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Volumn 25, Issue 2, 2013, Pages 75-81

Evolution of viral biomarkers in predicting outcomes of chronic hepatitis B patients: From DNA to surface antigen

Author keywords

HBsAg; HBV; HCC; Hepatitis; QHBsAg

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

EID: 84878116587     PISSN: 10163190     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tcmj.2013.03.005     Document Type: Review
Times cited : (4)

References (61)
  • 1
    • 84983726731 scopus 로고    scopus 로고
    • Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma: epidemiologic and molecular biological aspects
    • Kao J.H., Chen P.J., Chen D.S. Recent advances in the research of hepatitis B virus-related hepatocellular carcinoma: epidemiologic and molecular biological aspects. Adv Cancer Res 2010, 108:21-72.
    • (2010) Adv Cancer Res , vol.108 , pp. 21-72
    • Kao, J.H.1    Chen, P.J.2    Chen, D.S.3
  • 2
    • 0036293243 scopus 로고    scopus 로고
    • Global control of hepatitis B virus infection
    • Kao J.H., Chen D.S. Global control of hepatitis B virus infection. Lancet Infect Dis 2002, 2:395-403.
    • (2002) Lancet Infect Dis , vol.2 , pp. 395-403
    • Kao, J.H.1    Chen, D.S.2
  • 3
    • 0014376546 scopus 로고
    • Hepatitis and leukemia: their relation to Australia antigen
    • Blumberg B.S., Sutnick A.I., London W.T. Hepatitis and leukemia: their relation to Australia antigen. Bull N Y Acad Med 1968, 44:1566-1586.
    • (1968) Bull N Y Acad Med , vol.44 , pp. 1566-1586
    • Blumberg, B.S.1    Sutnick, A.I.2    London, W.T.3
  • 4
    • 29944436855 scopus 로고    scopus 로고
    • Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level
    • Chen C.J., Yang H.I., Su J., Jen C.L., You S.L., Lu S.N., et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006, 295:65-73.
    • (2006) JAMA , vol.295 , pp. 65-73
    • Chen, C.J.1    Yang, H.I.2    Su, J.3    Jen, C.L.4    You, S.L.5    Lu, S.N.6
  • 6
    • 84984552614 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters
    • e2
    • Tseng T.C., Liu C.J., Su T.H., Wang C.C., Chen C.L., Chen P.J., et al. Serum hepatitis B surface antigen levels predict surface antigen loss in hepatitis B e antigen seroconverters. Gastroenterology 2011, 141:517-525. e2.
    • (2011) Gastroenterology , vol.141 , pp. 517-525
    • Tseng, T.C.1    Liu, C.J.2    Su, T.H.3    Wang, C.C.4    Chen, C.L.5    Chen, P.J.6
  • 7
    • 84872498407 scopus 로고    scopus 로고
    • Clinical utility of quantitative HBsAg in natural history and nucleos(t)ide analogue treatment of chronic hepatitis B: new trick of old dog
    • Tseng T.C., Kao J.H. Clinical utility of quantitative HBsAg in natural history and nucleos(t)ide analogue treatment of chronic hepatitis B: new trick of old dog. JGastroenterol 2013, 48:13-21.
    • (2013) JGastroenterol , vol.48 , pp. 13-21
    • Tseng, T.C.1    Kao, J.H.2
  • 8
    • 0022577393 scopus 로고
    • Baseline seroepidemiology of hepatitis B virus infection in children in Taipei, 1984: a study just before mass hepatitis B vaccination program in Taiwan
    • Hsu H.Y., Chang M.H., Chen D.S., Lee C.Y., Sung J.L. Baseline seroepidemiology of hepatitis B virus infection in children in Taipei, 1984: a study just before mass hepatitis B vaccination program in Taiwan. JMed Virol 1986, 18:301-307.
    • (1986) JMed Virol , vol.18 , pp. 301-307
    • Hsu, H.Y.1    Chang, M.H.2    Chen, D.S.3    Lee, C.Y.4    Sung, J.L.5
  • 9
    • 0027422748 scopus 로고
    • From hepatitis to hepatoma: lessons from type B viral hepatitis
    • Chen D.S. From hepatitis to hepatoma: lessons from type B viral hepatitis. Science 1993, 262:369-370.
    • (1993) Science , vol.262 , pp. 369-370
    • Chen, D.S.1
  • 10
    • 59749096640 scopus 로고    scopus 로고
    • Hepatitis B virus infection
    • Liaw Y.F., Chu C.M. Hepatitis B virus infection. Lancet 2009, 373:582-592.
    • (2009) Lancet , vol.373 , pp. 582-592
    • Liaw, Y.F.1    Chu, C.M.2
  • 11
    • 77957901418 scopus 로고    scopus 로고
    • Hepatitis B e antigen seroconversion: a critical event in chronic hepatitis B virus infection
    • Liaw Y.F., Lau G.K., Kao J.H., Gane E. Hepatitis B e antigen seroconversion: a critical event in chronic hepatitis B virus infection. Dig Dis Sci 2010, 55:2727-2734.
    • (2010) Dig Dis Sci , vol.55 , pp. 2727-2734
    • Liaw, Y.F.1    Lau, G.K.2    Kao, J.H.3    Gane, E.4
  • 12
    • 35648952818 scopus 로고    scopus 로고
    • Predictive factors for reactivation of hepatitis B following hepatitis B e antigen seroconversion in chronic hepatitis B
    • Chu C.M., Liaw Y.F. Predictive factors for reactivation of hepatitis B following hepatitis B e antigen seroconversion in chronic hepatitis B. Gastroenterology 2007, 133:1458-1465.
    • (2007) Gastroenterology , vol.133 , pp. 1458-1465
    • Chu, C.M.1    Liaw, Y.F.2
  • 13
    • 75449105399 scopus 로고    scopus 로고
    • Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B
    • Chen Y.C., Chu C.M., Liaw Y.F. Age-specific prognosis following spontaneous hepatitis B e antigen seroconversion in chronic hepatitis B. Hepatology 2010, 51:435-444.
    • (2010) Hepatology , vol.51 , pp. 435-444
    • Chen, Y.C.1    Chu, C.M.2    Liaw, Y.F.3
  • 14
    • 84983727403 scopus 로고    scopus 로고
    • Serum hepatitis B virus-DNA levels correlate with long-term adverse outcomes in spontaneous hepatitis B e antigen seroconverters
    • Tseng T.C., Liu C.J., Chen C.L., Wang C.C., Su T.H., Kuo S.F., et al. Serum hepatitis B virus-DNA levels correlate with long-term adverse outcomes in spontaneous hepatitis B e antigen seroconverters. JInfect Dis 2012, 205:54-63.
    • (2012) JInfect Dis , vol.205 , pp. 54-63
    • Tseng, T.C.1    Liu, C.J.2    Chen, C.L.3    Wang, C.C.4    Su, T.H.5    Kuo, S.F.6
  • 15
    • 0036614299 scopus 로고    scopus 로고
    • Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B
    • Hsu Y.S., Chien R.N., Yeh C.T., Sheen I.S., Chiou H.Y., Chu C.M., et al. Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B. Hepatology 2002, 35:1522-1527.
    • (2002) Hepatology , vol.35 , pp. 1522-1527
    • Hsu, Y.S.1    Chien, R.N.2    Yeh, C.T.3    Sheen, I.S.4    Chiou, H.Y.5    Chu, C.M.6
  • 16
    • 67649199520 scopus 로고    scopus 로고
    • Long-term outcome of hepatitis B e antigen-negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time
    • Tai D.I., Lin S.M., Sheen I.S., Chu C.M., Lin D.Y., Liaw Y.F. Long-term outcome of hepatitis B e antigen-negative hepatitis B surface antigen carriers in relation to changes of alanine aminotransferase levels over time. Hepatology 2009, 49:1859-1867.
    • (2009) Hepatology , vol.49 , pp. 1859-1867
    • Tai, D.I.1    Lin, S.M.2    Sheen, I.S.3    Chu, C.M.4    Lin, D.Y.5    Liaw, Y.F.6
  • 17
    • 2642580655 scopus 로고    scopus 로고
    • Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels
    • Chu C.M., Hung S.J., Lin J., Tai D.I., Liaw Y.F. Natural history of hepatitis B e antigen to antibody seroconversion in patients with normal serum aminotransferase levels. Am J Med 2004, 116:829-834.
    • (2004) Am J Med , vol.116 , pp. 829-834
    • Chu, C.M.1    Hung, S.J.2    Lin, J.3    Tai, D.I.4    Liaw, Y.F.5
  • 18
    • 77950684115 scopus 로고    scopus 로고
    • Hepatitis B surface antigen seroclearance during chronic HBV infection
    • Chu C.M., Liaw Y.F. Hepatitis B surface antigen seroclearance during chronic HBV infection. Antivir Ther 2010, 15:133-143.
    • (2010) Antivir Ther , vol.15 , pp. 133-143
    • Chu, C.M.1    Liaw, Y.F.2
  • 19
    • 77957938721 scopus 로고    scopus 로고
    • Alongitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B
    • Chan H.L., Wong V.W., Wong G.L., Tse C.H., Chan H.Y., Sung J.J. Alongitudinal study on the natural history of serum hepatitis B surface antigen changes in chronic hepatitis B. Hepatology 2010, 52:1232-1241.
    • (2010) Hepatology , vol.52 , pp. 1232-1241
    • Chan, H.L.1    Wong, V.W.2    Wong, G.L.3    Tse, C.H.4    Chan, H.Y.5    Sung, J.J.6
  • 20
    • 77949655619 scopus 로고    scopus 로고
    • Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: a perspective on Asia
    • Nguyen T., Thompson A.J., Bowden S., Croagh C., Bell S., Desmond P.V., et al. Hepatitis B surface antigen levels during the natural history of chronic hepatitis B: a perspective on Asia. JHepatol 2010, 52:508-513.
    • (2010) JHepatol , vol.52 , pp. 508-513
    • Nguyen, T.1    Thompson, A.J.2    Bowden, S.3    Croagh, C.4    Bell, S.5    Desmond, P.V.6
  • 21
    • 77949656255 scopus 로고    scopus 로고
    • Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: a European perspective
    • Jaroszewicz J., Calle Serrano B., Wursthorn K., Deterding K., Schlue J., Raupach R., et al. Hepatitis B surface antigen (HBsAg) levels in the natural history of hepatitis B virus (HBV)-infection: a European perspective. JHepatol 2010, 52:514-522.
    • (2010) JHepatol , vol.52 , pp. 514-522
    • Jaroszewicz, J.1    Calle Serrano, B.2    Wursthorn, K.3    Deterding, K.4    Schlue, J.5    Raupach, R.6
  • 22
    • 0025753470 scopus 로고
    • Incidence, determinants and significance of delayed clearance of serum HBsAg in chronic hepatitis B virus infection: a prospective study
    • Liaw Y.F., Sheen I.S., Chen T.J., Chu C.M., Pao C.C. Incidence, determinants and significance of delayed clearance of serum HBsAg in chronic hepatitis B virus infection: a prospective study. Hepatology 1991, 13:627-631.
    • (1991) Hepatology , vol.13 , pp. 627-631
    • Liaw, Y.F.1    Sheen, I.S.2    Chen, T.J.3    Chu, C.M.4    Pao, C.C.5
  • 23
    • 34248679355 scopus 로고    scopus 로고
    • HBsAg seroclearance in asymptomatic carriers of high endemic areas: appreciably high rates during a long-term follow-up
    • Chu C.M., Liaw Y.F. HBsAg seroclearance in asymptomatic carriers of high endemic areas: appreciably high rates during a long-term follow-up. Hepatology 2007, 45:1187-1192.
    • (2007) Hepatology , vol.45 , pp. 1187-1192
    • Chu, C.M.1    Liaw, Y.F.2
  • 24
    • 0035818616 scopus 로고    scopus 로고
    • Serologic and clinical outcomes of 1536 Alaska Natives chronically infected with hepatitis B virus
    • McMahon B.J., Holck P., Bulkow L., Snowball M. Serologic and clinical outcomes of 1536 Alaska Natives chronically infected with hepatitis B virus. Ann Intern Med 2001, 135:759-768.
    • (2001) Ann Intern Med , vol.135 , pp. 759-768
    • McMahon, B.J.1    Holck, P.2    Bulkow, L.3    Snowball, M.4
  • 25
    • 44349194322 scopus 로고    scopus 로고
    • Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance: a prospective follow-up study
    • Kim J.H., Lee J.H., Park S.J., Bae M.H., Kim do Y., Kim J.K., et al. Factors associated with natural seroclearance of hepatitis B surface antigen and prognosis after seroclearance: a prospective follow-up study. Hepatogastroenterology 2008, 55:578-581.
    • (2008) Hepatogastroenterology , vol.55 , pp. 578-581
    • Kim, J.H.1    Lee, J.H.2    Park, S.J.3    Bae, M.H.4    Kim do, Y.5    Kim, J.K.6
  • 26
    • 77955483993 scopus 로고    scopus 로고
    • Incidence and determinants of spontaneous hepatitis B surface antigen seroclearance: a community-based follow-up study
    • Liu J., Yang H.I., Lee M.H., Lu S.N., Jen C.L., Wang L.Y., et al. Incidence and determinants of spontaneous hepatitis B surface antigen seroclearance: a community-based follow-up study. Gastroenterology 2010, 139:474-482.
    • (2010) Gastroenterology , vol.139 , pp. 474-482
    • Liu, J.1    Yang, H.I.2    Lee, M.H.3    Lu, S.N.4    Jen, C.L.5    Wang, L.Y.6
  • 27
    • 84984571825 scopus 로고    scopus 로고
    • Determinants of spontaneous surface antigen loss in hepatitis B e antigen-negative patients with a low viral load
    • Tseng T.C., Liu C.J., Yang H.C., Su T.H., Wang C.C., Chen C.L., et al. Determinants of spontaneous surface antigen loss in hepatitis B e antigen-negative patients with a low viral load. Hepatology 2012, 55:68-76.
    • (2012) Hepatology , vol.55 , pp. 68-76
    • Tseng, T.C.1    Liu, C.J.2    Yang, H.C.3    Su, T.H.4    Wang, C.C.5    Chen, C.L.6
  • 28
    • 0036789020 scopus 로고    scopus 로고
    • Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection
    • Chen Y.C., Sheen I.S., Chu C.M., Liaw Y.F. Prognosis following spontaneous HBsAg seroclearance in chronic hepatitis B patients with or without concurrent infection. Gastroenterology 2002, 123:1084-1089.
    • (2002) Gastroenterology , vol.123 , pp. 1084-1089
    • Chen, Y.C.1    Sheen, I.S.2    Chu, C.M.3    Liaw, Y.F.4
  • 29
    • 0001731999 scopus 로고    scopus 로고
    • Delayed clearance of serum HBsAg in compensated cirrhosis B: relation to interferon alpha therapy and disease prognosis. European Concerted Action on Viral Hepatitis (EUROHEP)
    • Fattovich G., Giustina G., Sanchez-Tapias J., Quero C., Mas A., Olivotto P.G., et al. Delayed clearance of serum HBsAg in compensated cirrhosis B: relation to interferon alpha therapy and disease prognosis. European Concerted Action on Viral Hepatitis (EUROHEP). Am J Gastroenterol 1998, 93:896-900.
    • (1998) Am J Gastroenterol , vol.93 , pp. 896-900
    • Fattovich, G.1    Giustina, G.2    Sanchez-Tapias, J.3    Quero, C.4    Mas, A.5    Olivotto, P.G.6
  • 30
    • 0031837430 scopus 로고    scopus 로고
    • Sero-clearance of hepatitis B surface antigen in chronic carriers does not necessarily imply a good prognosis
    • Huo T.I., Wu J.C., Lee P.C., Chau G.Y., Lui W.Y., Tsay S.H., et al. Sero-clearance of hepatitis B surface antigen in chronic carriers does not necessarily imply a good prognosis. Hepatology 1998, 28:231-236.
    • (1998) Hepatology , vol.28 , pp. 231-236
    • Huo, T.I.1    Wu, J.C.2    Lee, P.C.3    Chau, G.Y.4    Lui, W.Y.5    Tsay, S.H.6
  • 31
    • 2542516261 scopus 로고    scopus 로고
    • HBsAg seroclearance in chronic hepatitis B in the Chinese: virological, histological, and clinical aspects
    • Yuen M.F., Wong D.K., Sablon E., Tse E., Ng I.O., Yuan H.J., et al. HBsAg seroclearance in chronic hepatitis B in the Chinese: virological, histological, and clinical aspects. Hepatology 2004, 39:1694-1701.
    • (2004) Hepatology , vol.39 , pp. 1694-1701
    • Yuen, M.F.1    Wong, D.K.2    Sablon, E.3    Tse, E.4    Ng, I.O.5    Yuan, H.J.6
  • 32
    • 79960113229 scopus 로고    scopus 로고
    • Viral determinants of hepatitis B surface antigen seroclearance in hepatitis B e antigen-negative chronic hepatitis B patients
    • Chan H.L., Wong G.L., Tse C.H., Chan H.Y., Wong V.W. Viral determinants of hepatitis B surface antigen seroclearance in hepatitis B e antigen-negative chronic hepatitis B patients. JInfect Dis 2011, 204:408-414.
    • (2011) JInfect Dis , vol.204 , pp. 408-414
    • Chan, H.L.1    Wong, G.L.2    Tse, C.H.3    Chan, H.Y.4    Wong, V.W.5
  • 33
    • 84865535075 scopus 로고    scopus 로고
    • Alarge case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance
    • Seto W.K., Wong D.K., Fung J., Hung I.F., Fong D.Y., Yuen J.C., et al. Alarge case-control study on the predictability of hepatitis B surface antigen levels three years before hepatitis B surface antigen seroclearance. Hepatology 2012, 56:812-819.
    • (2012) Hepatology , vol.56 , pp. 812-819
    • Seto, W.K.1    Wong, D.K.2    Fung, J.3    Hung, I.F.4    Fong, D.Y.5    Yuen, J.C.6
  • 34
    • 84858794180 scopus 로고    scopus 로고
    • Spontaneous clearance of hepatitis B surface antigen during the natural history of chronic hepatitis B virus infection
    • Abstract 731
    • Chang M.H., Chiu Y.C., Wu J.F., Lin C.Y., Ni Y.H., Chen H.L., et al. Spontaneous clearance of hepatitis B surface antigen during the natural history of chronic hepatitis B virus infection. Hepatology 2011, 54. Abstract 731.
    • (2011) Hepatology , vol.54
    • Chang, M.H.1    Chiu, Y.C.2    Wu, J.F.3    Lin, C.Y.4    Ni, Y.H.5    Chen, H.L.6
  • 35
    • 84857194778 scopus 로고    scopus 로고
    • Decreasing levels of HBsAg predict HBsAg seroclearance in patients with inactive chronic hepatitis B virus infection
    • Chen Y.C., Jeng W.J., Chu C.M., Liaw Y.F. Decreasing levels of HBsAg predict HBsAg seroclearance in patients with inactive chronic hepatitis B virus infection. Clin Gastroenterol Hepatol 2012, 10:297-302.
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 297-302
    • Chen, Y.C.1    Jeng, W.J.2    Chu, C.M.3    Liaw, Y.F.4
  • 36
    • 84878164600 scopus 로고    scopus 로고
    • Apredictive scoring system for the seroclearance of HBsAg in HBeAg-seronegative chronic hepatitis B patients with genotype B or C infection
    • [Epub ahead of print]
    • Liu J., Lee M.H., Batrla-Utermann R., Jan C.L., Iloeje U.H., Lu S.N., et al. Apredictive scoring system for the seroclearance of HBsAg in HBeAg-seronegative chronic hepatitis B patients with genotype B or C infection. JHepatol 2012 Dec 13, [Epub ahead of print].
    • (2012) JHepatol
    • Liu, J.1    Lee, M.H.2    Batrla-Utermann, R.3    Jan, C.L.4    Iloeje, U.H.5    Lu, S.N.6
  • 37
    • 70349240414 scopus 로고    scopus 로고
    • Chronic hepatitis B: update 2009
    • Lok A.S., McMahon B.J. Chronic hepatitis B: update 2009. Hepatology 2009, 50:661-662.
    • (2009) Hepatology , vol.50 , pp. 661-662
    • Lok, A.S.1    McMahon, B.J.2
  • 38
    • 84865376141 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update
    • Liaw Y.F., Kao J.H., Piratvisuth T., Chan H.L., Chien R.N., Liu C.J., et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2012 update. Hepatol Int 2012, 6:531-561.
    • (2012) Hepatol Int , vol.6 , pp. 531-561
    • Liaw, Y.F.1    Kao, J.H.2    Piratvisuth, T.3    Chan, H.L.4    Chien, R.N.5    Liu, C.J.6
  • 39
    • 84862664371 scopus 로고    scopus 로고
    • EASL clinical practice guidelines: management of chronic hepatitis B virus infection
    • European Association for the Study of the Liver
    • EASL clinical practice guidelines: management of chronic hepatitis B virus infection. JHepatol 2012, 57:167-185. European Association for the Study of the Liver.
    • (2012) JHepatol , vol.57 , pp. 167-185
  • 40
    • 77950500095 scopus 로고    scopus 로고
    • Clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers
    • Wong V.W., Chan S.L., Mo F., Chan T.C., Loong H.H., Wong G.L., et al. Clinical scoring system to predict hepatocellular carcinoma in chronic hepatitis B carriers. JClin Oncol 2010, 28:1660-1665.
    • (2010) JClin Oncol , vol.28 , pp. 1660-1665
    • Wong, V.W.1    Chan, S.L.2    Mo, F.3    Chan, T.C.4    Loong, H.H.5    Wong, G.L.6
  • 41
    • 56949094767 scopus 로고    scopus 로고
    • Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B
    • Yuen M.F., Tanaka Y., Fong D.Y., Fung J., Wong D.K., Yuen J.C., et al. Independent risk factors and predictive score for the development of hepatocellular carcinoma in chronic hepatitis B. JHepatol 2009, 50:80-88.
    • (2009) JHepatol , vol.50 , pp. 80-88
    • Yuen, M.F.1    Tanaka, Y.2    Fong, D.Y.3    Fung, J.4    Wong, D.K.5    Yuen, J.C.6
  • 42
    • 35649014367 scopus 로고    scopus 로고
    • Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients
    • Chen C.H., Hung C.H., Lee C.M., Hu T.H., Wang J.H., Wang J.C., et al. Pre-S deletion and complex mutations of hepatitis B virus related to advanced liver disease in HBeAg-negative patients. Gastroenterology 2007, 133:1466-1474.
    • (2007) Gastroenterology , vol.133 , pp. 1466-1474
    • Chen, C.H.1    Hung, C.H.2    Lee, C.M.3    Hu, T.H.4    Wang, J.H.5    Wang, J.C.6
  • 43
    • 84984559412 scopus 로고    scopus 로고
    • Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers
    • Liu C.J., Chen B.F., Chen P.J., Lai M.Y., Huang W.L., Kao J.H., et al. Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. JInfect Dis 2006, 193:1258-1265.
    • (2006) JInfect Dis , vol.193 , pp. 1258-1265
    • Liu, C.J.1    Chen, B.F.2    Chen, P.J.3    Lai, M.Y.4    Huang, W.L.5    Kao, J.H.6
  • 44
    • 84984569467 scopus 로고    scopus 로고
    • Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: a case-control study
    • Liu C.J., Chen B.F., Chen P.J., Lai M.Y., Huang W.L., Kao J.H., et al. Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: a case-control study. JInfect Dis 2006, 194:594-599.
    • (2006) JInfect Dis , vol.194 , pp. 594-599
    • Liu, C.J.1    Chen, B.F.2    Chen, P.J.3    Lai, M.Y.4    Huang, W.L.5    Kao, J.H.6
  • 45
    • 33746675024 scopus 로고    scopus 로고
    • Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study
    • Chen G., Lin W., Shen F., Iloeje U.H., London W.T., Evans A.A. Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study. Am J Gastroenterol 2006, 101:1797-1803.
    • (2006) Am J Gastroenterol , vol.101 , pp. 1797-1803
    • Chen, G.1    Lin, W.2    Shen, F.3    Iloeje, U.H.4    London, W.T.5    Evans, A.A.6
  • 46
    • 13844322073 scopus 로고    scopus 로고
    • Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men
    • Yu M.W., Yeh S.H., Chen P.J., Liaw Y.F., Lin C.L., Liu C.J., et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. JNatl Cancer Inst 2005, 97:265-272.
    • (2005) JNatl Cancer Inst , vol.97 , pp. 265-272
    • Yu, M.W.1    Yeh, S.H.2    Chen, P.J.3    Liaw, Y.F.4    Lin, C.L.5    Liu, C.J.6
  • 47
    • 84983726112 scopus 로고    scopus 로고
    • High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load
    • e3
    • Tseng T.C., Liu C.J., Yang H.C., Su T.H., Wang C.C., Chen C.L., et al. High levels of hepatitis B surface antigen increase risk of hepatocellular carcinoma in patients with low HBV load. Gastroenterology 2012, 142:1140-1149. e3.
    • (2012) Gastroenterology , vol.142 , pp. 1140-1149
    • Tseng, T.C.1    Liu, C.J.2    Yang, H.C.3    Su, T.H.4    Wang, C.C.5    Chen, C.L.6
  • 48
    • 77951670101 scopus 로고    scopus 로고
    • Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death
    • Chen J.D., Yang H.I., Iloeje U.H., You S.L., Lu S.N., Wang L.Y., et al. Carriers of inactive hepatitis B virus are still at risk for hepatocellular carcinoma and liver-related death. Gastroenterology 2010, 138:1747-1754.
    • (2010) Gastroenterology , vol.138 , pp. 1747-1754
    • Chen, J.D.1    Yang, H.I.2    Iloeje, U.H.3    You, S.L.4    Lu, S.N.5    Wang, L.Y.6
  • 49
    • 84860112790 scopus 로고    scopus 로고
    • Quantitative serum levels of hepatitis B virus DNA and surface antigen are independent risk predictors of hepatocellular carcinoma
    • Abstract 1095
    • Chen C.J., Lee M.H., Jessica L., Ricard B.-U., Chin-Lan J., Uchenna I., et al. Quantitative serum levels of hepatitis B virus DNA and surface antigen are independent risk predictors of hepatocellular carcinoma. Hepatology 2011, 54. Abstract 1095.
    • (2011) Hepatology , vol.54
    • Chen, C.J.1    Lee, M.H.2    Jessica, L.3    Ricard, B.-U.4    Chin-Lan, J.5    Uchenna, I.6
  • 50
    • 33644858331 scopus 로고    scopus 로고
    • Predicting cirrhosis risk based on the level of circulating hepatitis B viral load
    • Iloeje U.H., Yang H.I., Su J., Jen C.L., You S.L., Chen C.J., et al. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006, 130:678-686.
    • (2006) Gastroenterology , vol.130 , pp. 678-686
    • Iloeje, U.H.1    Yang, H.I.2    Su, J.3    Jen, C.L.4    You, S.L.5    Chen, C.J.6
  • 51
    • 84984578046 scopus 로고    scopus 로고
    • Serum hepatitis B surface antigen levels help predict disease progression in patients with low HBV loads
    • Tseng T.C., Liu C.J., Yang H.C., Su T.H., Wang C.C., Chen C.L., et al. Serum hepatitis B surface antigen levels help predict disease progression in patients with low HBV loads. Hepatology 2013, 57:441-450.
    • (2013) Hepatology , vol.57 , pp. 441-450
    • Tseng, T.C.1    Liu, C.J.2    Yang, H.C.3    Su, T.H.4    Wang, C.C.5    Chen, C.L.6
  • 52
    • 77955494346 scopus 로고    scopus 로고
    • Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers
    • Brunetto M.R., Oliveri F., Colombatto P., Moriconi F., Ciccorossi P., Coco B., et al. Hepatitis B surface antigen serum levels help to distinguish active from inactive hepatitis B virus genotype D carriers. Gastroenterology 2010, 139:483-490.
    • (2010) Gastroenterology , vol.139 , pp. 483-490
    • Brunetto, M.R.1    Oliveri, F.2    Colombatto, P.3    Moriconi, F.4    Ciccorossi, P.5    Coco, B.6
  • 53
    • 77952514489 scopus 로고    scopus 로고
    • Nomograms for risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection
    • Yang H.I., Sherman M., Su J., Chen P.J., Liaw Y.F., Iloeje U.H., et al. Nomograms for risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection. JClin Oncol 2010, 28:2437-2444.
    • (2010) JClin Oncol , vol.28 , pp. 2437-2444
    • Yang, H.I.1    Sherman, M.2    Su, J.3    Chen, P.J.4    Liaw, Y.F.5    Iloeje, U.H.6
  • 54
    • 84984550778 scopus 로고    scopus 로고
    • Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score
    • Yang H.I., Yuen M.F., Chan H.L., Han K.H., Chen P.J., Kim D.Y., et al. Risk estimation for hepatocellular carcinoma in chronic hepatitis B (REACH-B): development and validation of a predictive score. Lancet Oncol 2011, 12:568-574.
    • (2011) Lancet Oncol , vol.12 , pp. 568-574
    • Yang, H.I.1    Yuen, M.F.2    Chan, H.L.3    Han, K.H.4    Chen, P.J.5    Kim, D.Y.6
  • 55
    • 80055059164 scopus 로고    scopus 로고
    • Shorter durations and lower doses of peginterferon alfa-2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or C
    • Liaw Y.F., Jia J.D., Chan H.L., Han K.H., Tanwandee T., Chuang W.L., et al. Shorter durations and lower doses of peginterferon alfa-2a are associated with inferior hepatitis B e antigen seroconversion rates in hepatitis B virus genotypes B or C. Hepatology 2011, 54:1591-1599.
    • (2011) Hepatology , vol.54 , pp. 1591-1599
    • Liaw, Y.F.1    Jia, J.D.2    Chan, H.L.3    Han, K.H.4    Tanwandee, T.5    Chuang, W.L.6
  • 56
    • 77957958049 scopus 로고    scopus 로고
    • Prediction of sustained response to peginterferon alfa-2b for hepatitis B e antigen-positive chronic hepatitis B using on-treatment hepatitis B surface antigen decline
    • Sonneveld M.J., Rijckborst V., Boucher C.A., Hansen B.E., Janssen H.L. Prediction of sustained response to peginterferon alfa-2b for hepatitis B e antigen-positive chronic hepatitis B using on-treatment hepatitis B surface antigen decline. Hepatology 2010, 52:1251-1257.
    • (2010) Hepatology , vol.52 , pp. 1251-1257
    • Sonneveld, M.J.1    Rijckborst, V.2    Boucher, C.A.3    Hansen, B.E.4    Janssen, H.L.5
  • 57
    • 65449117946 scopus 로고    scopus 로고
    • Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B
    • Brunetto M.R., Moriconi F., Bonino F., Lau G.K., Farci P., Yurdaydin C., et al. Hepatitis B virus surface antigen levels: a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology 2009, 49:1141-1150.
    • (2009) Hepatology , vol.49 , pp. 1141-1150
    • Brunetto, M.R.1    Moriconi, F.2    Bonino, F.3    Lau, G.K.4    Farci, P.5    Yurdaydin, C.6
  • 58
    • 65449123444 scopus 로고    scopus 로고
    • Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients
    • Moucari R., Mackiewicz V., Lada O., Ripault M.P., Castelnau C., Martinot-Peignoux M., et al. Early serum HBsAg drop: a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients. Hepatology 2009, 49:1151-1157.
    • (2009) Hepatology , vol.49 , pp. 1151-1157
    • Moucari, R.1    Mackiewicz, V.2    Lada, O.3    Ripault, M.P.4    Castelnau, C.5    Martinot-Peignoux, M.6
  • 59
    • 66449121130 scopus 로고    scopus 로고
    • Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a
    • e1-4
    • Marcellin P., Bonino F., Lau G.K., Farci P., Yurdaydin C., Piratvisuth T., et al. Sustained response of hepatitis B e antigen-negative patients 3 years after treatment with peginterferon alpha-2a. Gastroenterology 2009, 136:2169-2179. e1-4.
    • (2009) Gastroenterology , vol.136 , pp. 2169-2179
    • Marcellin, P.1    Bonino, F.2    Lau, G.K.3    Farci, P.4    Yurdaydin, C.5    Piratvisuth, T.6
  • 60
    • 84983726125 scopus 로고    scopus 로고
    • Young chronic hepatitis B patients with nucleos(t)ide analogue-induced hepatitis B e antigen seroconversion have a higher risk of HBV reactivation
    • Tseng T.C., Liu C.J., Su T.H., Yang H.C., Wang C.C., Chen C.L., et al. Young chronic hepatitis B patients with nucleos(t)ide analogue-induced hepatitis B e antigen seroconversion have a higher risk of HBV reactivation. JInfect Dis 2012, 206:1521-1531.
    • (2012) JInfect Dis , vol.206 , pp. 1521-1531
    • Tseng, T.C.1    Liu, C.J.2    Su, T.H.3    Yang, H.C.4    Wang, C.C.5    Chen, C.L.6
  • 61
    • 77955485392 scopus 로고    scopus 로고
    • Nucleos(t)ide analogues only induce temporary hepatitis B e antigen seroconversion in most patients with chronic hepatitis B
    • Reijnders J.G., Perquin M.J., Zhang N., Hansen B.E., Janssen H.L. Nucleos(t)ide analogues only induce temporary hepatitis B e antigen seroconversion in most patients with chronic hepatitis B. Gastroenterology 2010, 139:491-498.
    • (2010) Gastroenterology , vol.139 , pp. 491-498
    • Reijnders, J.G.1    Perquin, M.J.2    Zhang, N.3    Hansen, B.E.4    Janssen, H.L.5


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