ZC88, a novel 4-Amino piperidine analog, inhibits the growth of neuroblastoma cells through blocking hERG potassium channel

Cancer Biology and Therapy

Volumn 14, Issue 5, 2013, Pages 450-457

  Wei, Xiaoli ^a   Sun, Hongliang ^a   Yan, Haitao ^a   Zhang, Cheng ^a   Zhang, Shuzhuo ^a   Liu, Xiaoyan ^a   Hua, Nan ^a   Ma, Xiaoyun ^a   Zheng, Jianquan ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

Author keywords

4 Aminopiperidine; Cancer; Cell cycle; HERG; Neuroblastoma; Potassium channel; SH SY5Y

Indexed keywords

CALCIUM CHANNEL N TYPE; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; UNCLASSIFIED DRUG; ZC 88;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL STRAIN HEK293; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MECHANISM; DRUG POTENCY; DRUG SENSITIVITY; EXPERIMENTAL GUINEA PIG; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOSIS INHIBITION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; QT INTERVAL; QT PROLONGATION; XENOPUS;

4-AMINOPIPERIDINE; CANCER; CELL CYCLE; HERG; NEUROBLASTOMA; POTASSIUM CHANNEL; SH-SY5Y;

ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; GUINEA PIGS; HUMANS; MALE; MICE; MICE, NUDE; NEUROBLASTOMA; PIPERIDINES; POTASSIUM CHANNEL BLOCKERS; TRANSFECTION; XENOGRAFT MODEL ANTITUMOR ASSAYS; XENOPUS LAEVIS;

EID: 84877863672     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.24423     Document Type: Article

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