Viral infections in children with community-acquired pneumonia

Current Infectious Disease Reports

Volumn 15, Issue 2, 2013, Pages 177-183

  Woods, Charles R ^a   Bryant, Kristina A ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Adenovirus; Adolescent; Bacterial pneumonia; Bocavirus; Child; Community acquired pneumonia; Enterovirus; Infant; Influenza; Metapneumovirus; Parainfluenza virus; Respiratory syncytial virus; Rhinovirus; Staphylococcus aureus; Streptococcus pneumoniae; Viral infection; Viral respiratory tract infection

Indexed keywords

ANTIBIOTIC AGENT; CEFTRIAXONE; CEPHALOSPORIN; CLINDAMYCIN; INFLUENZA VACCINE; MACROLIDE; VANCOMYCIN;

ANTIGEN DETECTION; ANTIMICROBIAL THERAPY; ARTICLE; BACTERIAL PNEUMONIA; BRONCHIECTASIS; BRONCHIOLITIS OBLITERANS; CHILD DEATH; COMMUNITY ACQUIRED PNEUMONIA; DIAGNOSTIC TEST; DISEASE PREDISPOSITION; DISEASE SEVERITY; EPIDEMIC; HOSPITALIZATION; HUMAN; HUMAN METAPNEUMOVIRUS; HUMAN RHINOVIRUS; INFLUENZA; INFLUENZA VIRUS; INFLUENZA VIRUS A H1N1; MEDICAL DECISION MAKING; NONHUMAN; NUCLEIC ACID AMPLIFICATION; PANDEMIC INFLUENZA; PARAINFLUENZA VIRUS; PRACTICE GUIDELINE; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INFECTION; SEASONAL INFLUENZA; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS ISOLATION; VIRUS PNEUMONIA;

EID: 84877922782     PISSN: 15233847     EISSN: 15343146     Source Type: Journal    
DOI: 10.1007/s11908-013-0324-6     Document Type: Article

References (73)

1. Liu L, Johnson HL, Cousens S, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379:2151-61.
2. Rudan I, Boschi-Pinto C, Biloglav Z, et al. Epidemiology and etiology of childhood pneumonia. Bull World Health Org. 2009;86:408-16.
3. Kronman MP, Hersch AL, Feng R, et al. Ambulatory visit rates and antibiotic prescribing for children with pneumonia, 1994-2007. Pediatrics. 2011;127:411-8.
4. Lee GE, Lorch SA, Sheffler-Collin S, et al. National hospitalization trends for pediatric pneumonia and associated complications. Pediatrics. 2010;126:204-13.
5. Ruuskanen O, Lahti E, Jennings LC, Murdoch DR. Viral pneumonia. Lancet. 2011;377:1264-75.
6. Juvén T, Mersola J, Waris M, et al. Etiology of community-acquired pneumonia in 254 hospitalized children. Pediatr Infect Dis J. 2000;19:293-8.
7. Tsolia MN, Psarras S, Bossios A, et al. Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections. Clin Infect Dis. 2004;39:681-6.
8. Cilla G, Onate E, Perez-Yarza EG, et al. Viruses in community-acquired pneumonia in children aged less than 3 years old: high rates of viral coinfection. J Med Virol. 2008;80:1843-9.
9. Nascimento-Carvalho CM, Ribeiro CT, Cardoso MR, et al. The role of respiratory viral infections among children hospitalized for community-acquired pneumonia in a developing country. Pediatr Infect Dis J. 2008;27:939-41.
10. Cevey-Macharel M, Galetto-Lacour A, Gervaix A, et al. Etiology of community-acquired pneumonia in hospitalized children based on WHO clinical guidelines. Eur J Pediatr. 2009;168:1429-36.
11. Bradley JS, Byington CL, Shah SS, et al. The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America. Clin Infect Dis. 2011;53:e25-75. This is the first national U.S. clinical practice guideline for management of children with community-acquired pneumonia. It provides a comprehensive review of diagnostic and treatment issues and identifies gaps in knowledge that need to be addressed by future research.
12. Michelow IC, Olsen K, Lozano J, et al. Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized children. Pediatrics. 2004;113:701-7.
13. Ampofo K, Bender J, Sheng X, et al. Seasonal invasive pneumococcal disease in children: role of preceding respiratory viral infections. Pediatrics. 2008;122:229-37.
14. Talbot TR, Poehling KA, Hartet TV, et al. Seasonality of invasive pneumococcal disease: temporal relation to document influenza and respiratory syncytial virus circulation. Am J Med. 2005;118:285-91.
15. Randolph AG, Reder L, Englund JA. Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit. Pediatr Infect Dis J. 2004;23:990-4.
16. Nichol KP, Cherry JD. Bacterial-viral interrelations in respiratory infections of children. N Engl J Med. 1967;277:667-72.
17. Levin D, Tribuzio M, Green-Wrzesinki T, et al. Empiric antibiotics are justified for infants with respiratory syncytial virus lower respiratory tract infection presenting with respiratory failure: a prospective study and evidence review. Pediatr Crit Care Med. 2010;11:390-5.
18. Reed C, Kallen A, Patton M, et al. Infection with community-onset staphylococcus aureus and influenza virus in hospitalized children. Pediatr Infect Dis J. 2009;28:572-6.
19. Schrag SJ, Shay DK, Gershman K. Emerging infections program respiratory disease activity. Multistate surveillance for laboratory-confirmed influenza-associated hospitalizations in children: 2003-2004. Pediatr Infect Dis J. 2006;25:395-400.
20. Louie JK, Schecter R, Honarmand S, et al. Severe pediatric influenza in California, 2003-2005: implications for immunization recommendations. Pediatrics. 2006;117:e610-8.
21. Finelli L, Fiore A, Dhara R, et al. Influenza-associated pediatric mortality in the United States: increase in staphylococcus aureus coinfection. Pediatrics. 2008;122:805-11.
22. Thorburn K, Harigopal S, Reddy V, et al. High incidence of pulmonary bacterial co-infection in children with severe respiratory syncytial virus (RSV) bronchiolitis. Thorax. 2008;61:611-5.
23. Stockman LJ, Reed C, Kallen AJ, et al. Respiratory syncytial virus and Staphylococcus aureus coinfection in children hospitalized with pneumonia. Pediatr Infect Dis J. 2010;29:1048-50.
24. Pittet LA, Hall-Stoodley L, Rutkowski MR, et al. Influenza virus infection decreases tracheal mucociliary velocity and clearance of streptococcus pneumoniae. Am J Respir Cell Mol Biol. 2010;42:450-60.
25. Avandhanula V, Rodriguez CA, Devincenzo JP, et al. Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner. J Virol. 2006;80:1629-36.
26. Wang JH, Kwon HJ, Jang YJ. Rhinovirus enhances various bacterial adhesions to nasal epithelial cells simultaneously. Laryngoscope. 2009;119:1406-11.
27. Golda A, Malek N, Dudek B, et al. Infection with human coronavirus NL63 enhances streptococcal adherence to epithelial cells. J Gen Virol. 2011;92:1358-68.
28. Halfhide CP, Flanagan BF, Brearey SP, et al. Respiratory syncytial virus binds and undergoes transcription in neutrophils from the blood and airways of infants with severe bronchiolitis. J Infect Dis. 2011;204:451-8.
29. Hament J-M, Kimpen JLL, Fleer A, Wolfs TFW. Respiratory viral infection predisposing for bacterial disease: a concise review. FEMS Immunol Med Microbiol. 1999;26:189-96.
30. Honkinen M, Lahti E, Osterback R, et al. Viruses and bacteria in sputum samples of children with community-acquired pneumonia. Clin Microbiol Infect. 2012;18:300-7.
31. Garcia-Garcia ML, Calvo C, Pozo F, et al. Spectrum of respiratory viruses in children with community-aquired pneumonia. Pediatr Infect Dis J. 2012;31:808-13.
32. Pretorius MA, Madhi SA, Cohen C, et al. Respiratory viral coinfections identified by a 10-plex real-time reverse-transcription polymerase chain reaction assay in patients hospitalized with severe acute respiratory illness - South Africa, 2009-2010. J Infect Dis. 2012;206:S159-65.
33. Hoffman J, Rabezanahary H, Randriamarotia M, et al. Viral and atypical bacterial etiology of acute respiratory infections in children under 5 years old living in a rural tropical area of Madagascar. PLOS. 2012;7:e43666. doi: 10.1371/journal/pone.0043666.
34. Chang ML, Jordan-Villegas A, Evans A, et al. Respiratory viruses identified in an urban children's hospital emergency department during the 2009 influenza A(H1N1) pandemic. Pediatr Emerg Care. 2012;28:990-7.
35. Pavia AT. Viral infections of the lower respiratory tract: old viruses, new viruses, and the role of diagnosis. Clin Infect Dis. 2011;52:S284-9.
36. McCullers JA. Insights into the interaction between influenza virus and pneumococcus. Clin Microbiol Rev. 2006;19:571-82.
37. Williams DJ, Hall M, Brogan TV, et al. Influenza coinfection and outcomes in children with complicated pneumonia. Arch Pediatr Adol Med. 2011;165:506-12.
38. Cox CM, D'Mello T, Perez A, et al. Increase in rates of hospitalization due to laboratory-confirmed influenza among children and adults during the 2009 - 10 influenza pandemic. J Infect Dis. 2012;206:1350-8.
39. Centers for Disease Control and Prevention. Severe illness from 2009 pandemic influenza A (H1N1) - Utah, 2009 - 10 influenza season. MMWR. 2011;60:1310-4.
40. Weinberger DM, Simonsen L, Jordan R, et al. Impact of the 2009 influenza pandemic on pneumococcal pneumonia hospitalizations in the United States. J Infect Dis. 2012;205:458-68.
41. Nelson GE, Gershman K, Swerdlow DL, et al. Invasive pneumococcal disease and pandemic (H1N1) 2009, Denver, Colorado, USA. Emerg Infect Dis. 2012;18:208-16.
42. Tran D, Vaudry W, Moore DL, et al. Comparison of children hospitalized with seasonal versus pandemic influenza A, 2004-2009. Pediatrics. 2012;130:397-406.
43. Blumental S, Huisman E, Cornet M-C, et al. Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey. BMC Infect Dis. 2011;11:313. http://www.biomedcentral.com/1471-2334/11/313.
44. Udompornwattana S, Srajai K, Suwan P, et al. The clinical features, risk of prolonged hospitalization and household infections of hospitalized children for pandemic 2009 influenza A (H1N1) virus infection in Thailand. J Med Assoc Thai. 2012;95:403-11.
45. Lopez-Medina E, Arduara MI, Siegel JD, et al. 2009 influenza A in infants hospitalized at younger than 6 months. J Pediatr. 2012;160:626-31.
46. Peiris JS, Yuen KY, Osterhaus AD, et al. The severe acute respiratory syndrome. N Engl J Med. 2003;349:2431-41.
47. van der Hoek L, Pyrc K, Jebbink MF, et al. Identification of a new human coronarvirus. Nat Med. 2004;10:368-73.
48. Allander T. Human bocavirus. J Clin Virol. 2008;41:29-33.
49. Centers for Disease Control and Prevention. Clusters of acute respiratory illness associated with human enterovirus 68 - Asia, Europe, and United States, 2008-2010. MMWR. 2011;60:1301-4.
50. Schieble JH, Fox VL, Lennette EH. A probable new human picornavirus associated with respiratory disease. Am J Epidemiology. 1967;85:297-310.
51. Oberste MS, Maher K, Schnurr D, et al. Enterovirus 68 is associated with respiratory illness and shars biologic features with both the enteroviruses and the rhinoviruses. J Gen Virol. 2004;85:2577-84.
52. Centers for Disease Control and Prevention. Update: influenza A (H3N2)v transmission and guidelines - five states, 2011. MMWR. 2012;60:1741-4. This report illustrates the need for ongoing surveillance for new strains of influenza virus, including the recognition that these can arise in the U.S. as well as other parts of the world.
53. Skowronski DM, Janjua NZ, De Serres G, et al. Cross-reactive and vaccine-induced antibody to an emerging swine-origin variant of influenza A virus subtype H3N2 (H3N2v). J Infect Dis. 2012;206:1852-61.
54. Grijalva CG, Nuorti JP, Zhu Y, et al. Increasing incidence of empyema complicating childhood community-acquired pneumonia in the United States. Clin Infect Dis. 2010;50:805-13.
55. Li S-TT, Tancredi DJ. Empyema hospitalizations increased in US children despite pneumococcal vaccine. Pediatrics. 2010;125:26-33.
56. Cohen E, Mahant S, Dell SD, et al. The long-term outcomes of pediatric pleural empyema. Arch Pediatr Adolesc Med. 2012;166:999-1004.
57. Brogan TV, Hall M, Williams DJ, et al. Variability in processes of care and outcomes among children hospitalized with community-acquired pneumonia. Pediatr Infect Dis J. 2012;31:1036-41. This article presents analysis of management of community-acquired pneumonia in children admitted to 29 children's hospitals in the U.S. in 2009. Substantial variations in diagnostic testing for viral and bacterial etiologies of and types of antimicrobial treatments administered are described and indicate need for more standardized management nationally.
58. Smith MJ, Kong M, Cambon A, et al. Effectiveness of antimicrobial guidelines for community-acquired pneumonia in children. Pediatrics. 2012;129:e1326-33.
59. Pierce VM, Elkan M, Leet M, et al. Comparison of the Idaho technology film array system to real-time PCR for detection of respiratory pathogens in children. J Clin Microbiol. 2012;50:364-71.
60. Jarti T, Jarti L, Peltola V, et al. Identification of respiratory viruses in asymptomatic subjects: asymptomatic respiratory viral infections. Pediatr Infect Dis J. 2008;27:1103-7.
61. Bonner AB, Monroe KW, Talley LI, et al. Impact of the rapid diagnosis of influenza on physician decision-making and patient management in the pediatric emergency department: results of a randomized, prospective, controlled trial. Pediatrics. 2003;112:363-7.
62. Esposito S, Marchisio P, Moreli P, et al. Effect of a rapid influenza diagnosis. Arch Dis Child. 2003;88:525-6.
63. Benito-Fernandez J, Vazquez-Ronco MA, Morteruel-Aizkuren E, et al. Impact of rapid viral testing for influenza A and B viruses on management of febrile infants without signs of focal infection. Pediatr Infect Dis J. 2006;25:1153-7.
64. Doan QH, Kissoon N, Dobson S, et al. A randomized, controlled trial of the impact of early and rapid diagnosis of viral infections in children brought to an emergency department with febrile respiratory tract illnesses. J Pediatr. 2009;154:91-5.
65. Byington CL, Castillo H, Gerber K, et al. The effect of rapid respiratory viral diagnostic testing on antibiotic use in a children's hospital. Arch Pediatr Adol Med. 2002;156:1230-4.
66. Hyvrinen MK, Kotaniemi-Syrjnen A, Reijonen TM, et al. Lung function and bronchial hyper-responsiveness 11 years after hospitalization for bronchiolitis. Acta Paediatr. 2007;96:1464-9.
67. Stein RT, Sherrill D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999;354:541-5.
68. Martinez FD. Heterogeniety of the association between lower respiratory tract illness in infancy and subsequent asthma. Proc Am Thorac Soc. 2005;2:157-61.
69. Murtagh P, Guibergia V, Viale D, et al. Lower respiratory infections by adenovirus in children. Clinical features and risk factors for bronchiolitis obliterans and mortality. Pediatr Pulmonol. 2009;44:450-6.
70. Aguerre V, Castaňos C, Pena HG, et al. Postinfectious bronchiolitis obliterans in children: clinical and pulmonary function findings. Pediatr Pulmonol. 2010;45:1180-5.
71. Koh YY, da Jung E, Koh JY, et al. Bronchoalveolar cellurity and interleukin-8 levels in measles bronchiolitis obliterans. Chest. 2007;131:1454-60.
72. Sethi GR, Batra V. Bronchiectasis: causes and management. Indian J Pediatr. 2000;67:133-9.
73. Moss RB, Hansen C, Sanders RL, et al. A phase II study of DAS181, a novel host directed antiviral for the treatment of influenza infection. J Infect Dis. 2012;206:1844-51.