Mutations in NA That Induced Low pH-Stability and Enhanced the Replication of Pandemic (H1N1) 2009 Influenza A Virus at an Early Stage of the Pandemic

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Takahashi, Tadanobu ^a,b   Song, Jiasheng ^a   Suzuki, Takashi ^b   Kawaoka, Yoshihiro ^a,c,d  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS SIALIDASE;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; INFLUENZA VIRUS A H1N1; NEURAMINIDASE GENE; NONHUMAN; PANDEMIC; PH; REVERSE GENETICS; VIRUS REPLICATION;

CELL LINE; HUMANS; HYDROGEN-ION CONCENTRATION; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MUTATION; NEURAMINIDASE; PANDEMICS; PHYLOGENY; VIRUS REPLICATION;

EID: 84877830970     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064439     Document Type: Article

References (17)

1. Dawood FS, Jain S, Finelli L, Shaw MW, Lindstrom S, et al. (2009) Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 360: 2605-2615.
2. Ozawa M, Basnet S, Burley LM, Neumann G, Hatta M, et al. (2011) Impact of amino acid mutations in PB2, PB1-F2, and NS1 on the replication and pathogenicity of pandemic (H1N1) 2009 influenza viruses. J Virol 85: 4596-4601.
3. Sakabe S, Ozawa M, Takano R, Iwastuki-Horimoto K, Kawaoka Y, (2011) Mutations in PA, NP, and HA of a pandemic (H1N1) 2009 influenza virus contribute to its adaptation to mice. Virus Res 158: 124-129.
4. Takahashi T, Suzuki Y, Nishinaka D, Kawase N, Kobayashi Y, et al. (2001) Duck and human pandemic influenza A viruses retain sialidase activity under low pH conditions. J Biochem 130: 279-283.
5. Takahashi T, Suzuki T, Hidari KI, Miyamoto D, Suzuki Y, (2003) A molecular mechanism for the low-pH stability of sialidase activity of influenza A virus N2 neuraminidases. FEBS Lett 543: 71-75.
6. Suzuki T, Takahashi T, Saito T, Guo CT, Hidari KI, et al. (2004) Evolutional analysis of human influenza A virus N2 neuraminidase genes based on the transition of the low-pH stability of sialidase activity. FEBS Lett 557: 228-232.
7. Takahashi T, Kurebayashi Y, Ikeya K, Mizuno T, Fukushima K, et al. (2010) The low-pH stability discovered in neuraminidase of 1918 pandemic influenza A virus enhances virus replication. PLoS One 5: e15556.
8. Suzuki T, Takahashi T, Guo CT, Hidari KI, Miyamoto D, et al. (2005) Sialidase activity of influenza A virus in an endocytic pathway enhances viral replication. J Virol 79: 11705-11715.
9. Neumann G, Watanabe T, Ito H, Watanabe S, Goto H, et al. (1999) Generation of influenza A viruses entirely from cloned cDNAs. Proc Natl Acad Sci U S A 96: 9345-9350.
10. Li C, Hatta M, Watanabe S, Neumann G, Kawaoka Y, (2008) Compatibility among polymerase subunit proteins is a restricting factor in reassortment between equine H7N7 and human H3N2 influenza viruses. J Virol 82: 11880-11888.
11. Takahashi T, Nidom CA, Le MT, Suzuki T, Kawaoka Y, (2012) Amino acid determinants for low-pH-stable, human virus-like sialidase activity of H5N1 influenza A virus neuraminidase. FEBS Open Bio 2: 261-266.
12. Li C, Bankhead A 3rd, Eisfeld AJ, Hatta Y, Jeng S, et al (2011) Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus. J Virol 85: 10955-10967.
13. Varghese JN, Colman PM, (1991) Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution. J Mol Biol 221: 473-486.
14. Xu X, Zhu X, Dwek RA, Stevens J, Wilson IA (2008) Structural characterization of the 1918 influenza virus H1N1 neuraminidase. J Virol 82; 10493-10501.
15. Li Q, Qi J, Zhang W, Vavricka CJ, Shi Y, et al. (2010) The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nat Struct Mol Biol 17: 1266-1268.
16. Johansson BE, Brett IC, (2003) Variation in the divalent cation requirements of influenza a virus N2 neuraminidases. J Biochem 134: 345-352.
17. Brett IC, Johansson BE, (2006) Variation in the divalent cation requirements of influenza A virus N1 neuraminidases. J Biochem 139: 439-447.