Hemodynamic effects of combination therapy with inhaled nitric oxide and iloprost in patients with pulmonary hypertension and right ventricular dysfunction after high-risk cardiac surgery

Journal of Cardiothoracic and Vascular Anesthesia

Volumn 27, Issue 3, 2013, Pages 459-466

  Antoniou, Theofani ^a   Koletsis, Efstratios N ^b   Prokakis, Christos ^b   Rellia, Panagiota ^a   Thanopoulos, Apostolos ^a   Theodoraki, Kassiani ^c   Zarkalis, Dimitrios ^a   Sfyrakis, Petros ^a  

^a ONASSIS CARDIAC SURGERY CENTER   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

iloprost; inhaled nitric oxide; pulmonary hypertension; right ventricular dysfunction; tricuspid annular plane systolic excursion; tricuspid annular velocity

Indexed keywords

ILOPROST; NITRIC OXIDE;

ADULT; AGED; ARTERIAL PRESSURE; ARTICLE; CLINICAL ARTICLE; EXTRACORPOREAL CIRCULATION; FEMALE; HEART INDEX; HEART RIGHT VENTRICLE FUNCTION; HEART SURGERY; HEMODYNAMIC PARAMETERS; HIGH RISK PATIENT; HUMAN; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MALE; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RETROSPECTIVE STUDY; SYSTEMIC VASCULAR RESISTANCE; TRICUSPID VALVE; VALVULAR HEART DISEASE; VELOCITY; VENOUS OXYGEN TENSION;

AEROSOLS; AGED; ARTERIAL PRESSURE; CARDIAC SURGICAL PROCEDURES; ELECTROCARDIOGRAPHY; EXTRACORPOREAL CIRCULATION; FEMALE; HEART VALVES; HEMODYNAMICS; HUMANS; HYPERTENSION, PULMONARY; ILOPROST; MALE; MIDDLE AGED; NITRIC OXIDE; RISK; TREATMENT OUTCOME; VASCULAR RESISTANCE; VASODILATOR AGENTS; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 84877783711     PISSN: 10530770     EISSN: 15328422     Source Type: Journal    
DOI: 10.1053/j.jvca.2012.07.020     Document Type: Article

References (36)

1. M. Tidswell, T. Higgins The anesthesiologist and pulmonary arterial hypertension Semin Cardiothorac Vasc J Anesth 11 2007 93 95
2. G. Simonneau, N. Galiè, L.J. Rubin Clinical classification of pulmonary hypertension J Am Coll Cardiol 43 suppl 2004 5S 12S
3. F. Roques, S.A. Nashef, P. Michel Risk factors and outcome in European cardiac surgery: Analysis of the Euroscore multinational database of 19.030 patients Eur J Cardiothorac Surg 15 1999 816 823
4. P. Germann, A. Braschi, G. Della Rocca Inhaled nitric oxide therapy in adults: European expert recommendations Intensive Care Med 31 2005 1029 1041
5. F. Haddad, P. Couture, C. Tousignant The right ventricle in cardiac surgery, a perioperative perspective: II. Pathophysiology, clinical importance and management Anesth Analg 108 2009 422 433
6. M. Winterhalter, A. Simon, S. Fischer Comparison of inhaled iloprost and nitric oxide in patients with pulmonary hypertension during weaning from cardiopulmonary bypass in cardiac surgery: A prospective randomized trial J Cardiothorac Vasc Anesth 22 2008 406 413
7. S. Krug, A. Sablotzki, S. Hammerschmidt Inhaled iloprost for the control of pulmonary hypertension Vasc Health Risk Manag 5 2009 465 474
8. A. Sablotzki, T. Hentschel, E. Gruenig Hemodynamic effects of inhaled iloprost and inhaled nitric oxide in heart transplant candidates with elevated pulmonary vascular resistance Eur J Cardiothorac Surg 22 2002 746 752
9. H. Olschewski, H.A. Ghofrani, T. Schmehl et al. Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH Study Group Ann Intern Med 132 2000 435 443
10. N.W. Salomon, J.R. Plachetka, J.G. Copeland Comparison of dopamine and dobutamine following coronary artery bypass grafting Ann Thorac Surg 33 1982 48 54
11. T. Carrel, L. Englberger, P. Mohacsi Low systemic vascular resistance after cardiopulmonary bypass: Incidence, etiology and clinical importance J Cardiovasc Surg 15 2000 347 353
12. L.G. Fischer, H. Van Aken, H. Bürkle Management of pulmonary hypertension: Physiological and pharmacological considerations for anesthesiologists Anesth Analg 96 2003 1603 1616
13. G.M. Matuschak Pulmonary dysfunction after surgery involving cardiopulmonary bypass: Do we understand the mechanism? Crit Care Med 25 1997 1778 1780
14. B. Riedel The pathophysiology and management of perioperative pulmonary hypertension with specific emphasis on the period following cardiac surgery Int Anesthesiol Clin 37 1999 55 79
15. K. Subramaniam, J.P. Yarel Management of pulmonary hypertension in the operating room Semin Cardiothorac Vasc Anesth 11 2007 119 136
16. K. Fattouch, F. Sbraga, G. Bianco Inhaled prostacyclin, nitric oxide and nitroprusside in pulmonary hypertension after mitral valve replacement J Cardiovasc Surg 20 2005 171 176
17. E.R. Schmid, C. Bürki, M.H.C. Engel Inhaled nitric oxide versus intravenous vasodilators in severe pulmonary hypertension after cardiac surgery Anesth Analg 89 1999 1108 1115
18. D. Matamis, S. Pampori, A. Papathanasiou Inhaled NO and sildenafil combination in cardiac surgery patients with out-of-proportion pulmonary hypertension: Acute effects on postoperative gas exchange and hemodynamics Circ Heart Fail 5 2012 47 53
19. F. Santini, G. Casali, G. Franchi Hemodynamic effects of inhaled nitric oxide and phosphodiesterase inhibitor (dipyridamole) on secondary pulmonary hypertension following heart valve surgery in adults Int J Cardiol 103 2005 156 163
20. R.T. Schermuly, E. Krupnik, H. Tenor Coaerosolization of phosphodiesterase inhibitors markedly enhances the pulmonary vasodilatory response to inhaled iloprost in experimental pulmonary hypertension. Maintenance of lung selectivity Am J Respir Crit Care Med 164 2001 1694 1700
21. L.L. Hill, R.G. Pearl Combined inhaled nitric oxide and inhaled prostacyclin during experimental chronic pulmonary hypertension J Appl Physiol 86 1999 1160 1164
22. A. Haralsson, N. Kieler-Jensen, S.E. Ricksten The additive pulmonary vasodilatory effects of inhaled prostacyclin and inhaled milrinone in post cardiac surgical patients with pulmonary hypertension Anesth Analg 93 2001 1439 1445
23. T. Antoniou, C. Prokakis, G. Athanasopoulos Inhaled nitric oxide plus iloprost in the setting of post-left assist device right heart dysfunction Ann Thorac Surg 94 2012 792 798
24. M. Argenziano, A.F. Choudhri, N. Moazami Randomized, double blinded trial of inhaled nitric oxide in LVAD recipients with pulmonary hypertension Ann Thorac Surg 65 1998 340 345
25. T.S. Maxey, C.D. Smith, J.A. Kern Beneficial effects of inhaled nitric oxide in adult cardiac surgical patients Ann Thorac Surg 73 2002 529 532
26. J.R. Beck, L.B. Mongero, R.M. Kroslowitz Inhaled nitric oxide improves hemodynamics in patients with acute pulmonary hypertension after high-risk cardiac surgery Perfusion 14 1999 37 42
27. O. Sitbon, F. Brenot, A. Denjean Inhaled nitric oxide as a screening vasodilator agent in primary pulmonary hypertension. A dose response study and comparison with prostacyclin Am J Respir Crit Care Med 151 1995 384 389
28. J.W. Lee, R.F. Gonzalez, C.J. Chapin Nitric oxide decreases surfactant protein gene expression in primary cultures of type II pneumocytes Am J Physiol Lung Cell Mol Physiol 288 2005 L950 L957
29. A.J. Gow, S.R. Thom, H. Ischiropoulos Nitric oxide and peroxynitrite-mediated pulmonary cell death Am J Physiol Lung Cell Mol Physiol 274 1998 L112 L118
30. B. Weinberger, D.L. Laskin, D.E. Heck The toxicology of inhaled nitric oxide Toxicol Sci 59 2001 5 16
31. E.D. Morrell, B.M. Tsai, P.R. Crisostomo Experimental therapies for hypoxia-induced pulmonary hypertension during acute lung injury Shock 25 2006 214 226
32. A.M. Atz, I. Adatia, D.L. Wessel Rebound pulmonary hypertension after inhalation of nitric oxide Ann Thorac Surg 62 1996 1759 1764
33. S. Rex, G. Schaelte, S. Metzelder Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: A prospective randomized controlled trial Acta Anaesthesiol Scand 52 2008 65 72
34. K. Theodoraki, P. Rellia, A. Thanopoulos Inhaled iloprost controls pulmonary hypertension after cardiopulmonary bypass Can J Anaesth 49 2002 963 967
35. K. Theodoraki, D. Tsiapras, L. Tsourelis Inhaled iloprost in eight heart transplant recipients presenting with post-bypass acute right ventricular dysfunction Acta Anaesthesiol Scand 50 2006 1213 1217
36. G.D. Rocca, C. Coccia, L. Pompei Hemodynamic and oxygenation changes of combined therapy with inhaled nitric oxide and aerosolized prostacyclin J Cardiothorac Vasc Anesth 15 2001 224 227