Glioma Initiating Cells Form a Differentiation Niche Via the Induction of Extracellular Matrices and Integrin αV

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Niibori Nambu, Akiko ^a   Midorikawa, Uichi ^a,b   Mizuguchi, Souhei ^a   Hide, Takuichiro ^a   Nagai, Minako ^a   Komohara, Yoshihiro ^a   Nagayama, Megumi ^a   Hirayama, Mio ^a   Kobayashi, Daiki ^a   Tsubota, Nobuyuki ^a   Takezaki, Tatsuya ^a   Makino, Keishi ^a   Nakamura, Hideo ^a   Takeya, Motohiro ^a   Kuratsu, Junichi ^a   Araki, Norie ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b SHARP CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 INTEGRIN; CELL ADHESION MOLECULE; COLLAGEN TYPE 4; DNA; FIBRONECTIN; LAMININ ALPHA2; MESSENGER RNA; TEMOZOLOMIDE;

ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE COURSE; DNA MICROARRAY; DOWN REGULATION; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION; GLIOMA; HUMAN; IN VIVO STUDY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEOMICS; UPREGULATION; WESTERN BLOTTING; XENOGRAFT;

ANIMALS; BRAIN NEOPLASMS; CARCINOGENESIS; CELL ADHESION; CELL DIFFERENTIATION; CELL MOVEMENT; CELL SURVIVAL; DACARBAZINE; DISEASE PROGRESSION; EXTRACELLULAR MATRIX; FIBRONECTINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE ONTOLOGY; GLIOMA; HUMANS; INTEGRIN ALPHAV; MICE; NEOPLASM PROTEINS; NEOPLASTIC STEM CELLS; OLIGOPEPTIDES; PROTEOMICS; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SPHEROIDS, CELLULAR; SURVIVAL ANALYSIS;

EID: 84877964710     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0059558     Document Type: Article

References (26)

1. Stupp R, Pavlidis N, Jelic S, (2005) ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of malignant glioma. Annals of oncology: official journal of the European Society for Medical Oncology/ESMO 16 Suppl 1: i64-65.
2. Pollard SM, Yoshikawa K, Clarke ID, Danovi D, Stricker S, et al. (2009) Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 4: 568-580.
3. Rich JN, Bao S, (2007) Chemotherapy and cancer stem cells. Cell stem cell 1: 353-355.
4. Fuchs E, Tumbar T, Guasch G, (2004) Socializing with the neighbors: stem cells and their niche. Cell 116: 769-778.
5. Bar EE, Chaudhry A, Lin A, Fan X, Schreck K, et al. (2007) Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma. Stem cells 25: 2524-2533.
6. Ikushima H, Todo T, Ino Y, Takahashi M, Miyazawa K, et al. (2009) Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors. Cell stem cell 5: 504-514.
7. Kobayashi D, Kumagai J, Morikawa T, Wilson-Morifuji M, Wilson A, et al. (2009) An integrated approach of differential mass spectrometry and gene ontology analysis identified novel proteins regulating neuronal differentiation and survival. Molecular & cellular proteomics: MCP 8: 2350-2367.
8. Sheila K, Singh IDC, Terasaki Mizuhiko, Bonn Victoria E, Hawkins Cynthia, Squire Jeremy, Dirks PB, (2003) Identification of a Cancer Stem Cell in Human Brain Tumors. Cancer Research 63: 5821-5828.
9. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, et al. (2004) Identification of human brain tumour initiating cells. Nature 432: 396-401.
10. Oka N, Soeda A, Inagaki A, Onodera M, Maruyama H, et al. (2007) VEGF promotes tumorigenesis and angiogenesis of human glioblastoma stem cells. Biochemical and biophysical research communications 360: 553-559.
11. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, et al. (2007) Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes & development 21: 2683-2710.
12. Alvarez-Buylla A, Lim DA, (2004) For the long run: maintaining germinal niches in the adult brain. Neuron 41: 683-686.
13. Li HY, Liao CY, Lee KH, Chang HC, Chen YJ, et al. (2010) Collagen IV Significantly Enhances Migration and Transplantation of Embryonic Stem Cells: Involvement of alpha2beta1 Integrin-mediated Actin Remodeling. Cell transplantation.
14. Sun Y, Pollard S, Conti L, Toselli M, Biella G, et al. (2008) Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture. Molecular and cellular neurosciences 38: 245-258.
15. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, et al. (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438: 820-827.
16. Ohnishi T, Hiraga S, Izumoto S, Matsumura H, Kanemura Y, et al. (1998) Role of fibronectin-stimulated tumor cell migration in glioma invasion in vivo: clinical significance of fibronectin and fibronectin receptor expressed in human glioma tissues. Clinical & experimental metastasis 16: 729-741.
17. Fukushima Y, Tamura M, Nakagawa H, Itoh K, (2007) Induction of glioma cell migration by vitronectin in human serum and cerebrospinal fluid. Journal of neurosurgery 107: 578-585.
18. Pimton P, Sarkar S, Sheth N, Perets A, Marcinkiewicz C, et al. (2011) Fibronectin-mediated upregulation of alpha5beta1 integrin and cell adhesion during differentiation of mouse embryonic stem cells. Cell adhesion & migration 5: 73-82.
19. Hynes RO, (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687.
20. Wick W, Weller M, Weiler M, Batchelor T, Yung AW, et al. (2011) Pathway inhibition: emerging molecular targets for treating glioblastoma. Neuro-oncology 13: 566-579.
21. Gilbert MR, Kuhn J, Lamborn KR, Lieberman F, Wen PY, et al. (2012) Cilengitide in patients with recurrent glioblastoma: the results of NABTC 03-02, a phase II trial with measures of treatment delivery. Journal of neuro-oncology 106: 147-153.
22. Hall PE, Lathia JD, Miller NG, Caldwell MA, ffrench-Constant C, (2006) Integrins are markers of human neural stem cells. Stem Cells 24: 2078-2084.
23. Cosset EC, Godet J, Entz-Werle N, Guerin E, Guenot D, et al. (2011) Involvement of the TGFbeta pathway in the regulation of alpha(5) beta(1) integrins by caveolin-1 in human glioblastoma. International journal of cancer Journal international du cancer.
24. Ohka F, Natsume A, Wakabayashi T, (2012) Current trends in targeted therapies for glioblastoma multiforme. Neurology research international 2012: 878425.
25. Reardon DA, Cheresh D, (2011) Cilengitide: a prototypic integrin inhibitor for the treatment of glioblastoma and other malignancies. Genes & cancer 2: 1159-1165.
26. Hirayama M, Kobayashi D, Mizuguchi S, Morikawa T, Nagayama M, et al. (2013) Integrated proteomics identified novel activation of dynein IC2-GR-COX-1 signaling in NF1 disease model cells. Molecular & cellular proteomics: MCP.