Activity of halogeno-thiazolides against cryptosporidium parvum in experimentally infected immunosuppressed gerbils (meriones unguiculatus)

Antimicrobial Agents and Chemotherapy

Volumn 57, Issue 6, 2013, Pages 2821-2823

  Gargala, Gilles ^a   François, Arnaud ^a   Favennec, Loïc ^a   Rossignol, Jean François ^b  

^a ROUEN UNIVERSITY HOSPITAL   (France)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITAZOXANIDE; RM 4850; RM 4865; RM 5038; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; GERBIL; NONHUMAN; OOCYST; PRIORITY JOURNAL; TREATMENT DURATION;

ANIMALS; ANTIPARASITIC AGENTS; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DISEASE MODELS, ANIMAL; GERBILLINAE; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; THIAZOLES; TREATMENT OUTCOME;

EID: 84877873066     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01538-12     Document Type: Article

References (8)

1. Gargala G, Le Goff L, Ballet JJ, Favennec L, Stachulski AV, Rossignol JF. 2010. Evaluation of new thiazolide/thiadiazolide derivatives reveals nitrogroup-independent efficacy against Cryptosporidium parvum. Antimicrob. Agents Chemother. 54:1315-1318.
2. Gargala G, Le Goff L, Ballet JJ, Favennec L, Stachulski AV, Rossignol JF. 2009. In vitro efficacy of nitro-and halogeno-thiazolide and thiadiazolide derivatives against Sarcocystis neurona. Vet. Parasitol. 162:230-235.
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6. Müller J, Sidler D, Nachbur U, Wastling J, Brunner T, Hemphill A. 2008. Thiazolides inhibit growth and induce glutathione-S-transferase Pi (GSTP1)-dependent cell death in human colon cancer cells. Int. J. Cancer 123:1797-1806.
7. Gargala G, Baishanbo A, Favennec L, François A, Ballet JJ, Rossignol JF. 2005. Inhibitory activities of epidermal growth factor receptor tyrosine kinase-targeted dihydroxyisoflavone and trihydroxydeoxybenzoin derivatives on Sarcocystis neurona, Neospora caninum, and Cryptosporidium parvum development. Antimicrob. Agents Chemother. 49:4628-4634.
8. Stachulski AV, Berry NG, Lilian Low AC, Moores SL, Row E, Warhurst DC, Adagu IS, Rossignol JF. 2006. Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo. J. Med. Chem. 49:1450-1454.