ALDH1 expression indicates chemotherapy resistance and poor outcome in node-negative rectal cancer

Human Pathology

Volumn 44, Issue 6, 2013, Pages 966-974

  Avoranta, S Tuulia ^a   Korkeila, Eija A ^a   Ristamäki, Raija H ^a   Syrjänen, Kari J ^a,b   Carpén, Olli M ^a   Pyrhönen, Seppo O ^a   Sundström, Jari T T ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b BARRETOS CANCER HOSPITAL   (Brazil)

Author keywords

ALDH1; Cancer stem cells; Radiotherapy; Rectal cancer; Survival

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; BETA CATENIN; CAPECITABINE; FLUOROURACIL; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG; WNT PROTEIN;

AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHEMORADIOTHERAPY; COMPUTER ASSISTED TOMOGRAPHY; DISEASE FREE SURVIVAL; DISEASE SPECIFIC SURVIVAL; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LONG TERM CARE; LYMPH VESSEL METASTASIS; MAJOR CLINICAL STUDY; MALE; PREOPERATIVE CARE; PROTEIN EXPRESSION; RECTUM ABDOMINOPERINEAL RESECTION; RECTUM CANCER; SHORT COURSE THERAPY; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR BIOPSY;

AGED; CARCINOMA; CHEMORADIOTHERAPY; DIGESTIVE SYSTEM SURGICAL PROCEDURES; DISEASE-FREE SURVIVAL; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; KAPLAN-MEIER ESTIMATE; MALE; NEOPLASM STAGING; PROPORTIONAL HAZARDS MODELS; RECTAL NEOPLASMS; RETINAL DEHYDROGENASE; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84878114651     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2012.10.003     Document Type: Article

References (29)

1. L. Ricci-Vitiani, D.G. Lombardi, and E. Pilozzi Identification and expansion of human colon-cancer-initiating cells Nature 445 2007 111 115
2. T. Reya, S.J. Morrison, M.F. Clarke, and I.L. Weissman Stem cells, cancer, and cancer stem cells Nature 414 2001 105 111
3. S.J. Dylla, L. Beviglia, and I.K. Park Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy PLoS One 3 2008 e2428
4. J.N. Rich Cancer stem cells in radiation resistance Cancer Res 67 2007 8980 8984
5. E.H. Huang, M.J. Hynes, and T. Zhang Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis Cancer Res 69 2009 3382 3389
6. L. Vermeulen, E. De Sousa, F. Melo, and M. van der Heijden Wnt activity defines colon cancer stem cells and is regulated by the microenvironment Nat Cell Biol 12 2010 468 476
7. P.S. Oh, V.B. Patel, and M.A. Sanders Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells Am J Physiol Gastronintest Liver Physiol 301 2011 G347 G355
8. C. Ginestier, M.H. Hur, and E. Charafe-Jauffret ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome Cell Stem Cell 1 2007 555 567
9. S. Deng, X. Yang, and H. Lassus Distinct expression levels and patterns of stem cell marker, aldehyde dehydrogenase isoform 1 (ALDH1), in human epithelial cancers PLoS One 5 2010 e10277
10. A.C. Dillard, and M.A. Lane Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines Mol Carcinog 46 2007 315 329
11. C.J. Hessman, E.J. Bubbers, K.G. Billingsley, D.O. Herzig, and M.H. Wong Loss of expression of the cancer stem cell marker aldehyde dehydrogenase 1 correlates with advanced-stage colorectal cancer Am J Surg 203 2012 649 653
12. F. Jiang, Q. Qui, and A. Khanna Aldehyde dehydrogenase 1 is a tumor stem-cell associated marker in lung cancer Mol Cancer Res 7 2009 330 338
13. Y. Wang, H. Zhe, P. Gao, N. Zhang, G. Li, and J. Qin Cancer stem cell marker ALDH1 expression is associated with lymph node metastasis and poor survival in esophageal squamous cell carcinoma: a study from high incidence area of northern China Dis Esophagus 25 2012 560 565
14. Y. Wakamatsu, O. Sakamoto, and H.Z. Oo Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer Pathol Int 62 2012 112 119
15. C. Kahlert, F. Bergmann, and J. Beck Low expression of aldehyde dehydrogenase 1A1 (ALDH1A1) is a prognostic marker for poor survival in pancreatic cancer BMC Cancer 11 2011 275
16. A. Lugli, G. Iezzi, and I. Hostettler Prognostic impact of the expression of putative cancer stem cell markers CD133, CD166, CD44s, EpCAM, and ALDH1 in colorectal cancer Br J Cancer 103 2010 382 390
17. T. Vogler, L. Kriegl, and D. Horst The expression pattern of aldehyde dehydrogenase 1 (ALDH1) is an independent prognostic marker for low survival in colorectal tumors Exp Mol Pathol 92 2012 111 117
18. Y.C. Chen, Y.W. Chen, and H.S. Hsu Aldehyde dehydrogenase 1 is a putative marker for stem cells in head and neck squamous cancer Biochem Biophys Res Commun 385 2009 307 313
19. L.H. Sobin, and C. Wittekind Colon and rectum L.H. Sobin, C. Wittekind, TNM Classification of Malignant Tumours 6th ed. UICC 2002 Wiley New York, NY 72 76
20. B. Glimelius, L. Påhlman, and A. Cervantes ESMO Guidelines Working Group. Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up Ann Oncol 21 Suppl 5 2010 v82 v86
21. D. Horst, S. Reu, L. Kriegl, J. Engel, T. Kirchner, and A. Jung The intratumoural distribution of nuclear beta-catenin is a prognostic marker in colon cancer Cancer 115 2009 2063 2070
22. E. Korkeila, K. Talvinen, and P.M. Jaakkola Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer Br J Cancer 100 2009 874 880
23. P. Dalerba, S.J. Dylla, and I.K. Park Phenotypic characterization of human colorectal cancer stem cells Proc Natl Acad Sci U S A 104 2007 10158 10163
24. Y. Chen, D.J. Orlicky, A. Matsumoto, S. Singh, D.C. Thompson, and V. Vasiliou Aldehyde dehydrogenase B1 (ALDH1B) is a potential biomarker for human colon cancer Biochem Biophys Res Commun 405 2011 173 179
25. D. Horst, L. Kriegl, J. Engel, T. Kirchner, and A. Jung Prognostic significance of the cancer stem cells markers CD133, CD44 and CD166 in colorectal cancer Cancer Invest 27 2009 844 850
26. A.D. Toll, B.M. Boman, and J.P. Palazzo Dysplastic lesions in inflammatory bowel disease show increased positivity for the stem cell marker aldehyde dehydrogenase Hum Pathol 43 2012 238 242
27. A. Yoshida, L.C. Hsu, and V. Davé Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase Enzyme 46 1992 239 244
28. M. Todaro, M.G. Francipane, J.P. Medema, and G. Stassi Colon cancer stem cells: promise of targeted therapy Gastroenterology 138 2010 2151 2162
29. T. Tanei, K. Morimoto, and K. Shimazu Association of breast cancer stem cells identified by aldehyde dehydrogenase 1 expression with resistance to sequential Paclitaxel and epirubicin-based chemotherapy for breast cancers Clin Cancer Res 15 2009 4234 4241