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Sauter KA, Wood LJ, Wong J, et al. Doxorubicin and daunorubicin induce processing and release of interleukin-1beta through activation of the NLRP3 inflammasome. Cancer Biol Ther 2011;11:1008-1016. This article demonstrates for the first time that a CCA initiates the formation of the NLRP3 inflammasome to promote the secretion of IL-1b by immune cells. This finding supports the idea that symptoms related to exposure to cytotoxic agents may be caused by IL-1b.
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This article demonstrates the central role that ZAK plays in doxorubicin-induced IL-1b production by immune cells. Nilotinib and sorafenib, which target ZAK, block doxorubicin-induced IL-1b production and consequently may be useful in reducing CTRSs
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Inflammation-induced lethargy is mediated by suppression of orexin neuron activity
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This article demonstrates that suppressed orexin neuron activity is associated with the measured fatigue/lethargy outcome and that central replacement of the orexin neurotransmitter partially ameliorates lethargy following endotoxin treatment
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