First structure of protein kinase CK2 catalytic subunit with an effective CK2β-competitive ligand

ACS Chemical Biology

Volumn 8, Issue 5, 2013, Pages 901-907

  Raaf, Jennifer ^a   Guerra, Barbara ^b   Neundorf, Ines ^a   Bopp, Bertan ^c   Issinger, Olaf Georg ^b   Jose, Joachim ^c   Pietsch, Markus ^d   Niefind, Karsten ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c UNIVERSITY OF MÜNSTER   (Germany)

^d UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

13 MERIC CYCLIC PEPTIDE; CASEIN KINASE II; CASEIN KINASE IIALPHA; CASEIN KINASE IIBETA; CYCLOPEPTIDE; HOLOENZYME; PEPTIDOMIMETIC AGENT; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; ALANINE; CASEIN KINASE 2, ALPHA, HUMAN; LIGAND; PEPTIDE FRAGMENT; TYROSINE;

ARTICLE; BINDING AFFINITY; ENTHALPY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; PRIORITY JOURNAL; THERMODYNAMICS; AMINO ACID SUBSTITUTION; BINDING COMPETITION; CALORIMETRY; CHEMISTRY; GENETICS; METABOLISM; PROCEDURES; PROTEIN CONFORMATION; X RAY CRYSTALLOGRAPHY;

ALANINE; AMINO ACID SUBSTITUTION; BINDING, COMPETITIVE; CALORIMETRY; CASEIN KINASE II; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; LIGANDS; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; THERMODYNAMICS; TYROSINE;

EID: 84878085324     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb3007133     Document Type: Article

References (25)

1. Niefind, K., Guerra, B., Ermakowa, I., and Issinger, O.-G. (2001) Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme EMBO J. 20, 5320-5331 (Pubitemid 32959451)
2. Guerra, B. and Issinger, O.-G. (2008) Protein kinase CK2 in human diseases Curr. Med. Chem. 15, 1870-1886
3. Ahmed, K., Gerber, D. A., and Cochet, C. (2002) Joining the cell survival squad: an emerging role for protein kinase CK2 Trends Cell Biol. 12, 226-230 (Pubitemid 34327615)
4. Ruzzene, M. and Pinna, L. A. (2010) Addiction to protein kinase CK2: A common denominator of diverse cancer cells? Biochim. Biophys. Acta, Proteins Proteomics 1804, 499-504
5. Cozza, G., Meggio, F., and Moro, S. (2011) The dark side of protein kinase CK2 inhibition Curr. Med. Chem. 18, 2867-2884
6. Prudent, R. and Cochet, C. (2009) New protein kinase CK2 inhibitors: jumping out of the catalytic box Chem. Biol. 16, 112-120
7. Filhol, O., Nueda, A., Martel, V. V., Gerber-Scokaert, D., Benitez, M. J., Souchier, C., Saoudi, Y., and Cochet, C. (2003) Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits Mol. Cell. Biol. 23, 975-987 (Pubitemid 36133515)
8. Boldyreff, B., Meggio, F., Pinna, L. A., and Issinger, O.-G. (1993) Reconstitution of normal and hyperactivated forms of casein kinase-2 by variably mutated β-subunits Biochemistry 32, 12672-12677 (Pubitemid 24005864)
9. Pinna, L. A. (2002) Protein kinase CK2: a challenge to canons J. Cell Sci. 115, 3873-3878 (Pubitemid 35256488)
10. Raaf, J., Brunstein, E., Issinger, O.-G., and Niefind, K. (2008) The CK2α/CK2β interface of human protein kinase CK2 harbors a binding pocket for small molecules Chem. Biol. 15, 111-117 (Pubitemid 351253616)
11. Laudet, B., Barette, C., Dulery, V., Renaudet, O., Dumy, P., Metz, A., Prudent, R., Deshiere, A., Dideberg, O., Filhol, O., and Cochet, C. (2007) Structure-based design of small peptide inhibitors of protein kinase CK2 subunit interaction Biochem. J. 408, 363-373
12. Laudet, B., Moucadel, V., Prudent, R., Filhol, O., Wong, Y.-S., Royer, D., and Cochet, C. (2008) Identification of chemical inhibitors of protein-kinase CK2 subunit interaction Mol. Cell. Biochem. 316, 63-69
13. Jose, J., Maas, R. M., and Teese, M. G. (2012) Autodisplay of enzymes: molecular basis and perspectives J. Biotechnol. 161, 92-103
14. Raaf, J., Brunstein, E., Issinger, O.-G., and Niefind, K. (2008) The interaction of CK2α and CK2β, the subunits of protein kinase CK2, requires CK2β in a preformed conformation and is enthalpically driven Protein Sci. 17, 2180-2186
15. Ermakova, I., Boldyreff, B., Issinger, O.-G., and Niefind, K. (2003) Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit J. Mol. Biol. 330, 925-934 (Pubitemid 36818891)
16. Lolli, G., Pinna, L. A., and Battistutta, R. (2012) Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization ACS Chem. Biol. 7, 1158-1163
17. Raaf, J., Bischoff, N., Klopffleisch, K., Brunstein, E., Olsen, B. B., Vilk, G., Litchfield, D. W., Issinger, O.-G., and Niefind, K. (2011) Interaction between CK2α and CK2β, the subunits of protein kinase CK2: thermodynamic contributions of key residues on the CK2α surface Biochemistry 50, 512-522
18. Swindells, M. B., MacArthur, M. W., and Thornton, J. M. (1995) Intrinsic φ,ψ propensities of amino acids, derived from the coil regions of known structures Nat. Struct. Biol. 2, 596-603
19. Andreotti, A. H. (2003) Native state proline isomerization: an intrinsic molecular switch Biochemistry 42, 9515-9524 (Pubitemid 36993127)
20. Grankowski, N., Boldyreff, B., and Issinger, O.-G. (1991) Isolation and characterization of recombinant human casein kinase II subunits α and β from bacteria Eur. J. Biochem. 198, 25-30
21. Jose, J., Betscheider, D., and Zangen, D. (2005) Bacterial Surface Display Library Screening by target enzyme labelling: Identification of new human cathepsin G inhibitors Anal. Biochem. 346, 258-267 (Pubitemid 41550256)
22. Kabsch, W. (2010) XDS Acta Crystallogr. D66, 125-132
23. McCoy, A. J., Grosse-Kunstleve, R. W., Adams, P. D., Winn, M. D., Storoni, L. C., and Read, R. J. (2007) Phaser crystallographic software J. Appl. Crystallogr. 40, 658-674 (Pubitemid 47080256)
24. Adams, P. D., Afonine, P. V., Bunkóczi, G., Chen, V. B., Davis, I. W., Echols, N., Headd, J. J., Hung, L.-W., Kapral, G. J., Grosse-Kunstleve, R. W., McCoy, A. J., Moriarty, N. W., Oeffner, R., Read, R. J., Richardson, D. C., Richardson, J. S., Terwilliger, T. C., and Zwart, P. H. (2010) PHENIX: a comprehensive Python-based system for macromolecular structure solution Acta Crystallogr. D66, 213-321
25. Emsley, P., Lohkamp, B., Scott, W. G., and Cowtan, K. (2010) Features and development of Coot Acta Crystallogr. D66, 486-501