MicroRNAs and targeted therapy: Small molecules of unlimited potentials

Current Opinion in Genetics and Development

Volumn 23, Issue 1, 2013, Pages 75-77

  Fassan, Matteo ^a   Baffa, Raffaele ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b SANOFI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BIOLOGICAL MARKER; DOUBLE STRANDED DNA; LOCKED NUCLEIC ACID; MICRORNA; MICRORNA 15A; MICRORNA 16; MICRORNA 16 1; MIRAVIRSEN; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

CANCER PROGNOSIS; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL PRACTICE; EXOSOME; GENE EXPRESSION REGULATION; GENE MUTATION; GENE SILENCING; HEPATITIS C; HUMAN; LEUKEMOGENESIS; METASTASIS POTENTIAL; MOLECULARLY TARGETED THERAPY; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NOTE; PREDICTION; PRIORITY JOURNAL; RNA INTERFERENCE; RNA PROCESSING; RNA TRANSLATION; UNSPECIFIED SIDE EFFECT;

HUMANS; MICRORNAS; MOLECULAR TARGETED THERAPY; OLIGONUCLEOTIDES;

EID: 84877925731     PISSN: 0959437X     EISSN: 18790380     Source Type: Journal    
DOI: 10.1016/j.gde.2013.02.009     Document Type: Note

References (10)

1. Lee R.C., Feinbaum R.L., Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75:843-854.
2. Calin G.A., Dumitru C.D., Shimizu M., Bichi R., Zupo S., Noch E., Aldler H., Rattan S., Keating M., Rai K., et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A 2002, 99:15524-15529.
3. Fassan M., Baffa R., Kiss A., Zaninotto G., Rugge M MicroRNA dysregulation in esophageal neoplasia: the biological rationale for novel therapeutic options. Curr Pharm Des 2013, 19:1236-1241.
4. Fire A., Xu S., Montgomery M.K., Kostas S.A., Driver S.E., Mello C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391:806-811.
5. Baffa R., Fassan M., Volinia S., O'Hara B., Liu C.G., Palazzo J.P., Gardiman M., Rugge M., Gomella L.G., Croce C.M., Rosenberg A. MicroRNA expression profiling of human metastatic cancers identifies cancer gene targets. J Pathol 2009, 219:214-221.
6. Garzon R., Marcucci G., Croce C.M. Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov 2010, 9:775-789.
7. Kong Y.W., Ferland-McCollough D., Jackson T.J., Bushell M. microRNAs in cancer management. Lancet Oncol 2012, 13:e249-e258.
8. Landford R.E., Hildebrandt-Eriksen E.S., Petri A., Persson R., Lindow M., Munk M.E., Kauppinen S., Ørum H. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 2010, 327:198-201.
9. Lindow M., Kauppinen S. Discovering the first microRNA-targeted drug. J Cell Biol 2012, 199:407-412.
10. Fabbri M. TLRs as miRNA receptors. Cancer Res 2012, 72:6333-6337.