Evolution of biologics screening technologies

Pharmaceuticals

Volumn 6, Issue 5, 2013, Pages 681-688

  Cariuk, Peter ^a   Gardener, Matthew J ^a   Vaughan, Tristan J ^a  

^a MEDIMMUNE   (United States)

Author keywords

Assay technologies; High throughput screening; Therapeutic antibodies

Indexed keywords

ALKALINE PHOSPHATASE; BETA ARRESTIN; BIOLOGICAL PRODUCT; G PROTEIN COUPLED RECEPTOR;

ANTIBODY DETECTION; AUTOMATION; BIOLOGICAL THERAPY; DRUG SCREENING; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH THROUGHPUT SCREENING; PHAGE DISPLAY; REVIEW; SCREENING TEST; SIGNAL TRANSDUCTION;

EID: 84877970449     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph6050681     Document Type: Review

References (22)

1. Lloyd, C.; Lowe, D.; Edwards, B.; Welsh, F.; Dilks, T.; Hardman, C.; Vaughan, T. Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens. Protein Eng. Des. Sel. 2009, 22, 159-168.
2. McCafferty, J.; Griffiths, A.D.; Winter, G.; Chiswell, D.J. Phage antibodies: filamentous phage displaying antibody variable domains. Nature 1990, 348, 552-554.
3. Lequin, R.M. Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA). Clin. Chem. 2005, 51, 2415-2418.
4. Hemmila, I.; Dakubu, S.; Mukkala, V.M.; Siitari, H.; Lovgren, T. Europium as a label in time-resolved immunofluorometric assays. Anal. Biochem. 1984, 137, 335-343.
5. Pakard Instrument Company. Two methods of harvesting receptor binding assays. TopCount Topics 1992, TCA-010.
6. Bosse, R.; Garlick, R.; Brown, B.; Menard, L. Development of nonseparation binding and functional assays for G protein-coupled receptors for high throughput screening: Pharmacological characterization of the immobilized CCR5 receptor on flashplate. J. Biomol. Screening 1998, 3, 285-292.
7. Cook, N.D. Scintillation proximity assay: a versatile high-throughput screening technology. Drug Discov. Today 1996, 1, 287-294.
8. Kolb, J.M.; Yamanaka, G.; Manly, S.P. Use of a Novel Homogeneous Fluorescent Technology in High Throughput Screening. J. Biomol. Screening 1996, 1, 203-210.
9. Dickson, E.F.; Pollak, A.; Diamandis, E.P. Ultrasensitive bioanalytical assays using time-resolved fluorescence detection. Pharmacol. Ther. 1995, 66, 207-235.
10. Ullman, E.F.; Kirakossian, H.; Singh, S.; Wu, Z.P.; Irvin, B.R.; Pease, J.S.; Switchenko, A.C.; Irvine, J.D.; Dafforn, A.; Skold, C.N. Luminescent oxygen channeling immunoassay: measurement of particle binding kinetics by chemiluminescence. Proc. Natl. Acad. Sci. USA 1994, 91, 5426-5430.
11. Zwier, J.M.; Roux, T.; Cottet, M.; Durroux, T.; Douzon, S.; Bdioui, S.; Gregor, N.; Bourrier, M.; Oueslati, N.; Nicolas, L.; et al. A fluorescent ligand-binding alternative using tag-lite® technology. J. Biomol. Screening 2010, 15, 1248-1259.
12. Yan, H.; Gu, W.; Yang, J.; Bi, V.; Shen, Y.; Lee, E.; Winters, K.A.; Komorowski, R.; Zhang, C.; Patel, J.J.; et al. Fully human monoclonal antibodies antagonizing the glucagon receptor improve glucose homeostasis in mice and monkeys. Pharmacol. Ther. 2009, 329, 102-111.
13. Miraglia, S.; Swartzman, E.E.; Mellentin-Michelotti, J.; Evangelista, L.; Smith, C.; Gunawan, I.I.; Lohman, K.; Goldberg, E.M.; Manian, B.; Yuan, P.M. Homogeneous cell- and bead-based assays for high throughput screening using fluorometric microvolume assay technology. J. Biomol. Screening 1999, 4, 193-204.
14. Black, C.B.; Duesing, T.B.; Trinkle, L.S.; Dunlay, T.R. Cell-Based screening using high-throughput flow cytometry. Assay Drug Dev. Technol. 2011, 9, 13-20.
15. Zhao, X.; Jones, A.; Olson, K.R.; Peng, K.; Wehrman, T.; Park, A.; Mallari, R.; Nebalasca, D.; Young, S.W.; Xiao, S.H. A homogeneous enzyme fragment complementation-based beta-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors. J. Biomol. Screening 2008, 13, 737-747.
16. Hanson, B.J.; Wetter, J.; Bercher, M.R.; Kopp, L.; Fuerstenau-Sharp, M.; Vedvik, K.L.; Zielinski, T.; Doucette, C.; Whitney, P.J.; Revankar, C. A homogeneous fluorescent live-cell assay for measuring 7-transmembrane receptor activity and agonist functional selectivity through beta-arrestin recruitment. J. Biomol. Screening 2009, 14, 798-810.
17. Asphahani, F.; Zhang, M. Cellular impedance biosensors for drug screening and toxin detection. Analyst 2007, 132, 835-841.
18. Lee, P.H.; Gao, A.; van Staden, C.; Ly, J.; Salon, J.; Xu, A.; Fang, Y.; Verkleeren, R. Evaluation of dynamic mass redistribution technology for pharmacological studies of recombinant and endogenously expressed g protein-coupled receptors. Assay Drug Dev. Technol. 2008, 6, 83-94.
19. Karlsson, R.; Michaelsson, A.; Mattsson, L. Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system. J. Immunol. Methods 1991, 145, 229-240.
20. Abdiche, Y.; Malashock, D.; Pinkerton, A.; Pons, J. Determining kinetics and affinities of protein interactions using a parallel real-time label-free biosensor, the Octet. Anal. Biochem. 2008, 377, 209-217.
21. Glaser, V. High throughput screening retools for the future. Available online: http://www.bio-itworld.com/BioIT_Article.aspx?id=86836/ (accessed on 23 April 2013).
22. McCoy, P.J., Jr. High-content screening: getting more from less. Nat. Methods 2011, 8, 390-391.