Celastrol, an inhibitor of heat shock protein 90β potently suppresses the expression of matrix metalloproteinases, inducible nitric oxide synthase and cyclooxygenase-2 in primary human osteoarthritic chondrocytes

European Journal of Pharmacology

Volumn 708, Issue 1-3, 2013, Pages 1-7

  Ding, Qian Hai ^a   Cheng, Ye ^a   Chen, Wei Ping ^a   Zhong, Hui Ming ^a   Wang, Xiang Hua ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Celastrol; Chondrocytes; Cyclooxygenase 2; Inducible nitric oxide synthase; Matrix metalloproteinases; Osteoarthritis

Indexed keywords

CELASTROL; CHONDROPROTECTIVE AGENT; COLLAGENASE 3; CYCLOOXYGENASE 2; HEAT SHOCK PROTEIN 90; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; STROMELYSIN;

ARTICLE; CARTILAGE CELL; CELL VIABILITY; CHONDROPROTECTION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE CONTROL; DISEASE EXACERBATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION; GENE FUNCTION; HUMAN; HUMAN CELL; OSTEOARTHRITIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRIPTERYGIUM WILFORDII;

ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; CHONDROCYTES; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME INHIBITORS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INTERLEUKIN-1BETA; MATRIX METALLOPROTEINASES; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; TRITERPENES;

EID: 84877818621     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.01.057     Document Type: Article

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