Intracerebroventricular injection of interleukin-1 stimulates the release of high levels of interleukin-6 and interleukin-1 receptor antagonist into peripheral blood in the primate

Journal of Neuroimmunology

Volumn 97, Issue 1-2, 1999, Pages 70-76

  Xiao, Ennian ^a   Xia, Linna ^a   Ferin, Michel ^a   Wardlaw, Sharon L ^a  

^a Columbia Univ Coll Phys Surgs ^*  (United States)

Author keywords

ACTH; Hypothalamic pituitary adrenal axis; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 6

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6;

ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; OVARIECTOMY; PERIPHERAL CIRCULATION; PRIMATE; PRIORITY JOURNAL; RHESUS MONKEY;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; ANTIRHEUMATIC AGENTS; FEMALE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INJECTIONS, INTRAVENOUS; INJECTIONS, INTRAVENTRICULAR; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; INTERLEUKIN-6; MACACA MULATTA; PITUITARY-ADRENAL SYSTEM; SIALOGLYCOPROTEINS;

EID: 0032912989     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00050-8     Document Type: Article

References (47)

1. Akira S., Taga T., Kishimoto T. Interleukin-6 in biology and medicine. Adv. Immunol. 54:1993;1-75.
2. Benveniste E.N. Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action. Am. J. Physiol. 263(32):1992;C1-C16. Cell Physiol.
3. Berkenbosch F., Van Oers J., Del Rey A., Tilders F., Besedovsky H. Corticotropin-releasing factor-producing neurons in the rat activated by interleukin-1. Science. 238:1987;524-526.
4. 125I -labeled interleukin-6 from brain into blood following intracerebroventricular injection in rats Endocrinology. 138:1997;4830-4836.
5. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. New Engl. J. Med. 332:1995;1351-1362.
6. De Simoni M.G., Sironi M., De Luigi A., Manfridi A., Mantovani A., Ghezzi P. Intracerebroventricular injection of interleukin 1 induces high circulating levels of interleukin 6. J. Exp. Med. 171:1990;1773-1778.
7. De Simoni M.G., De Lugi A., Sironi G.M., Manfridi A., Ghezzi P. Modulation of systemic interleukin-6 induction by central interleukin-1. Am. J. Physiol. 265:1993;R739-R742.
8. De Simoni M.G., Del Bo R., De Luigi A., Simard S., Forloni G. Central endotoxin induces different patterns of interleukin (IL)-1β and IL-6 messenger ribonucleic acid expression and IL-6 secretion in the brain and periphery. Endocrinology. 136:1995;897-902.
9. Dinarello C.A. Interleukin-1 and interleukin-1 antagonism. Blood. 77:1991;1627-1652.
10. Feng Y.-J., Shalts E., Xia L., Rivier J., Rivier C., Vale W., Ferin M. An inhibitory effect of interleukin-1α on basal gonadotropin release in the ovariectomized rhesus monkey: reversal by a corticotropin-releasing factor antagonist. Endocrinology. 128:1991;2077-2082.
11. Friedman E.M., Coe C.L., Ershler W.B. Bidirectional effects of interleukin-1 on immune responses in rhesus monkeys. Brain, Behavior, and Immunity. 8:1994;87-99.
12. Gallo P., Frei K., Rordorf C., Lazdins J., Tavolat B., Fontana A. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid. J. Neuroimmunol. 23:1989;109-116.
13. Goland S., Conwell I.M., Warren W.B., Wardlaw S.L. Placental corticotropin-releasing hormone and pituitary-adrenal function during pregnancy. Neuroendocrinology. 56:1992;742-749.
14. Gruol D.L., Nelson T.E. Physiological and pathological roles of interleukin- 6 in the central nervous system. Mol. Neurobiol. 15:1997;307-339.
15. Hopkins S.J., Rothwell N.J. Cytokines and the nervous system: I. Expression and recognition. Trends Neurosci. 18:1995;83-88.
16. Irwin M. Brain corticotropin-releasing hormone- and interleukin-1β-induced suppression of specific antibody production. Endocrinology. 133:1993;1352-1360.
17. Irwin M., Vale W., Rivier C. Central corticotropin-releasing factor mediates the suppressive effect of stress on natural killer cytotoxicity. Endocrinology. 126:1990;2837-2844.
18. Jain R., Zwickler D., Hollander C.S., Brand H., Saperstein A., Huchinson B., Brown C., Audhya T. Corticotropin-releasing factor modulates the immune response to stress in the rat. Endocrinology. 128:1991;1329-1336.
19. Kopf M., Baumann H., Freer G., Freudenberg M., Lamers M., Kishimoto T., Zinkernagel R., Bluethmann H., Köhler G. Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature. 368:1994;339-342.
20. Lee S., Rivier C. Effect of exposure to an alcohol diet for ten days on the ability of interleukin-1β to release ACTH and corticosterone in the adult ovariectomized femals rat. Alcohol. Clin. Exp. Res. 17:1993;1009-1013.
21. Licinio J., Wong M.-L., Gold P.W. Localization of Interleukin-1 receptor antagonist mRNA in rat brain. Endocrinology. 129:1991;562-564.
22. McClain C., Cohen D., Phillips R., Ott L., Young B. Increased plasma and ventricular fluid interleukin-6 levels in patients with head injury. J. Lab. Clin. Med. 118:1991;225-231.
23. Minami M., Kuraishi Y., Yamaguchi T., Nakai S., Hirai Y., Satoh M. Immobilization stress induces interleukin-1β mRNA in the rat hypothalamus. Neurosci. Lett. 123:1991;254-256.
24. Minami M., Kuraishi Y., Yabuuchi K., Yamazaki A., Satoh M. Introduction of interleukin-1β mRNA in rat brain after transient forebrain ischemia. J. Neurochem. 58:1992;390-392.
25. Nguyen K.T., Deak T., Owens S.M., Kohno T., Fleshner M., Watkins L.R., Maier S.F. Exposure to acute stress induces brain interleukin-1β protein in the rat. J. Neurosci. 18:1998;2239-2246.
26. Pottratz S.T., Bellido T., Mocharla H., Crabb D., Manolagas S.C. 17β-estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J. Clin. Invest. 93:1994;944-950.
27. Ray A., Prefontaine K.E., Prabir R. Down-modulation of interleukin-6 gene expression by 17β-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J. Biol. Chem. 269:1994;12940-12946.
28. Reichlin S. Neuroendocrine-immune interactions. New Engl. J. Med. 329:1993;1246-1253.
29. Romero L.I., Kakucska I., Lechan R.M., Reichlin S. Interleukin-6 (IL-6) is secreted from the brain after intracerebroventricular injection of IL-1β in rats. Am. J. Physiol. 270:1996;R518-R524. Regulatory Integrative Comp. Physiol. 39.
30. Rothwell N.J. Functions and mechanisms of interleukin 1 in the brain. TiPS. 12:1991;430-436.
31. Rothwell N.J., Hopkins S.J. Cytokines and the nervous system II: actions and mechanisms of action. Trends Neurosci. 18:1995;130-136.
32. Saperstein A., Brand H., Tapan A., Nabriski D., Hutchinson B., Rosenzweig S., Hollander C.S. Interleukin 1β mediates stress-induced immunosuppression via corticotropin-releasing factor. Endocrinology. 130:1992;152-158.
33. Sapolsky R., Rivier C., Yamamoto G., Plotsky P., Vale W. Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science. 238:1987;522-524.
34. Schöbitz B., deKloet E.R., Sutanto W., Holsboer F. Cellular localiztion of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Eur. J. Neurosci. 5:1993;1426-1435.
35. Shalts E., Feng Y.-J., Ferin M., Wardlaw S.L. α-Melanocyte-stimulating hormone antagonizes the neuroendocrine effects of corticotropin-releasing factor and interleukin-1a in the primate. Endocrinology. 131:1992;132-138.
36. Snider, R.S., Lee, J.C., 1961. A stereotaxic atlas of the monkey brain (Macaca mulatta). The University of Chicago Press, Chicago.
37. Sullivan G.M., Canfield S.M., Lederman S., Xiao E., Ferin M., Wardlaw S.L. Intracerebroventricular injection of interleukin-1 suppresses peripheral lymphocyte function in the primate. Neuroimmunomodulation. 4:1997;12-18.
38. Sundar S.K., Becker K.J., Cierpial M.A., Carpenter M.D., Rankin L.A., Fleener S.L., Ritchie J.C., Simson P.E., Weiss J.M. Intracerebroventricular infusion of interleukin 1 rapidly decreases peripheral cellular immune responses. Proc. Natl. Acad. Sci. USA. 86:1989;6398-6402.
39. Sundar S.K., Cierpial M.A., Kilts C., Ritchie J.C., Weiss J.M. Brain IL-1-induced immunosuppression occurs through activation of both pituitary-adrenal axis and sympathetic nervous system by corticotropin-releasing factor. J. Neurosci. 10:1990;3701-3706.
40. Sundar S.K., Cierpial M.A., Kamaraju L.S., Long S., Hsieh S., Lorenz C., Aaron M., Ritchie J.C., Weiss J.M. Human immunodeficiency virus glycoprotein (gp120) infused into rat brain induces interleukin 1 to elevate pituitary-adrenal activity and decrease peripheral cellular immune responses. Proc. Natl. Acad. Sci. USA. 88:1991;11246-11250.
41. Taupin V., Toulmond S., Serrano A., Benavides J., Zavala F. Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion. J. Neuroimmunol. 42:1993;177-186.
42. Van Vugt D.A., Diefenbach W.D., Alston E., Ferin M. Gonadotropin-releasing hormone pulses in third ventricular cerebrospinal fluid of ovariectomized rhesus monkeys: correlation with luteinizing hormone pulses. Endocrinology. 117:1985;1550-1558.
43. Waage A., Halstensen A., Shalaby R., Brandtzaeg P., Kierulf P.et al. Local production of tumor necrosis factor-α, interleukin 1, and interleukin 6 in meningococcal meningitis: relation to the inflammatory response. J. Exp. Med. 170:1989;1859-1867.
44. Weiss J.M., Quan N., Sundar S.K. Widespread activation and consequences of interleukin-1 in the brain. Ann. NY Acad. Sci. 741:1994;338-357.
45. Woodroofe M.N., Sarna G.S., Wadhwa M., Hayes G.M., Loughlin A.J., Tinker A., Cuzner M.L. Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production. J. Neuroimmunol. 33:1991;227-236.
46. Xia-Zang L., Xiao E., Ferin M. A 5-day estradiol therapy, in amounts reproducing concentrations of the early-mid follicular phase, prevents the activation of the hypothalamo-pituitary-adrenal axis by interleukin-1α in the ovariectomized rhesus monkey. J. Neuroendocrinol. 7:1995;387-392.
47. Xia L., Matera C., Ferin M., Wardlaw S.L. Interleukin-1 stimulates the central release of corticotropin-releasing hormone in the primate. Neuroendocrinology. 63:1996;79-84.