Functional outcomes following multiple acute rejections in experimental vascularized composite allotransplantation

Plastic and Reconstructive Surgery

Volumn 131, Issue 5, 2013, Pages

  Unadkat, Jignesh V ^a   Bourbeau, Dennis ^a   Afrooz, Paul N ^a   Solari, Mario G ^a   Washington, Kia M ^a   Pulikkottil, Benson J ^a   Weber, Douglas J ^a   Lee, W P Andrew ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOSPORIN; DEXAMETHASONE; IMMUNOSUPPRESSIVE AGENT;

ACUTE DISEASE; ALLOTRANSPLANTATION; ANIMAL; ARTICLE; BROWN NORWAY RAT; CONVALESCENCE; DRUG PULSE THERAPY; GRAFT REJECTION; HINDLIMB; LEWIS RAT; LOCOMOTION; MALE; MUSCLE ATROPHY; NERVE CONDUCTION; NERVE REGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTOPERATIVE COMPLICATION; RAT; SCIATIC NERVE; TRANSPLANTATION;

ACUTE DISEASE; ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOSPORINE; DEXAMETHASONE; GRAFT REJECTION; HINDLIMB; IMMUNOSUPPRESSIVE AGENTS; LOCOMOTION; MALE; MUSCULAR ATROPHY; NERVE REGENERATION; NEURAL CONDUCTION; POSTOPERATIVE COMPLICATIONS; PULSE THERAPY, DRUG; RATS; RATS, INBRED BN; RATS, INBRED LEW; RECOVERY OF FUNCTION; SCIATIC NERVE; TRANSPLANTATION, HOMOLOGOUS;

MLCS; MLOWN;

EID: 84877738544     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e3182879e85     Document Type: Article

References (15)

1. Petruzzo P, Lanzetta M, Dubernard JM, et al. The International Registry on Hand and Composite Tissue Transplantation. Transplantation 2010;90:1590-1594.
2. Breidenbach WC, Gonzales NR, Kaufman CL, Klapheke M, Tobin GR, Gorantla VS. Outcomes of the first 2 American hand transplants at 8 and 6 years posttransplant. J Hand Surg Am. 2008;33:1039-1047.
3. Schneeberger S, Ninkovic M, Gabl M, et al. First forearm transplantation: Outcome at 3 years. Am J Transplant. 2007;7:1753-1762.
4. Landin L, Cavadas PC, Garcia-Cosmes P, Thione A, Vera- Sempere F. Perioperative ischemic injury and fibrotic degeneration of muscle in a forearm allograft: Functional follow-up at 32 months post transplantation. Ann Plast Surg. 2011;66:202-209.
5. Petruzzo P, Kanitakis J, Badet L, et al. Long-term follow-up in composite tissue allotransplantation: In-depth study of five (hand and face) recipients. Am J Transplant. 2011;11:808-816.
6. Jensen JN, Brenner MJ, Tung TH, Hunter DA, Mackinnon SE. Effect of FK506 on peripheral nerve regeneration through long grafts in inbred swine. Ann Plast Surg. 2005;54:420-427.
7. Nguyen VT, Taieb A, Sacks JM, et al. Allopeptide-pulsed dendritic cells and composite tissue allograft survival. Microsurgery 2007;27:105-111.
8. Unadkat JV, Schneeberger S, Horibe EH, et al. Composite tissue vasculopathy and degeneration following multiple episodes of acute rejection in reconstructive transplantation. Am J Transplant. 2010;10:251-261.
9. Sacks JM, Kuo YR, Taieb A, et al. Prolongation of composite tissue allograft survival by immature recipient dendritic cells pulsed with donor antigen and transient low-dose immunosuppression. Plast Reconstr Surg. 2008;121:37-49.
10. Thalhammer JG, Vladimirova M, Bershadsky B, Strichartz GR. Neurologic evaluation of the rat during sciatic nerve block with lidocaine. Anesthesiology 1995;82:1013-1025.
11. Kanitakis J, Petruzzo P, Jullien D, et al. Pathological score for the evaluation of allograft rejection in human hand (composite tissue) allotransplantation. Eur J Dermatol. 2005;15:235-238.
12. Landin L, Cavadas PC, Ibañez J, Roger I, Vera-Sempere F. CD3+-mediated rejection and C4d deposition in two composite tissue (bilateral hand) allograft recipients after induction with alemtuzumab. Transplantation 2009;87: 776-781.
13. Hautz T, Zelger B, Brandacher G, et al. Histopathologic characterization of mild rejection (grade I) in skin biopsies of human hand allografts. Transpl Int. 2012;25:56-63.
14. Moore AM, Ray WZ, Chenard KE, Tung T, Mackinnon SE. Nerve allotransplantation as it pertains to composite tissue transplantation. Hand (N Y) 2009;4:239-244.
15. Whitlock EL, Myckatyn TM, Tong AY, et al. Dynamic quantification of host Schwann cell migration into peripheral nerve allografts. Exp Neurol. 2010;225:310-319