HERG1 gene expression as a specific tumor marker in colorectal tissues

European Journal of Surgical Oncology

Volumn 36, Issue 1, 2010, Pages 72-77

  Dolderer, J H ^a,b   Schuldes, H ^b   Bockhorn, H ^a   Altmannsberger, M ^a   Lambers, C ^c   von Zabern, D ^d   Jonas, D ^b   Schwegler, H ^e   Linke, R ^e   Schroder U H ^f  

^a GOETHE UNIVERSITY   (Germany)

^b Center of Surgery   (Germany)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d UNIVERSITY OF HEIDELBERG   (Germany)

^e O von Guerike University   (Germany)

^f LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

Author keywords

Carcinoembryonic antigen; Colorectal cancer tumor marker; Cytokeratin 19; Cytokeratin 20; HERG1; Molecular therapeutic agent E 4031

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; CARCINOEMBRYONIC ANTIGEN; CYTOKERATIN 19; CYTOKERATIN 20; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL HERG1; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER INHIBITION; CANCER PATIENT; CARCINOMA CELL; CELL ASSAY; CELL PROLIFERATION; COLON DIVERTICULOSIS; COLORECTAL ADENOMA; COLORECTAL CARCINOMA; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCHEMISTRY; MALE; PRIORITY JOURNAL; RELIABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TUMOR BIOPSY; TUMOR CELL; TUMOR RECURRENCE; TUMOR VOLUME;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; CARCINOEMBRYONIC ANTIGEN; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-19; KERATIN-20; MALE; MIDDLE AGED; PIPERIDINES; POLYMERASE CHAIN REACTION; PYRIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 73249122449     PISSN: 07487983     EISSN: 15322157     Source Type: Journal    
DOI: 10.1016/j.ejso.2009.05.009     Document Type: Article

References (29)

1. Steele Jr. G.D. The National cancer data Base report on colorectal cancer. Cancer 74 (1994) 1979-1989
2. Obrand D.I., and Gordon P.H. Incidence and patterns of recurrence following curative resection for colorectal carcinoma. Dis Colon Rectum 40 (1997) 15-24
3. Moll R. Cytokeratins in the histological diagnosis of malignant tumors. Int J Biol Markers 9 (1994) 63-69
4. Duffy M.J. Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful?. Clin Chem 47 (2001) 624-630
5. Boucher D., Cournoyer D., Stanners C.P., and Fuks A. Studies on the control of gene expression of the carcinoembryonic antigen family in human tissue. Cancer Res 49 (1989) 847-852
6. Moll R., Lowe A., Laufer J., and Franke W.W. Cytokeratin 20 in human carcinomas. A new histodiagnostic marker detected by monoclonal antibodies. Am J Pathol 140 (1992) 427-447
7. Fujisaki J., and Shimoda T. Expression of cytokeratin subtypes in colorectal mucosa, adenoma, and carcinoma. Gastroenterol Jpn 28 (1993) 647-656
8. Wildi S., Kleeff J., Maruyama H., et al. Characterization of cytokeratin 20 expression in pancreatic and colorectal cancer. Clin Cancer Res 5 (1999) 2840-2847
9. Schwarz J.R., and Bauer C.K. The ether-a-go-go-related gene K(+) current: functions of a Strange inward Rectifier. News Physiol Sci 14 (1999) 135-142
10. Wang H., Zhang Y., Cao L., et al. HERG K+ channel, a regulator of tumor cell apoptosis and proliferation. Cancer Res 62 (2002) 4843-4848
11. Smith G.A., Tsui H.W., Newell E.W., et al. Functional up-regulation of HERG K+ channels in neoplastic hematopoietic cells. J Biol Chem 277 (2002) 18528-18534
12. Shi W., Wymore R.S., Wang H.S., et al. Identification of two nervous system-specific members of the erg potassium channel gene family. J Neurosci 17 (1997) 9423-9432
13. Bauer C.K., Schafer R., Schiemann D., Reid G., Hanganu I., and Schwarz J.R. A functional role of the erg-like inward-rectifying K+ current in prolactin secretion from rat lactotrophs. Mol Cell Endocrinol 148 (1999) 37-45
14. Emmi A., Wenzel H.J., Schwartzkroin P.A., et al. Do glia have heart? Expression and functional role for ether-a-go-go currents in hippocampal astrocytes. J Neurosci 20 (2000) 3915-3925
15. Tseng G.N. I(Kr): the hERG channel. J Mol Cell Cardiol 33 (2001) 835-849
16. Bianchi L., Wible B., Arcangeli A., et al. Herg encodes a K+ current highly conserved in tumors of different histogenesis: a selective advantage for cancer cells?. Cancer Res 58 (1998) 815-822
17. Pardo L.A., del Camino D., Sanchez A., et al. Oncogenic potential of EAG K(+) channels. Embo J 18 (1999) 5540-5547
18. Cherubini A., Taddei G.L., Crociani O., et al. HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium. Br J Cancer 83 (2000) 1722-1729
19. Lastraioli E., Guasti L., Crociani O., et al. Herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells. Cancer Res 64 (2004) 606-611
20. Hermanek P. Tumors of the gastrointestinal tract and the pancreas: histopathology, staging and prognosis. Anticancer Res 19 (1999) 2393-2396
21. Gerhard M., Juhl H., Kalthoff H., Schreiber H.W., Wagener C., and Neumaier M. Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction. J Clin Oncol 12 (1994) 725-729
22. Denis M.G., Lipart C., Leborgne J., et al. Detection of disseminated tumor cells in peripheral blood of colorectal cancer patients. Int J Cancer 74 (1997) 540-544
23. Soeth E., Roder C., Juhl H., Kruger U., Kremer B., and Kalthoff H. The detection of disseminated tumor cells in bone marrow from colorectal-cancer patients by a cytokeratin-20-specific nested reverse-transcriptase-polymerase-chain reaction is related to the stage of disease. Int J Cancer 69 (1996) 278-282
24. Bauer C.K., Flitsch J., Schafer R., et al. HERG currents in human prolactinoma cells. Pflügers Archiv 439 (2000) R292
25. Tokunaga K., Nakamura Y., Sakata K., et al. Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers. Cancer Res 47 (1987) 5616-5619
26. Hsu S.M., Raine L., and Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29 (1981) 577-580
27. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65 (1983) 55-63
28. McLeod H.L., and Murray G.I. Tumour markers of prognosis in colorectal cancer. Br J Cancer 79 (1999) 191-203
29. Bhatnagar J., Tewari H.B., Bhatnagar M., and Austin G.E. Comparison of carcinoembryonic antigen in tissue and serum with grade and stage of colon cancer. Anticancer Res 19 (1999) 2181-2187