Complex mixtures: Relevance of combined exposure to substances at low dose levels

Food and Chemical Toxicology

Volumn 58, Issue , 2013, Pages 141-148

  Leeman, Winfried R ^a   Krul, Lisette ^a   Houben, Geert F ^a  

^a TNO   (Netherlands)

Author keywords

Chemically complex food matrices; Complex mixtures; Cumulative effects; Mixture toxicity; Risk assessment; Threshold of Toxicological Concern (TTC)

Indexed keywords

ACETYLCHOLINESTERASE; CARBAMIC ACID DERIVATIVE; CHOLINERGIC RECEPTOR; FOOD ADDITIVE; ORGANOPHOSPHATE; PHTHALIC ACID;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONCEPTUAL FRAMEWORK; ENVIRONMENTAL EXPOSURE; FOOD SAFETY; GENOTOXICITY; HEALTH HAZARD; HIGH THROUGHPUT SCREENING; HYDROLYSIS; MICHAELIS MENTEN KINETICS; NEUROTRANSMISSION; PHARMACODYNAMICS; RISK ASSESSMENT; SAFETY; STATISTICAL SIGNIFICANCE; THRESHOLD OF TOXICOLOGICAL CONCERN; WORKSHOP;

ACCEPTABLE DAILY INTAKE; ACETYL CHOLINESTERASE; ACHE; ACUTE REFERENCE DOSE; ADI; ANALYTICAL THRESHOLD; ARFD; AT; BENCHMARK DOSE LEVEL; BMDL; CAG; CCFM; CHEMICALLY COMPLEX FOOD MATRICES; COMPLEX MIXTURES; CUMULATIVE ASSESSMENT GROUP; CUMULATIVE EFFECTS; LOAEL; LOWEST OBSERVED ADVERSE EFFECT LEVEL; MIXTURE TOXICITY; MOA; MODE OF ACTION; NAEL; NO ADVERSE EFFECT LEVEL; NO OBSERVED ADVERSE EFFECT LEVEL; NOAEL; RISK ASSESSMENT; TDI; THRESHOLD OF TOXICOLOGICAL CONCERN; THRESHOLD OF TOXICOLOGICAL CONCERN (TTC); TOLERABLE DAILY INTAKE; TTC;

ANIMALS; COMPLEX MIXTURES; DOSE-RESPONSE RELATIONSHIP, DRUG; FOOD CONTAMINATION; NO-OBSERVED-ADVERSE-EFFECT LEVEL;

EID: 84877823539     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.03.050     Document Type: Article

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