X, Zhang J, Sun Q etal. p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction. J. Biol. Chem. 2012; 287: 13705-13712.
21. Wilkes MC, Repellin CE, Hong M etal. Erbin and the NF2 tumor suppressor Merlin cooperatively regulate cell-type-specific activation of PAK2 by TGF-β. Dev. Cell 2009; 16: 433-444.
22. Zaret KS. Hepatocyte differentiation: from the endoderm and beyond. Curr. Opin. Genet. Dev. 2001; 11: 568-574.
23. Wu X-Z, Chen D. Origin of hepatocellular carcinoma: role of stem cells. J. Gastroenterol. Hepatol. 2006; 21: 1093-1098.
24. Hartsough MT, Mulderi KM. Transforming growth factor β activation of p44mapk in proliferating cultures of epithelial cells. J. Biol. Chem. 1995; 270: 7117-7124.
25. Chong C, Tan L, Lim L, Manser E. The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J. Biol. Chem. 2001; 276: 17347-17353.
26. Bandapalli OR, Macher-Goeppinger S, Schirmacher P, Brand K. Paracrine signalling in colorectal liver metastases involving tumor cell-derived PDGF-C and hepatic stellate cell-derived PAK-2. Clin. Exp. Metastasis 2012; 29: 409-417.
27. Ching YP, Leong VY, Lee MF, Xu HT, Jin DY, Ng IO. P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. Cancer Res. 2007; 67: 3601-3608.
28. Coniglio SJ, Zavarella S, Symons MH. Pak1 and Pak2 mediate tumor cell invasion through distinct signaling mechanisms. Mol. Cell. Biol. 2008; 28: 4162-4172.
29. Siu MK, Wong ES, Chan HY etal. Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion. Int. J. Cancer 2010; 127: 21-31.