The impact of acute mental stress on brachial artery flow-mediated dilation differs when shear stress is elevated by reactive hyperemia versus handgrip exercise

Applied Physiology, Nutrition and Metabolism

Volumn 38, Issue 5, 2013, Pages 498-506

  Szijgyarto, Ingrid C ^a   King, Trevor J ^a   Ku, Jennifer ^a   Poitras, Veronica J ^a   Gurd, Brendon J ^a   Pyke, Kyra E ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Conduit artery; Cortisol; Doppler ultrasound; Endothelial function; Flow mediated dilation; FMD; Psychological stress; Shear rate

Indexed keywords

BLOOD FLOW; BRACHIAL ARTERY; HAND STRENGTH; HUMAN; HYPEREMIA; VASODILATATION;

BRACHIAL ARTERY; HAND STRENGTH; HUMANS; HYPEREMIA; REGIONAL BLOOD FLOW; VASODILATION;

EID: 84877733324     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2012-0328     Document Type: Article

References (51)

1. Bellien, J., Iacob, M., Gutierrez, L., Isabelle, M., Lahary, A., Thuillez, C., et al. 2006. Crucial role of NO and endothelium-derived hyperpolarizing factor in human sustained conduit artery flow-mediated dilatation. Hypertension, 48: 1088-1094. doi:10.1161/01.HYP.0000246672.72188.bd. PMID:17075035.
2. Bellien, J., Costentin, A., Dutheil-Maillochaud, B., Iacob, M., Kuhn, J.M., Thuillez, C., et al. 2010. Early stage detection of conduit artery endothelial dysfunction in patients with type 1 diabetes. Diab. Vasc. Dis. Res. 7: 158-166. doi:10.1177/1479164109360470. PMID:20382780.
3. Black, P.H., and Garbutt, L.D. 2002. Stress, inflammation and cardiovascular disease. J. Psychosom. Res. 52: 1-23. doi:10.1016/S0022-3999(01)00302-6. PMID: 11801260.
4. Broadley, A.J., Korszun, A., Abdelaal, E., Moskvina, V., Jones, C.J., Nash, G.B., et al. 2005. Inhibition of cortisol production with metyrapone prevents mental stress-induced endothelial dysfunction and baroreflex impairment. J. Am. Coll. Cardiol. 46: 344-350. doi:10.1016/j.jacc.2005.03.068. PMID:16022966.
5. Celermajer, D.S., Sorensen, K.E., Gooch, V.M., Spiegelhalter, D.J., Miller, O.I., Sullivan, I.D., et al. 1992. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet, 340: 1111-1115. doi: 10.1016/0140-6736(92)93147-F. PMID:1359209.
6. Celermajer, D.S., Sorensen, K.E., Georgakopoulos, D., Bull, C., Thomas, O., Robinson, J., et al. 1993. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation, 88: 2149-2155. doi:10.1161/01.CIR.88.5. 2149. PMID:8222109.
7. Cunningham, K.S., and Gotlieb, A.I. 2005. The role of shear stress in the pathogenesis of atherosclerosis. Lab. Invest. 85: 9-23. doi:10.1038/labinvest. 3700215. PMID:15568038.
8. Dickerson, S.S., and Kemeny, M.E. 2004. Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research. Psychol. Bull. 130: 355-391. doi:10.1037/0033-2909.130.3.355. PMID:15122924.
9. Dyson, K.S., Shoemaker, J.K., and Hughson, R.L. 2006. Effect of acute sympathetic nervous system activation on flow-mediated dilation of brachial artery.Am.J.Physiol.HeartCirc.Physiol 290:H1446-H1453. doi:10.1152/ajpheart. 00771.2005. PMID:16284236.
10. Feletou, M., and Vanhoutte, P.M. 2006. Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture). Am. J. Physiol. Heart Circ. Physiol. 291: H985-H1002. doi:10.1152/ajpheart.00292.2006. PMID:16632549.
11. Gaenzer, H., Neumayr, G., Marschang, P., Sturm, W., Kirchmair, R., and Patsch, J.R. 2001. Flow-mediated vasodilation of the femoral and brachial artery induced by exercise in healthy nonsmoking and smoking men. J. Am. Coll. Cardiol. 38: 1313-1319. doi:10.1016/S0735-1097(01)01575-3. PMID:11691501.
12. Garde, A.H., and Hansen, A.M. 2005. Long-term stability of salivary cortisol. Scand. J. Clin. Lab. Invest. 65: 433-436. doi:10.1080/00365510510025773. PMID:16081365.
13. Ghiadoni, L., Donald, A.E., Cropley, M., Mullen, M.J., Oakley, G., Taylor, M., et al. 2000. Mental stress induces transient endothelial dysfunction in humans. Circulation, 102: 2473-2478. doi:10.1161/01.CIR.102.20.2473. PMID:11076819.
14. Gokce, N., Keaney, J.F., Jr., Hunter, L.M., Watkins, M.T., Nedeljkovic, Z.S., Menzoian, J.O., et al. 2003. Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J. Am. Coll. Cardiol. 41: 1769-1775. doi:10.1016/ S0735-1097(03)00333-4. PMID:12767663.
15. Gottdiener, J.S., Kop, W.J., Hausner, E., McCeney, M.K., Herrington, D., and Krantz, D.S. 2003. Effects of mental stress on flow-mediated brachial arterial dilation and influence of behavioral factors and hypercholesterolemia in subjects without cardiovascular disease. Am. J. Cardiol. 92: 687-691. doi:10. 1016/S0002-9149(03)00823-3. PMID:12972107.
16. Grzelak, P., Olszycki, M., Majos, A., Czupryniak, L., Strzelczyk, J., and Stefanczyk, L. 2010. Hand exercise test for the assessment of endothelium- dependent vasodilatation in subjects with type 1 diabetes. Diabetes Technol. Ther. 12: 605-611. doi:10.1089/dia.2010.0001. PMID:20615101.
17. Harkness, K.L., Stewart, J.G., and Wynne-Edwards, K.E. 2011. Cortisol reactivity to social stress in adolescents: role of depression severity and child maltreatment. Psychoneuroendocrinology, 36: 173-181. doi:10.1016/j.psyneuen.2010. 07.006. PMID:20688438.
18. Harris, C.W., Edwards, J.L., Baruch, A., Riley, W.A., Pusser, B.E., Rejeski, W.J., et al. 2000. Effects of mental stress on brachial artery flow-mediated vasodilation in healthy normal individuals. Am. Heart J. 139: 405-411. doi:10.1016/ S0002-8703(00)90083-8. PMID:10689254.
19. Hijmering, M.L., Stroes, E.S., Olijhoek, J., Hutten, B.A., Blankestijn, P.J., and Rabelink, T.J. 2002. Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. J. Am. Coll. Cardiol. 39: 683-688. doi:10.1016/S0735-1097(01)01786-7. PMID:11849869.
20. Jambrik, Z., Chunzeng, L., Santarcangelo, E.L., Sebastiani, L., Ghelarducci, B., and Picano, E. 2004a. Traditional acupuncture does not modulate the endothelial dysfunction induced by mental stress. Int. J. Cardiovasc. Imaging, 20: 357-362. doi:10.1023/B:CAIM.0000041939.61963.b0. PMID:15765857.
21. Jambrik, Z., Santarcangelo, E.L., Ghelarducci, B., Picano, E., and Sebastiani, L. 2004b. Does hypnotizability modulate the stress-related endothelial dysfunction? Brain Res. Bull. 63: 213-216. doi:10.1016/j.brainresbull.2004.01.011. PMID:15145140.
22. Jambrik, Z., Sebastiani, L., Picano, E., Ghelarducci, B., and Santarcangelo, E.L. 2005. Hypnotic modulation of flow-mediated endothelial response to mental stress. Int. J. Psychophysiol. 55: 221-227. doi:10.1016/j.ijpsycho.2004.07.007. PMID:15649553.
23. Jazuli, F., and Pyke, K.E. 2011. The impact of baseline artery diameter on flowmediated vasodilation: a comparison of brachial and radial artery responses to matched levels of shear stress. Am. J. Physiol. Heart Circ. Physiol. 301: H1667-H1677. doi:10.1152/ajpheart.00487.2011. PMID:21784988.
24. Kirschbaum, C., Pirke, K.M., and Hellhammer, D.H. 1993. The 'Trier Social Stress Test' - a tool for investigating psychobiological stress responses in a laboratory setting. Neuropsychobiology, 28: 76-81. doi:10.1159/000119004. PMID: 8255414.
25. Kirschbaum, C., Prussner, J.C., Stone, A.A., Federenko, I., Gaab, J., Lintz, D., et al. 1995. Persistent high cortisol responses to repeated psychological stress in a subpopulation of healthy men.Psychosom. Med. 57: 468-474. PMID:8552738.
26. Kunz-Ebrecht, S.R., Mohamed-Ali, V., Feldman, P.J., Kirschbaum, C., and Steptoe, A. 2003. Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines. Brain Behav. Immun. 17: 373-383. doi:10.1016/S0889-1591(03)00029-1. PMID:12946659.
27. Lind, L., Johansson, K., and Hall, J. 2002. The effects of mental stress and the cold pressure test on flow-mediated vasodilation. Blood Press, 11: 22-27. doi:10. 1080/080370502753543927. PMID:11926347.
28. Lynch, J.J., Long, J.M., Thomas, S.A., Malinow, K.L., and Katcher, A.H. 1981. The effects of talking on the blood pressure of hypertensive and normotensive individuals. Psychosom. Med. 43: 25-33.
29. Mullen, M.J., Kharbanda, R.K., Cross, J., Donald, A.E., Taylor, M., Vallance, P., et al. 2001. Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia. Circ. Res. 88: 145-151. doi:10.1161/01.RES.88.2.145. PMID:11157665.
30. Neunteufl, T., Katzenschlager, R., Hassan, A., Klaar, U., Schwarzacher, S., Glogar, D., et al 1997. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis, 129: 111-118. doi:10.1016/S0021-9150(96)06018-2. PMID:9069525.
31. Padilla, J., Harris, R.A., Fly, A.D., Rink, L.D., and Wallace, J.P. 2006. A comparison between active- and reactive-hyperaemia-induced brachial artery vasodilation. Clin. Sci. (Lond.), 110: 387-392. doi:10.1042/CS20050328. PMID:16356163.
32. Padilla, J., Johnson, B.D., Newcomer, S.C., Wilhite, D.P., Mickleborough, T.D., Fly, A.D., et al. 2008. Normalization of flow-mediated dilation to shear stress area under the curve eliminates the impact of variable hyperemic stimulus. Cardiovasc. Ultrasound, 6: 44. doi:10.1186/1476-7120-6-44. PMID:18771594.
33. Parker, B.A., Tschakovsky, M.E., Augeri, A.L., Polk, D.M., Thompson, P.D., and Kiernan, F.J. 2011. Heterogenous vasodilator pathways underlie flow-mediated dilation in men and women. Am. J. Physiol. Heart Circ. Physiol. 301: H1118-H1126. doi:10.1152/ajpheart.00400.2011. PMID:21642502.
34. Parkhurst, K.L., Lin, H.F., Devan, A.E., Barnes, J.N., Tarumi, T., and Tanaka, H. 2012. Contribution of blood viscosity in the assessment of flow-mediated dilation and arterial stiffness. Vasc. Med. 17: 231-234. doi:10.1177/1358863X12450095. PMID:22848085.
35. Patti, G., Pasceri, V., Melfi, R., Goffredo, C., Chello, M., D'Ambrosio, A., et al. 2005. Impaired flow-mediated dilation and risk of restenosis in patients undergoing coronary stent implantation. Circulation, 111: 70-75. doi:10.1161/01.CIR. 0000151308.06673.D2. PMID:15630038.
36. Pierce, G.L., Beske, S.D., Lawson, B.R., Southall, K.L., Benay, F.J., Donato, A.J., et al. 2008. Weight Loss Alone Improves Conduit and Resistance Artery Endothelial Function in Young and Older Overweight/Obese Adults. Hypertension, doi:10.1161/HYPERTENSIONAHA.108.111427. PMID:18504322.
37. Poll, E.M., Kreitschmann-Andermahr, I., Langejuergen, Y., Stanzel, S., Gilsbach, J.M., Gressner, A., et al 2007. Saliva collection method affects pre- dictability of serum cortisol. Clin. Chim. Acta, 382: 15-19. doi:10.1016/j.cca. 2007.03.009. PMID:17449021.
38. Pyke, K.E., and Jazuli, F. 2010. Impact of repeated increases in shear stress via reactive hyperaemia and handgrip exercise: No evidence of systematic changes in brachial artery FMD. Am. J. Physiol Heart Circ. Physiol. doi:10.1152/ ajpheart.00736.2010. PMID:21186268.
39. Pyke, K.E., and Tschakovsky, M.E. 2007. Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation?. J.Appl. Physiol 102: 1510-1519. doi:10.1152/japplphysiol.01024.2006. PMID:17170205.
40. Pyke, K.E., Hartnett, J.A., and Tschakovsky, M.E. 2008a. Are the dynamic response characteristics of brachial artery flow mediated dilation sensitive to the magnitude of increase in shear stimulus? J. Appl. Physiol 105: 282-292. doi:10.1152/japplphysiol.01190.2007. PMID:18467554.
41. Pyke, K.E., Poitras, V., and Tschakovsky, M.E. 2008b. Brachial artery flow mediated dilation during handgrip exercise: evidence for endothelial transduction of the mean shear stimulus. Am. J. Physiol. Heart Circ. Physiol. 294: H2669-H2679. doi:10.1152/ajpheart.01372.2007. PMID:18408123.
42. Pyke, K., Green, D.J., Weisbrod, C., Best, M., Dembo, L., O'Driscoll, G., et al. 2010. Nitric oxide is not obligatory for radial artery flow-mediated dilation following release of 5 or 10 min distal occlusion. Am. J. Physiol. Heart Circ. Physiol. 298: H119-H126. doi:10.1152/ajpheart.00571.2009. PMID:19880668.
43. Rogers, A.M., Saunders, N.R., Pyke, K.E., and Tschakovsky, M.E. 2006. Rapid vasoregulatory mechanisms in exercising human skeletal muscle: dynamic response to repeated changes in contraction intensity. Am. J. Physiol. Heart Circ. Physiol. 291: H1065-H1073. doi:10.1152/ajpheart.00368.2006. PMID:16679396.
44. Rozanski, A., Blumenthal, J.A., and Kaplan, J. 1999. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation, 99: 2192-2217. doi:10.1161/01.CIR.99.16.2192. PMID: 10217662.
45. Schommer, N.C., Hellhammer, D.H., and Kirschbaum, C. 2003. Dissociation between reactivity of the hypothalamus-pituitary-adrenal axis and the sympathetic-adrenal-medullary system to repeated psychosocial stress. Psychosom. Med. 65: 450-460. doi:10.1097/01.PSY.0000035721.12441.17. PMID: 12764219.
46. Spieker, L.E., Hurlimann, D., Ruschitzka, F., Corti, R., Enseleit, F., Shaw, S., et al. 2002. Mental stress induces prolonged endothelial dysfunction viaendothelin-A receptors. Circulation, 105: 2817-2820. doi:10.1161/01.CIR. 0000021598.15895.34. PMID:12070106.
47. Thijssen, D.H., Black, M.A., Pyke, K.E., Padilla, J., Atkinson, G., Harris, R.A., et al. 2011. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am. J. Physiol. Heart Circ. Physiol. 300: H2-H12. doi:10.1152/ajpheart.00471.2010. PMID:20952670.
48. Toda, N., and Nakanishi-Toda, M. 2011. How mental stress affects endothelial function. Pflugers Arch. 462: 779-794. doi:10.1007/s00424-011-1022-6. PMID: 21947555.
49. Woodman, R.J., Playford, D.A., Watts, G.F., Cheetham, C., Reed, C., Taylor, R.R., et al. 2001. Improved analysis of brachial artery ultrasound using a novel edge-detection software system. J. Appl. Physiol. 91: 929-937. PMID:11457812.
50. Wray, D.W., Witman, M.A., Ives, S.J., McDaniel, J., Fjeldstad, A.S., Trinity, J.D., et al. 2011. Progressive handgrip exercise: evidence of nitric oxide-dependent vasodilation and blood flow regulation in humans. Am. J. Physiol. Heart Circ. Physiol. 300: H1101-H1107. doi:10.1152/ajpheart.01115.2010. PMID:21217074.
51. Yeboah, J., Folsom, A.R., Burke, G.L., Johnson, C., Polak, J.F., Post, W., et al. 2009. Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation, 120: 502-509. doi:10.1161/CIRCULATIONAHA.109.864801. PMID:19635967.