P2X receptor stimulation amplifies complement-induced haemolysis

Pflugers Archiv European Journal of Physiology

Volumn 465, Issue 4, 2013, Pages 529-541

  Hejl, J L ^a   Skals, M ^a   Leipziger, J ^a   Praetorius, H A ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

Adenosine 5 triphosphate (ATP); Complement; Erythrocytes; Haemolysis; P2; Purinergic signalling

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOXIN; CALCIUM ION; LEUKOTOXIN; POTASSIUM CHANNEL; POTASSIUM CHANNEL KCA3.1; PURINERGIC P2X RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X7 RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; COMPLEMENT ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ERYTHROCYTE VOLUME; HEMOLYSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SHEEP; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CHICKENS; COMPLEMENT SYSTEM PROTEINS; ERYTHROCYTE VOLUME; ERYTHROCYTES; GUINEA PIGS; HEMOLYSIS; HUMANS; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RECEPTORS, PURINERGIC P2X1; RECEPTORS, PURINERGIC P2X7;

EID: 84877826829     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-012-1174-z     Document Type: Article

References (23)

1. Davidson JS, Baumgarten IM, Harley EH (1986) Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid. Biochem Biophys Res Commun 134:29-36
2. De Franceschi L, Rivera A, Fleming MD, Honczarenko M, Peters LL, Gascard P, Mohandas N, Brugnara C (2005) Evidence for a protective role of the Gardos channel against hemolysis in murine spherocytosis. Blood 106:1454-1459
3. Dunkelberger JR, Song WC (2010) Complement and its role in innate and adaptive immune responses. Cell Res 20:34-50
4. + channel for the short-term survival of injured erythrocytes. Pflugers Arch 460:1029-1044
5. Fong JS, Good RA (1972) Suramin - a potent reversible and competitive inhibitor of complement systems. Clin Exp Immunol 10:127-138
6. Iglesias R, Spray DC, Scemes E (2009) Mefloquine blockade of pannexin1 currents: resolution of a conflict. Cell Commun Adhes 16:131-137
7. Kelk P, Abd H, Claesson R, Sandstrom G, Sjostedt A, Johansson A (2011) Cellular and molecular response of human macrophages exposed to Aggregatibacter actinomycetemcomitans leukotoxin. Cell Death Dis 2:e126
8. Kroes BH, Beukelman CJ, van den Berg AJ, Wolbink GJ, van Dijk H, Labadie RP (1997) Inhibition of human complement by beta-glycyrrhetinic acid. Immunology 90:115-120
9. Larsen CK, Skals M, Wang T, Cheema MU, Leipziger J, Praetorius HA (2011) Python erythrocytes are resistant to alpha-hemolysin from Escherichia coli. J Membr Biol 244:131-140
10. Locovei S, Bao L, Dahl G (2006) Pannexin 1 in erythrocytes: function without a gap. Proc Natl Acad Sci USA 103:7655-7659
11. Munksgaard PS, Vorup-Jensen T, Reinholdt J, Söderström CM, Poulsen K, Leipziger J, Praetorius HA, Skals M (2012) Leukotoxin from Aggregatibacter actinomycetemcomitans causes shrinkage and P2X receptor-dependent lysis of human erythrocytes. Cell Microbiol. doi: 10.1111/cmi.12021
12. Orth D, Wurzner R (2010) Complement in typical hemolytic uremic syndrome. Semin Thromb Hemost 36:620-624
13. Roumenina LT, Loirat C, Dragon-Durey MA, Halbwachs-Mecarelli L, Sautes-Fridman C, Fremeaux-Bacchi V (2011) Alternative complement pathway assessment in patients with atypical HUS. J Immunol Methods 365:8-26
14. Saez C, Thielens NM, Bjes ES, Esser AF (1999) Association of terminal complement proteins in solution and modulation by suramin. Biochemistry 38:6807-6816
15. Silverman W, Locovei S, Dahl G (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol 295:C761-C767
16. Skals MG, Jorgensen NR, Leipziger J, Praetorius HA (2009) α-Hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis. Proc Natl Acad Sci USA 106:4030-4035
17. Ca 3.1 and TMEM16A channels with subsequent phosphatidylserine exposure. J Biol Chem 285:15557-15565
18. Skals M, Leipziger J, Praetorius HA (2011) Haemolysis induced by α-toxin from Staphylococcus aureus requires P2X receptor activation. Pflugers Arch 462:669-679
19. Sluyter R, Shemon AN, Barden JA, Wiley JS (2004) Extracellular ATP increases cation fluxes in human erythrocytes by activation of the P2X 7 receptor. J Biol Chem 279:44749-44755
20. Tanneur V, Duranton C, Brand VB, Sandu CD, Akkaya C, Kasinathan RS, Gachet C, Sluyter R, Barden JA, Wiley JS, Lang F, Huber SM (2006) Purinoceptors are involved in the induction of an osmolyte permeability in malaria-infected and oxidized human erythrocytes. FASEB J 20:133-135
21. Wang L, Olivecrona G, Gotberg M, Olsson ML, Winzell MS, Erlinge D (2005) ADP acting on P2Y 13 receptors is a negative feedback pathway for ATP release from human red blood cells. Circ Res 96:189-196
22. Wiedmer T, Hall SE, Ortel TL, Kane WH, Rosse WF, Sims PJ (1993) Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria. Blood 82:1192-1196
23. Zalman LS, Brothers MA, Muller-Eberhard HJ (1985) A C9 related channel forming protein in the cytoplasmic granules of human large granular lymphocytes. Biosci Rep 5:1093-1100