A novel inhibitor, 16-hydroxy-cleroda-3,13-dien-16,15-olide, blocks the autophosphorylation site of focal adhesion kinase (Y397) by molecular docking

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 8, 2013, Pages 4091-4101

  Thiyagarajan, Varadharajan ^a   Lin, Shih Hung ^a   Chia, Yi Chen ^b   Weng, Ching Feng ^a  

^a NATIONAL DONG HWA UNIVERSITY   (Taiwan)

^b TAJEN UNIVERSITY   (Taiwan)

Author keywords

16 hydroxy cleroda 3,13 dien 16,15 olide; Anti tumorigenesis; Epithelial mesenchymal transition; Filopodia; Focal adhesion kinase

Indexed keywords

16 HYDROXYCLERODA 3,13 DIEN 16,15 OLIDE; 3,4 DIHYDROXYPHENYL ACETIC ACID; 4 HYDROXYPHENYLACETIC ACID; ACTINODAPHNINE; CATECHIN HYDRATE; CELL PROTEIN; CINNAMIC ACID BENZYL ESTER; CISPLATIN; CURCUMIN; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE INHIBITOR; GELATINASE A; GELATINASE B; KAEMPFEROL; NATURAL PRODUCT; PROTEIN CDC42; QUERCETIN; RAC1 PROTEIN; RESVERATROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; BINDING AFFINITY; BIOENERGY; CELL CYCLE ARREST; CELL STRAIN; CELL STRAIN C6; CELL STRAIN N18; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; EPITHELIAL MESENCHYMAL TRANSITION; FILOPODIUM; G0 CELL CYCLE ARREST; G1 PHASE CELL CYCLE CHECKPOINT; GLIOMA CELL; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DITERPENES; FOCAL ADHESION PROTEIN-TYROSINE KINASES; MICE; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; SIGNAL TRANSDUCTION;

EID: 84877829471     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.04.027     Document Type: Article

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