Zinc transporter type 8 autoantibodies (ZnT8A): Prevalence and phenotypic associations in latent autoimmune diabetes patients and patients with adult onset type 1 diabetes

Autoimmunity

Volumn 46, Issue 4, 2013, Pages 251-258

  Andersen, Mette K ^a,b   Härkönen, Taina ^a   Forsblom, Carol ^b,c   Groop, Per Henrik ^b,c,d   Knip, Mikael ^a,b,e   Tuomi, Tiinamaija ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b FOLKHÄLSAN RESEARCH CENTER   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^e TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

GADA; HLA DQB1; Insulin secretion; LADA; SLC30A8; ZnT8A

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE ANTIBODY; HLA DQB1 ANTIGEN; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER TYPE 8 AUTOANTIBODY;

ADULT; ALLELE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE DURATION; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PHENOTYPE; PREVALENCE;

ADULT; AGE FACTORS; AGE OF ONSET; AGED; AUTOANTIBODIES; CATION TRANSPORT PROTEINS; DIABETES MELLITUS, TYPE 1; FEMALE; GENOTYPE; HLA-DQ BETA-CHAINS; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; PREVALENCE;

EID: 84877788349     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2012.741155     Document Type: Article

References (36)

1. Wenzlau, J. M., K. Juhl, L. Yu, et al. 2007. The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes. Proc. Natl. Acad. Sci. USA 104: 17040-17045
2. Knip, M., and H. Siljander. 2008. Autoimmune mechanisms in type 1 diabetes. Autoimmun. Rev. 7: 550-557
3. Chimienti, F., S. Devergnas, F. Pattou, et al. 2006. In vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretion. J. Cell Sci. 119: 4199-4206
4. Cauchi, S., S. Del Guerra, H. Choquet, et al. 2010. Metaanalysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets. Mol. Genet. Metab. 100: 77-82
5. Pettersen, E., F. Skorpen, K. Kvaloy, K. Midthjell, and V. Grill. 2010. Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: Results from the Nord-Trondelag Health Study. Diabetes 59: 302-310
6. Xu, K., M. Zha, X. Wu, et al. 2011. Association between rs13266634 C/T polymorphisms of solute carrier family 30 member 8 (SLC30A8) and type 2 diabetes, impaired glucose tolerance, type 1 diabetes-A meta-analysis. Diabetes Res. Clin. Pract. 91: 195-202
7. Steinthorsdottir, V., G. Thorleifsson, I. Reynisdottir, et al. 2007. A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 39: 770-775
8. Staiger, H., F. Machicao, N. Stefan, et al. 2007. Polymorphisms within novel risk loci for type 2 diabetes determine betacell function. PLoS One 2: e832
9. Kirchhoff, K., F. Machicao, A. Haupt, et al. 2008. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia 51: 597-601
10. Boesgaard, T.W., J. Zilinskaite, M. Vanttinen, et al. 2008. The common SLC30A8 Arg325Trp variant is associated with reduced first-phase insulin release in 846 non-diabetic offspring of type 2 diabetes patients-The EUGENE2 study. Diabetologia 51: 816-820
11. Wenzlau, J. M., Y. Liu, L. Yu, et al. 2008. A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes. Diabetes 57: 2693-2697
12. van Deutekom, A. W., R. J. Heine, and S. Simsek. 2008. The islet autoantibody titres: Their clinical relevance in latent autoimmune diabetes in adults (LADA) and the classification of diabetes mellitus. Diabet. Med. 25: 117-125
13. Groop, L., C. Forsblom, M. Lehtovirta, et al. 1996. Metabolic consequences of a family history of NIDDM (the Botnia study): evidence for sex-specific parental effects. Diabetes 45: 1585-1593
14. Thorn, L. M., C. Forsblom, J. Fagerudd, et al. 2005. Metabolic syndrome in type 1 diabetes: Association with diabetic nephropathy and glycemic control (the FinnDiane study). Diabetes Care 28: 2019-2024
15. Hanson, R. L., R. E. Pratley, C. Bogardus, et al. 2000. Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am. J. Epidemiol. 151: 190-198
16. Tuomi, T., A. Carlsson, H. Li, et al. 1999. Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies. Diabetes 48: 150-157
17. Lampasona, V., M. Schlosser, P. W. Mueller, et al. 2011. Diabetes antibody standardization program: First proficiency evaluation of assays for autoantibodies to zinc transporter 8. Clin. Chem. 57: 1693-1702
18. Isomaa, B., B. Forsen, K. Lahti, et al. 2010. A family history of diabetes is associated with reduced physical fitness in the Prevalence, Prediction and Prevention of Diabetes (PPP)-Botnia study. Diabetologia 53: 1709-1713
19. Sjoroos, M., A. Iitia, J. Ilonen, H. Reijonen, and T. Lovgren. 1995. Triple-label hybridization assay for type-1 diabetesrelated HLA alleles. BioTechniques 18: 870-877
20. Kawasaki, E., M. Uga, K. Nakamura, et al. 2008. Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes. Diabetologia 51: 2299-2302
21. Vaziri-Sani, F., S. Oak, J. Radtke, et al. 2010. ZnT8 autoantibody titers in type 1 diabetes patients decline rapidly after clinical onset. Autoimmunity 43: 598-606
22. Kawasaki, E., K. Nakamura, G. Kuriya, et al. 2011. Differences in the humoral autoreactivity to zinc transporter 8 between childhood- and adult-onset type 1 diabetes in Japanese patients. Clin. Immunol. 138: 146-153
23. Wenzlau, J. M.,M.Walter, T. J. Gardner, et al. 2010. Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects. J. Clin. Endocrinol. Metab. 95: 4712-4719
24. Nielsen, L. B., F. Vaziri-Sani, S. Porksen, et al. 2011. Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes. Autoimmunity 44: 616-623
25. Brorsson, C., F. Vaziri-Sani, R. Bergholdt, et al. 2011. Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes. Autoimmunity 44: 107-114
26. Andersson, C., K. Larsson, F. Vaziri-Sani, et al. 2011. The three ZNT8 autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes. Autoimmunity 44: 394-405
27. Howson, J. M., S. Krause, H. Stevens, et al. 2012. Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases. Diabetologia 55: 1978-1984
28. Trabucchi, A., N. I. Faccinetti, L. L. Guerra, et al. 2012. Detection and characterization of ZnT8 autoantibodies could help to screen latent autoimmune diabetes in adult-onset patients with type 2 phenotype. Autoimmunity 45: 137-142
29. Lampasona, V., A. Petrone, C. Tiberti, et al. 2010. Zinc transporter 8 antibodies complement GAD and IA-2 antibodies in the identification and characterization of adultonset autoimmune diabetes: Non Insulin Requiring Autoimmune Diabetes (NIRAD) 4. Diabetes Care 33: 104-108
30. Kawasaki, E., K. Nakamura, G. Kuriya, et al. 2010. Autoantibodies to insulin, insulinoma-associated antigen-2, and zinc transporter 8 improve the prediction of early insulin requirement in adult-onset autoimmune diabetes. J Clin Endocrinol Metab 95: 707-713
31. Zampetti, S., M. Spoletini, A. Petrone, et al. 2010. Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5). Diabet. Med. 27: 701-704
32. Buzzetti, R., S. Di Pietro, A. Giaccari, et al. 2007. High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes. Diabetes Care 30: 932-938
33. Andersen, M. K., V. Lundgren, J. A. Turunen, et al. 2010. Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years. Diabetes Care 33: 2062-2064
34. Petrone, A., C. Suraci, M. Capizzi, et al. 2008. The protein tyrosine phosphatase nonreceptor 22 (PTPN22) is associated with high GAD antibody titer in latent autoimmune diabetes in adults: Non Insulin Requiring Autoimmune Diabetes (NIRAD) Study 3. Diabetes Care 31: 534-538
35. Nicolson, T. J., E. A. Bellomo, N. Wijesekara, et al. 2009. Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants. Diabetes 58: 2070-2083
36. Fu, Y., W. Tian, E. B. Pratt, et al. 2009. Down-regulation of ZnT8 expression in INS-1 rat pancreatic beta cells reduces insulin content and glucose-inducible insulin secretion. PLoS One 4: e5679