From technology to biology: A malaria genetic toolbox for the functional dissection of essential genes

Molecular Microbiology

Volumn 88, Issue 4, 2013, Pages 650-654

  Pino, Paco ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; RECOMBINASE; ZINC FINGER NUCLEASE;

3' UNTRANSLATED REGION; AMA1 GENE; GENE; GENE CONTROL; GENE DELETION; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC MANIPULATION; GENETIC TRANSCRIPTION; NONHUMAN; NOTE; OPERATOR GENE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN STABILITY; PROTOZOAL GENETICS; RNA INTERFERENCE; RNA TRANSLATION; SERA5 GENE; TETO GENE; TOXOPLASMA GONDII;

GENE DELETION; GENETICS, MICROBIAL; INTEGRASES; MOLECULAR BIOLOGY; PARASITOLOGY; PLASMODIUM FALCIPARUM;

EID: 84877828024     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/mmi.12232     Document Type: Note

References (27)

1. Agop-Nersesian, C., Pfahler, J., Lanzer, M., and Meissner, M. (2008) Functional expression of ribozymes in Apicomplexa: towards exogenous control of gene expression by inducible RNA-cleavage. Int J Parasitol 38: 673-681.
2. Andenmatten, N., Egarter, S., Jackson, A.J., Jullien, N., Herman, J.P., and Meissner, M. (2013) Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms. Nat Methods 10: 125-127.
3. Armstrong, C.M., and Goldberg, D.E. (2007) An FKBP destabilization domain modulates protein levels in Plasmodium falciparum. Nat Methods 4: 1007-1009.
4. Augagneur, Y., Wesolowski, D., Tae, H.S., Altman, S., and Ben Mamoun, C. (2012) Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. Proc Natl Acad Sci USA 109: 6235-6240.
5. de Azevedo, M.F., Gilson, P.R., Gabriel, H.B., Simoes, R.F., Angrisano, F., Baum, J., etal. (2012) Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum. PLoS ONE 7: e40981.
6. Banaszynski, L.A., Chen, L.C., Maynard-Smith, L.A., Ooi, A.G., and Wandless, T.J. (2006) A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126: 995-1004.
7. Barnes, R.L., Shi, H., Kolev, N.G., Tschudi, C., and Ullu, E. (2012) Comparative genomics reveals two novel RNAi factors in Trypanosoma brucei and provides insight into the core machinery. PLoS Pathog 8: e1002678.
8. Blackman, M.J. (2008) Malarial proteases and host cell egress: an 'emerging' cascade. Cell Microbiol 10: 1925-1934.
9. Brecht, S., Erdhart, H., Soete, M., and Soldati, D. (1999) Genome engineering of Toxoplasma gondii using the site-specific recombinase Cre. Gene 234: 239-247.
10. Bujard, H. (1999) Controlling genes with tetracyclines. J Gene Med 1: 372-374.
11. Carvalho, T.G., Thiberge, S., Sakamoto, H., and Menard, R. (2004) Conditional mutagenesis using site-specific recombination in Plasmodium berghei. Proc Natl Acad Sci USA 101: 14931-14936.
12. Collins, C.R., Das, S., Wong, E.H., Andenmatten, N., Stallmach, R., Hackett, F., etal. (2013) Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle. Mol Microbiol 88: 688-701.
13. Combe, A., Giovannini, D., Carvalho, T.G., Spath, S., Boisson, B., Loussert, C., etal. (2009) Clonal conditional mutagenesis in malaria parasites. Cell Host Microbe 5: 386-396.
14. Gissot, M., Briquet, S., Refour, P., Boschet, C., and Vaquero, C. (2005) PfMyb1, a Plasmodium falciparum transcription factor, is required for intra-erythrocytic growth and controls key genes for cell cycle regulation. J Mol Biol 346: 29-42.
15. Goldfless, S.J., Belmont, B.J., de Paz, A.M., Liu, J.F., and Niles, J.C. (2012) Direct and specific chemical control of eukaryotic translation with a synthetic RNA-protein interaction. Nucleic Acids Res 40: e64.
16. Herm-Gotz, A., Agop-Nersesian, C., Munter, S., Grimley, J.S., Wandless, T.J., Frischknecht, F., and Meissner, M. (2007) Rapid control of protein level in the apicomplexan Toxoplasma gondii. Nat Methods 4: 1003-1005.
17. Jullien, N., Sampieri, F., Enjalbert, A., and Herman, J.P. (2003) Regulation of Cre recombinase by ligand-induced complementation of inactive fragments. Nucleic Acids Res 31: e131.
18. Kolev, N.G., Tschudi, C., and Ullu, E. (2011) RNA interference in protozoan parasites: achievements and challenges. Eukaryot Cell 10: 1156-1163.
19. Limenitakis, J., and Soldati-Favre, D. (2011) Functional genetics in Apicomplexa: potentials and limits. FEBS Lett 585: 1579-1588.
20. Meissner, M., Schluter, D., and Soldati, D. (2002) Role of Toxoplasma gondii myosin A in powering parasite gliding and host cell invasion. Science 298: 837-840.
21. Meissner, M., Krejany, E., Gilson, P.R., de Koning-Ward, T.F., Soldati, D., and Crabb, B.S. (2005) Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators. Proc Natl Acad Sci USA 102: 2980-2985.
22. Muralidharan, V., Oksman, A., Iwamoto, M., Wandless, T.J., and Goldberg, D.E. (2011) Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag. Proc Natl Acad Sci USA 108: 4411-4416.
23. O'Neill, M.T., Phuong, T., Healer, J., Richard, D., and Cowman, A.F. (2011) Gene deletion from Plasmodium falciparum using FLP and Cre recombinases: implications for applied site-specific recombination. Int J Parasitol 41: 117-123.
24. Pino, P., Sebastian, S., Kim, E.A., Bush, E., Brochet, M., Volkmann, K., etal. (2012) A tetracycline-repressible transactivator system to study essential genes in malaria parasites. Cell Host Microbe 12: 824-834.
25. van Schaijk, B.C., Vos, M.W., Janse, C.J., Sauerwein, R.W., and Khan, S.M. (2010) Removal of heterologous sequences from Plasmodium falciparum mutants using FLPe-recombinase. PLoS ONE 5: e15121.
26. Siden-Kiamos, I., Ganter, M., Kunze, A., Hliscs, M., Steinbuchel, M., Mendoza, J., etal. (2011) Stage-specific depletion of myosin A supports an essential role in motility of malarial ookinetes. Cell Microbiol 13: 1996-2006.
27. Straimer, J., Lee, M.C., Lee, A.H., Zeitler, B., Williams, A.E., Pearl, J.R., etal. (2012) Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases. Nat Methods 9: 993-998.