Nerve growth factor reduces myocardial ischemia/reperfusion injury in rat hearts

Journal of Basic and Clinical Physiology and Pharmacology

Volumn 24, Issue 1, 2013, Pages 81-84

  Strande, Jennifer L ^b   Routhu, Kasi V ^b   Lecht, Shimon ^c   Lazarovici, Philip ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c Temple University   (United States)

Author keywords

Cardioprotection; Infarct; Myocardial ischemia reperfusion; NGF

Indexed keywords

N(G) METHYLARGININE; NERVE GROWTH FACTOR; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; DRUG INHIBITION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART PROTECTION; MALE; NONHUMAN; RAT; REPERFUSION INJURY;

EID: 84877958678     PISSN: 07926855     EISSN: 21910286     Source Type: Journal    
DOI: 10.1515/jbcpp-2012-0045     Document Type: Article

References (19)

1. Levi-Montalcini R. The nerve growth factor 35 years later. Science 1987;237:1154-62.
2. Lazarovici P, Marcinkiewicz C, Lelkes PI. Cross talk between the cardiovascular and nervous systems: neurotrophic effects of vascular endothelial growth factor (VEGF) and angiogenic effects of nerve growth factor (NGF)-implications in drug development. Curr Pharm Des 2006;12:2609-22.
3. Caporali A, Emanueli C. Cardiovascular actions of neurotrophins. Physiol Rev 2009;89:279-308.
4. Govoni S, Pascale A, Amadio M, Calvillo L, D'Elia E, Cereda C, et al. NGF and heart: is there a role in heart disease ? Pharmacol Res 2011;63:266-77.
5. Routhu KV, Tsopanoglou NE, Strande JL. Parstatin(1-26): the putative signal peptide of protease-Activated receptor 1 confers potent protection from myocardial ischemia-reperfusion injury. J Pharmacol Exp Ther 2010;332:898-905.
6. Strande JL, Widlansky ME, Tsopanoglou NE, Su J, Wang J, Hsu A, et al. Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury. Cardiovasc Res 2009;83:325-34.
7. Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE. Inhibiting protease-Activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling. J Pharmacol Exp Ther 2008;324:1045-54.
8. Cai Z, Semenza GL. Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury. Circulation 2004;109:2050-3.
9. Wang D, Yang XP, Liu YH, Carretero OA, LaPointe MC. Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase. Am J Hypertens 1999;12:174-82.
10. Caporali A, Sala-Newby GB, Meloni M, Graiani G, Pani E, Cristofaro B, et al. Identification of the prosurvival activity of nerve growth factor on cardiac myocytes. Cell Death Differ 2008;15:299-311.
11. Schonhoff CM, Bulseco DA, Brancho DM, Parada LF, Ross AH. The Ras-ERK pathway is required for the induction of neuronal nitric oxide synthase in differentiating PC12 cells. J Neurochem 2001;78:631-9.
12. Bonthius DJ, Karacay B, Dai D, Pantazis NJ. FGF-2, NGF and IGF-1, but not BDNF, utilize a nitric oxide pathway to signal neurotrophic and neuroprotective effects against alcohol toxicity in cerebellar granule cell cultures. Brain Res Dev Brain Res 2003;140:15-28.
13. Ravingerova T. Intrinsic defensive mechanisms in the heart: a potential novel approach to cardiac protection against ischemic injury. Gen Physiol Biophys 2007;26:3-13.
14. Ferdinandy P, Schulz R, Baxter GF. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol Rev 2007;59:418-58.
15. Meloni M, Caporali A, Graiani G, Lagrasta C, Katare R, Van Linthout S, et al. Nerve growth factor promotes cardiac repair following myocardial infarction. Circ Res 2010;106:1275-84.
16. Basalay M, Barsukevich V, Mastitskaya S, Mrochek A, Pernow J, Sjoquist PO, et al. Remote ischaemic pre-And delayed postconditioning-similar degree of cardioprotection but distinct mechanisms. Exp Physiol 2012;97:908-17.
17. Lecht S, Foerster C, Arien-Zakay H, Marcinkiewicz C, Lazarovici P, Lelkes PI. Cardiac microvascular endothelial cells express and release nerve growth factor but not fibroblast growth factor-2. In Vitro Cell Dev Biol Anim 2010;46:469-76.
18. Qin F, Vulapalli RS, Stevens SY, Liang CS. Loss of cardiac sympathetic neurotransmitters in heart failure and NE infusion is associated with reduced NGF. Am J Physiol Heart Circ Physiol 2002;282:H363-71.
19. Golomb E, Nyska A, Schwalb H. Occult cardiotoxicity-Toxic effects on cardiac ischemic tolerance. Toxicol Pathol 2009;37:572-93.