Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection

ACS Chemical Biology

Volumn 8, Issue 5, 2013, Pages 908-913

  Evans, Bradley S ^a   Zhao, Changming ^a,d   Gao, Jiangtao ^a   Evans, Courtney M ^a   Ju, Kou San ^a   Doroghazi, James R ^a   Van Der Donk, Wilfred A ^a,b   Kelleher, Neil L ^c   Metcalf, William W ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PHOSACETAMYCIN; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; ANTIINFECTIVE AGENT; PHOSPHATE; PHOSPHOROUS ACID;

ANTIMICROBIAL ACTIVITY; ARTICLE; BIOSYNTHESIS; CELL MEMBRANE PERMEABILITY; EPIMERIZATION; GENE CLUSTER; GROWTH INHIBITION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVERSED PHASE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; AFFINITY CHROMATOGRAPHY; BACTERIAL GENOME; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; ESCHERICHIA COLI; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; MULTIGENE FAMILY; PROCEDURES; STREPTOMYCES;

ACETAMIDES; ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; CHROMATOGRAPHY, AFFINITY; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI; GENOME, BACTERIAL; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MULTIGENE FAMILY; PHOSPHATES; PHOSPHOROUS ACIDS; STREPTOMYCES;

EID: 84878046614     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb400102t     Document Type: Article

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