A DNA vaccine co-expressing Trichinella spiralis MIF and MCD-1 with murine ubiquitin induces partial protective immunity in mice

Journal of Helminthology

Volumn 87, Issue 1, 2013, Pages 24-33

  Tang, F ^a   Xu, L ^a   Yan, R ^a   Song, X ^a   Li, X ^a  

^a NANJING AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTATIN LIKE DOMAIN PROTEIN; DNA VACCINE; GAMMA INTERFERON; HYBRID PROTEIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G2B ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; MACROPHAGE MIGRATION INHIBITION FACTOR; PLASMID VECTOR; PROTEIN; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIBODY TITER; ARTICLE; CD4 CD8 RATIO; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DNA IMMUNIZATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMORAL IMMUNITY; IMMUNITY; MOUSE; NONHUMAN; SPLEEN CELL; TH1 CELL; TRICHINELLA SPIRALIS; TRICHINOSIS; WESTERN BLOTTING;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; INTRAMOLECULAR OXIDOREDUCTASES; MACROPHAGE MIGRATION-INHIBITORY FACTORS; MICE; MICE, INBRED BALB C; PARASITE LOAD; T-LYMPHOCYTES; TRICHINELLA SPIRALIS; TRICHINELLOSIS; UBIQUITIN; VACCINATION; VACCINES, DNA;

EID: 84877942456     PISSN: 0022149X     EISSN: 14752697     Source Type: Journal    
DOI: 10.1017/S0022149X1100068X     Document Type: Article

References (40)

1. Bautista-Garfias, C.R., Ixta, O., Orduna, M., Martinez, F., Aguilar, B. & Cortes, A. (1999) Enhancement of resistance in mice treated with Lactobacillus casei: effect on Trichinella spiralis infection. Veterinary Parasitology 80, 251-260.
2. Chou, B., Hiromatsu, K., Hisaeda, H., Duan, X., Imai, T., Murata, S., Tanaka, K. & Himeno, K. (2010) Genetic immunization based on the ubiquitin-fusion degradation pathway against Trypanosoma cruzi. Biochemical and Biophysical Research Communications 392, 277-282.
3. Dantuma, N.P., Lindsten, K., Glas, R., Jellne, M. & Masucci, M.G. (2000) Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells. Nature Biotechnology 18, 538-543.
4. Dea-Ayuela, M.A., Rama-Iniguez, S. & Bolas-Fernandez, F. (2006) Vaccination of mice against intestinal Trichinella spiralis infections by oral administration of antigens microencapsulated in methacrilic acid copolymers. Vaccine 24, 2772-2780.
5. Delogu, G., Howard, A., Collins, F.M. & Morris, S.L. (2000) DNA vaccination against tuberculosis: expression of a ubiquitin-conjugated tuberculosis protein enhances antimycobacterial immunity. Infection and Immunity 68, 3097-3102.
6. Fabre, M.V., Beiting, D.P., Bliss, S.K. & Appleton, J.A. (2009) Immunity to Trichinella spiralis muscle infection. Veterinary Parasitology 159, 245-248.
7. Finkelman, F.D., Shea-Donohue, T., Morris, S.C., Gildea, L., Strait, R., Madden, K.B., Schopf, L. & Urban, J.F. Jr. (2004) Interleukin-4-and interleukin-13-mediated host protection against intestinal nematode parasites. Immunological Reviews 201, 139-155.
8. Finley, D. (2009) Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annual Review of Biochemistry 78, 477-513.
9. Frigerio, L., Jolliffe, N.A., Di Cola, A., Felipe, D.H., Paris, N., Neuhaus, J.M., Lord, J.M., Ceriotti, A. & Roberts, L.M. (2001) The internal propeptide of the ricin precursor carries a sequence-specific determinant for vacuolar sorting. Plant Physiology 126, 167-175.
10. Froscher, W., Gullotta, F., Saathoff, M. & Tackmann, W. (1988) Chronic trichinosis, Clinical, bioptic, serological and electromyographic observations. European Neurology 28, 221-226.
11. Gaczynska, M., Rock, K.L. & Goldberg, A.L. (1993) Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature 365, 264-267.
12. Gravier, R., Dory, D., Rodriguez, F., Bougeard, S., Beven, V., Cariolet, R. & Jestin, A. (2007) Immune and protective abilities of ubiquitinated and non-ubiquitinated pseudorabies virus glycoproteins. Acta Virologica 51, 35-45.
13. Hershko, A. & Ciechanover, A. (1998) The ubiquitin system. Annual Review of Biochemistry 67, 425-479.
14. Hogaboam, C.M., Collins, S.M. & Blennerhassett, M.G. (1996) Effects of oral L-NAME during Trichinella spiralis infection in rats. American Journal of Physiology Gastrointestinal and Liver Physiology 271, G338-G346.
15. Hou, Y.H., Chen, J., Tong, G.Z., Tian, Z.J., Zhou, Y.J., Li, G.X., Li, X., Peng, J.M., An, T.Q. & Yang, H.C. (2008) A recombinant plasmid co-expressing swine ubiquitin and the GP5 encoding-gene of porcine reproductive and respiratory syndrome virus induces protective immunity in piglets. Vaccine 26, 1438-1449.
16. Hu, W., Li, F., Yang, X., Li, Z., Xia, H., Li, G., Wang, Y. & Zhang, Z. (2004) A flexible peptide linker enhances the immunoreactivity of two copies HBsAg preS1 (21-47) fusion protein. Journal of Biotechnology 107, 83-90.
17. Ishikawa, N., Goyal, P.K., Mahida, Y.R., Li, K.F. & Wakelin, D. (1998) Early cytokine responses during intestinal parasitic infections. Immunology 93, 257-263.
18. Johnson, E.S., Ma, P.C., Ota, I.M. & Varshavsky, A. (1995) A proteolytic pathway that recognizes ubiquitin as a degradation signal. Journal of Biological Chemistry 270, 17442-17456.
19. Khan, W.I. & Collins, S.M. (2004) Immune-mediated alterationingut physiology and its roleinhostdefencein nematode infection. Parasite Immunology 26, 319-326.
20. Kolodziej-Sobocinska, M., Dvoroznakova, E. & Dziemian, E. (2006) Trichinella spiralis: macrophage activity and antibody response in chronic murine infection. Experimental Parasitology 112, 52-62.
21. Kozak, M. (1987) An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Research 15, 8125-8148.
22. + T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis. Immunology 128, e385-394.
23. Nagano, I., Wu, Z. & Takahashi, Y. (2009) Functional genes and proteins of Trichinella spp. Parasitology Research 104, 197-207.
24. Nathan, C.F., Murray, H.W., Wiebe, M.E. & Rubin, B.Y. (1983) Identification of interferon-gamma as the lymphokine that activates human macrophage oxi-dative metabolism and antimicrobial activity. Journal of Experimental Medicine 158, 670-689.
25. Ortmann, B., Androlewicz, M.J. & Cresswell, P. (1994) MHC class I/beta 2-microglobulin complexes associate with TAP transporters before peptide binding. Nature 368, 864-867.
26. Pennock, J.L., Behnke, J.M., Bickle, Q.D., Devaney, E., Grencis, R.K., Isaac, R.E., Joshua, G.W., Selkirk, M.E., Zhang, Y. & Meyer, D.J. (1998) Rapid purification and characterization of L-dopachrome-methyl ester tauto-merase (macrophage-migration-inhibitory factor) from Trichinella spiralis, Trichuris muris and Brugia pahangi. Biochemical Journal 335, 495-498.
27. Pickart, C.M. (2001) Mechanisms underlying ubiquitina-tion. Annual Review of Biochemistry 70, 503-533.
28. Pond, L., Wassom, D.L. & Hayes, C.E. (1989) Evidence for differential induction of helper T cell subsets during Trichinella spiralis infection. Journal of Immunology 143, 4232-4237.
29. Robinson, K., Bellaby, T. & Wakelin, D. (1995) Oral and parenteral vaccination against Trichinella spiralis infections in high-and low-responder mice. International Journal for Parasitology 25, 989-992.
30. Robinson, M.W., Greig, R., Beattie, K.A., Lamont, D.J. & Connolly, B. (2007) Comparative analysis of the excretory-secretory proteome of the muscle larva of Trichinella pseudospiralis and Trichinella spiralis. International Journal for Parasitology 37, 139-148.
31. Rodriguez, F., Zhang, J. & Whitton, J.L. (1997) DNA immunization: ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction. Journal of Virology 71, 8497-8503.
32. Suzuki, Y., Orellana, M.A., Schreiber, R.D. & Remington, J.S. (1988) Interferon-gamma: the major mediator of resistance against Toxoplasma gondii. Science 240, 516-518.
33. Tan, T.H., Edgerton, S.A., Kumari, R., McAlister, M.S., Roe, S.M., Nagl, S., Pearl, L.H., Selkirk, M.E., Bianco, A.E., Totty, N.F., Engwerda, C., Gray, C.A. & Meyer, D.J. (2001) Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis. Biochemical Journal 357, 373-383.
34. Tanaka, K. & Kasahara, M. (1998) The MHC class I ligand-generating system: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28. Immunological Reviews 163, 161-176.
35. Wakelin, D., Goyal, P.K., Dehlawi, M.S. & Hermanek, J. (1994) Immune responses to Trichinella spiralis and T. pseudospiralis in mice. Immunology 81, 475-479.
36. Wan, Q.H., Wang, J.L., He, L.F., Liu, H. & Zhang, X. (2006) Serum IL-12 level in mice infected with Trichinella spiralis. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng chong Bing Za Zhi 24, 475-476.
37. Wang, Q.M., Kang, L. & Wang, X.H. (2009) Improved cellular immune response elicited by a ubiquitin-fused ESAT-6 DNA vaccine against Mycobacterium tuberculosis. Microbiology and Immunology 53, 384-390.
38. Whitton, J.L., Rodriguez, , F., Zhang, J. & Hassett, D.E. (1999) DNA immunization: mechanistic studies. Vaccine 17, 1612-1619.
39. Wu, Z., Boonmars, T., Nagano, I., Nakada, T. & Takahashi, Y. (2003) Molecular expression and characterization of a homologue of host cytokine macrophage migration inhibitory factor from Trichinella spp. Journal of Parasitology 89, 507-515.
40. Zhu, X., Long, G., Xu, F. & Gui, Y. (1993) Trichinellosis. 1st edn. pp. 258-260. Zhengzhou, Henan Science and Technology Press.