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Volumn 21, Issue 1, 2013, Pages 6-14

Update of the drug resistance mutations in HIV-1: March 2013

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; ATAZANAVIR PLUS RITONAVIR; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; COBICISTAT PLUS ELVITEGRAVIR PLUS EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; DARUNAVIR PLUS RITONAVIR; DIDANOSINE; DOLUTEGRAVIR; EFAVIRENZ; ELVITEGRAVIR; EMTRICITABINE; ENFUVIRTIDE; ETRAVIRINE; FOSAMPRENAVIR PLUS RITONAVIR; INDINAVIR PLUS RITONAVIR; INTEGRASE; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; MARAVIROC; NELFINAVIR; NEVIRAPINE; PROTEINASE; RALTEGRAVIR; RILPIVIRINE; RITONAVIR PLUS SAQUINAVIR; RITONAVIR PLUS TIPRANAVIR; RNA DIRECTED DNA POLYMERASE; STAVUDINE; TENOFOVIR; UNINDEXED DRUG; ZIDOVUDINE;

EID: 84877759801     PISSN: 21615861     EISSN: 21615853     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (231)

References (97)
  • 1
    • 33646376232 scopus 로고    scopus 로고
    • Reverse transcriptase mutations 118I, 208Y, and 215Y cause HIV-1 hypersusceptibility to non-nucleoside reverse transcriptase inhibitors
    • Clark SA, Shulman NS, Bosch RJ, Mellors JW. Reverse transcriptase mutations 118I, 208Y, and 215Y cause HIV-1 hypersusceptibility to non-nucleoside reverse transcriptase inhibitors. AIDS. 2006;20(7):981-984.
    • (2006) AIDS. , vol.20 , Issue.7 , pp. 981-984
    • Clark, S.A.1    Shulman, N.S.2    Bosch, R.J.3    Mellors, J.W.4
  • 2
    • 68649105007 scopus 로고    scopus 로고
    • Nucleoside-associated mutations cause hypersusceptibility to etravirine
    • Picchio G, Vingerhoets J, Parkin N, Azijn H, de Bethune MP. Nucleoside-associated mutations cause hypersusceptibility to etravirine. [Abstract 23.] Antivir Ther. 2008;13(Suppl 3):A25.
    • (2008) Antivir Ther. , vol.13 , Issue.SUPPL. 3
    • Picchio, G.1    Vingerhoets, J.2    Parkin, N.3    Azijn, H.4    de Bethune, M.P.5
  • 4
    • 38949183670 scopus 로고    scopus 로고
    • Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience
    • Demeter LM, DeGruttola V, Lustgarten S, et al. Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience. HIV Clin Trials. 2008;9(1):11-25.
    • (2008) HIV Clin Trials. , vol.9 , Issue.1 , pp. 11-25
    • Demeter, L.M.1    DeGruttola, V.2    Lustgarten, S.3
  • 5
    • 18344409610 scopus 로고    scopus 로고
    • The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: A prospective cohort analysis
    • Haubrich RH, Kemper CA, Hellmann NS, et al. The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis. AIDS. 2002;16(15):F33-F40.
    • (2002) AIDS. , vol.16 , Issue.15
    • Haubrich, R.H.1    Kemper, C.A.2    Hellmann, N.S.3
  • 6
    • 2442419529 scopus 로고    scopus 로고
    • Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: Effect on response to efavirenz-based therapy in an urban observational cohort
    • Tozzi V, Zaccarelli M, Narciso P, et al. Mutations in HIV-1 reverse transcriptase potentially associated with hypersusceptibility to nonnucleoside reverse-transcriptase inhibitors: effect on response to efavirenz-based therapy in an urban observational cohort. J Infect Dis. 2004;189(9):1688-1695.
    • (2004) J Infect Dis. , vol.189 , Issue.9 , pp. 1688-1695
    • Tozzi, V.1    Zaccarelli, M.2    Narciso, P.3
  • 7
    • 0037626084 scopus 로고    scopus 로고
    • Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs
    • Katzenstein DA, Bosch RJ, Hellmann N, et al. Phenotypic susceptibility and virological outcome in nucleoside-experienced patients receiving three or four antiretroviral drugs. AIDS. 2003;17(6):821-830.
    • (2003) AIDS. , vol.17 , Issue.6 , pp. 821-830
    • Katzenstein, D.A.1    Bosch, R.J.2    Hellmann, N.3
  • 8
    • 77955786296 scopus 로고    scopus 로고
    • HIV-1 reverse transcriptase connection domain mutations: Dynamics of emergence and implications for success of combination antiretroviral therapy
    • von Wyl V, Ehteshami M, Demeter LM, et al. HIV-1 reverse transcriptase connection domain mutations: dynamics of emergence and implications for success of combination antiretroviral therapy. Clin Infect Dis. 2010;51(5):620-628.
    • (2010) Clin Infect Dis. , vol.51 , Issue.5 , pp. 620-628
    • von Wyl, V.1    Ehteshami, M.2    Demeter, L.M.3
  • 9
    • 79956301190 scopus 로고    scopus 로고
    • Connection domain mutations in HIV-1 reverse transcriptase do not impact etravirine susceptibility and virologic responses to etravirine-containing regimens
    • Gupta S, Vingerhoets J, Fransen S, et al. Connection domain mutations in HIV-1 reverse transcriptase do not impact etravirine susceptibility and virologic responses to etravirine-containing regimens. Antimicrob Agents Chemother. 2011;55(6):2872-2879.
    • (2011) Antimicrob Agents Chemother. , vol.55 , Issue.6 , pp. 2872-2879
    • Gupta, S.1    Vingerhoets, J.2    Fransen, S.3
  • 10
    • 84887129643 scopus 로고    scopus 로고
    • Reverse transcriptase connection domain mutations were not associated with virological failure or phenotypic resistance in rilpivirine-treated patients from the ECHO and THRIVE Phase III trials (week 96 analysis)
    • Rimsky L, Van Eygen V, Vingerhoets J, Leijskens E, Picchio G. Reverse transcriptase connection domain mutations were not associated with virological failure or phenotypic resistance in rilpivirine-treated patients from the ECHO and THRIVE Phase III trials (week 96 analysis). [Abstract 28.] Antivir Ther. 2012;17:A36.
    • (2012) Antivir Ther. , vol.17
    • Rimsky, L.1    van Eygen, V.2    Vingerhoets, J.3    Leijskens, E.4    Picchio, G.5
  • 11
    • 1542327561 scopus 로고    scopus 로고
    • Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients
    • Miller MD, Margot N, Lu B, et al. Genotypic and phenotypic predictors of the magnitude of response to tenofovir disoproxil fumarate treatment in antiretroviral-experienced patients. J Infect Dis. 2004;189(5):837-846.
    • (2004) J Infect Dis. , vol.189 , Issue.5 , pp. 837-846
    • Miller, M.D.1    Margot, N.2    Lu, B.3
  • 12
    • 0142042463 scopus 로고    scopus 로고
    • Broad nucleoside reverse-transcriptase inhibitor cross-resistance in human immunodeficiency virus type 1 clinical isolates
    • Whitcomb JM, Parkin NT, Chappey C, Hellman NS, Petropoulos CJ. Broad nucleoside reverse-transcriptase inhibitor cross-resistance in human immunodeficiency virus type 1 clinical isolates. J Infect Dis. 2003;188(7):992-1000.
    • (2003) J Infect Dis. , vol.188 , Issue.7 , pp. 992-1000
    • Whitcomb, J.M.1    Parkin, N.T.2    Chappey, C.3    Hellman, N.S.4    Petropoulos, C.J.5
  • 13
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder BA, Kemp SD. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science. 1989;246(4934):1155-1158.
    • (1989) Science. , vol.246 , Issue.4934 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 14
    • 0026565278 scopus 로고
    • Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine
    • Kellam P, Boucher CA, Larder BA. Fifth mutation in human immunodeficiency virus type 1 reverse transcriptase contributes to the development of high-level resistance to zidovudine. Proc Natl Acad Sci USA. 1992;89(5):1934-1938.
    • (1992) Proc Natl Acad Sci USA. , vol.89 , Issue.5 , pp. 1934-1938
    • Kellam, P.1    Boucher, C.A.2    Larder, B.A.3
  • 15
    • 0036768696 scopus 로고    scopus 로고
    • Impact of stavudine phenotype and thymidine analogues mutations on viral response to stavudine plus lamivudine in ALTIS 2 ANRS trial
    • Calvez V, Costagliola D, Descamps D, et al. Impact of stavudine phenotype and thymidine analogues mutations on viral response to stavudine plus lamivudine in ALTIS 2 ANRS trial. Antivir Ther. 2002;7(3):211-218.
    • (2002) Antivir Ther. , vol.7 , Issue.3 , pp. 211-218
    • Calvez, V.1    Costagliola, D.2    Descamps, D.3
  • 16
    • 2142650638 scopus 로고    scopus 로고
    • Rate of thymidine analogue resistance mutation accumulation with zidovudine-or stavudine-based regimens
    • Kuritzkes DR, Bassett RL, Hazelwood JD, et al. Rate of thymidine analogue resistance mutation accumulation with zidovudine-or stavudine-based regimens. JAIDS. 2004;36(1):600-603.
    • (2004) JAIDS. , vol.36 , Issue.1 , pp. 600-603
    • Kuritzkes, D.R.1    Bassett, R.L.2    Hazelwood, J.D.3
  • 17
    • 0036534427 scopus 로고    scopus 로고
    • Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118
    • Romano L, Venturi G, Bloor S, et al. Broad nucleoside-analogue resistance implications for human immunodeficiency virus type 1 reverse-transcriptase mutations at codons 44 and 118. J Infect Dis. 2002;185(7):898-904.
    • (2002) J Infect Dis. , vol.185 , Issue.7 , pp. 898-904
    • Romano, L.1    Venturi, G.2    Bloor, S.3
  • 18
    • 0036135318 scopus 로고    scopus 로고
    • Prediction of abacavir resistance from genotypic data: Impact of zidovudine and lamivudine resistance in vitro and in vivo
    • Walter H, Schmidt B, Werwein M, Schwingel E, Korn K. Prediction of abacavir resistance from genotypic data: impact of zidovudine and lamivudine resistance in vitro and in vivo. Antimicrob Agents Chemother. 2002;46(1):89-94.
    • (2002) Antimicrob Agents Chemother. , vol.46 , Issue.1 , pp. 89-94
    • Walter, H.1    Schmidt, B.2    Werwein, M.3    Schwingel, E.4    Korn, K.5
  • 19
    • 38149026249 scopus 로고    scopus 로고
    • Effect of isolated V118I mutation in reverse transcriptase on response to first-line antiretroviral therapy
    • Mihailidis C, Dunn D, Pillay D, Pozniak A. Effect of isolated V118I mutation in reverse transcriptase on response to first-line antiretroviral therapy. AIDS. 2008;22(3):427-430.
    • (2008) AIDS. , vol.22 , Issue.3 , pp. 427-430
    • Mihailidis, C.1    Dunn, D.2    Pillay, D.3    Pozniak, A.4
  • 20
    • 0034088720 scopus 로고    scopus 로고
    • Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy
    • CNA2001 Investigative Group
    • Harrigan PR, Stone C, Griffin P, et al. Resistance profile of the human immunodeficiency virus type 1 reverse transcriptase inhibitor abacavir (1592U89) after monotherapy and combination therapy. CNA2001 Investigative Group. J Infect Dis. 2000;181(3):912-920.
    • (2000) J Infect Dis. , vol.181 , Issue.3 , pp. 912-920
    • Harrigan, P.R.1    Stone, C.2    Griffin, P.3
  • 21
    • 12144290105 scopus 로고    scopus 로고
    • Antiviral efficacy of abacavir in antiretroviral therapy-experienced adults harbouring HIV-1 with specific patterns of resistance to nucleoside reverse transcriptase inhibitors
    • Lanier ER, Ait-Khaled M, Scott J, et al. Antiviral efficacy of abacavir in antiretroviral therapy-experienced adults harbouring HIV-1 with specific patterns of resistance to nucleoside reverse transcriptase inhibitors. Antivir Ther. 2004;9(1):37-45.
    • (2004) Antivir Ther. , vol.9 , Issue.1 , pp. 37-45
    • Lanier, E.R.1    Ait-Khaled, M.2    Scott, J.3
  • 22
    • 0030892246 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years
    • z1414
    • Winters MA, Shafer RW, Jellinger RA, Mamtora G, Gingeras T, Merigan TC. Human immunodeficiency virus type 1 reverse transcriptase genotype and drug susceptibility changes in infected individuals receiving dideoxyinosine monotherapy for 1 to 2 years. Antimicrob Agents Chemother. 1997;41(4):757-762. z1414.
    • (1997) Antimicrob Agents Chemother. , vol.41 , Issue.4 , pp. 757-762
    • Winters, M.A.1    Shafer, R.W.2    Jellinger, R.A.3    Mamtora, G.4    Gingeras, T.5    Merigan, T.C.6
  • 23
    • 34748849507 scopus 로고    scopus 로고
    • Low-level K65R mutation in HIV-1 reverse transcriptase of treatment-experienced patients exposed to abacavir or didanosine
    • Svarovskaia ES, Margot NA, Bae AS, et al. Low-level K65R mutation in HIV-1 reverse transcriptase of treatment-experienced patients exposed to abacavir or didanosine. JAIDS. 2007;46(2):174-180.
    • (2007) JAIDS. , vol.46 , Issue.2 , pp. 174-180
    • Svarovskaia, E.S.1    Margot, N.A.2    Bae, A.S.3
  • 24
    • 18244406016 scopus 로고    scopus 로고
    • Clinically relevant genotype interpretation of resistance to didanosine
    • Marcelin AG, Flandre P, Pavie J, et al. Clinically relevant genotype interpretation of resistance to didanosine. Antimicrob Agents Chemother. 2005;49(5):1739-1744.
    • (2005) Antimicrob Agents Chemother. , vol.49 , Issue.5 , pp. 1739-1744
    • Marcelin, A.G.1    Flandre, P.2    Pavie, J.3
  • 25
    • 14844300816 scopus 로고    scopus 로고
    • Didanosine in HIV-1-infected patients experiencing failure of antiretroviral therapy: A randomized placebo-controlled trial
    • Molina JM, Marcelin AG, Pavie J, et al. Didanosine in HIV-1-infected patients experiencing failure of antiretroviral therapy: a randomized placebo-controlled trial. J Infect Dis. 2005;191(6):840-847.
    • (2005) J Infect Dis. , vol.191 , Issue.6 , pp. 840-847
    • Molina, J.M.1    Marcelin, A.G.2    Pavie, J.3
  • 26
    • 70349656911 scopus 로고    scopus 로고
    • Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria
    • Hawkins CA, Chaplin B, Idoko J, et al. Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. JAIDS. 2009;52(2):228-234.
    • (2009) JAIDS. , vol.52 , Issue.2 , pp. 228-234
    • Hawkins, C.A.1    Chaplin, B.2    Idoko, J.3
  • 27
    • 77949363519 scopus 로고    scopus 로고
    • Varied patterns of HIV-1 drug resistance on failing first-line antiretroviral therapy in South Africa
    • Wallis CL, Mellors JW, Venter WD, Sanne I, Stevens W. Varied patterns of HIV-1 drug resistance on failing first-line antiretroviral therapy in South Africa. JAIDS. 2010;53(4):480-484.
    • (2010) JAIDS. , vol.53 , Issue.4 , pp. 480-484
    • Wallis, C.L.1    Mellors, J.W.2    Venter, W.D.3    Sanne, I.4    Stevens, W.5
  • 28
    • 8944256865 scopus 로고    scopus 로고
    • Drug resistance and virologic response in NUCA 3001, a randomized trial of lamivudine (3TC) versus zidovudine (ZDV) versus ZDV plus 3TC in previously untreated patients
    • Kuritzkes DR, Quinn JB, Benoit SL, et al. Drug resistance and virologic response in NUCA 3001, a randomized trial of lamivudine (3TC) versus zidovudine (ZDV) versus ZDV plus 3TC in previously untreated patients. AIDS. 1996;10(9):975-981.
    • (1996) AIDS. , vol.10 , Issue.9 , pp. 975-981
    • Kuritzkes, D.R.1    Quinn, J.B.2    Benoit, S.L.3
  • 29
    • 10744228522 scopus 로고    scopus 로고
    • Risk of failure in patients with 215 HIV-1 revertants starting their first thymidine analog-containing highly active antiretroviral therapy
    • Violin M, Cozzi-Lepri A, Velleca R, et al. Risk of failure in patients with 215 HIV-1 revertants starting their first thymidine analog-containing highly active antiretroviral therapy. AIDS. 2004;18(2):227-235.
    • (2004) AIDS. , vol.18 , Issue.2 , pp. 227-235
    • Violin, M.1    Cozzi-Lepri, A.2    Velleca, R.3
  • 30
    • 84878858854 scopus 로고    scopus 로고
    • Evolution of amino acid 215 in HIV-1 reverse transcriptase in response to intermittent drug selection
    • Chappey C, Wrin T, Deeks S, Petropoulos CJ. Evolution of amino acid 215 in HIV-1 reverse transcriptase in response to intermittent drug selection. [Abstract 32.] Antivir Ther. 2003;8:S37.
    • (2003) Antivir Ther. , vol.8
    • Chappey, C.1    Wrin, T.2    Deeks, S.3    Petropoulos, C.J.4
  • 31
    • 19244372885 scopus 로고    scopus 로고
    • Transmitted human immunodeficiency virus type 1 carrying the D67N or K219Q/E mutation evolves rapidly to zidovudine resistance in vitro and shows a high replicative fitness in the presence of zidovudine
    • Garcia-Lerma JG, MacInnes H, Bennett D, Weinstock H, Heneine W. Transmitted human immunodeficiency virus type 1 carrying the D67N or K219Q/E mutation evolves rapidly to zidovudine resistance in vitro and shows a high replicative fitness in the presence of zidovudine. J Virol. 2004;78(14):7545-7552.
    • (2004) J Virol. , vol.78 , Issue.14 , pp. 7545-7552
    • Garcia-Lerma, J.G.1    McInnes, H.2    Bennett, D.3    Weinstock, H.4    Heneine, W.5
  • 32
    • 34250847144 scopus 로고    scopus 로고
    • Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase
    • Parikh UM, Zelina S, Sluis-Cremer N, Mellors JW. Molecular mechanisms of bidirectional antagonism between K65R and thymidine analog mutations in HIV-1 reverse transcriptase. AIDS. 2007;21(11):1405-1414.
    • (2007) AIDS. , vol.21 , Issue.11 , pp. 1405-1414
    • Parikh, U.M.1    Zelina, S.2    Sluis-Cremer, N.3    Mellors, J.W.4
  • 33
    • 33748052358 scopus 로고    scopus 로고
    • Antagonism between the HIV-1 reverse-transcriptase mutation K65R and thymidine-analogue mutations at the genomic level
    • Parikh UM, Barnas DC, Faruki H, Mellors JW. Antagonism between the HIV-1 reverse-transcriptase mutation K65R and thymidine-analogue mutations at the genomic level. J Infect Dis. 2006;194(5):651-660.
    • (2006) J Infect Dis. , vol.194 , Issue.5 , pp. 651-660
    • Parikh, U.M.1    Barnas, D.C.2    Faruki, H.3    Mellors, J.W.4
  • 34
    • 42549164299 scopus 로고    scopus 로고
    • Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovir
    • von Wyl V, Yerly S, Böni J, et al. Factors associated with the emergence of K65R in patients with HIV-1 infection treated with combination antiretroviral therapy containing tenofovir. Clin Infect Dis. 2008;46(8):1299-1309.
    • (2008) Clin Infect Dis. , vol.46 , Issue.8 , pp. 1299-1309
    • von Wyl, V.1    Yerly, S.2    Böni, J.3
  • 35
    • 0036376786 scopus 로고    scopus 로고
    • Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure
    • Antinori A, Zaccarelli M, Cingolani A, et al. Cross-resistance among nonnucleoside reverse transcriptase inhibitors limits recycling efavirenz after nevirapine failure. AIDS Res Hum Retroviruses. 2002;18(12):835-838.
    • (2002) AIDS Res Hum Retroviruses. , vol.18 , Issue.12 , pp. 835-838
    • Antinori, A.1    Zaccarelli, M.2    Cingolani, A.3
  • 36
    • 58149505548 scopus 로고    scopus 로고
    • HIV-1 genotype algorithms for prediction of etravirine susceptibility: Novel mutations and weighting factors identified through correlations to phenotype
    • Benhamida J, Chappey C, Coakley E, Parkin NT. HIV-1 genotype algorithms for prediction of etravirine susceptibility: novel mutations and weighting factors identified through correlations to phenotype. [Abstract 130.] Antivir Ther. 2008;13:A142.
    • (2008) Antivir Ther. , vol.13
    • Benhamida, J.1    Chappey, C.2    Coakley, E.3    Parkin, N.T.4
  • 37
    • 58149515307 scopus 로고    scopus 로고
    • Biological and clinical cut-off analyses for etravirine in the PhenoSense HIV assay
    • Coakley E, Chappey C, Benhamida J, et al. Biological and clinical cut-off analyses for etravirine in the PhenoSense HIV assay. [Abstract 122.] Antivir Ther. 2008;13:A134.
    • (2008) Antivir Ther. , vol.13
    • Coakley, E.1    Chappey, C.2    Benhamida, J.3
  • 38
    • 77649254869 scopus 로고    scopus 로고
    • Resistance profile of etravirine: Combined analysis of baseline genotypic and phenotypic data from the randomized, controlled Phase III clinical studies
    • Vingerhoets J, Tambuyzer L, Azijn H, et al. Resistance profile of etravirine: combined analysis of baseline genotypic and phenotypic data from the randomized, controlled Phase III clinical studies. AIDS. 2010;24(4):503-514.
    • (2010) AIDS. , vol.24 , Issue.4 , pp. 503-514
    • Vingerhoets, J.1    Tambuyzer, L.2    Azijn, H.3
  • 39
    • 82455164684 scopus 로고    scopus 로고
    • Improved genotypic algorithm for predicting etravirine susceptibility: Comprehensive list of mutations identified through correlation with matched phenotype
    • [Abstract 574.], February 16-19,; San Francisco, CA
    • Haddad M, Stawiski E, Benhamida J, Coakley E. Improved genotypic algorithm for predicting etravirine susceptibility: comprehensive list of mutations identified through correlation with matched phenotype. [Abstract 574.] 17th Conference on Retroviruses and Opportunistic Infections (CROI). February 16-19, 2010; San Francisco, CA.
    • (2010) 17th Conference on Retroviruses and Opportunistic Infections (CROI)
    • Haddad, M.1    Stawiski, E.2    Benhamida, J.3    Coakley, E.4
  • 40
    • 77649198248 scopus 로고    scopus 로고
    • Bridgewater, NJ: Tibotec Therapeutics
    • Etravirine [package insert]. Bridgewater, NJ: Tibotec Therapeutics; 2008.
    • (2008) Etravirine [package insert]
  • 41
    • 70449601946 scopus 로고    scopus 로고
    • Prevalence of etravirine mutations and impact on response to treatment in routine clinical care: The Swiss HIV Cohort Study (SHCS)
    • Scherrer AU, Hasse B, Von Wyl V, et al. Prevalence of etravirine mutations and impact on response to treatment in routine clinical care: the Swiss HIV Cohort Study (SHCS). HIV Med. 2009;10(10):647-656.
    • (2009) HIV Med. , vol.10 , Issue.10 , pp. 647-656
    • Scherrer, A.U.1    Hasse, B.2    von Wyl, V.3
  • 42
    • 80055110312 scopus 로고    scopus 로고
    • Effect of mutations at position E138 in HIV-1 reverse transcriptase on phenotypic susceptibility and virologic response to etravirine
    • Tambuyzer L, Nijs S, Daems B, Picchio G, Vingerhoets J. Effect of mutations at position E138 in HIV-1 reverse transcriptase on phenotypic susceptibility and virologic response to etravirine. JAIDS. 2011;58(1):18-22.
    • (2011) JAIDS. , vol.58 , Issue.1 , pp. 18-22
    • Tambuyzer, L.1    Nijs, S.2    Daems, B.3    Picchio, G.4    Vingerhoets, J.5
  • 43
    • 84887130146 scopus 로고    scopus 로고
    • Baseline and emerging resistance to etravirine in HIV-infected children and adolescents: Final results from the Phase II PIANO Study
    • Tambuyzer L, Nijs S, Tomaka F, Picchio G, Vingerhoets J. Baseline and emerging resistance to etravirine in HIV-infected children and adolescents: final results from the Phase II PIANO Study. [Abstract 47.] Antivir Ther. 2012;17:A58.
    • (2012) Antivir Ther. , vol.17
    • Tambuyzer, L.1    Nijs, S.2    Tomaka, F.3    Picchio, G.4    Vingerhoets, J.5
  • 44
    • 84876391037 scopus 로고    scopus 로고
    • Titusville, NJ: Tibotec Pharmaceuticals
    • Rilpivirine [package insert]. Titusville, NJ: Tibotec Pharmaceuticals; 2011.
    • (2011) Rilpivirine [package insert]
  • 45
    • 75749118495 scopus 로고    scopus 로고
    • TMC278, a next-generation nonnucleoside reverse tran scriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1
    • Azijn H, Tirry I, Vingerhoets J, et al. TMC278, a next-generation nonnucleoside reverse tran scriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. Antimicrob Agents Chemother. 2010;54(2):718-727.
    • (2010) Antimicrob Agents Chemother. , vol.54 , Issue.2 , pp. 718-727
    • Azijn, H.1    Tirry, I.2    Vingerhoets, J.3
  • 47
    • 83655198855 scopus 로고    scopus 로고
    • Impact of HIV-1 reverse transcriptase E138 mutations on rilpivirine drug susceptibility
    • Haddad M, Napolitano LA, Paquet AC, et al. Impact of HIV-1 reverse transcriptase E138 mutations on rilpivirine drug susceptibility. [Abstract 10.] Antivir Ther. 2011;16:A18.
    • (2011) Antivir Ther. , vol.16
    • Haddad, M.1    Napolitano, L.A.2    Paquet, A.C.3
  • 48
    • 79960358849 scopus 로고    scopus 로고
    • Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): A phase 3, randomised, non-inferiority trial
    • Cohen CJ, Andrade-Villanueva J, Clotet B, et al. Rilpivirine versus efavirenz with two background nucleoside or nucleotide reverse transcriptase inhibitors in treatment-naive adults infected with HIV-1 (THRIVE): a phase 3, randomised, non-inferiority trial. Lancet. 2011;378(9787):229-237.
    • (2011) Lancet. , vol.378 , Issue.9787 , pp. 229-237
    • Cohen, C.J.1    Andrade-Villanueva, J.2    Clotet, B.3
  • 49
    • 79960381844 scopus 로고    scopus 로고
    • Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): A phase 3 randomised double-blind active-controlled trial
    • Molina JM, Cahn P, Grinsztejn B, et al. Rilpivirine versus efavirenz with tenofovir and emtricitabine in treatment-naive adults infected with HIV-1 (ECHO): a phase 3 randomised double-blind active-controlled trial. Lancet. 2011;378(9787):238-246.
    • (2011) Lancet. , vol.378 , Issue.9787 , pp. 238-246
    • Molina, J.M.1    Cahn, P.2    Grinsztejn, B.3
  • 50
    • 83655163698 scopus 로고    scopus 로고
    • Genotypic and phenotypic characterization of HIV-1 isolates obtained from patients on rilpivirine therapy experiencing virologic failure in the phase 3 ECHO and THRIVE studies: 48-week analysis
    • Rimsky L, Vingerhoets J, Van Eygen V, et al. Genotypic and phenotypic characterization of HIV-1 isolates obtained from patients on rilpivirine therapy experiencing virologic failure in the phase 3 ECHO and THRIVE studies: 48-week analysis. JAIDS. 2012;59(1):39-46.
    • (2012) JAIDS. , vol.59 , Issue.1 , pp. 39-46
    • Rimsky, L.1    Vingerhoets, J.2    van Eygen, V.3
  • 51
    • 83655201316 scopus 로고    scopus 로고
    • The HIV-1 reverse transcriptase M184I mutation enhances the E138K-associated resistance to rilpivirine and decreases viral fitness
    • Kulkarni R, Babaoglu K, Lansdon EB, et al. The HIV-1 reverse transcriptase M184I mutation enhances the E138K-associated resistance to rilpivirine and decreases viral fitness. JAIDS. 2012;59(1):47-54.
    • (2012) JAIDS. , vol.59 , Issue.1 , pp. 47-54
    • Kulkarni, R.1    Babaoglu, K.2    Lansdon, E.B.3
  • 52
    • 80055103177 scopus 로고    scopus 로고
    • Interaction of reverse transcriptase (RT) mutations conferring resistance to lamivudine and etravirine: Effects on fitness and RT activity of human immunodeficiency virus type 1
    • Hu Z, Kuritzkes DR. Interaction of reverse transcriptase (RT) mutations conferring resistance to lamivudine and etravirine: effects on fitness and RT activity of human immunodeficiency virus type 1. J Virol. 2011;85(21):11309-11314.
    • (2011) J Virol. , vol.85 , Issue.21 , pp. 11309-11314
    • Hu, Z.1    Kuritzkes, D.R.2
  • 53
    • 80055119045 scopus 로고    scopus 로고
    • Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations
    • Xu HT, Asahchop EL, Oliveira M, et al. Compensation by the E138K mutation in HIV-1 reverse transcriptase for deficits in viral replication capacity and enzyme processivity associated with the M184I/V mutations. J Virol. 2011;85(21):11300-11308.
    • (2011) J Virol. , vol.85 , Issue.21 , pp. 11300-11308
    • Xu, H.T.1    Asahchop, E.L.2    Oliveira, M.3
  • 54
    • 46349112103 scopus 로고    scopus 로고
    • Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel
    • Hirsch MS, Günthard HF, Schapiro JM, et al. Antiretroviral drug resistance testing in adult HIV-1 infection: 2008 recommendations of an International AIDS Society-USA panel. Clin Infect Dis. 2008;47(2):266-285.
    • (2008) Clin Infect Dis. , vol.47 , Issue.2 , pp. 266-285
    • Hirsch, M.S.1    Günthard, H.F.2    Schapiro, J.M.3
  • 55
    • 78049257332 scopus 로고    scopus 로고
    • Prevalence, mutation patterns, and effects on protease inhibitor susceptibility of the L76V mutation in HIV-1 protease
    • Young TP, Parkin NT, Stawiski E, et al. Prevalence, mutation patterns, and effects on protease inhibitor susceptibility of the L76V mutation in HIV-1 protease. Antimicrob Agents Chemother. 2010;54(11):4903-4906.
    • (2010) Antimicrob Agents Chemother. , vol.54 , Issue.11 , pp. 4903-4906
    • Young, T.P.1    Parkin, N.T.2    Stawiski, E.3
  • 56
    • 77749317669 scopus 로고    scopus 로고
    • Confirmation of the negative impact of protease mutations I47V, I54M, T74P and I84V and the positive impact of protease mutation V82A on virological response to darunavir/ritonavir
    • De Meyer S, Descamps D, Van Baelen B, et al. Confirmation of the negative impact of protease mutations I47V, I54M, T74P and I84V and the positive impact of protease mutation V82A on virological response to darunavir/ritonavir. [Abstract 126.] Antivir Ther. 2009;14:A147.
    • (2009) Antivir Ther. , vol.14
    • de Meyer, S.1    Descamps, D.2    van Baelen, B.3
  • 57
    • 60749130473 scopus 로고    scopus 로고
    • Mutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients
    • Descamps D, Lambert-Niclot S, Marcelin AG, et al. Mutations associated with virological response to darunavir/ritonavir in HIV-1-infected protease inhibitor-experienced patients. J Antimicrob Chemother. 2009;63(3):585-592.
    • (2009) J Antimicrob Chemother. , vol.63 , Issue.3 , pp. 585-592
    • Descamps, D.1    Lambert-Niclot, S.2    Marcelin, A.G.3
  • 58
    • 35748933494 scopus 로고    scopus 로고
    • Update of the drug resistance mutations in HIV-1: 2007
    • Johnson VA, Brun-Vézinet F, Clotet B, et al. Update of the drug resistance mutations in HIV-1: 2007. Top HIV Med. 2007;15(4):119-125.
    • (2007) Top HIV Med. , vol.15 , Issue.4 , pp. 119-125
    • Johnson, V.A.1    Brun-Vézinet, F.2    Clotet, B.3
  • 59
    • 70349189262 scopus 로고    scopus 로고
    • Phenotypic and genotypic determinants of resistance to darunavir: Analysis of data from treatment-experienced patients in POWER 1, 2, 3 and DUET-1 and 2
    • De Meyer S, Dierynck I, Lathouwers E, et al. Phenotypic and genotypic determinants of resistance to darunavir: analysis of data from treatment-experienced patients in POWER 1, 2, 3 and DUET-1 and 2. [Abstract 31.] Antivir Ther. 2008;13:A33.
    • (2008) Antivir Ther. , vol.13
    • de Meyer, S.1    Dierynck, I.2    Lathouwers, E.3
  • 60
    • 0036720761 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 genotypic and pharmacokinetic determinants of the virological response to lopinavir-ritonavir-containing therapy in protease inhibitor-experienced patients
    • Masquelier B, Breilh D, Neau D, et al. Human immunodeficiency virus type 1 genotypic and pharmacokinetic determinants of the virological response to lopinavir-ritonavir-containing therapy in protease inhibitor-experienced patients. Antimicrob Agents Chemother. 2002;46(9):2926-2932.
    • (2002) Antimicrob Agents Chemother. , vol.46 , Issue.9 , pp. 2926-2932
    • Masquelier, B.1    Breilh, D.2    Neau, D.3
  • 61
    • 0034909925 scopus 로고    scopus 로고
    • Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients
    • Kempf DJ, Isaacson JD, King MS, et al. Identification of genotypic changes in human immunodeficiency virus protease that correlate with reduced susceptibility to the protease inhibitor lopinavir among viral isolates from protease inhibitor-experienced patients. J Virol. 2001;75(16):7462-7469.
    • (2001) J Virol. , vol.75 , Issue.16 , pp. 7462-7469
    • Kempf, D.J.1    Isaacson, J.D.2    King, M.S.3
  • 63
    • 14744283486 scopus 로고    scopus 로고
    • Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir-and ritonavir-based therapy: Mutation patterns and baseline correlates
    • Mo H, King MS, King K, Molla A, Brun S, Kempf DJ. Selection of resistance in protease inhibitor-experienced, human immunodeficiency virus type 1-infected subjects failing lopinavir-and ritonavir-based therapy: mutation patterns and baseline correlates. J Virol. 2005;79(6):3329-3338.
    • (2005) J Virol. , vol.79 , Issue.6 , pp. 3329-3338
    • Mo, H.1    King, M.S.2    King, K.3    Molla, A.4    Brun, S.5    Kempf, D.J.6
  • 64
    • 4744349522 scopus 로고    scopus 로고
    • Isolated lopinavir resistance after virological rebound of a ritonavir/lopinavir-based regimen
    • Friend J, Parkin N, Liegler T, Martin JN, Deeks SG. Isolated lopinavir resistance after virological rebound of a ritonavir/lopinavir-based regimen. AIDS. 2004;18(14):1965-1966.
    • (2004) AIDS. , vol.18 , Issue.14 , pp. 1965-1966
    • Friend, J.1    Parkin, N.2    Liegler, T.3    Martin, J.N.4    Deeks, S.G.5
  • 65
    • 22244462118 scopus 로고    scopus 로고
    • Structural analysis of an HIV-1 protease I47A mutant resistant to the protease inhibitor lopinavir
    • Kagan RM, Shenderovich M, Heseltine PN, Ramnarayan K. Structural analysis of an HIV-1 protease I47A mutant resistant to the protease inhibitor lopinavir. Protein Sci. 2005;14(7):1870-1878.
    • (2005) Protein Sci. , vol.14 , Issue.7 , pp. 1870-1878
    • Kagan, R.M.1    Shenderovich, M.2    Heseltine, P.N.3    Ramnarayan, K.4
  • 66
    • 4344641898 scopus 로고    scopus 로고
    • Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases
    • Gonzalez LM, Brindeiro RM, Aguiar RS, et al. Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases. Antimicrob Agents Chemother. 2004;48(9):3552-3555.
    • (2004) Antimicrob Agents Chemother. , vol.48 , Issue.9 , pp. 3552-3555
    • Gonzalez, L.M.1    Brindeiro, R.M.2    Aguiar, R.S.3
  • 67
    • 77957351212 scopus 로고    scopus 로고
    • HIV-1 protease mutations and protease inhibitor cross-resistance
    • Rhee SY, Taylor J, Fessel WJ, et al. HIV-1 protease mutations and protease inhibitor cross-resistance. Antimicrob Agents Chemo-ther. 2010;54(10):4253-4261.
    • (2010) Antimicrob Agents Chemo-ther. , vol.54 , Issue.10 , pp. 4253-4261
    • Rhee, S.Y.1    Taylor, J.2    Fessel, W.J.3
  • 68
    • 78651098695 scopus 로고    scopus 로고
    • Improving the prediction of virological response to tipranavir: The development and validation of a tipranavir-weighted mutation score
    • Schapiro JM, Scherer J, Boucher CA, et al. Improving the prediction of virological response to tipranavir: the development and validation of a tipranavir-weighted mutation score. Antivir Ther. 2010;15(7):1011-1019.
    • (2010) Antivir Ther. , vol.15 , Issue.7 , pp. 1011-1019
    • Schapiro, J.M.1    Scherer, J.2    Boucher, C.A.3
  • 69
    • 50949126474 scopus 로고    scopus 로고
    • Tipranavir-ritonavir genotypic resistance score in protease inhibitor-experienced patients
    • Marcelin AG, Masquelier B, Descamps D, et al. Tipranavir-ritonavir genotypic resistance score in protease inhibitor-experienced patients. Antimicrob Agents Chemother. 2008;52(9):3237-3243.
    • (2008) Antimicrob Agents Chemother. , vol.52 , Issue.9 , pp. 3237-3243
    • Marcelin, A.G.1    Masquelier, B.2    Descamps, D.3
  • 70
    • 0037059049 scopus 로고    scopus 로고
    • Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
    • Reeves JD, Gallo SA, Ahmad N, et al. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc Natl Acad Sci USA. 2002;99(25):16249-16254.
    • (2002) Proc Natl Acad Sci USA. , vol.99 , Issue.25 , pp. 16249-16254
    • Reeves, J.D.1    Gallo, S.A.2    Ahmad, N.3
  • 71
    • 2342514225 scopus 로고    scopus 로고
    • Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity
    • Reeves JD, Miamidian JL, Biscone MJ, et al. Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity. J Virol. 2004;78(10):5476-5485.
    • (2004) J Virol. , vol.78 , Issue.10 , pp. 5476-5485
    • Reeves, J.D.1    Miamidian, J.L.2    Biscone, M.J.3
  • 72
    • 20044371998 scopus 로고    scopus 로고
    • Emergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41
    • Xu L, Pozniak A, Wildfire A, et al. Emergence and evolution of enfuvirtide resistance following long-term therapy involves heptad repeat 2 mutations within gp41. Antimicrob Agents Chemother. 2005;49(3):1113-1119.
    • (2005) Antimicrob Agents Chemother. , vol.49 , Issue.3 , pp. 1113-1119
    • Xu, L.1    Pozniak, A.2    Wildfire, A.3
  • 73
    • 84860837386 scopus 로고    scopus 로고
    • Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance
    • Anastassopoulou CG, Ketas TJ, Sanders RW, Klasse PJ, Moore JP. Effects of sequence changes in the HIV-1 gp41 fusion peptide on CCR5 inhibitor resistance. Virology. 2012;428(2):86-97.
    • (2012) Virology. , vol.428 , Issue.2 , pp. 86-97
    • Anastassopoulou, C.G.1    Ketas, T.J.2    Sanders, R.W.3    Klasse, P.J.4    Moore, J.P.5
  • 74
    • 78751697293 scopus 로고    scopus 로고
    • In vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor
    • Kobayashi M, Yoshinaga T, Seki T, et al. In vitro antiretroviral properties of S/GSK1349572, a next-generation HIV integrase inhibitor. Antimicrob Agents Chemother. 2011;55(2):813-821.
    • (2011) Antimicrob Agents Chemother. , vol.55 , Issue.2 , pp. 813-821
    • Kobayashi, M.1    Yoshinaga, T.2    Seki, T.3
  • 75
    • 79952653025 scopus 로고    scopus 로고
    • Activity of the integrase inhibitor S/GSK1349572 in subjects with HIV exhibiting raltegravir resistance: Week 24 results of the VIKING study (ING112961)
    • Eron J, Livrozet JM, Morlat P, et al. Activity of the integrase inhibitor S/GSK1349572 in subjects with HIV exhibiting raltegravir resistance: week 24 results of the VIKING study (ING112961). J Int AIDS Soc. 2010;13(Suppl 4):O51.
    • (2010) J Int AIDS Soc. , vol.13 , Issue.SUPPL. 4
    • Eron, J.1    Livrozet, J.M.2    Morlat, P.3
  • 76
    • 84877859630 scopus 로고    scopus 로고
    • Dolutegravir treatment of HIV subjects with raltegravir resistance: Integrase resistance evolution in cohort II of the VIKING study
    • [Abstract 5.]
    • Vavro CL, Dudas KC, Hasan S, Huang JO, Yeo JM, Underwood MR. Dolutegravir treatment of HIV subjects with raltegravir resistance: integrase resistance evolution in cohort II of the VIKING study. [Abstract 5.] Antivir Ther. 2012;Suppl 1.
    • (2012) Antivir Ther , vol.1
    • Vavro, C.L.1    Dudas, K.C.2    Hasan, S.3    Huang, J.O.4    Yeo, J.M.5    Underwood, M.R.6
  • 77
    • 84878883987 scopus 로고    scopus 로고
    • HIV integrase resistance profiles and S/GSK1349572 baseline phenotypic susceptibility for individuals experiencing virologic failure on raltegravir and enrolling in the VIKING Phase IIb Pilot Study (ING112961)
    • [Abstract 50]. June 8-12, Dubrovnik, Croatia
    • Clotet B, Katlama C, Lalezari J, et al. HIV integrase resistance profiles and S/GSK1349572 baseline phenotypic susceptibility for individuals experiencing virologic failure on raltegravir and enrolling in the VIKING Phase IIb Pilot Study (ING112961). [Abstract 50.] 19th International HIV & Hepatitis Virus Resistance Workshop & Curative Strategies. June 8-12, 2010; Dubrovnik, Croatia.
    • (2010) 19th International HIV & Hepatitis Virus Resistance Workshop & Curative Strategies
    • Clotet, B.1    Katlama, C.2    Lalezari, J.3
  • 78
    • 84874411899 scopus 로고    scopus 로고
    • Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study
    • Raffi F, Rachlis A, Stellbrink HJ, et al. Once-daily dolutegravir versus raltegravir in antiretroviral-naive adults with HIV-1 infection: 48 week results from the randomised, double-blind, non-inferiority SPRING-2 study. Lancet. 2013;381(9868)735-743.
    • (2013) Lancet. , vol.381 , Issue.9868 , pp. 735-743
    • Raffi, F.1    Rachlis, A.2    Stellbrink, H.J.3
  • 79
    • 84873633830 scopus 로고    scopus 로고
    • Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study
    • Eron JJ, Clotet B, Durant J, et al. Safety and efficacy of dolutegravir in treatment-experienced subjects with raltegravir-resistant HIV type 1 infection: 24-week results of the VIKING Study. J Infect Dis. 2013;207(5):740-748.
    • (2013) J Infect Dis. , vol.207 , Issue.5 , pp. 740-748
    • Eron, J.J.1    Clotet, B.2    Durant, J.3
  • 81
    • 84867399598 scopus 로고    scopus 로고
    • A high barrier to resistance for dolutegravir (DTG, S/GSK1349572) against raltegravir resistant Y143 mutants: An in vitro passage study
    • [Abstract 51]. June 5-9, Sitges, Spain
    • Seki T, Kobayashi M, Miki S, et al. A high barrier to resistance for dolutegravir (DTG, S/GSK1349572) against raltegravir resistant Y143 mutants: an in vitro passage study. [Abstract 51.] 21st International Workshop on HIV & Hepatitis Virus Drug Resistance and Curative Strategies. June 5-9, 2012; Sitges, Spain.
    • (2012) 21st International Workshop on HIV & Hepatitis Virus Drug Resistance and Curative Strategies
    • Seki, T.1    Kobayashi, M.2    Miki, S.3
  • 82
    • 52749097450 scopus 로고    scopus 로고
    • Integrase inhibitor resistance involves complex interactions among primary and second resistance mutations: A novel mutation L68V/I associates with E92Q and increases resistance
    • Goodman D, Hluhanich R, Waters J, et al. Integrase inhibitor resistance involves complex interactions among primary and second resistance mutations: a novel mutation L68V/I associates with E92Q and increases resistance. [Abstract 13.] Antivir Ther. 2008;13:A15.
    • (2008) Antivir Ther. , vol.13
    • Goodman, D.1    Hluhanich, R.2    Waters, J.3
  • 83
    • 77953602761 scopus 로고    scopus 로고
    • Evolution of resistance to the HIV integrase inhibitor (INI) elvitegravir can involve genotypic switching among primary INI resistance patterns
    • Waters J, Margot N, Hluhanich R, et al. Evolution of resistance to the HIV integrase inhibitor (INI) elvitegravir can involve genotypic switching among primary INI resistance patterns. [Abstract 116.] Antivir Ther. 2009;14:A137.
    • (2009) Antivir Ther. , vol.14
    • Waters, J.1    Margot, N.2    Hluhanich, R.3
  • 84
    • 79952692178 scopus 로고    scopus 로고
    • Prevalence and patterns of raltegravir resistance in treated patients in Europe
    • Geretti AM, Fearnhill E, Ceccherini-Silberstein F, et al. Prevalence and patterns of raltegravir resistance in treated patients in Europe. [Abstract 51.] Antivir Ther. 2010;159:A62.
    • (2010) Antivir Ther. , vol.159
    • Geretti, A.M.1    Fearnhill, E.2    Ceccherini-Silberstein, F.3
  • 85
    • 84878886967 scopus 로고    scopus 로고
    • Effect of primary elvitegravir resistance mutations in HIV-1 integrase on drug susceptibility and viral replicative fitness
    • [Abstract 3.]
    • Abram ME, Hluhanich RM, Goodman DD, et al. Effect of primary elvitegravir resistance mutations in HIV-1 integrase on drug susceptibility and viral replicative fitness. [Abstract 3.] Antivir Ther. 2012;17.
    • (2012) Antivir Ther. , vol.17
    • Abram, M.E.1    Hluhanich, R.M.2    Goodman, D.D.3
  • 86
    • 84878828175 scopus 로고    scopus 로고
    • Integrated analysis of emergent drug resistance from the HIV-1 Phase 3 QUAD studies through week 48
    • White KL, Kulkarni R, Szwareberg J, Quirk E, Cheng AK, Miles AJG. Integrated analysis of emergent drug resistance from the HIV-1 Phase 3 QUAD studies through week 48. [Abstract 4.] Antivir Ther. 2012;17:A11.
    • (2012) Antivir Ther. , vol.17
    • White, K.L.1    Kulkarni, R.2    Szwareberg, J.3    Quirk, E.4    Cheng, A.K.5    Miles, A.J.G.6
  • 87
    • 84862876886 scopus 로고    scopus 로고
    • Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: A randomised, double-blind, phase 3 trial, analysis of results after 48 weeks
    • Sax PE, DeJesus E, Mills A, et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus co-formulated efavirenz, emtricitabine, and tenofovir for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3 trial, analysis of results after 48 weeks. Lancet. 2012;379(9835):2439-2448.
    • (2012) Lancet. , vol.379 , Issue.9835 , pp. 2439-2448
    • Sax, P.E.1    DeJesus, E.2    Mills, A.3
  • 88
    • 84862843404 scopus 로고    scopus 로고
    • Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: A randomised, double-blind, phase 3, non-inferiority trial
    • DeJesus E, Rockstroh J, Henry K, et al. Co-formulated elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate versus ritonavir-boosted atazanavir plus co-formulated emtricitabine and tenofovir disoproxil fumarate for initial treatment of HIV-1 infection: a randomised, double-blind, phase 3, non-inferiority trial. Lancet. 2012;379(9835):2429-2438.
    • (2012) Lancet. , vol.379 , Issue.9835 , pp. 2429-2438
    • DeJesus, E.1    Rockstroh, J.2    Henry, K.3
  • 89
    • 37249065868 scopus 로고    scopus 로고
    • Resistance to the HIV-integrase inhibitor raltegravir: Analysis of protocol 005, a phase II study in patients with triple-class resistant HIV-1 infection
    • for the P005 Study Team
    • Hazuda DF, Miller MD, Nguyen BY, Zhao J, for the P005 Study Team. Resistance to the HIV-integrase inhibitor raltegravir: analysis of protocol 005, a phase II study in patients with triple-class resistant HIV-1 infection. Antivir Ther. 2007;12:S10.
    • (2007) Antivir Ther. , vol.12
    • Hazuda, D.F.1    Miller, M.D.2    Nguyen, B.Y.3    Zhao, J.4
  • 90
    • 77949381837 scopus 로고    scopus 로고
    • Long-term efficacy and safety of the HIV integrase inhibitor raltegravir in patients with limited treatment options in a Phase II study
    • Gatell JM, Katlama C, Grinsztejn B, et al. Long-term efficacy and safety of the HIV integrase inhibitor raltegravir in patients with limited treatment options in a Phase II study. JAIDS. 2010;53(4):456-463.
    • (2010) JAIDS. , vol.53 , Issue.4 , pp. 456-463
    • Gatell, J.M.1    Katlama, C.2    Grinsztejn, B.3
  • 91
    • 70350666377 scopus 로고    scopus 로고
    • Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways
    • Fransen S, Gupta S, Danovich R, et al. Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways. J Virol. 2009;83(22):11440-11446.
    • (2009) J Virol. , vol.83 , Issue.22 , pp. 11440-11446
    • Fransen, S.1    Gupta, S.2    Danovich, R.3
  • 92
    • 77955504896 scopus 로고    scopus 로고
    • Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy
    • Hatano H, Lampiris H, Fransen S, et al. Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy. J Acquir Immune Defic Syndr. 2010;54(4):389-393.
    • (2010) J Acquir Immune Defic Syndr. , vol.54 , Issue.4 , pp. 389-393
    • Hatano, H.1    Lampiris, H.2    Fransen, S.3
  • 93
    • 65749106963 scopus 로고    scopus 로고
    • Virological and immunological response in HIV-1-infected patients with multiple treatment failures receiving raltegravir and optimized background therapy, ANRS CO3 Aquitaine Cohort
    • Wittkop L, Breilh D, Da Silva D, et al. Virological and immunological response in HIV-1-infected patients with multiple treatment failures receiving raltegravir and optimized background therapy, ANRS CO3 Aquitaine Cohort. J Antimicrob Chemother. 2009;63(6):1251-1255.
    • (2009) J Antimicrob Chemother. , vol.63 , Issue.6 , pp. 1251-1255
    • Wittkop, L.1    Breilh, D.2    da Silva, D.3
  • 94
    • 84856247092 scopus 로고    scopus 로고
    • Study of genotypic and phenotypic HIV-1 dynamics of integrase mutations during raltegravir treatment: A refined analysis by ultra-deep 454 pyrosequencing
    • Armenia D, Vandenbroucke I, Fabeni L, et al. Study of genotypic and phenotypic HIV-1 dynamics of integrase mutations during raltegravir treatment: a refined analysis by ultra-deep 454 pyrosequencing. J Infect Dis. 2012;205(4):557-567.
    • (2012) J Infect Dis. , vol.205 , Issue.4 , pp. 557-567
    • Armenia, D.1    Vandenbroucke, I.2    Fabeni, L.3
  • 95
    • 47949114939 scopus 로고    scopus 로고
    • Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
    • Cooper DA, Steigbigel RT, Gatell JM, et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med. 2008;359(4):355-365.
    • (2008) N Engl J Med. , vol.359 , Issue.4 , pp. 355-365
    • Cooper, D.A.1    Steigbigel, R.T.2    Gatell, J.M.3
  • 96
    • 42049119625 scopus 로고    scopus 로고
    • Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
    • Malet I, Delelis O, Valantin MA, et al. Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. Antimicrob Agents Chemo-ther. 2008;52(4):1351-1358.
    • (2008) Antimicrob Agents Chemo-ther. , vol.52 , Issue.4 , pp. 1351-1358
    • Malet, I.1    Delelis, O.2    Valantin, M.A.3
  • 97
    • 79954626457 scopus 로고    scopus 로고
    • HIV-1 integrase inhibitor resistance and its clinical implications
    • Blanco JL, Varghese V, Rhee SY, Gatell JM, Shafer RW. HIV-1 integrase inhibitor resistance and its clinical implications. J Infect Dis. 2011;203(9):1204-1214.
    • (2011) J Infect Dis. , vol.203 , Issue.9 , pp. 1204-1214
    • Blanco, J.L.1    Varghese, V.2    Rhee, S.Y.3    Gatell, J.M.4    Shafer, R.W.5


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