Hemodynamic effects of inhaled aerosolized iloprost and inhaled nitric oxide in heart transplant candidates with elevated pulmonary vascular resistance

European Journal of Cardio-thoracic Surgery

Volumn 22, Issue 5, 2002, Pages 746-752

  Sablotzki, Armin ^a   Hentschel, Thomas ^a   Gruenig, Ekkehard ^b   Schubert, Susann ^a   Friedrich, Ivar ^a   Mühling, Jörg ^c   Dehne, Marius G ^c   Czeslick, Elke ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Heart transplantation; Iloprost; Nitric oxide; Pulmonary hypertension

Indexed keywords

ILOPROST; NITRIC OXIDE;

ADULT; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HEART GRAFT; HEART INDEX; HEMODYNAMICS; HUMAN; ISCHEMIC HEART DISEASE; LUNG ARTERY PRESSURE; LUNG VASCULAR RESISTANCE; MALE; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SYSTEMIC VASCULAR RESISTANCE; VASODILATATION;

ADMINISTRATION, INHALATION; ADULT; AEROSOLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART FAILURE, CONGESTIVE; HEART TRANSPLANTATION; HEMODYNAMIC PROCESSES; HUMANS; HYPERTENSION, PULMONARY; ILOPROST; MALE; MIDDLE AGED; NITRIC OXIDE; OXYGEN CONSUMPTION; PREOPERATIVE CARE; PULMONARY ARTERY; VASCULAR RESISTANCE; VASODILATOR AGENTS;

EID: 0036842915     PISSN: 10107940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1010-7940(02)00488-8     Document Type: Article

References (29)

1. Kirklin J.K., Naftel D.C., Kirklin J.W., Blackstone E.H., White-Williams C., Bourge R.C. Pulmonary vascular resistance and the risk of heart transplantation. J Heart Transplant. 7:1988;331-336.
2. Erickson K., Costanzo-Nordin M., O'Sullivan E., Johnson M.R., Zucker M.J., Pifarre R., Lawless C.E., Robinson J.A., Scanlon P.J. Influence of preoperative transpulmonary gradient on late mortality after orthotopic heart transplantation. J Heart Lung Transplant. 9:1990;526-537.
3. Murali S., Uretsky B.F., Reddy P.S., Tokarczyk T.R., Betschart A.R. Reversibility of pulmonary hypertension in congestive heart failure patients evaluated for cardiac transplantation: comparative effects of various pharmacologic agents. Am Heart J. 122:1991;1375-1381.
4. Kieler-Jensen N., Milocco I., Ricksten S.E. Pulmonary vasodilation after heart transplantation: a comparison among prostacyclin, sodium nitroprusside and nitroglycerin on right ventricular function and pulmonary selectivity. J Heart Lung Transplant. 12:1993;179-184.
5. Pepke-Zaba J., Higenbottam T., Dinh-Xuan A.T., Stone D., Wallwork J. Inhaled nitric oxide as a cause of selective pulmonary vasodilation in pulmonary hypertension. Lancet. 338:1991;1173-1174.
6. Snow D., Gray S., Ghosh S., Foubert L., Oduro A., Higenbottam T.W., Wells F.C., Latimer R.D. Inhaled nitric oxide in patients with normal and increased pulmonary vascular resistance after cardiac surgery. Br J Anaesth. 72:1994;185-189.
7. Loh E., Stamler J.S., Hare J., Loscalzo J., Coluzzi W.S. Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation. 90:1994;2780-2785.
8. Haraldsson A., Kieler-Jensen N., Nathorst-Westfelt U., Bergh C.H., Ricksten S.E. Comparison of inhaled nitric oxide and inhaled aerosolized prostacyclin in the evaluation of heart transplant candidates with elevated pulmonary vascular resistance. Chest. 114:1998;780-786.
9. Foubert L., Fleming B., Latimer R., Jonas M., Oduro A., Borland C., Higenbottam T. Safety guidelines for use of nitric oxide. Lancet. 339:1992;1615-1616.
10. Bocchi E.A., Bacal F., Auler J.O. Jr, Carmone M.J., Bellotti G., Pileggi F. Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure. Am J Cardiol. 74:1994;70-72.
11. Miller O.I., Tang S.F., Keech A., Celermajer D.S. Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide. Lancet. 346:1995;51-52.
12. Weston M.W., Isaac B.F., Crain C. The use of inhaled prostacyclin in nitroprusside-resistant pulmonary artery hypertension. J Heart Lung Transplant. 20:2001;1340-1344.
13. Olschewski H., Walmrath D., Schermuly R., Ghofrani A., Grimminger F., Seeger W. Aerosolized prostacyclin and iloprost in severe pulmonary hypertension. Ann Intern Med. 124:1996;820-824.
14. Hoeper M.M., Olschewski H., Ghofrani H.A., Wilkens H., Winkler J., Borst M.M., Niedermeyer J., Fabel H., Seeger W. A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. J Am Coll Cardiol. 35:2000;176-182.
15. Langer F., Wendler O., Wilhelm W., Tscholl D., Schäfers H.J. Treatment of a case of acute right heart failure by inhalation of iloprost, a long-acting prostacyclin analog. Eur J Anaesth. 18:2001;770-773.
16. Wittwer T., Pethig K., Struber M., Hoeper M., Harringer W., Haverich A., Franke U., Wahlers T. Aerosolized iloprost for severe pulmonary hypertension as a bridge to heart transplantation. Ann Thorac Surg. 71:2001;1004-1006.
17. Sachs L. Angewandte statistik. 1997;76 Springer Verlag, Berlin, New York.
18. Pagano D., Townend J.N., Horton R., Smith C., Clutton-Brock T., Bonser R.S. A comparison of inhaled nitric oxide with intravenous vasodilators in the assessment of pulmonary hemodynamics prior to cardiac transplantation. Eur J Cardiothorac Surg. 10:1996;1120-1126.
19. Kieler-Jensen N., Ricksten S.E., Stenquist O., Bergh C.H., Lindelov B., Wennmalm A., Waagstein F., Lundin S. Inhaled nitric oxide in the evaluation of heart-transplant candidates with elevated pulmonary vascular resistance. J Heart Lung Transplant. 13:1994;366-375.
20. Girard C., Durand P.G., Vedrinne C., Pannetier J.C., Estanove S., Falke K., Adnot S., Lemaire F. Inhaled nitric oxide for right ventricular failure after heart transplantation: case conference. J Cardiothorac Vasc Anesth. 78:1993;427-435.
21. Rich G.F., Murphy J.G.D., Ross C.M., Jahns R.A. Inhaled nitric oxide: selective pulmonary vasodilation in cardiac surgical patients. Anesthesiology. 78:1993;1028-1035.
22. Walmrath D., Schneider R., Schermuly R., Olschewski H., Grimminger F., Seeger W. Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. Am J Respir Crit Care Med. 153:1996;991-995.
23. Snell G.I., Salamonsen R.F., Bergin P., Esmore D.S., Khan S., Williams T.J. Inhaled nitric oxide as a bridge to heart-lung transplantation in a patient with end-stage pulmonary hypertension. Am J Respir Crit Care Med. 151:1995;1263-1266.
24. Haraldsson A., Kieler-Jensen N., Ricksten S.E. Inhaled prostacyclin for treatment of pulmonary hypertension after cardiac surgery or heart transplantation: a pharmacodynamic study. J Cardiothorac Vasc Anesth. 10:1996;864-868.
25. Rebsamen M.C., Church D.J., Morabito D., Vallotton M.B., Lang U. Role of cAMP and calcium influx in endothelin-1-induced ANP release in rat cardiomyocytes. Am J Physiol. 273:1997;922-931.
26. 2) verbessern die linksventrikuläre Kontraktilität in vivo. Anästh Intensivmed. 42:2001;479-536.
27. Olschewski H., Ghofrani H.A., Walmrath D., Temmesfeld-Wollbrück B., Grimminger F., Seeger W. Recovery from circulatory shock in severe primary pulmonary hypertension (PPH) with aerosolization of iloprost. Int Care Med. 24:1998;631-634.
28. Sitbon O., Brenot F., Denjean A., Bergeron A., Parent F., Azarian R., Herve P., Raffestin B., Simmoneau G. Inhaled nitric oxide as a screening vasodilator agent in primary pulmonary hypertension: a dose-response study and comparison with prostacyclin. Am J Respir Crit Care Med. 151:1995;384-389.
29. Voelkel N.F., Lobel K., Westcott J.Y., Burke T.J. Nitric oxide-related vasoconstriction in lungs perfused with red cell lysate. FASEB J. 5:1995;379-386.