The importance of problem formulations in risk assessment: A case study involving dioxin-contaminated soil

Regulatory Toxicology and Pharmacology

Volumn 66, Issue 2, 2013, Pages 208-216

  Dourson, Michael L ^a   Gadagbui, Bernard ^a   Griffin, Susan ^b   Garabrant, David H ^c   Haws, Laurie C ^d   Kirman, Christopher ^e   Tohyama, Chiharu ^f  

^a Toxicology Excellence for Risk Assessment   (United States)

^b US Environmental Protection Agency Region 8   (United States)

^c UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^d ToxStrategies Inc   (United States)

^e LLP   (United States)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

Dioxin; Exposure assessment; Problem formulation; Risk assessment; Soil exposure

Indexed keywords

2,3,4,7,8 PENTACHLORODIBENZOFURAN; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 2,4,5 TRICHLOROPHENOXYACETIC ACID; CARCINOGEN; DIOXIN; FURAN DERIVATIVE; HERBICIDE; HEXACHLORODIBENZOFURAN DERIVATIVE; OCTACHLORODIBENZO 4 DIOXIN; PCB 105; PCB 118; PENTACHLORODIBENZOFURAN DERIVATIVE; POLYCHLORINATED BIPHENYL; POLYCHLORINATED DIBENZODIOXIN; POLYCHLORINATED DIBENZOFURAN; RUNOFF; SURFACE WATER; TETRACHLORODIBENZOFURAN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOACCUMULATION; BIOLOGICAL MONITORING; BIOREMEDIATION; DECISION MAKING; ECOTOXICITY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; ENVIRONMENTAL IMPACT; HAZARDOUS WASTE; HEALTH HAZARD; HUMAN; JAPAN; MATHEMATICAL ANALYSIS; MONTE CARLO METHOD; NEOPLASM; NONHUMAN; POLLUTION MONITORING; POPULATION RISK; PRIORITY JOURNAL; PROBLEM FORMULATION; RISK ASSESSMENT; RISK MANAGEMENT; SOIL ANALYSIS; SOIL POLLUTION; TOXICITY TESTING; TOXICOKINETICS; TREND STUDY; UNITED STATES; WIND EROSION;

ADULT; CARCINOGENS; CHILD; DIOXINS; ENVIRONMENTAL EXPOSURE; HUMANS; MODELS, THEORETICAL; RISK ASSESSMENT; SOIL POLLUTANTS;

EID: 84877808331     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2013.03.010     Document Type: Article

References (38)

1. Aberg A., Tysklind M., Nilsson T., MacLeod M., Hanberg A., Andersson R., Bergek S., Lindberg R., Wiberg K. Exposure assessment at a PCDD/F contaminated site in Sweden - field measurements of exposure media and blood serum analysis. Environ. Sci. Pollut. Res. 2010, 17:26-39.
2. ARA (Alliance for Risk Assessment), 2012. Workshop reports and framework. Available at http://www.allianceforrisk.org/ARA_Dose-Response.htm.
3. Aylward L.L., Lakind J.S., Hays S.M. Derivation of biomonitoring equivalent (BE) values for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds: a screening tool for interpretation of biomonitoring data in a risk assessment context. J. Toxicol. Environ. Health A 2008, 71(22):1499-1508.
4. Dahlgren J., Takhar H., Schecter A., Schmidt R., Horsak R., Paepke O., Warshaw R., Less A., Anderson-Mahoney P. Residential and biological exposure assessment of chemicals from a wood treatment plant. Chemosphere 2007, 67:S279-S285.
5. Demond A., Franzblau A., Garabrant D., Jiang X., Adriaens P., Chen Q., Gillespie B., Hao W., Hong B., Jolliet O., Lepkowski J. Human exposure from dioxins in soil. Environ. Sci. Technol. 2011, 46(3):1296-1302.
6. De Rosa C.T., Brown D., Dhara R., Garrett W., Hansen H., Holler J., Jones D., Jordan-Izaguirre D., O'Conner R., Pohl H., Xintaras C. Dioxin and dioxin-like compounds in soil, Part I: ATSDR policy guideline. Toxicol. Ind. Health 1999, 15(6):552-557.
7. Diliberto, J., Sirinek, L., Becker, J., Jude, D., Patterson, D., Turner, W., Burkhalter, B., Haws, L., Tachovsky, A., Landy, R., Birnbaum, L., 2010. Cohort of women living in a highly industrialized area of Kanawha river valley in West Virginia: endometriosis and blood levels of dioxin and dioxin-like chemicals. In: Organohalogen Compounds; presented at Dioxin 2010, San Antonio, TX.
8. EFSA (European Food Safety Authority), 2004. EFSA Scientific Colloquium Summary Report: Dioxins - Methodologies and principles for setting tolerable intake levels for dioxins, furans and dioxin-like PCBs, 28-29 June 2004, Brussels, Belgium.
9. Franzblau A., Hedgeman E., Jolliet O., Knutson K., Towey T., Chen Q., Hong B., Adriaens P., Demond A., Garabrant D.H., Gillespie B.W., Lepkowski J. The University of Michigan dioxin exposure study: a follow-up investigation of a case with high serum concentration of 2,3,4,7,8-pentachlorodibenzofuran. Environ. Health Perspect. 2010, 118:1313-1317.
10. Garabrant D.H., Franzblau A., Lepkowski J., Gillespie B.W., Adriaens P., Demond K., Hedgeman E., Knutson K., Zwica L., Olson K., Towey T., Chen Q., Hong B., Chang C.W., Lee S.Y., Ward B., LaDronka K., Luksemburg W., Maier M. The University of Michigan Dioxin Exposure Study: predictors of human serum dioxin concentrations in Midland and Saginaw, Michigan. Environ. Health Perspect. 2009, 117:818-824.
11. Garabrant D.H., Franzblau A., Lepkowski J., Gillespie B.W., Adriaens P., Demond A., Ward B., LaDronka K., Hedgeman E., Knutson K., Zwica L., Olson K., Towey T., Chen Q., Hong B. The University of Michigan Dioxin Exposure Study: methods for an environmental exposure study of polychlorinated dioxins, furans and biphenyls. Environ. Health Perspect. 2009, 117:803-810.
12. Hatfield Consultants, 2009. Comprehensive assessment of dioxin contamination in Da Nang Airport, Viet Nam: Environmental levels, human exposure and options for mitigating impacts. Final Report, DANDI-II 1450.3. North Vancouver, British Columbia, Canada.
13. Hays S.M., Aylward L.L. Dioxin risks in perspective: past, present, and future. Regul. Toxicol. Pharmacol. 2003, 37(2):202-217.
14. JECFA (Joint UN Food and Agriculture Organization/WHO Expert Committee on Food Additives), 2001. Joint FAO/WHO Food Standards Programme, In: 57th Meeting, Rome, June 5-14. Summary and Conclusions. Available: Accessed 15-1-2008. http://www.who.int/ipcs/food/jecfa/summaries/en/summary_57.pdf.
15. Karouna-Renier N.K., Rao K.R., Lanza J.J., Davis D.A., Wilson P.A. Serum profiles of PCDDs and PCDFs, individuals near the Escambia Wood Treatment Company Superfund site in Pensacola, FL. Chemosphere 2007, 69:1312-1319.
16. Kimbrough R.D., Falk H., Stehr P., Fries G. Health implications of 2,3,7,8-tetrachlorodibenzodioxin (TCDD) contamination of residential soil. J. Toxicol. Environ. Health A 1984, 14(1):47-93.
17. Kimbrough R.D., Krouskas C.A., Carson M.L., Long T.F., Bevan C., Tardiff R.G. Human uptake of persistent chemicals from contaminated soil: PCDD/Fs and PCBs. Regul. Toxicol. Pharm. 2009, 57:43-54.
18. Kirman C., Budinsky R.A., Yost L., Baker B., Zabik J.M., Rowlands J.C. Derivation of soil clean-up levels for 2,3,7,8-tetrachloro-dibenzo-pdioxin (TCDD) toxicity equivalence (TEQD/F) in soil through deterministic and probabilistic risk assessment of exposure and toxicity. Hum. Ecol. Risk Assess. 2011, 17(1):125-158.
19. Lorber M., Patterson D., Huwe J., Kahn H. Evaluation of background exposures of Americans to dioxin-like compounds in the 1990s and the 2000s. Chemosphere 2009, 77(5):640-651.
20. NAS (National Academy of Sciences) Science and Decisions: advancing risk assessment/Committee on improving risk analysis approaches used by the US EPA, Board on Environmental Studies and Toxicology 2009, The National Academies Press, Washington, DC, USA, Division on Earth and Life Studies.
21. OEHHA (Office of Environmental Health Hazard Assessment), 2011. Office of Environmental Health Hazard Assessment Toxicity Criteria Database. California EPA. Available at: http://www.oehha.ca.gov/tcdb/.
22. Pirard C., Eppe G., Massart A.C., Fierens S., DePauw E., Focant J.F. Environmental and human impact of an old timer incinerator in terms of dioxin and PCB level: a case study. Environ. Sci. Technol. 2005, 39:4721-4728.
23. Riss A., Hagenmaier H., Weberruss U., Schlatter C., Wacker R. Comparison of PCDD/PCDF levels in soil, grass, cow's milk, human blood and spruce needles in an area of PCDD/PCDF contamination through emissions from a metal reclamation plant. Chemosphere 1990, 21:1451-1456.
24. Simon T., Aylward L.L., Kirman C.R., Rowlands J.C., Budinsky R.A. Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics. Toxicol. Sci. 2009, 112(2):490-506.
25. Tohyama C., Uchiyama I., Hoshi S., Hijiya M., Miyata H., Nagai M., Nakai S., Yauchi M., Ohkubo S. Polychlorinated dioxins, furans and biphenyls in the blood of children and adults living in a dioxin-contaminated area in Tokyo. Environ. Health Prev. Med. 2011, 16:6-15.
26. US EPA (U.S. Environmental Protection Agency), 1991a. Risk assessment guidelines for Superfund, Volume I - Human health evaluation manual. Part B, Development of preliminary remediation goals. EPA/540/R-92/003.
27. US EPA (U.S. Environmental Protection Agency), 1991b. Risk assessment guidance for Superfund, Volume I - Human health evaluation manual. Supplemental Guidance, Standard Default Exposure Factors. OSWER Directive 9285.6-03. Office of Emergency and Remedial Response, Washington DC. Available at: http://www.epa.gov/oswer/riskassessment/pdf/oswer_directive_9285_6-03.pdf.
28. US EPA (U.S. Environmental Protection Agency), 1997. U.S. EPA Exposure Factors Handbook (Final Report). U.S. Environmental Protection Agency, Washington, DC, EPA/600/P-95/002F a-c, 1997. Available at: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=12464#Download.
29. US EPA (U.S. Environmental Protection Agency), 1998a. Guidelines for ecological risk assessment. Office of Research and Development, Washington, DC. EPA 630/R-95-002F.
30. US EPA (U.S. Environmental Protection Agency), 1998b. Approach for addressing dioxin in soil at CERCLA and RCRA sites. OSWER Directive 9200.4-26. Office of Solid Waste and Emergency Response, Washington, DC, USA.
31. US EPA (U.S. Environmental Protection Agency), 2002a. Short Sheet: Overview of the IEUBK model for lead in children. EPA #PB 99-9636-8.
32. US EPA (U.S. Environmental Protection Agency), 2002b. Denver front range study of dioxins in surface soil. Summary Report. US Environmental Protection Agency Region 8. Denver, Colorado.
33. US EPA (U.S. Environmental Protection Agency), 2003a. Framework for cumulative risk assessment. Office of Research and Development, National Center for Environment Assessment, Washington, DC. EPA/630/P-02/001F.
34. US EPA (U.S. Environmental Protection Agency), 2009a. Draft recommended interim preliminary remediation goals for dioxin in soil at CERLCA and RCRA sites. Office of Superfund Remediation and Technology Innovation, Washington, DC. OSWER Directive 9200.3-56, December 30, 2009.
35. US EPA (U.S. Environmental Protection Agency), 2009b. Review of the University of Michigan dioxin exposure study. National Center for Environmental Assessment, Office of Research and Development, Washington, DC 20460, September, 2009.
36. US EPA (U.S. Environmental Protection Agency), 2010. Recommended toxicity equivalency factors (TEFs) for human health risk assessments of 2,3,7,8- tetrachlorodibenzo-p-dioxin and dioxin-like compounds EPA/100/R 10/005. Office of the Science Advisor Risk Assessment Forum Washington DC. Available at: http://www.epa.gov/raf/files/tefs-for-dioxin-epa-00-r-10-005-final.pdf.
37. US EPA (U.S. Environmental Protection Agency), 2011. Regional screening levels tables. Available at: Accessed January, 2012. http://www.epa.gov/reg3hwmd/risk/human/rb-concentration_table/Generic_Tables/pdf/master_sl_table_run_NOV2011.pdf.
38. US EPA (U.S. Environmental Protection Agency), 2012. Integrated Risk Information System (IRIS). Available at: http://www.epa.gov/iris/.