Glutathione supplementation improves macrophage functions in HIV

Journal of Interferon and Cytokine Research

Volumn 33, Issue 5, 2013, Pages 270-279

  Morris, Devin ^a   Guerra, Carlos ^a   Khurasany, Melissa ^a   Guilford, Frederick ^b   Saviola, Beatrice ^a   Huang, Ying ^a   Venketaraman, Vishwanath ^a  

^a WESTERN UNIVERSITY OF HEALTH SCIENCES   (United States)

^b Your Energy Systems   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; FREE RADICAL; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE REDUCTASE; GLUTATHIONE SYNTHASE;

ARTICLE; BACTERIAL GROWTH; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG EFFECT; DRUG FORMULATION; ENZYME ACTIVE SITE; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INNATE IMMUNITY; INTRACELLULAR BACTERIUM; LIPOSOMAL DELIVERY; MACROPHAGE FUNCTION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SUPPLEMENTATION; TUBERCULOSIS CONTROL;

ACETYLCYSTEINE; CELL GROWTH PROCESSES; CELLS, CULTURED; COLONY COUNT, MICROBIAL; DIETARY SUPPLEMENTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HIV INFECTIONS; HUMANS; IMMUNITY, INNATE; IMMUNOSUPPRESSION; MACROPHAGES, ALVEOLAR; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

EID: 84877872677     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2012.0103     Document Type: Article

References (25)

1. Bakin AV, Stourman NV, Sekhar KR, Rinehart C, Yan X. 2005. Smad3-ATF3 signaling mediates TGF-b suppression of genes encoding phase II detoxifying proteins. Free Radic Biol Med 38:375-387.
2. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. Chiang CY, Centis R, Migliori GB. 2010. Drug-resistant tuberculosis: Past, present, future. Respirology 15(3):413-432.
4. Dayaram YK, Talaue MT, Connell, ND, Venketaraman V. 2006. Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione. J Bacteriol 188(4):1364-1372.
5. Dutta NK, Mehra S, Kaushal D. 2010. A Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazine. PLoS One 5(4):e10069.
6. Foreman HJ, Zhang H, Rinna A. 2009. Glutathione: Overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med 30:1-12.
7. Franklin CC, Rosenfeld-Franklin ME, White C, Kavanagh TJ, Fausto N. 2003. TGFb1-induced suppression of glutathione antioxidant defenses in hepatocytes: Caspace-dependent posttranslational and caspace-independent transcriptional regulatory mechanisms. FASEB J 17(11):1535-1537.
8. Griffith O. 1982. Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J Biol Chem 257(22): 13704-13712.
9. Guerra C, Johal K, Morris D, Moreno S, Alvarado O, et al. 2012. Control of Mycobacterium tuberculosis growth by activated natural killer cells. Clin Exp Immunol 168(1):142-152.
10. Guerra C, Morris D, Donohue C, Sipin A, Kung S, et al. 2011. Adaptive immune responses against Mycobacterium tuberculosis infection in healthy and HIV infected individuals. PLoS One 6(12):e28378.
11. Hur W, Gray NS. 2011. Small molecule modulators of antioxidant response pathway. Curr Opin Chem Biol 15:162-173.
12. Liu PT, Modlin RL. 2008. Human macrophage host defense against Mycobacterium tuberculosis. Curr Opin Immunol 20:371-376.
13. Millman AC, Salman M, Dayaram YK, Connell ND, Venketaraman V. 2008. Natural killer cells, glutathione, cytokines and innate immunity against Mycobacterium tuberculosis. J Interferon Cytokine Res 28:1-13.
14. Morris D, Guerra C, Donohue C, Oh H, Khurasany M, et al. 2012. Unveiling the mechanisms for decreased glutathione in individuals with HIV infection. Clin Dev Immunol 2012:734125.
15. Nathan C, Shiloh MU. 2000. Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens. Proc Natl Acad Sci U S A 97:8841-8848.
16. Russell DG, VanderVen BC, Lee W, Abramovitch RB, Kim MJ, et al. 2012. Mycobacterium tuberculosis wears what it eats. Cell Host Microbe 8(1):68-76.
17. Venketaraman V, Dayaram YK, Amin AG, Ngo R, Green RM, et al. 2003. Role of glutathione in macrophage control of Mycobacteria. Infect Immun 71(4):1864-1871.
18. Venketaraman V, Dayaram YK, Talaue MT, Connell ND. 2005. Glutathione and nitrosoglutathione in macrophage defense against M. tuberculosis. Infect Immun 73(3):1886-1889.
19. Venketaraman V, Millman AC, Salman M, Swaminathan S, Goetz M, et al. 2008. Glutathione levels and immune responses in tuberculosis patients. Microb Pathog 44:255-261.
20. Venketaraman V, Rodgers T, Linnares R, Reilly N, Swaminathan S, et al. 2006. Tuberculosis immunity in healthy and HIVinfected subjects. AIDS Res Ther 3(1):5.
21. World Health Organization. 2010. Global HIV/AIDS response: Epidemic update and health sector progress towards universal access. Available at www.who.int/entity/hiv/pub/progress- report2011/summary-en.pdf
22. Wu G, Fang YZ, Yang S. 2004. Glutathione metabolism and its implications for health. J Nutr 134:489-492.
23. Yagi K. 1998. Simple assay for the level of total lipid peroxides in serum or plasma. Methods Mol Biol 108:101-106.
24. Zeevalk GD, Bernard LP, Guilford FT. 2010. Liposomalglutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells. Neurochem Res 35(10):1575-1587.
25. Zhang HS, Li HY, Zhou Y, Wu MR, Zhou HS. 2009. Nrf2 is involved in inhibiting Tat-induced HIV-1 long terminal repeat transactivation. Free Radic Biol Med 47:261-268.