Critical process parameters evaluation of modified nanoprecipitation method on lomustine nanoparticles and cytostatic activity study on L132 human cancer cell line

Journal of Nanomedicine and Nanotechnology

Volumn 3, Issue 7, 2012, Pages 6-

  Mehrotra, Archana ^a   Pandit, Jayanta K ^b  

^a Oriental University   (India)

^b BANARAS HINDU UNIVERSITY   (India)

Author keywords

Homogenization; Human lung cancer cell line 132; Modified nanoprecipitation; PLA nanoparticles; Stabilizer PVA

Indexed keywords

EID: 84878077072     PISSN: None     EISSN: 21577439     Source Type: Journal    
DOI: 10.4172/2157-7439.1000149     Document Type: Article

References (31)

1. Helle A, Hirsjarvi S, Peltonen L, Hirvonen J, Wiedmer SK, et al. (2010) Novel, dynamic on-line analytical separation system for dissolution of drugs from poly (lactic acid) nanoparticles. J Pharm Biomed Anal 51: 125-130.
2. Belbella A, Vauthier C, Fessi H, Devissaguet JP, Puisieux F (1996) In vitro degradation of nanospheres from poly (D,L-lactides) of different molecular weights and polydispersities. Int J Pharm 129: 95-102.
3. Makino K, Arakawa M, Kondo T (1985) Preparation and in vitro degradation properties of polylactide microcapsules. Chem Pharm Bull (Tokyo) 33: 1195-1201.
4. Fessi, H, Puisieux F, Devissaguet JP, Ammoury N, Benita S (1989) Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 55: R1-R4.
5. Allemann E, Gurny R, Doelker E (1992) Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size. Int J Pharm 87: 247-253.
6. Niwa T, Takeuchi H, Hino T, Kunou N, Kawashima Y (1994) In vitro drug release behaviour of D,L-lactide/glycolide copolymer (PLGA) nanospheres with nafarelin acetate prepared by a novel spontaneous emulsification solvent diffusion method. J Pharm Sci 83: 727-732.
7. Quintanar-Guerrero D, Allemann E, Fessi H, Doelker E (1998) Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. Drug Dev Ind Pharm 24: 1113-1128.
8. Italia JL, Yahya MM, Singh D, Ravi Kumar MN (2009) Biodegradable nanoparticles improve oral bioavailability of amphotericin B and show reduced nephrotoxicity compared to intravenous Fungizone. Pharm Res 26: 1324-1331.
9. Yen FL, Wu TH, Lin LT, Cham TM, Lin CC (2009) Naringenin-loaded nanoparticles improve the physicochemical properties and the hepatoprotective effects of naringenin in orally-administered rats with CCl(4)- induced acute liver failure. Pharm Res 26: 893-902.
10. Wu TH, Yen FL, Lin LT, Tsai TR, Lin CC, et al. (2008) Preparation, physicochemical characterization, and antioxidant effects of quercetin nanoparticles. Int J Pharm 346: 160-168.
11. Keck CM, Muller RH (2006) Drug nanocrystals of poorly soluble drugs produced by high-pressure homogenization. Eur J Pharm Biopharm 62: 3-16.
12. Peltonen L, Koistinen P, Hirvonen J (2003) Preparation of nanoparticles by the nanoprecipitation of low molecular weight poly (l)lactide. AAPS PharmSciTech 13: 299-304.
13. Hyvonen S, Peltonen L, Karjalainen M, Hirvonen J (2005) Effect of nanoprecipitation on the physicochemical properties of low molecular weight poly (L-lactic acid) nanoparticles loaded with salbutamol sulphate and beclomethasone dipropionate. Int J Pharm 295: 269-281.
14. Chacon M, Berges L, Molpeceres J, Aberturas MR, Guzman M (1996) Optimized preparation of poly D,L (lactic-glycolic) microspheres and nanoparticles for oral administration. Int J Pharm 141: 81-91.
15. Molpeceres J, Guzman M, Aberturas MR, Chacon M, Berges L (1996) Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement. J Pharm Sci 85: 206-213.
16. Chorny M, Fishbein I, Danenberg HD, Golomb G (2002) Lipophilic drug loaded nanospheres prepared by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics. J Control Release 83: 389-400.
17. Govender T, Riley T, Ehtezazi T, Garnett MC, Stolnik S, et al. (2000) Defining the drug incorporation properties of PLA-PEG nanoparticles. Int J Pharm 199: 95-110.
18. Lamprecht A, Ubrich N, Yamamoto H, Schafer U, Takeuchi H, et al. (2001) Design of rolipram-loaded nanoparticles: comparison of two preparation methods. J Control Release 71: 297-306.
19. Gao H, Yang YW, Fan YG, Ma JB (2006) Conjugates of poly (DL-lactic acid) with ethylenediamino or diethylenetriamino bridged bis(β-cyclodextrin)s and their nanoparticles as protein delivery systems. J Control Release 112: 301--311.
20. Muthu MS, Singh S (2008) Studies on biodegradable polymeric nanoparticles of risperidone: in vitro and in vivo evaluation. Nanomedicine (Lond) 3: 305-319.
21. Michailova V, Berlinova I, Iliev P, Ivanov L, Titeva S, et al. (2010) Nanoparticles formed from PNIPAM-g-PEO copolymers in the presence of indomethacin. Int J Pharm 384: 154-164.
22. Jain AK, Goyal AK, Gupta PN, Khatri K, Mishra N, et al. (2009) Synthesis, characterization and evaluation of novel triblock copolymer based nanoparticles for vaccine delivery against hepatitis B. J Control Release 136: 161-169.
23. Freitas MN, Marchetti JM (2005) Nimesulide PLA microspheres as a potential sustained release system for the treatment of inflammatory diseases. Int J Pharm 295: 201-211.
24. Lerouell-Le Verger M, Fluckiger L, Kim YI, Hoffman M, Maincent P (1998) Preparation and characterization of nanoparticles containing an antihypertensive agent. Eur J Pharm Biopharm 46: 137-143.
25. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudziski WE (2001) Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release 70: 1-20.
26. Leo E, Brina B, Forni F, Vandelli MA (2004) In vitro evaluation of PLA nanoparticles containing a lipophilic drug in water-soluble or insoluble form. Int J Pharm 278: 133-141.
27. Brigger I, Dubernet C, Couvreur P (2012) Nanoparticles in cancer therapy and diagnosis. Adv Drug Deliv Rev 54.
28. Bilati U, Allemann E, Doelker E (2005) Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. Eur J Pharm Sci 24: 67-75.
29. Stainmesse S, Orecchioni AM, Nakache E (1992) Modelling of an original process to obtain biocompatible polymeric nanospheres. Proc Sixth Congr Int Technol Pharm 1: 89-97.
30. Mu X, Zhong Z (2006) Preparation and properties of poly(vinyl alcohol)-stabilized liposomes. Int J Pharm 318: 55-61.
31. Sehra S, Dhake AS (2005) Formulation and evaluation of sustained release microspheres of poly-lactide-co-glycolide containing tamoxifen citrate. J Microencapsul 22: 521-528.