Hematologic manifestations of systemic lupus erythematosus

Lupus: Symptoms, Treatment and Potential Complications

Volumn , Issue , 2012, Pages 129-143

  Newman, Kam ^a   El Hemaidi, Ihab ^b   Akhtari, Mojtaba ^c  

^a JAMAICA HOSPITAL MEDICAL CENTER   (United States)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84877797637     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (79)

1. Budman DR, Steinberg AD. Hematologic aspects of systemic lupus erythematosus. Current concepts. Ann Intern Med. 1977; 86: 220-229.
2. Keeling DM, Isenberg DA. Haematological manifestations of systemic lupus erythematosus. Blood Rev. 1993; 7: 199-207.
3. Kao AH, Manzi S, Ramsey-Goldman R. Review of ACR hematologic criteria in systemic lupus erythematosus. Lupus. 2004; 13: 865-868.
4. Voulgaris M, Kokori SIG, Ioannidis JPA, Tzioufas AG, Kyriaki D, Moutsopoulos HM. Anaemia in systemic lupus erythematosus: aetiological profile and the role of erythropoietin. Ann. Rheum. Dis. 2000; 59: 217-222.
5. Beyan E, Beyan C, Turan M. Hematological presentation in systemic lupus erythematosus and its relationship with disease activity. Hematology. 2007; 12(3): 257-261.
6. Fietta P, Delsanta G, Quaini F. Hematologic manifestation of connective autoimmune diseases. Clin. Exp. Rheumatol. 2009; 27: 140-154.
7. Giannouli S, Voulgarelis M, Ziakas PD, Tziofas AG. Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment. Ann. Rheum. Dis. 2006; 65: 144-148.
8. Tzioufas AG, Kokori SI, Petrovas CI, Moutsopoulos HM. Autoantibodies to human recombinant erythropoietin in patients with systemic lupus erythematosus: correlation with anemia. Arthritis Rheum. 1997; 40 (12): 2212-6.
9. Schett G, Firbas U, Furder W, Hiesberger H, Winkler S, Wachauer D, Koller M, Kapiotis S, Smolen J. decreased serum erythropoietin and its relation to anti-erythropoietin antibodies in anaemia of systemic lupus erythematosus. Rheumatology. 2001; 40: 424-431.
10. Ripley BJM, Goncalves B, Isenberg DA, Latchman DS, Rahman A. Raised levels of interleukin 6 in systemic lupus erythematosus correlate with anaemia. Ann. Rheum. Dis. 2005; 64: 849-853.
11. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 102: 783-788.
12. Levine AB, Erkan D. Clinical assessment and management of cytopenia in lupus patients. Curr. Rheumatol. Rep. 2011. 13: 291-299.
13. Kasitanon N, Magder LS, Petri M. predictors of survival in systemic lupus erythematosus. Medicine (Baltimore). 2006; 85: 147-156.
14. Jeffries M, Hamadeh F, Aberle T, Glenn S, Kamen DL, Kelly JA, Reichlin M, Harley JB, Sawalha AH. Haemolytic anaemia in a multi-ethnic cohort of lupus patients: a clinical and serological perspective. Lupus. 2008; 17: 739-743.
15. Kokori SIG, Ioannidis PA, Voulgarelis M, Tzioufas AG, Moutsopoulos HM. Autoimmune hemolytic anemia in patients with systemic lupus erythematosus. Am. J. Med. 2000; 108: 198-204.
16. Sultan SM, Begum S, Isenberg DA. Prevalence, patterns of disease and outcome in patients with systemic lupus erythematosus who develop sever haematological problems. Rheumatology (Oxford). 2003; 42: 230-234.
17. Duran S, Apte M, Alarcon GS, Marion MC, Edberg JC, Kimberly RP, Zhang J, Langefeld CD, Vila LM, Reveille JD. Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort. Arthritis and Rheumatism. 2008; 59 (9): 1332-1340.
18. Rottem M, Krause I, Fraser A, Stojanovich L, Rovensky J, Shoenfeld Y. autoimmune hemolytic anemia in the Antiphospholipid syndrome. Lupus. 2006; 15: 473-477.
19. Domiciano DS, Shinjo SK. Autoimmune hemolytic anemia in systemic lupus erythematosus: association with thrombocytopenia. Clin. Rheumatol. 2010; 29: 1427-1431.
20. Richaud-Patin Y, Perez-Romano B, Carrillo-Maravilla E, Rodriguez AB, Simon AJ, Cabiedes J, Jakez-Ocampo J, Llorente L, Ruiz-Arguelles A. Deficiency of red cell bound CD55 and CD59 in patients with systemic lupus erythematosus. Immunology Letters. 2003; 88: 95-99.
21. Ruiz-Delgado GJ, Vazquez-Garza E, Mendez-Ramirez N, Gomez-Almaguer D. Abnormalities in the expression of CD55 and CD59 surface molecules on peripheral blood cells are not specific to paroxysmal nocturnal hemoglobinuria. Hematology. 2009; 14(1): 33-37.
22. Packman CH. Hemolytic anemia due to warm autoantibodies: new and traditional approaches to treatment. Clin. Adv. Hematol. Oncol. 2008; 6 (10): 739-741.
23. Jacobsen S, Petersen J, Ullman S, Junker P, Voss A, Rasmussen JM, Tarp U, Poulsen LH, van Overeem Hansen G, Skaarup B, Hansen TM, Podenphant J, Halberg P. a multicentre study of 513 Danish patients with systemic lupus erythematosus. II. Disease mortality and clinical factors of prognostic value. Clin. Rheumatol. 1998; 17: 478-484.
24. Tagoe C, Shah A, Yee H, Belmont HM. Aplastic anemia in systemic lupus erythematosus: a distinct presentation of acquired aplastic anemia? J. Clin. Rheumatol. 2001; 7: 377-383.
25. Singh NP, Prakash A, Garg D, Makhija A, Pathania A, Prakash N, Kubba S, Agarwal SK. aplastic anemia complicating systemic lupus erythematosus: successful management with cyclosporine. Rheumatol. Int. 2004; 24(1): 40-2.
26. Hara A, Wada T, Kitajima S, Toyama T, Okumura T, Kitagawa K, Iwata Y, Sakai N, Furuichi K, Higuchi M, Kaneko S. cpmbined pure red cell aplasia and autoimmune hemolytic anemia in systemic lupus erythematosus with anti-erythropoietin autoantibodies. Am. J. Hematol. 2008; 83: 750-752.
27. Habib GS, Saliba WR, Froom P. Pure red cell aplasia and lupus. Semin. Arthritis. Rheum. 2002; 31: 279-283.
28. Jimeno Sainz A, Blazquez Encinar JC, Conesa V. Pure red cell aplasia as the first manifestation of systemic lupus erythematosus. Am. J. Med. 2001; 111 (1): 78-9.
29. Lambotte O, Khellaf M, Harmouche H, Bader-Meunier B, Manceron V, Goujard C, Amoura Z, Godeau B, Piette JC, Delfraissy JF. Characteristic and long-term outcome of 15 episodes of systemic lupus erythematosus-associated hemophagocytic syndrome. Medicine (Baltimore). 2006; 85 (3): 169-182.
30. Paquette RL, Meshkinpour A, Rosen PJ. A steroid-responsive cause of bone marrow fibrosis associated with systemic lupus erythematosus. Medicine (Baltimore). 1994; 73 (3): 145-152.
31. Dias AM, do Couto MC, Duarte CC, Ines LP, Malcata AB. White blood cell abnormalities and infections in one-year follow-up of 124 patients with SLE. Ann. N. Y. Acad. Sci. 2009; 1173: 103-107.
32. Cervera R, Khamashta MA, Font J, Sebastiani GD, Gil A, Lavilla P, Aydintug AO, Jedryka-Goral A, De Ramon E, Fernandez-Nebro A, Geleazzi M, Haga HJ, Mathieu A, Houssiau F, Ruiz-Irastorza G, Ingelmo M, Hughes GR. Morbidity and mortality in systemic lupus erythematosus during a 5-year period. Medicine (Baltimore). 1999; 78: 167-75.
33. Ward MM, Pyun E, Studenski S. mortality risks associated with specific clinical manifestations of systemic lupus erythematosus. Arch. Intern. Med. 1996; 156(12): 1337-44.
34. NG WL, Chu CM, Wu AKL, Cheng VCC, Yuen KY. Lymphopenia at presentation is associated with increased risk of infections in patients with systemic lupus erythematosus. Q. J. Med. 2006; 99: 37-47.
35. Mirzayan MJ, Schmidt RE, Witte T. prognostic parameters for flare in systemic lupus erythematosus. Rheumatology (Oxford). 39 (12): 1316-9.
36. Vila LM, Alarcon GS, McGwin G, Bastian HM, Fessler BJ, Reveille JD. Systemic lupus erythematosus in a multiethnic US cohort, XXXVII: association of lymphopenia with clinical manifestations, serologic abnormalities, disease activity, and damage accrual. Arthritis. Rheum. 2006; 55 (5): 799-806.
37. Yu HH, Wang LC, Lee JH, Lee CC, Yang YH, Chiang BL. Lymphopenia is associated with neuropsychiatric manifestations and disease activity in paediatric systemic lupus erythematosus patients. Rheumatology. 2007; 46: 1492-1494.
38. Rivero SJ, Diaz-Jouanen E, Alarcon-Segovia D. lymphopenia in systemic lupus erythematosus. Clinical, diagnostic, and prognostic significance. Arthritis. Rheumat. 1978; 21 (3): 295-305.
39. Odendahl M, Jacobi A, Hansen A, Feist E, Hiepe F, Burmester GR, Lipsky PE, Radbruch A, Dorner T. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. The journal of immunology. 2000; 165: 5970-5979.
40. Gomez-Martin D, Diaz-Zamudio M, Vanoye G, Crispin JC, Alcocer-Varela J. quantitative and functional profiles of CD4+ lymphocytes subsets in systemic lupus erythematosus patients with lymphopenia. Clin. Exp. Immunol. 2011; 164 (1): 17-25.
41. Lenert P, Lenert G, Senecal J. CD-$ reactive antibodies in systemic lupus erythematosus. Human Immunology. 1996; 49: 38-48.
42. Alegretti AP, Mucenic T, Merzoni J, Faulhaber GA, Silla LM, Xavier RM. Expression of CD55 and CD59 on peripheral blood cells from systemic lupus erythematosus (SLE) patients. Cellular Immunology. 2010; 265: 127-132.
43. Garcia-Valladares I, Atisha-Fregoso, Richaud-Patin Y, Jakez-Ocampo J, Soto-Vega E, Elias-Lopez D, Carrillo-Maravilla E, Cabiedes J, Ruiz-Arguelles A, Llorente L. Lupus. 2006; 15: 600-605.
44. Massardo L, Metz C, Pardo E, Mezzano V, Babul M, Jarpa E, Guzman AM, Andre S, Kaltner H, Gabius HJ, Jacobelli S, Gonzalez A, Soza A. Autoantibodies against galectin-8: their specificity, association with lymphopenia in system lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Lupus. 18: 539-546.
45. Silva LM, Garcia AB, Bonadi EA. Increased lymphocyte death by neglect-apoptosis is associated with lymphopenia and autoantibodies in lupus patients presenting with neuropsychiatric manifestations. J. Neurol. 2002; 249: 1048-1054.
46. Martinez-Banos D, Crispin JC, Lazo-Langner A, Sanchez-Guerrero J. Moderate and sever neutropenia in patients with systemic lupus erythematosus. Rheumatology. 2006; 45: 994-998.
47. Newman KA, Akhtari M. Management of autoimmune neutropenia in Felty's syndrome and systemic lupus erythematosus. Autoimmune Rev. 2011; 10: 432-437.
48. Zhao H, Li S, Yang R. Thrombocytopenia in patients with systemic lupus erythematosus: significant in the clinical implication and prognosis. Platelets. 2010; 21 (5): 380-385.
49. Ziakas PD, Giannouli S, Zintzaras E, Tziofas AG, Voulgarelis M. Lupus thrombocytopenia: clinical implications and prognostic significance. Ann. Rheum. Dis. 2005; 64: 1366-1369.
50. Pujol M, Ribera A, Vilardell M, Ordi J, Feliu E. High prevalence of platelet autoantibodies in patients with systemic lupus erythematosus. Br. J. Haematol. 1995; 89: 137-141.
51. Ziakas PD, Giannouli S, Tasidou A, Tziofas AG, Voulgarelis M. Suspects in the tale of lupus-associated thrombocytopenia. Clin. Exp. Immunol. 2006; 145 (1): 71-80.
52. Nakamura M, Tanaka Y, Satoh T, Kawai M, Hirakata M, Kaburaki J, Kawakami Y, Ikeda Y, Kuwana M. Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia but not thromboembolism. Rheumatology (Oxford). 2006; 45: 150-156.
53. Macchi L, Rispal P, Clofent-Sanchez G, Pellegrin J, Nurden P, Leng B, Nurden AT. Anti-platelet antibodies in patients with systemic lupus erythematosus and the primary antiphospholipid antibody syndrome: their relationship with the observed thrombocytopenia. B. J. Haematology. 1997; 98: 336-341.
54. Clines DB, Liebman H, Stasi R. Pathophysiology of secondary immune thrombocytopenia. Semin. Hematol. 46 (1 suppl 2): S2-14.
55. Wu H, Birmingham DJ, Rovin B, Hackshaw KV, Haddad N, Haden D, Yu CY, Hebert LA. D-dimer level and the risk for thrombosis in systemic lupus erythematosus. Clin. J. Am. Soc. Nephrol. 2008; 3: 1628-1636.
56. Uthman I, Godeau B, Taher A, Khamashta M. The hematologic manifestations of the antiphospholipid syndrome. Blood Rev. 2008; 22: 187-194.
57. Vaidya S, Abul-ezz S, Lipsmeyer E. Thrombotic thrombocytopenic purpura and systemic lupus erythematosus. Scand. J. Rheumatol. 2001; 30: 308-10.
58. Vasoo S, Thumboo J, Fong K-Y. Thrombotic thrombocytopenic purpura in systemic lupus erythematosus: disease activity and the use of cytotoxic drugs. Lupus. 2002; 11: 443-450.
59. Musio F, Bohen EM, Yuan CM, Welch PG. Review of thrombotic thrombocytopenic purpura in the setting of systemic lupus erythematosus. Semin. Arthrit. Rheumat. 1998; 28 (1): 1-19.
60. Kwok SK, Ju JH, Cho CS, Kim HY, Park SH. Thrombotic thrombocytopenic purpura in systemic lupus erythematosus: risk factors and clinical outcome: a single centre study. Lupus. 2009; 18: 16-21.
61. Aleem A, Al-Sugair S. Thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus. Acta Haematol. 2006; 115: 68-73.
62. Nesher G, Hanna VE, Moore TL, Hersh M, Osborn TG. Thrombotic microangiopathic hemolytic anemia in systemic lupus erythematosus. Semin. Arthrit. Rheumat. 1994; 24 (3): 165-172.
63. Dold S, Singh R, Sarwar H, Menon Y, Candia L, Espinoza LR. Frequency of microangiopathic hemolytic anemia in patients with systemic lupus erythematosus exacerbation: distinction from thrombotic thrombocytopenic purpura, prognosis, and outcome. Arthrit. Rheumat. 2005; 53 (6): 982-985.
64. George JN, Vesely SK, James JA. Overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus. South Med. J. 2007; 100 (5): 512-514.
65. Shah AA, Higgins JP, Chakravarty EF. Thrombotic microangiopathic hemolytic anemia in a patient with SLE: diagnostic difficulties. Nat. Clin. Pract. Rheumatol. 2007; 3 (6): 357-62.
66. Cheung WY. Thrombotic thrombocytopenic purpura and systemic lupus erythematosus-distinct entities or overlapping syndromes? Transfus. Apher. Sci. 2006; 34 (3): 263-266.
67. Hunt BJ, Tueger S, Pattison J, Cavenagh J, D'Cruz DP. Microangiopathic haemolytic anaemia secondary to lupus nephritis: an important differential diagnosis of thrombotic thrombocytopenic purpura. Lupus. 2007; 16: 358-362.
68. Chen J, Fu X, Wang Y, Ling M, McMullen B, Kulman J, Chung DW, Lopez JA. Oxidative modification of von Willebrand factor by neutrophile oxidants inhibits its cleavage by ADAMS 13. Blood. 2010; 115: 706-712.
69. Lansigan F, Isufi I, Tagoe CE. Microangiopathic haemolytic anaemia resembling thrombotic thrombocytopenic purpura in systemic lupus erythematosus: the role of ADAMTS13. Rheumatology (Oxford). 2011; 50: 824-829.
70. Matsuyama T, Kuwana M, Matsumoto M, Isonishi A, Inokuma S. Heterogeneous pathogenic processes of thrombotic microangiopathies in patients with connective tissue diseases. Thromb. Haemost. 2009; 102: 371-378.
71. Maruoka H, Koga T, Inoue Y, Honda S, Takeo M, Fukuda T, Aizawa H. Recurrent thrombotic thrombocytopenic purpura in a patient with systemic lupus erythematosus. Mod. Rheumatol. 2007; 17: 426-428.
72. Austin SK, Starke RD, Lawrie AS, Cohen H, Machin SJ, Mackie IJ. The VWF/ADAMTS13 axis in the antiphospholipid syndrome: ADAMTS13 antibodies and ADAMTS13 dysfunction. B. J. Haematology. 2008; 141: 536-544.
73. Comellas-Kirkerup L, Hernandez-Molina G, Cabral AR. Antiphospholipid-associated thrombocytopenia or autoimmune hemolytic anemia in patients with or without definite primary antiphospholipid syndrome according to the Sapporo revised classification criteria: a 6-year follow-up study. Blood. 2010; 116 (16): 3058-3063.
74. Pereira RMR, Velloso ERP, Menezes Y, Gualandro S, Vassalo J, Yoshinari NH. Bone marrow findings in systemic lupus erythematosus patients with peripheral cytopenias. Clin. Rheumatol. 1998; 17: 219-222.
75. Voulgarelis M, Giannouli S, Tasidou A, Anagnostou D, Ziakas PD, Tziofas AG. Bone marrow histological findings in systemic lupus erythematosus with hematologic abnormalities: a clinicopathological study. Am. J. Hematol. 2006; 81: 590-597.
76. Taylor KE, Chung SA, Graham RR, Ortmann WA, Lee AT, Langefeld CD, Jacob CO, Kamboh MI, Alarcon-Riquelme ME, Tsao BP, Moser KL, Gaffney PM, Harley JB, Petri M, Manzi S, Gregersen PK, Behrens TW, Criswell LA. Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet. 2011; 7 (2): e1001311.
77. Strand V. Lessons learned from clinical trials in SLE. Autoimmun Rev. 2007; 6 (4): 209-214.
78. Font J, Cervera R, Ramos-Casals M, Garcia-Carrasco M, Sentis J, Herrero C, Del Olmo JA, Darnell A, Ingelmo M. Clusters of clinical and immunologic features in systemic lupus erythematosus: analysis of 600 patients from a single center. Sem. Arthrit. Rheumat. 2004; 23 (4): 217-230.
79. Tokano Y, Morimoto S, Amano H, Kawanishi T, Yano T, Tomyo M, Sugawara M, Kobayashi S, Tsuda H, Takasaki Y, Hashimoto H. The relationship between initial clinical manifestation and long-term prognosis of patients with systemic lupus erythematosus. Mod. Rheumatol. 2005; 15: 275-282.