Genetic immunization based on the ubiquitin-fusion degradation pathway against Trypanosoma cruzi

Biochemical and Biophysical Research Communications

Volumn 392, Issue 3, 2010, Pages 277-282

  Chou, Bin ^a,b   Hiromatsu, Kenji ^a   Hisaeda, Hajime ^b   Duan, Xuefeng ^b   Imai, Takashi ^b   Murata, Shigeo ^c   Tanaka, Keiji ^c   Himeno, Kunisuke ^b  

^a FUKUOKA UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Amastigote surface protein 2; DNA vaccine; Trypanosoma cruzi; Ubiquitin fusion degradation

Indexed keywords

AMASTIGOTE SURFACE PROTEIN 2; MEMBRANE PROTEIN; PROTEASOME; PROTEIN LMP2; PROTEIN LMP7; PROTEIN SUBUNIT; TRYPANOSOMA CRUZI VACCINE; UBIQUITIN; UNCLASSIFIED DRUG;

AMASTIGOTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CHAGAS DISEASE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC CODE; GENETIC IMMUNIZATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; SURVIVAL; TRYPANOSOMA CRUZI;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CHAGAS DISEASE; CYSTEINE ENDOPEPTIDASES; FEMALE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; NEURAMINIDASE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTOZOAN VACCINES; TRYPANOSOMA CRUZI; UBIQUITIN; VACCINATION; VACCINES, DNA;

MUS; PROTOZOA; TRYPANOSOMA CRUZI;

EID: 76349087113     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.12.166     Document Type: Article

References (24)

1. Camandaroba E.L., Reis E.A., Goncalves M.S., Reis M.G., and Andrade S.G. Trypanosoma cruzi: susceptibility to chemotherapy with benznidazole of clones isolated from the highly resistant Colombian strain. Rev. Soc. Bras. Med. Trop. 36 (2003) 201-209
2. Brener Z., and Gazzinelli R.T. Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease. Int. Arch. Allergy Immunol. 114 (1997) 103-110
3. Tanaka K., and Kasahara M. The MHC class I ligand-generating system: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28. Immunol. Rev. 163 (1998) 161-176
4. Tarleton R.L., and Zhang L. Chagas disease etiology: autoimmunity or parasite persistence?. Parasitol. Today 15 (1999) 94-99
5. Pickart C.M. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70 (2001) 503-533
6. Johnson E.S., Ma P.C., Ota I.M., and Varshavsky A. A proteolytic pathway that recognizes ubiquitin as a degradation signal. J. Biol. Chem. 270 (1995) 17442-17456
7. Zhang M., Obata C., Hisaeda H., Ishii K., Murata S., Chiba T., Tanaka K., Li Y., Furue M., Chou B., Imai T., Duan X., and Himeno K. A novel DNA vaccine based on ubiquitin-proteasome pathway targeting 'self'-antigens expressed in melanoma/melanocyte. Gene Ther. 12 (2005) 1049-1057
8. Campo V.A., Buscaglia C.A., Di Noia J.M., and Frasch A.C. Immunocharacterization of the mucin-type proteins from the intracellular stage of Trypanosoma cruzi. Microbes Infect. 8 (2006) 401-409
9. Wizel B., Nunes M., and Tarleton R.L. Identification of Trypanosoma cruzi trans-sialidase family members as targets of protective CD8+ TC1 responses. J. Immunol. 159 (1997) 6120-6130
10. Low H.P., Santos M.A., Wizel B., and Tarleton R.L. Amastigote surface proteins of Trypanosoma cruzi are targets for CD8+ CTL. J. Immunol. 160 (1998) 1817-1823
11. Low H.P., and Tarleton R.L. Molecular cloning of the gene encoding the 83 kDa amastigote surface protein and its identification as a member of the Trypanosoma cruzi sialidase superfamily. Mol. Biochem. Parasitol. 88 (1997) 137-149
12. Chou B., Hisaeda H., Shen J., Duan X., Imai T., Tu L., Murata S., Tanaka K., and Himeno K. Critical contribution of immunoproteasomes in the induction of protective immunity against Trypanosoma cruzi in mice vaccinated with a plasmid encoding a CTL epitope fused to green fluorescence protein. Microbes Infect. 10 (2008) 241-250
13. Zhang M., Ishii K., Hisaeda H., Murata S., Chiba T., Tanaka K., Li Y., Obata C., Furue M., and Himeno K. Ubiquitin-fusion degradation pathway plays an indispensable role in naked DNA vaccination with a chimeric gene encoding a syngeneic cytotoxic T lymphocyte epitope of melanocyte and green fluorescent protein. Immunology 112 (2004) 567-574
14. Claser C., Espindola N.M., Sasso G., Vaz A.J., Boscardin S.B., and Rodrigues M.M. Immunologically relevant strain polymorphism in the Amastigote Surface Protein 2 of Trypanosoma cruzi. Microbes Infect. 9 (2007) 1011-1019
15. Machado A.V., Cardoso J.E., Claser C., Rodrigues M.M., Gazzinelli R.T., and Bruna-Romero O. Long-term protective immunity induced against Trypanosoma cruzi infection after vaccination with recombinant adenoviruses encoding amastigote surface protein-2 and trans-sialidase. Hum. Gene Ther. 17 (2006) 898-908
16. Fehling H.J., Swat W., Laplace C., Kuhn R., Rajewsky K., Muller U., and von Boehmer H. MHC class I expression in mice lacking the proteasome subunit LMP-7. Science 265 (1994) 1234-1237
17. Van Kaer L., Ashton-Rickardt P.G., Eichelberger M., Gaczynska M., Nagashima K., Rock K.L., Goldberg A.L., Doherty P.C., and Tonegawa S. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity 1 (1994) 533-541
18. Murata S., Udono H., Tanahashi N., Hamada N., Watanabe K., Adachi K., Yamano T., Yui K., Kobayashi N., Kasahara M., Tanaka K., and Chiba T. Immunoproteasome assembly and antigen presentation in mice lacking both PA28alpha and PA28beta. Embo J. 20 (2001) 5898-5907
19. Rechsteiner M., Realini C., and Ustrell V. The proteasome activator 11 S REG (PA28) and class I antigen presentation. Biochem. J. 345 Pt 1 (2000) 1-15
20. Groettrup M., Soza A., Eggers M., Kuehn L., Dick T.P., Schild H., Rammensee H.G., Koszinowski U.H., and Kloetzel P.M. A role for the proteasome regulator PA28alpha in antigen presentation. Nature 381 (1996) 166-168
21. Kloetzel P.M., and Ossendorp F. Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Curr. Opin. Immunol. 16 (2004) 76-81
22. Driscoll J., Brown M.G., Finley D., and Monaco J.J. MHC-linked LMP gene products specifically alter peptidase activities of the proteasome. Nature 365 (1993) 262-264
23. Gaczynska M., Rock K.L., and Goldberg A.L. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature 365 (1993) 264-267
24. Vaidian A.K., Weiss L.M., and Tanowitz H.B. Chagas' disease and AIDS. Kinetoplastid Biol. Dis. 3 (2004) 2