Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1450-1454

  Stachulski, Andrew V ^a   Berry, Neil G ^a   Low, Lilian A C ^a   Moores, Shelley L ^a   Row, Eleanor ^a   Warhurst, David C ^b   Adagu, Ipemida S ^b   Rossignol, Jean François ^c  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^c Romark Institute for Medical Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CARBOETHOXYISOFLAVONE; 3 (3 BROMOPHENYL) 5,7 DIHYDROXY 4 OXO 4H CHROMENE 2 CARBOXYLIC ACID ETHYL ESTER; ANTICRYPTOSPORIDIAL AGENT; ANTIPROTOZOAL AGENT; GENISTEIN; ISOFLAVONE DERIVATIVE; NITAZOXANIDE; PAROMOMYCIN; RM 6427; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DOSE RESPONSE; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; TREATMENT OUTCOME;

ANIMALS; CATTLE; CELL LINE, TUMOR; COCCIDIOSTATS; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; FEMALE; GENISTEIN; GERBILLINAE; HUMANS; IMMUNOCOMPROMISED HOST; ISOFLAVONES; MALE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33144458741     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050973f     Document Type: Article

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