Arginase inhibition reduces infarct size via nitric oxide, protein kinase C epsilon and mitochondrial ATP-dependent K+ channels

European Journal of Pharmacology

Volumn 712, Issue 1-3, 2013, Pages 16-21

  Tratsiakovich, Yahor ^a   Thomas Gonon, Adrian ^b   Krook, Anna ^a   Yang, Jiangning ^a   Shemyakin, Alexey ^a   Sjöquist, Per Ove ^a   Pernow, John ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Arginase; Ischemia reperfusion; Nitric oxide

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; ARGINASE; ENZYME INHIBITOR; N OMEGA HYDROXYNORARGININE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNEL; PROTEIN KINASE C EPSILON; PROTEIN KINASE C INHIBITOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; ENZYME ACTIVATION; ENZYME INHIBITION; HEART INFARCTION; HEART INFARCTION SIZE; HEART PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ANIMALS; ARGINASE; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEMODYNAMICS; ION CHANNEL GATING; MALE; MYOCARDIAL INFARCTION; NITRIC OXIDE; POTASSIUM CHANNELS; PROTEIN KINASE C-EPSILON; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84878121933     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.04.044     Document Type: Article

References (32)

1. D.E. Berkowitz, R. White, D. Li, K.M. Minhas, A. Cernetich, S. Kim, S. Burke, A.A. Shoukas, D. Nyhan, H.C. Champion, and J.M. Hare Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels Circulation 108 2003 2000 2006 (Pubitemid 37296546)
2. A. Bulhak, J. Roy, U. Hedin, P.O. Sjöquist, and J. Pernow Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation Am. J. Physiol. Heart Circ. Physiol. 292 2007 H3158 H3163
3. A.A. Bulhak, P.O. Sjöquist, C.B. Xu, L. Edvinsson, and J. Pernow Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1 Basic Res. Cardiol. 101 2006 244 252
4. Y. Chai, D.M. Zhang, and Y.F. Lin Activation of cGMP-dependent protein kinase stimulates cardiac ATP-sensitive potassium channels via a ROS/calmodulin/CaMKII signaling cascade PLoS One 6 2011 e18191
5. M.V. Cohen, X.M. Yang, and J.M. Downey Nitric oxide is a preconditioning mimetic and cardioprotectant and is the basis of many available infarct-sparing strategies Cardiovasc. Res. 70 2006 231 239 (Pubitemid 44316808)
6. A.D. Costa, and K.D. Garlid Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT Am. J. Physiol. Heart Circ. Physiol. 295 2008 H874 H882
7. T. Deuse, T. Koyanagi, R.G. Erben, X. Hua, J. Velden, F. Ikeno, H. Reichenspurner, R.C. Robbins, D. Mochly-Rosen, and S. Schrepfer Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting Circulation 122 2010 S170 S178
8. W. Durante, F.K. Johnson, and R.A. Johnson Arginase: a critical regulator of nitric oxide synthesis and vascular function Clin. Exp. Pharmacol. Physiol. 34 2007 906 911 (Pubitemid 47083958)
9. R.M. Fryer, A.K. Hsu, and G.J. Gross Mitochondrial K(ATP) channel opening is important during index ischemia and following myocardial reperfusion in ischemic preconditioned rat hearts J. Mol. Cell. Cardiol. 33 2001 831 834 (Pubitemid 32538995)
10. A.T. Gonon, A.V. Gourine, and J. Pernow Cardioprotection from ischemia and reperfusion injury by an endothelin A-receptor antagonist in relation to nitric oxide production J. Cardiovasc. Pharmacol. 36 2000 405 412 (Pubitemid 30660473)
11. A.T. Gonon, C. Jung, A. Katz, H. Westerblad, A. Shemyakin, P.O. Sjöquist, J.O. Lundberg, and J. Pernow Local arginase inhibition during early reperfusion mediates cardioprotection via increased nitric oxide production PLoS One 7 2012 e42038
12. A.V. Gourine, A.I. Molosh, D. Poputnikov, A. Bulhak, P.O. Sjöquist, and J. Pernow Endothelin-1 exerts a preconditioning-like cardioprotective effect against ischaemia/reperfusion injury via the ET(A) receptor and the mitochondrial K(ATP) channel in the rat in vivo Br. J. Pharmacol. 144 2005 331 337 (Pubitemid 40313679)
13. T.W. Hein, C. Zhang, W. Wang, C.I. Chang, N. Thengchaisri, and L. Kuo Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase FASEB J. 17 2003 2328 2330 (Pubitemid 39561482)
14. G. Heusch, K. Boengler, and R. Schulz Cardioprotection: nitric oxide, protein kinases, and mitochondria Circulation 118 2008 1915 1919
15. G. Johnson, P.S. Tsao, and A.M. Lefer Cardioprotective effects of authentic nitric oxide in myocardial ischemia with reperfusion Crit. Care Med. 19 1991 244 252
16. S.P. Jones, W.G. Girod, P.L. Huang, and D.J. Lefer Myocardial reperfusion injury in neuronal nitric oxide synthase deficient mice Coron. Artery Dis. 11 2000 593 597
17. C. Jung, A.T. Gonon, P.O. Sjöquist, J.O. Lundberg, and J. Pernow Arginase inhibition mediates cardioprotection during ischaemia-reperfusion Cardiovasc. Res. 85 2010 147 154
18. J.H. Kim, L.J. Bugaj, Y.J. Oh, T.J. Bivalacqua, S. Ryoo, K.G. Soucy, L. Santhanam, A. Webb, A. Camara, G. Sikka, D. Nyhan, A.A Shoukas, M. Ilies, D.W. Christianson, H.C. Champion, and D.E. Berkowitz Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats J. Appl. Physiol. 107 2009 1249 1257
19. J.J. Lemasters, J.M. Bond, E. Chacon, I.S. Harper, S.H. Kaplan, H. Ohata, D.R. Trollinger, B. Herman, and W.E. Cascio The pH paradox in ischemia-reperfusion injury to cardiac myocytes EXS 76 1996 99 114
20. J. Li, C.A. Bombeck, S. Yang, Y.M. Kim, and T.R. Billiar Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes J. Biol. Chem. 274 1999 17325 17333
21. X.L. Ma, A.S. Weyrich, D.J. Lefer, and A.M. Lefer Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium Circ. Res. 72 1993 403 412 (Pubitemid 23024528)
22. T.B. McCall, N.K. Boughton-Smith, R.M. Palmer, B.J. Whittle, and S. Moncada Synthesis of nitric oxide from l-arginine by neutrophils. Release and interaction with superoxide anion Biochem. J. 261 1989 293 296 (Pubitemid 19174794)
23. Pernow, J, Jung, C., 2013. Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal? Cardiovasc. Res. doi: 10.1093/cvr/cvt036.
24. M.J. Romero, D.H. Platt, H.E. Tawfik, M. Labazi, A.B. El-Remessy, M. Bartoli, R.B. Caldwell, and R.W. Caldwell Diabetes-induced coronary vascular dysfunction involves increased arginase activity Circ. Res. 102 2008 95 102
25. S. Ryoo, D.E. Berkowitz, and H.K. Lim Endothelial arginase II and atherosclerosis Korean J. Anesthesiol. 61 2011 3 11
26. S. Ryoo, G. Gupta, A. Benjo, H.K. Lim, A. Camara, G. Sikka, J. Sohi, L. Santhanam, K. Soucy, E. Tuday, E. Baraban, M. Ilies, G. Gerstenblith, D. Nyhan, A. Shoukas, D.W. Christianson, N.J. Alp, H.C. Champion, D. Huso, and D.E. Berkowitz Endothelial arginase II: a novel target for the treatment of atherosclerosis Circ. Res. 102 2008 923 932 (Pubitemid 351591553)
27. S. Sanada, M. Kitakaze, H. Asanuma, K. Harada, H. Ogita, K. Node, S. Takashima, Y. Sakata, M. Asakura, Y. Shinozaki, H. Mori, T. Kuzuya, and M. Hori Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart Am. J. Physiol. Heart Circ. Physiol. 280 2001 H256 H263
28. S. Sanada, I. Komuro, and M. Kitakaze Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures Am. J. Physiol. Heart Circ. Physiol. 301 2011 H1723 H1741
29. 2 impairs endothelium-dependent nitric oxide-mediated dilation of coronary arterioles Arterioscler. Thromb. Vasc. Biol. 26 2006 2035 2042 (Pubitemid 44253785)
30. A.T. Turer, and J.A. Hill Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy Am. J. Cardiol. 106 2010 360 368
31. P.M. Vanhoutte Arginine and arginase: endothelial NO synthase double crossed? Circ. Res. 102 2008 866 868 (Pubitemid 351591541)
32. U. Walter, and S. Gambaryan cGMP and cGMP-dependent protein kinase in platelets and blood cells Handb. Exp. Pharmacol. 191 2009 533 548